LOCUS       NM_001004051            3536 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens G protein-coupled receptor associated sorting protein
            2 (GPRASP2), transcript variant 1, mRNA.
ACCESSION   NM_001004051
VERSION     NM_001004051.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3536)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3536)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3536)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3536)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3536)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3536)
  AUTHORS   Piton,A., Gauthier,J., Hamdan,F.F., Lafreniere,R.G., Yang,Y.,
            Henrion,E., Laurent,S., Noreau,A., Thibodeau,P., Karemera,L.,
            Spiegelman,D., Kuku,F., Duguay,J., Destroismaisons,L., Jolivet,P.,
            Cote,M., Lachapelle,K., Diallo,O., Raymond,A., Marineau,C.,
            Champagne,N., Xiong,L., Gaspar,C., Riviere,J.B., Tarabeux,J.,
            Cossette,P., Krebs,M.O., Rapoport,J.L., Addington,A., Delisi,L.E.,
            Mottron,L., Joober,R., Fombonne,E., Drapeau,P. and Rouleau,G.A.
  TITLE     Systematic resequencing of X-chromosome synaptic genes in autism
            spectrum disorder and schizophrenia
  JOURNAL   Mol Psychiatry 16 (8), 867-880 (2011)
   PUBMED   20479760
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3536)
  AUTHORS   Horn,S.C., Lalowski,M., Goehler,H., Droge,A., Wanker,E.E. and
            Stelzl,U.
  TITLE     Huntingtin interacts with the receptor sorting family protein GASP2
  JOURNAL   J Neural Transm (Vienna) 113 (8), 1081-1090 (2006)
   PUBMED   16835690
  REMARK    GeneRIF: that huntingtin protein and GASP2 form a complex in
            cotransfected mammalian cells
REFERENCE   8  (bases 1 to 3536)
  AUTHORS   Winter,E.E. and Ponting,C.P.
  TITLE     Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism
            sustained by gene conversion events
  JOURNAL   BMC Evol Biol 5, 54 (2005)
   PUBMED   16221301
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3536)
  AUTHORS   Goehler,H., Lalowski,M., Stelzl,U., Waelter,S., Stroedicke,M.,
            Worm,U., Droege,A., Lindenberg,K.S., Knoblich,M., Haenig,C.,
            Herbst,M., Suopanki,J., Scherzinger,E., Abraham,C., Bauer,B.,
            Hasenbank,R., Fritzsche,A., Ludewig,A.H., Bussow,K., Coleman,S.H.,
            Gutekunst,C.A., Landwehrmeyer,B.G., Lehrach,H. and Wanker,E.E.
  TITLE     A protein interaction network links GIT1, an enhancer of huntingtin
            aggregation, to Huntington's disease
  JOURNAL   Mol Cell 15 (6), 853-865 (2004)
   PUBMED   15383276
  REMARK    Erratum:[Mol Cell. 2005 Jul 22;19(2):287. Buessow, Konrad
            [corrected to Bussow, Konrad]]
REFERENCE   10 (bases 1 to 3536)
  AUTHORS   Simonin,F., Karcher,P., Boeuf,J.J., Matifas,A. and Kieffer,B.L.
  TITLE     Identification of a novel family of G protein-coupled receptor
            associated sorting proteins
  JOURNAL   J Neurochem 89 (3), 766-775 (2004)
   PUBMED   15086532
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK123832.1, AL522674.3 and
            BC051707.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001004051.3.
            
            Summary: The protein encoded by this gene is a member of a family
            that regulates the activity of G protein-coupled receptors (GPCRs).
            The encoded protein has been shown to be capable of interacting
            with several GPCRs, including the M1 muscarinic acetylcholine
            receptor and the calcitonin receptor. Several transcript variants
            encoding the same protein have been found for this gene. [provided
            by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 3. All five variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.107159.1,
                                           SRR1660809.197059.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000483720.7/ ENSP00000507692.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AK123832.1         273-285
            14-893              AL522674.3         1-880
            894-2756            BC051707.1         1556-3418
            2757-3535           AK123832.1         2941-3719
            3536-3536           BC051707.1         4198-4198
FEATURES             Location/Qualifiers
     source          1..3536
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..3536
                     /gene="GPRASP2"
                     /gene_synonym="DFNX7; GASP2"
                     /note="G protein-coupled receptor associated sorting
                     protein 2"
                     /db_xref="GeneID:114928"
                     /db_xref="HGNC:HGNC:25169"
                     /db_xref="MIM:300969"
     exon            1..105
                     /gene="GPRASP2"
                     /gene_synonym="DFNX7; GASP2"
                     /inference="alignment:Splign:2.1.0"
     exon            106..193
                     /gene="GPRASP2"
                     /gene_synonym="DFNX7; GASP2"
                     /inference="alignment:Splign:2.1.0"
     exon            194..261
                     /gene="GPRASP2"
                     /gene_synonym="DFNX7; GASP2"
                     /inference="alignment:Splign:2.1.0"
     exon            262..339
                     /gene="GPRASP2"
                     /gene_synonym="DFNX7; GASP2"
                     /inference="alignment:Splign:2.1.0"
     exon            340..3536
                     /gene="GPRASP2"
                     /gene_synonym="DFNX7; GASP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             673..3189
                     /gene="GPRASP2"
                     /gene_synonym="DFNX7; GASP2"
                     /codon_start=1
                     /product="G-protein coupled receptor-associated sorting
                     protein 2"
                     /protein_id="NP_001004051.1"
                     /db_xref="GeneID:114928"
                     /db_xref="HGNC:HGNC:25169"
                     /db_xref="MIM:300969"
                     /translation="MTGAEIEPSAQAKPEKKAGEEVIAGPERENDVPLVVRPKVRTQA
                     TTGARPKTETKSVPAARPKTEAQAMSGARPKTEVQVMGGARPKTEAQGITGARPKTDA
                     RAVGGARSKTDAKAIPGARPKDEAQAWAQSEFGTEAVSQAEGVSQTNAVAWPLATAES
                     GSVTKSKGLSMDRELVNVDAETFPGTQGQKGIQPWFGPGEETNMGSWCYSRPRAREEA
                     SNESGFWSADETSTASSFWTGEETSVRSWPREESNTRSRHRAKHQTNPRSRPRSKQEA
                     YVDSWSGSEDEASNPFSFWVGENTNNLFRPRVREEANIRSKLRTNREDCFESESEDEF
                     YKQSWVLPGEEANSRFRHRDKEDPNTALKLRAQKDVDSDRVKQEPRFEEEVIIGSWFW
                     AEKEASLEGGASAICESEPGTEEGAIGGSAYWAEEKSSLGAVAREEAKPESEEEAIFG
                     SWFWDRDEACFDLNPCPVYKVSDRFRDAAEELNASSRPQTWDEVTVEFKPGLFHGVGF
                     RSTSPFGIPEEASEMLEAKPKNLELSPEGEEQESLLQPDQPSPEFTFQYDPSYRSVRE
                     IREHLRARESAESESWSCSCIQCELKIGSEEFEEFLLLMDKIRDPFIHEISKIAMGMR
                     SASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIHMAPPYPNLNMIETFICQV
                     CEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGFLSLLTTANARTKFHVLK
                     MLLNLSENPAVAKKLFSAKALSIFVGLFNIEETNDNIQIVIKMFQNISNIIKSGKMSL
                     IDDDFSLEPLISAFREFEELAKQLQAQIDNQNDPEVGQQS"
     regulatory      3511..3516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPRASP2"
                     /gene_synonym="DFNX7; GASP2"
                     /note="hexamer: AATAAA"
     polyA_site      3536
                     /gene="GPRASP2"
                     /gene_synonym="DFNX7; GASP2"
                     /note="major polyA site"
ORIGIN      
        1 gtctttcccg ttcggatcgc ggggaaagca gtggctccaa gtgagccaga ggagagctga
       61 ggagaggagg gggaggccga cgacctgggc cctgggcctc tgaaggtctg gcgtattctg
      121 acaggacaca gtgagcgtct gtagaggaga ggcttgaaat aaaggagcac gaatattgcc
      181 tggatttctg gaggcctact ttaaggctgg ccaattctgc aagaaaggca aggaggagga
      241 gactggctca cagctctgga ggaccccctt ctgtcagctg tggggcttga caccacttga
      301 acaagaaaag gagggggaaa ctgcaccaca tcagtgaaga tccacctcca gtggctgctc
      361 tgctggtggt ggagttgctg ctgacaacca ccctcaacgg gtctgcaccc atccaggaaa
      421 tatctgtctt cctttagctt ggttgtacct gttctcactc tatctgtatt attgaattat
      481 tgactgagac tgtgtttggg aaggaggctg agtgactact ggactggata ttgactctaa
      541 ctcttattcc caagcttata tccttaatca cctaaagatc agagtgtgaa gaaacaaacc
      601 tgtgacagat ctgtggttga ggtttagact acgggaggag tatattacct gactttcttt
      661 gtaacttgta ccatgactgg ggcagagatt gagcctagtg cccaggccaa gcctgaaaag
      721 aaggctgggg aagaggttat cgctgggcct gagagagaga atgatgtccc tctggtggtc
      781 agacccaagg ttaggaccca ggcaactact ggggcaaggc ccaaaactga gaccaagtct
      841 gtgcctgcgg caaggcccaa aactgaggcc caagcaatgt ctggggcaag gcccaaaact
      901 gaggtccaag taatgggtgg tgcaagaccc aaaacggagg ctcaaggaat cacaggggcc
      961 aggcccaaaa ccgatgccag ggcagtaggt ggcgctcgtt ctaaaactga tgccaaggca
     1021 atccctggag caaggcccaa ggatgaggcc caggcatggg cccagagtga atttgggact
     1081 gaagcagtgt cacaggcaga aggagtgtcc cagactaatg ccgttgcttg gccactggcc
     1141 actgctgagt ctggatcagt tactaaatct aagggcctgt ctatggatag agaactagtc
     1201 aatgtggatg ctgaaacctt tcctggcacc cagggtcaga aaggaatcca gccctggttt
     1261 ggaccagggg aggagactaa tatggggtct tggtgctatt ccaggcccag ggccagagag
     1321 gaggcctcta atgagtctgg gttctggtca gcagatgaga cctctacagc gtcttctttc
     1381 tggactggag aagagacaag tgtcagatca tggcccaggg aagagtccaa taccaggtcc
     1441 aggcacaggg ctaaacatca gactaatccc aggtccaggc ccagatccaa gcaagaagcc
     1501 tatgttgatt cctggtctgg atctgaggat gaggccagca acccattctc cttctgggtt
     1561 ggagaaaata ccaataactt gttcaggccc agagtcaggg aggaggcaaa tatcaggtcc
     1621 aagctcagga caaatagaga agattgtttt gaatctgagt ctgaagatga gttctataag
     1681 cagtcctggg ttttgcctgg agaagaggcc aatagtagat tcaggcacag agacaaagaa
     1741 gatcctaata ctgccttgaa actcagggcc cagaaagatg ttgacagtga tagggtcaaa
     1801 caagaaccca ggtttgagga ggaagtcatt attgggtcct ggttctgggc agaaaaagag
     1861 gccagtttgg agggtggagc ttcagcaatc tgtgaatctg agccaggaac tgaggagggg
     1921 gccattggcg gatccgcgta ctgggctgag gaaaagtcca gtttgggggc tgtggccaga
     1981 gaagaggcca agccggagtc tgaagaagag gccatatttg ggtcctggtt ctgggacaga
     2041 gatgaggcct gctttgacct aaatccctgt cctgtgtaca aggtcagtga taggttcaga
     2101 gatgcagctg aggagcttaa tgcatcctcc aggccccaaa cctgggacga ggtcactgtt
     2161 gaattcaaac ctggtctttt tcatggggtt ggcttccgat ccacaagccc ctttggaatt
     2221 cccgaagagg cttctgaaat gcttgaggca aagcccaaga acctggaact tagcccagaa
     2281 ggagaagagc aggaatcttt gcttcagcct gatcagccta gtcctgagtt cacatttcag
     2341 tatgatcctt cctaccggtc agtccgggaa attcgagagc atcttagggc cagggagagt
     2401 gcagagtctg agagttggtc ctgcagctgc atacaatgtg agctgaaaat tggttctgaa
     2461 gagtttgaag aattcctttt attaatggac aaaattcggg atccttttat tcatgaaata
     2521 tctaaaattg caatgggtat gagaagtgct tctcaattta cccgagattt cattcgagat
     2581 tcaggtgttg tctcacttat tgaaaccttg cttaattatc catcctctag agttaggaca
     2641 agttttttgg aaaatatgat tcacatggct ccaccttatc caaatctaaa catgattgag
     2701 acattcatat gtcaagtgtg tgaggaaacc cttgcacata gtgtggattc ccttgagcag
     2761 ctgactggaa taaggatgct tagacacctc actatgacta ttgactatca cacactgatt
     2821 gccaactata tgtccgggtt tctctcctta ttaaccacag ccaatgcgag aacgaagttt
     2881 cacgttctga aaatgctatt gaatttgtct gaaaatcctg ctgtggcaaa aaaactattc
     2941 agtgccaaag ctctttcaat atttgtgggt ctctttaaca tagaagagac aaatgataat
     3001 attcaaattg ttattaaaat gtttcagaat atcagtaaca ttataaaaag tggaaagatg
     3061 tccttaattg atgatgattt cagtcttgag ccgcttattt ctgcatttcg tgaatttgag
     3121 gagttagcta agcaactaca agcccaaata gacaaccaaa atgatcctga ggtgggacaa
     3181 caaagttaat atgattaacc acctgccgct gatcagcctt atgttcccaa agagccctga
     3241 gtagtgcttt ggtgttcaca gtctgttttt ttgttgtaac ttatattttt taatgctgat
     3301 gttaactttg tcaaactctt gttttgagct ggatcatttt gtggatgcca aatgaatatc
     3361 aaaactgaaa acacatttgt tgatatttgt cttgctgtcc agattgcggt atttttcagt
     3421 attaagtttt caatgaactg tgtcacctaa gtaagctacc ctgctattcg ttgtttaaat
     3481 atatggttct ctatttgagt ctgtgttttc aataaagttc tatgttaaaa ttggca
//
