LOCUS       NM_003979               6582 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens G protein-coupled receptor class C group 5 member A
            (GPRC5A), mRNA.
ACCESSION   NM_003979
VERSION     NM_003979.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6582)
  AUTHORS   Yang,J., Li,X., Chen,S., Li,G., Pu,P., Yang,Y., Wu,W., Geng,Y. and
            Liu,Y.
  TITLE     GPRC5A promotes gallbladder cancer metastasis by upregulating TNS4
            via the JAK2-STAT3 pathway
  JOURNAL   Cancer Lett 598, 217067 (2024)
   PUBMED   38942137
  REMARK    GeneRIF: GPRC5A promotes gallbladder cancer metastasis by
            upregulating TNS4 via the JAK2-STAT3 pathway.
REFERENCE   2  (bases 1 to 6582)
  AUTHORS   Wang,Y., Gao,L., Wang,F., Yu,C., Chen,C. and Xia,C.
  TITLE     GPRC5A promotes paclitaxel resistance and glucose content in NSCLC
  JOURNAL   Anticancer Drugs 35 (7), 606-614 (2024)
   PUBMED   38602327
  REMARK    GeneRIF: GPRC5A promotes paclitaxel resistance and glucose content
            in NSCLC.
REFERENCE   3  (bases 1 to 6582)
  AUTHORS   Hu,Y.H., Shang,L.L. and Ge,S.H.
  TITLE     [Inhibitory effect of downregulating G protein-coupled receptor
            class C group 5 member A expression on lipopolysaccharide-induced
            inflammatory response in human gingival fibroblasts]
  JOURNAL   Zhonghua Kou Qiang Yi Xue Za Zhi 59 (4), 344-353 (2024)
   PUBMED   38548591
  REMARK    GeneRIF: [Inhibitory effect of downregulating G protein-coupled
            receptor class C group 5 member A expression on
            lipopolysaccharide-induced inflammatory response in human gingival
            fibroblasts].
REFERENCE   4  (bases 1 to 6582)
  AUTHORS   Wu,Y., He,B., Hua,J., Hu,W., Han,Y. and Zhang,J.
  TITLE     Deciphering the molecular regulatory of RAB32/GPRC5A axis in
            chronic obstructive pulmonary disease
  JOURNAL   Respir Res 25 (1), 116 (2024)
   PUBMED   38448858
  REMARK    GeneRIF: Deciphering the molecular regulatory of RAB32/GPRC5A axis
            in chronic obstructive pulmonary disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6582)
  AUTHORS   Li,Y., Cui,W.W., Yang,Z.F., Liu,W.H., Bian,M.W., Deng,J. and
            Wang,T.
  TITLE     Influence of GPRC5A-Regulated ABCB1 Expression on Lung
            Adenocarcinoma Proliferation
  JOURNAL   Chin Med Sci J 39 (1), 9-18 (2024)
   PUBMED   38426412
  REMARK    GeneRIF: Influence of GPRC5A-Regulated ABCB1 Expression on Lung
            Adenocarcinoma Proliferation.
REFERENCE   6  (bases 1 to 6582)
  AUTHORS   Tao,Q., Cheng,Y., Clifford,J. and Lotan,R.
  TITLE     Characterization of the murine orphan G-protein-coupled receptor
            gene Rai3 and its regulation by retinoic acid
  JOURNAL   Genomics 83 (2), 270-280 (2004)
   PUBMED   14706456
REFERENCE   7  (bases 1 to 6582)
  AUTHORS   Robbins,M.J., Michalovich,D., Hill,J., Calver,A.R., Medhurst,A.D.,
            Gloger,I., Sims,M., Middlemiss,D.N. and Pangalos,M.N.
  TITLE     Molecular cloning and characterization of two novel retinoic
            acid-inducible orphan G-protein-coupled receptors (GPRC5B and
            GPRC5C)
  JOURNAL   Genomics 67 (1), 8-18 (2000)
   PUBMED   10945465
REFERENCE   8  (bases 1 to 6582)
  AUTHORS   Brauner-Osborne,H. and Krogsgaard-Larsen,P.
  TITLE     Sequence and expression pattern of a novel human orphan
            G-protein-coupled receptor, GPRC5B, a family C receptor with a
            short amino-terminal domain
  JOURNAL   Genomics 65 (2), 121-128 (2000)
   PUBMED   10783259
REFERENCE   9  (bases 1 to 6582)
  AUTHORS   Cheng,Y. and Lotan,R.
  TITLE     Molecular cloning and characterization of a novel retinoic
            acid-inducible gene that encodes a putative G protein-coupled
            receptor
  JOURNAL   J Biol Chem 273 (52), 35008-35015 (1998)
   PUBMED   9857033
REFERENCE   10 (bases 1 to 6582)
  AUTHORS   Cafferata,E.G., Gonzalez-Guerrico,A.M., Pivetta,O.H. and
            Santa-Coloma,T.A.
  TITLE     Identification by differential display of a mRNA specifically
            induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human
            colon carcinoma cells
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 42 (5), 797-804 (1996)
   PUBMED   8832110
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK122672.1, AF095448.1,
            AI587426.1 and AC007688.15.
            
            On Aug 14, 2019 this sequence version replaced NM_003979.3.
            
            Summary: This gene encodes a member of the type 3 G
            protein-coupling receptor family, characterized by the signature
            7-transmembrane domain motif. The encoded protein may be involved
            in interaction between retinoid acid and G protein signalling
            pathways. Retinoic acid plays a critical role in development,
            cellular growth, and differentiation. This gene may play a role in
            embryonic development and epithelial cell differentiation.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.6587.1,
                                           SRR11853562.6909.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000014914.6/ ENSP00000014914.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AK122672.1         781-791
            12-2300             AF095448.1         1-2289
            2301-2311           AI587426.1         6-16                c
            2312-6582           AC007688.15        89457-93727         c
FEATURES             Location/Qualifiers
     source          1..6582
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.1"
     gene            1..6582
                     /gene="GPRC5A"
                     /gene_synonym="GPCR5A; PEIG-1; RAI3; RAIG1; TIG1"
                     /note="G protein-coupled receptor class C group 5 member
                     A"
                     /db_xref="GeneID:9052"
                     /db_xref="HGNC:HGNC:9836"
                     /db_xref="MIM:604138"
     exon            1..103
                     /gene="GPRC5A"
                     /gene_synonym="GPCR5A; PEIG-1; RAI3; RAIG1; TIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            104..1032
                     /gene="GPRC5A"
                     /gene_synonym="GPCR5A; PEIG-1; RAI3; RAIG1; TIG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1184
                     /gene="GPRC5A"
                     /gene_synonym="GPCR5A; PEIG-1; RAI3; RAIG1; TIG1"
                     /note="retinoic acid responsive; retinoic acid induced 3;
                     retinoic acid-induced gene 1 protein; phorbol ester
                     induced protein-1; TPA induced gene 1; orphan
                     G-protein-coupling receptor PEIG-1; G-protein coupled
                     receptor family C group 5 member A; phorbol ester induced
                     gene 1"
                     /codon_start=1
                     /product="retinoic acid-induced protein 3"
                     /protein_id="NP_003970.1"
                     /db_xref="CCDS:CCDS8657.1"
                     /db_xref="GeneID:9052"
                     /db_xref="HGNC:HGNC:9836"
                     /db_xref="MIM:604138"
                     /translation="MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVA
                     FMLTLPILVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFG
                     ILFSICFSCLLAHAVSLTKLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRT
                     NVNVFSELSAPRRNEDFVLLLTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLTML
                     LSIAIWVAWITLLMLPDFDRRWDDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMD
                     YPVEDAFCKPQLVKKSYGVENRAYSQEEITQGFEETGDTLYAPYSTHFQLQNQPPQKE
                     FSIPRAHAWPSPYKDYEVKKEGS"
     exon            1033..1091
                     /gene="GPRC5A"
                     /gene_synonym="GPCR5A; PEIG-1; RAI3; RAIG1; TIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..6582
                     /gene="GPRC5A"
                     /gene_synonym="GPCR5A; PEIG-1; RAI3; RAIG1; TIG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6563..6568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPRC5A"
                     /gene_synonym="GPCR5A; PEIG-1; RAI3; RAIG1; TIG1"
                     /note="hexamer: AATAAA"
     polyA_site      6582
                     /gene="GPRC5A"
                     /gene_synonym="GPCR5A; PEIG-1; RAI3; RAIG1; TIG1"
                     /note="major polyA site"
ORIGIN      
        1 gggatagctg tccaaggtct cccccagcac tgaggagctc gcctgctgcc ctcttgcgcg
       61 cgggaagcag caccaagttc acggccaacg ccttggcact agggtccaga atggctacaa
      121 cagtccctga tggttgccgc aatggcctga aatccaagta ctacagactt tgtgataagg
      181 ctgaagcttg gggcatcgtc ctagaaacgg tggccacagc cggggttgtg acctcggtgg
      241 ccttcatgct cactctcccg atcctcgtct gcaaggtgca ggactccaac aggcgaaaaa
      301 tgctgcctac tcagtttctc ttcctcctgg gtgtgttggg catctttggc ctcaccttcg
      361 ccttcatcat cggactggac gggagcacag ggcccacacg cttcttcctc tttgggatcc
      421 tcttttccat ctgcttctcc tgcctgctgg ctcatgctgt cagtctgacc aagctcgtcc
      481 gggggaggaa gcccctttcc ctgttggtga ttctgggtct ggccgtgggc ttcagcctag
      541 tccaggatgt tatcgctatt gaatatattg tcctgaccat gaataggacc aacgtcaatg
      601 tcttttctga gctttccgct cctcgtcgca atgaagactt tgtcctcctg ctcacctacg
      661 tcctcttctt gatggcgctg accttcctca tgtcctcctt caccttctgt ggttccttca
      721 cgggctggaa gagacatggg gcccacatct acctcacgat gctcctctcc attgccatct
      781 gggtggcctg gatcaccctg ctcatgcttc ctgactttga ccgcaggtgg gatgacacca
      841 tcctcagctc cgccttggct gccaatggct gggtgttcct gttggcttat gttagtcccg
      901 agttttggct gctcacaaag caacgaaacc ccatggatta tcctgttgag gatgctttct
      961 gtaaacctca actcgtgaag aagagctatg gtgtggagaa cagagcctac tctcaagagg
     1021 aaatcactca aggttttgaa gagacagggg acacgctcta tgccccctat tccacacatt
     1081 ttcagctgca gaaccagcct ccccaaaagg aattctccat cccacgggcc cacgcttggc
     1141 cgagccctta caaagactat gaagtaaaga aagagggcag ctaactctgt cctgaagagt
     1201 gggacaaatg cagccgggcg gcagatctag cgggagctca aagggatgtg ggcgaaatct
     1261 tgagtcttct gagaaaactg tacaagacac tacgggaaca gtttgcctcc ctcccagcct
     1321 caaccacaat tcttccatgc tggggctgat gtgggctagt aagactccag ttcttagagg
     1381 cgctgtagta tttttttttt tttgtctcat cctttggata cttcttttaa gtgggagtct
     1441 caggcaactc aagtttagac ccttactctt tttgtttgtt ttttgaaaca ggatcttgct
     1501 ctgtcaccca ggcttgagtg cagtggtgcg atcacagccc agtgcagcct cgaccacctg
     1561 tgctcaagca atcctcccat ctccatctcc caaagtgctg ggatgacagg cgtgagccac
     1621 agctcccagc ctaggccctt aatcttgctg ttattttcca tggactaaag gtctggtcat
     1681 ctgagctcac gctggctcac acagctctag gggcctgctc ctctaactca cagtgggttt
     1741 tgtgaggctc tgtggcccag agcagacctg catatctgag caaaaatagc aaaagcctct
     1801 ctcagcccac tggcctgaat ctacactgga agccaacttg ctggcacccc cgctccccaa
     1861 cccttcttgc ctgggtagga gaggctaaag atcaccctaa atttactcat ctctctagtg
     1921 ctgcctcaca ttgggcctca gcagctcccc agcaccaatt cacaggtcac ccctctcttc
     1981 ttgcactgtc cccaaacttg ctgtcaattc cgagatctaa tctcccccta cgctctgcca
     2041 ggaattcttt cagacctcac tagcacaagc ccggttgctc cttgtcagga gaatttgtag
     2101 atcattctca cttcaaattc ctggggctga tacttctctc atcttgcacc ccaacctctg
     2161 taaatagatt taccgcattt acggctgcat tctgtaagtg ggcatggtct cctaatggag
     2221 gagtgttcat tgtataataa gttattcacc tgagtatgca ataaagatgt ggtggccact
     2281 ctttcatggt ggtggcagca gttaccagta atgagcatta gactctgggg gatagaacac
     2341 gggctgccct gagagcttca tgttggagct gaagttcaag gttcacttcc tttgggtttg
     2401 tacttgaccc ttcttcatgt gtctctcccg ttccctctaa aacaagtgtg tttcccctca
     2461 tttttgaggc tgtcaatggt gtgagagcca ggatcatcac ggggcctgag gttttactcc
     2521 agaaaagcag aggagtggca accttggctt ggggtttggc agcccaggaa aggcagggag
     2581 gagagctcaa agccggtttc atgtttcacc caaggtctaa ttgtgggaga ggacaaatcc
     2641 agatcccctg tttgacagaa ttagttcaca aatgtctctt ggcaaaaaca tgtgacacct
     2701 aaccatgata attgacttaa tccaagaaag agctctgtag ggcagagcaa taggaaatct
     2761 ctctttcgtt atggaaaaaa aataatccct ctacatagaa actgagtgac atgtaaaaat
     2821 gtgtagctaa gtcagggagt tacttcctaa gagcctgacg ctctgctttt catcaaaagg
     2881 aaaaaccagc gtgaggcaga ggcgagggag gtggaggtga gtggatgatg tgctgagtta
     2941 gggatgttta tatgccgcaa aggtttggtt ggtaggcttc gcgctaagat tagcctggct
     3001 ttgtactgaa aagggggaag gacacatagt gacacagatc cttctggtct ttcccaggag
     3061 gtgtgaccta atgaggtttg ttgtgagaat aaagcaatgt ggtttcacat atattatcta
     3121 tcataggcta gggactcaag aaatgcatat tcccccccca ctttctttct ctctttcctt
     3181 ccttccttcc tttcttcttt ctttctttct ttctttcttt ctttctttct ttctttcttt
     3241 ctctctctct ctctctctct ctttctttct ttctttttga gatagagtct cactctgtca
     3301 tccaggctgg agtgcagtgg catgatctca gctcactgca gcctccgcat cctgggttca
     3361 agcgattttc gtgcctcggc cttctgagta gctgggatta caggcgtgcg tgcgccacca
     3421 cgcctggcta atttttgtat ttttagtaca gacgaggttt caccatgttg accaggctgg
     3481 tcttgaactc ctgatcttaa gtgatctgcc cgccttggcc tcccaaagtg ctgggattac
     3541 gggtgggaat caccatgccc agcctccttt ccatcttttc tttccttctc tggtcttcat
     3601 actaccaacc aagcaaggga ggaggagtaa aaggtaaaat cacaaaatac tctggatcgg
     3661 catttttttt tttttttttt tttgagacag ggtctagctc tatggcccag gctggagtgc
     3721 agtggcacaa tcatagctca ctgcagcctc aactttctgt gctcgagtga ttctcctgcc
     3781 tcagtctcct gagtagctgg gaccacagac gtgcactacc acacttggct aattttattt
     3841 tttcagagat cacatgtggt ttgagggagg atagagagga cagggtgtca agaacagcat
     3901 ttttaccaag ttgatataaa aatgaaacag gatccaggca tgggtcttta cactgatagt
     3961 tacagtaagt tttaaaatct gagcagcaat ttgaatcact tgttgaaaaa cacacaaaat
     4021 atattttttg tagaggtggg ggtcttgctc tgttgcccag gctggtcttg aactcgagat
     4081 tctcctgctt tggcctccca caagtgctgg gattacaggc gtgagctact gcacccggcc
     4141 tgctttcttt ttagtgaaaa ggatctgtgg gagcttttat tcccatggct gccttcctca
     4201 agtcaacctc tttccccgga aatggcatca tctctggact gttgtttctc cttcttcctt
     4261 ctcctccttc tcctcctcct cctcctccac catgcccggc tgatttttgt atttttagta
     4321 gagacagggt ttcactatat gggccaggca gatctcgaac tccaaacctc gtgatccacc
     4381 taccttggcc tctgaaagtg ctgggatacc gtggcctctg aaagtgctgg gattacaggc
     4441 atgagccacc gcgcccggcc ccgttgtttc ccttctaaga aacgcagtgg tctctgaagc
     4501 ctgcaggggc aggccagccc tgcactgaac gcctgttctt gccaggtggc agaaggttgc
     4561 tgctcatttg agcagtacct gtcacccctc ctcccactgc tgcggctgtt aactcatctt
     4621 caggtctcac accttctgca cataaataag ctatttttaa aagttattat ttttttactc
     4681 tttcttttct ttggagaggg taccaaagga tagctgttct gtttaagtag ggacctctca
     4741 tggcctacag gctttgacat ctgagaatca aactggagaa cattccgaag ccgttcttat
     4801 aagtgtctcc atctctacct gggctgaaat ggaatgtgca aatgtagccc agcctggtcc
     4861 ttgggtgttg ccagttgatt gatgactggg agccaaagtg gcatctcctt tgacctaaac
     4921 gggcgatgat gaaataaaac tcaacagcct ttctctcatc ttgcattgtg agatgcgaaa
     4981 tagagcgtgt ctctctgcct ctcattttag gctgaggccg tccaaagcgg ccatgcccca
     5041 tgtttccact agatggcgct gacacttcag gcatcaaccc tcatggcctc tcagccttgc
     5101 aaaggcagcc acttaaagtc ggtgtcctgt gtggggcacc aagctgagct gcagacaccc
     5161 agtaggcgcg aggcaaatgc gtcccatttt aagaggcttg tatttatgag ctctttgctt
     5221 cctccctccc actaacttta aagaattgct ctccatctcc tttggcaaag ttcctttgcc
     5281 ctttgtctta tttttgtgaa accctccaag gtatttccag tccatttgca tccaatctgg
     5341 catctttacg gagagcggtc tcatatgcta ttgttgttaa cgtggactag tatttatgtg
     5401 ttgagaacac tggctgtttg tcaggaaaag tgtgccaaaa caaagagtac ggccggccct
     5461 ggaaatgcat cagcaaaacc catttccccc gtgcactcat tctgagcttc cttccttcat
     5521 ttctgtcatt actgctgaga actggactgt gcccagctga cctttccctt ccttgccctc
     5581 atcttgctgc cagggtctgc aggtttgcca ccgtcccggc cccagtctga aacatgggat
     5641 tatttcagaa ttggaggtgg cagcttcaga aaaaaatcct tctcgtgtgt tgactgctga
     5701 gatccaggaa ctgggaaatc aacccccagt ttgtagattg ctctctttgg aaattctgtg
     5761 gcccaacctc gtggctgttt tctggaattc cttctatcgg ggcagacagt gctgtgcctt
     5821 tcttgacttc aggatgttcc aaggatgctg ctggatctgt gtgtgtgtgt gtgtgtgtgt
     5881 gtgtgtgtgt gtgtgtgcgt gcgtgcgtgt atgtgcgcct gaccctgatt tctgcaacct
     5941 ccagatttct ttcttgaccc ttcaaagtgg aacagtccag tgccaaaaat tttagagttt
     6001 gagaaggtca cagaaatcct ctagttggtg cctccacagt cttcatttta cagaggaact
     6061 cagggctaat ggagttaatg caactagatc agggttttgg gtctgtgttc tttctaccgt
     6121 cagcacctgt gtggtcaatt ctggacactt cccagagaag tctttgagta gagaatccta
     6181 ctcaaatttc actgtatatt ttaagcattc ctctcctttc cctttgcctc ccctgttgcc
     6241 ttttcttccc ctgatttctc ctctggtcat ctcctctccc ttctgcgtgt aagccatggg
     6301 aaagggatga gggaggacag cttctggtta aacacaggtc cctcttccac atcaaatgaa
     6361 cattggcttc ctgggacaga aggccttcaa aggagggatt gcaaagcaag gcaaagcgtt
     6421 ctgtcttcat tttccccatc cccatgagac aagactgatg gaaagggtgg tggggcaaca
     6481 ctgcttaatg gatgcctttt cacatcattt cagtttttag ccctcatgac tgtattttct
     6541 aatcagagac aataacattt taaataaaac aacgacaaag aa
//
