LOCUS       NM_022036               1813 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens G protein-coupled receptor class C group 5 member C
            (GPRC5C), transcript variant 1, mRNA.
ACCESSION   NM_022036
VERSION     NM_022036.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1813)
  AUTHORS   Zhang,Y.W., Velasco-Hernandez,T., Mess,J., Lalioti,M.E.,
            Romero-Mulero,M.C., Obier,N., Karantzelis,N., Rettkowski,J.,
            Schonberger,K., Karabacz,N., Jacklein,K., Morishima,T.,
            Trincado,J.L., Romecin,P., Martinez,A., Takizawa,H.,
            Shoumariyeh,K., Renders,S., Zeiser,R., Pahl,H.L., Beliveau,F.,
            Hebert,J., Lehnertz,B., Sauvageau,G., Menendez,P. and
            Cabezas-Wallscheid,N.
  TITLE     GPRC5C drives branched-chain amino acid metabolism in
            leukemogenesis
  JOURNAL   Blood Adv 7 (24), 7525-7538 (2023)
   PUBMED   37639313
  REMARK    GeneRIF: GPRC5C drives branched-chain amino acid metabolism in
            leukemogenesis.
REFERENCE   2  (bases 1 to 1813)
  AUTHORS   Amisten,S., Mohammad Al-Amily,I., Soni,A., Hawkes,R., Atanes,P.,
            Persaud,S.J., Rorsman,P. and Salehi,A.
  TITLE     Anti-diabetic action of all-trans retinoic acid and the orphan G
            protein coupled receptor GPRC5C in pancreatic beta-cells
  JOURNAL   Endocr J 64 (3), 325-338 (2017)
   PUBMED   28228611
  REMARK    GeneRIF: Data suggest that agents (such as all-trans retinoic acid)
            that activate GPRC5C restore and/or maintain functional
            insulin-secreting cells; GPRC5C appears to play role in regulation
            of expression of genes controlling apoptosis, cell survival, and
            cell proliferation in insulin-secreting cells.
REFERENCE   3  (bases 1 to 1813)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   4  (bases 1 to 1813)
  AUTHORS   Kesimer,M., Scull,M., Brighton,B., DeMaria,G., Burns,K., O'Neal,W.,
            Pickles,R.J. and Sheehan,J.K.
  TITLE     Characterization of exosome-like vesicles released from human
            tracheobronchial ciliated epithelium: a possible role in innate
            defense
  JOURNAL   FASEB J 23 (6), 1858-1868 (2009)
   PUBMED   19190083
REFERENCE   5  (bases 1 to 1813)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 1813)
  AUTHORS   Lehner,B., Semple,J.I., Brown,S.E., Counsell,D., Campbell,R.D. and
            Sanderson,C.M.
  TITLE     Analysis of a high-throughput yeast two-hybrid system and its use
            to predict the function of intracellular proteins encoded within
            the human MHC class III region
  JOURNAL   Genomics 83 (1), 153-167 (2004)
   PUBMED   14667819
REFERENCE   7  (bases 1 to 1813)
  AUTHORS   Brauner-Osborne,H., Jensen,A.A., Sheppard,P.O., Brodin,B.,
            Krogsgaard-Larsen,P. and O'Hara,P.
  TITLE     Cloning and characterization of a human orphan family C G-protein
            coupled receptor GPRC5D
  JOURNAL   Biochim Biophys Acta 1518 (3), 237-248 (2001)
   PUBMED   11311935
REFERENCE   8  (bases 1 to 1813)
  AUTHORS   Robbins,M.J., Michalovich,D., Hill,J., Calver,A.R., Medhurst,A.D.,
            Gloger,I., Sims,M., Middlemiss,D.N. and Pangalos,M.N.
  TITLE     Molecular cloning and characterization of two novel retinoic
            acid-inducible orphan G-protein-coupled receptors (GPRC5B and
            GPRC5C)
  JOURNAL   Genomics 67 (1), 8-18 (2000)
   PUBMED   10945465
REFERENCE   9  (bases 1 to 1813)
  AUTHORS   Brauner-Osborne,H. and Krogsgaard-Larsen,P.
  TITLE     Sequence and expression pattern of a novel human orphan
            G-protein-coupled receptor, GPRC5B, a family C receptor with a
            short amino-terminal domain
  JOURNAL   Genomics 65 (2), 121-128 (2000)
   PUBMED   10783259
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079325.10.
            
            On May 17, 2019 this sequence version replaced NM_022036.3.
            
            Summary: The protein encoded by this gene is a member of the type 3
            G protein-coupled receptor family. Members of this superfamily are
            characterized by a signature 7-transmembrane domain motif. The
            specific function of this protein is unknown; however, this protein
            may mediate the cellular effects of retinoic acid on the G protein
            signal transduction cascade. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes isoform a. Variants 1,
            2 and 4 encode isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110848.1, AK222909.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392627.7/ ENSP00000376403.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AC079325.10        164021-164074       c
            55-1137             AC079325.10        155335-156417       c
            1138-1232           AC079325.10        152250-152344       c
            1233-1813           AC079325.10        148733-149313       c
FEATURES             Location/Qualifiers
     source          1..1813
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..1813
                     /gene="GPRC5C"
                     /gene_synonym="RAIG-3; RAIG3"
                     /note="G protein-coupled receptor class C group 5 member
                     C"
                     /db_xref="GeneID:55890"
                     /db_xref="HGNC:HGNC:13309"
                     /db_xref="MIM:605949"
     exon            1..54
                     /gene="GPRC5C"
                     /gene_synonym="RAIG-3; RAIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            55..1137
                     /gene="GPRC5C"
                     /gene_synonym="RAIG-3; RAIG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1412
                     /gene="GPRC5C"
                     /gene_synonym="RAIG-3; RAIG3"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; retinoic acid responsive gene protein; orphan
                     G-protein coupled receptor; G-protein coupled receptor
                     family C group 5 member C; retinoic acid-induced gene 3
                     protein"
                     /codon_start=1
                     /product="G-protein coupled receptor family C group 5
                     member C isoform a precursor"
                     /protein_id="NP_071319.3"
                     /db_xref="CCDS:CCDS11699.2"
                     /db_xref="GeneID:55890"
                     /db_xref="HGNC:HGNC:13309"
                     /db_xref="MIM:605949"
                     /translation="MAIHKALVMCLGLPLFLFPGAWAQGHVPPGCSQGLNPLYYNLCD
                     RSGAWGIVLEAVAGAGIVTTFVLTIILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFC
                     LVFACVVKPDFSTCASRRFLFGVLFAICFSCLAAHVFALNFLARKNHGPRGWVIFTVA
                     LLLTLVEVIINTEWLIITLVRGSGEGGPQGNSSAGWAVASPCAIANMDFVMALIYVML
                     LLLGAFLGAWPALCGRYKRWRKHGVFVLLTTATSVAIWVVWIVMYTYGNKQHNSPTWD
                     DPTLAIALAANAWAFVLFYVIPEVSQVTKSSPEQSYQGDMYPTRGVGYETILKEQKGQ
                     SMFVENKAFSMDEPVAAKRPVSPYSGYNGQLLTSVYQPTEMALMHKVPSEGAYDIILP
                     RATANSQVMGSANSTLRAEDMYSAQSHQAATPPKDGKNSQVFRNPYVWD"
     exon            1138..1232
                     /gene="GPRC5C"
                     /gene_synonym="RAIG-3; RAIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1813
                     /gene="GPRC5C"
                     /gene_synonym="RAIG-3; RAIG3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1793..1798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPRC5C"
                     /gene_synonym="RAIG-3; RAIG3"
                     /note="hexamer: AATACA"
     polyA_site      1813
                     /gene="GPRC5C"
                     /gene_synonym="RAIG-3; RAIG3"
                     /note="major polyA site"
ORIGIN      
        1 agaaactccc atctccctca ccagccggaa agtacgagtc ggctcagcct ggagggaccc
       61 aaccagagcc tggcctggga gccaggatgg ccatccacaa agccttggtg atgtgcctgg
      121 gactgcctct cttcctgttc ccaggggcct gggcccaggg ccatgtccca cccggctgca
      181 gccaaggcct caaccccctg tactacaacc tgtgtgaccg ctctggggcg tggggcatcg
      241 tcctggaggc cgtggctggg gcgggcattg tcaccacgtt tgtgctcacc atcatcctgg
      301 tggccagcct cccctttgtg caggacacca agaaacggag cctgctgggg acccaggtat
      361 tcttccttct ggggaccctg ggcctcttct gcctcgtgtt tgcctgtgtg gtgaagcccg
      421 acttctccac ctgtgcctct cggcgcttcc tctttggggt tctgttcgcc atctgcttct
      481 cttgtctggc ggctcacgtc tttgccctca acttcctggc ccggaagaac cacgggcccc
      541 ggggctgggt gatcttcact gtggctctgc tgctgaccct ggtagaggtc atcatcaata
      601 cagagtggct gatcatcacc ctggttcggg gcagtggcga gggcggccct cagggcaaca
      661 gcagcgcagg ctgggccgtg gcctccccct gtgccatcgc caacatggac tttgtcatgg
      721 cactcatcta cgtcatgctg ctgctgctgg gtgccttcct gggggcctgg cccgccctgt
      781 gtggccgcta caagcgctgg cgtaagcatg gggtctttgt gctcctcacc acagccacct
      841 ccgttgccat atgggtggtg tggatcgtca tgtatactta cggcaacaag cagcacaaca
      901 gtcccacctg ggatgacccc acgctggcca tcgccctcgc cgccaatgcc tgggccttcg
      961 tcctcttcta cgtcatcccc gaggtctccc aggtgaccaa gtccagccca gagcaaagct
     1021 accaggggga catgtacccc acccggggcg tgggctatga gaccatcctg aaagagcaga
     1081 agggtcagag catgttcgtg gagaacaagg ccttttccat ggatgagccg gttgcagcta
     1141 agaggccggt gtcaccatac agcgggtaca atgggcagct gctgaccagt gtgtaccagc
     1201 ccactgagat ggccctgatg cacaaagttc cgtccgaagg agcttacgac atcatcctcc
     1261 cacgggccac cgccaacagc caggtgatgg gcagtgccaa ctcgaccctg cgggctgaag
     1321 acatgtactc ggcccagagc caccaggcgg ccacaccgcc gaaagacggc aagaactctc
     1381 aggtctttag aaacccctac gtgtgggact gagtcagcgg tggcgaggag aggcgggcgg
     1441 atttggggag ggccctgagg acctggcccc gggcaaggga ctctccaggc tcctcctccc
     1501 cctggcaggc ccagcaacat gtgccccaga tctggaaggg cctccctctc tgccagtgtt
     1561 tgggtgggtg tcatgggtgt ccccacccac tcctcagtgt ttgtggagtc gaggagccaa
     1621 ccccagcctc ctgccaggat cacctcggcg gtcacactcc agccaaatag tgttctcggg
     1681 gtggtggctg ggcagcgcct atgtttctct ggagattcct gcaacctcaa gagacttccc
     1741 aggcgctcag gcctggatct tgctcctctg tgaggaacaa gggtgcctaa taaatacatt
     1801 tctgctttat taa
//
