LOCUS       NM_016334               2160 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens G protein-coupled receptor 89B (GPR89B), transcript
            variant 1, mRNA.
ACCESSION   NM_016334 XM_001133713
VERSION     NM_016334.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2160)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2160)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2160)
  AUTHORS   Maeda,Y., Ide,T., Koike,M., Uchiyama,Y. and Kinoshita,T.
  TITLE     GPHR is a novel anion channel critical for acidification and
            functions of the Golgi apparatus
  JOURNAL   Nat Cell Biol 10 (10), 1135-1145 (2008)
   PUBMED   18794847
REFERENCE   4  (bases 1 to 2160)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   5  (bases 1 to 2160)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL133020.1, U78723.1, AW137222.1 and AW002571.1.
            
            On May 17, 2019 this sequence version replaced NM_016334.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1 and 2 encode the same protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.919987.1,
                                           SRR1660803.151153.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314163.12/ ENSP00000358233.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-844               AL133020.1         12-855
            845-1799            U78723.1           831-1785
            1800-2143           AW137222.1         34-377              c
            2144-2144           AW002571.1         21-21               c
            2145-2160           AW137222.1         17-32               c
FEATURES             Location/Qualifiers
     source          1..2160
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..2160
                     /gene="GPR89B"
                     /gene_synonym="GPHR; GPR89; GPR89C; LINC02804; SH120;
                     UNQ192"
                     /note="G protein-coupled receptor 89B"
                     /db_xref="GeneID:51463"
                     /db_xref="HGNC:HGNC:13840"
                     /db_xref="MIM:612806"
     exon            1..159
                     /gene="GPR89B"
                     /gene_synonym="GPHR; GPR89; GPR89C; LINC02804; SH120;
                     UNQ192"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1485
                     /gene="GPR89B"
                     /gene_synonym="GPHR; GPR89; GPR89C; LINC02804; SH120;
                     UNQ192"
                     /note="isoform 1 is encoded by transcript variant 1; Golgi
                     pH regulator B; protein GPR89; Golgi pH regulator A;
                     putative MAPK-activating protein PM01; putative
                     NF-kappa-B-activating protein 90; G protein-coupled
                     receptor 89C; putative Golgi pH regulator C; putative
                     protein GPR89C; long intergenic non-protein coding RNA
                     2804"
                     /codon_start=1
                     /product="Golgi pH regulator B isoform 1"
                     /protein_id="NP_057418.1"
                     /db_xref="CCDS:CCDS930.1"
                     /db_xref="GeneID:51463"
                     /db_xref="HGNC:HGNC:13840"
                     /db_xref="MIM:612806"
                     /translation="MSFLIDSSIMITSQILFFGFGWLFFMRQLFKDYEIRQYVVQVIF
                     SVTFAFSCTMFELIIFEILGVLNSSSRYFHWKMNLCVILLILVFMVPFYIGYFIVSNI
                     RLLHKQRLLFSCLLWLTFMYFFWKLGDPFPILSPKHGILSIEQLISRVGVIGVTLMAL
                     LSGFGAVNCPYTYMSYFLRNVTDTDILALERRLLQTMDMIISKKKRMAMARRTMFQKG
                     EVHNKPSGFWGMIKSVTTSASGSENLTLIQQEVDALEELSRQLFLETADLYATKERIE
                     YSKTFKGKYFNFLGYFFSIYCVWKIFMATINIVFDRVGKTDPVTRGIEITVNYLGIQF
                     DVKFWSQHISFILVGIIIVTSIRGLLITLTKFFYAISSSKSSNVIVLLLAQIMGMYFV
                     SSVLLIRMSMPLEYRTIITEVLGELQFNFYHRWFDVIFLVSALSSILFLYLAHKQAPE
                     KQMAP"
     exon            160..219
                     /gene="GPR89B"
                     /gene_synonym="GPHR; GPR89; GPR89C; LINC02804; SH120;
                     UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            220..323
                     /gene="GPR89B"
                     /gene_synonym="GPHR; GPR89; GPR89C; LINC02804; SH120;
                     UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            324..430
                     /gene="GPR89B"
                     /gene_synonym="GPHR; GPR89; GPR89C; LINC02804; SH120;
                     UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            431..532
                     /gene="GPR89B"
                     /gene_synonym="GPHR; GPR89; GPR89C; LINC02804; SH120;
                     UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            533..653
                     /gene="GPR89B"
                     /gene_synonym="GPHR; GPR89; GPR89C; LINC02804; SH120;
                     UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            654..734
                     /gene="GPR89B"
                     /gene_synonym="GPHR; GPR89; GPR89C; LINC02804; SH120;
                     UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            735..844
                     /gene="GPR89B"
                     /gene_synonym="GPHR; GPR89; GPR89C; LINC02804; SH120;
                     UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            845..933
                     /gene="GPR89B"
                     /gene_synonym="GPHR; GPR89; GPR89C; LINC02804; SH120;
                     UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1026
                     /gene="GPR89B"
                     /gene_synonym="GPHR; GPR89; GPR89C; LINC02804; SH120;
                     UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1122
                     /gene="GPR89B"
                     /gene_synonym="GPHR; GPR89; GPR89C; LINC02804; SH120;
                     UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1212
                     /gene="GPR89B"
                     /gene_synonym="GPHR; GPR89; GPR89C; LINC02804; SH120;
                     UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1278
                     /gene="GPR89B"
                     /gene_synonym="GPHR; GPR89; GPR89C; LINC02804; SH120;
                     UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..2160
                     /gene="GPR89B"
                     /gene_synonym="GPHR; GPR89; GPR89C; LINC02804; SH120;
                     UNQ192"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2071..2076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR89B"
                     /gene_synonym="GPHR; GPR89; GPR89C; LINC02804; SH120;
                     UNQ192"
                     /note="hexamer: AATAGA"
     polyA_site      2091
                     /gene="GPR89B"
                     /gene_synonym="GPHR; GPR89; GPR89C; LINC02804; SH120;
                     UNQ192"
                     /note="major polyA site"
     regulatory      2136..2141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR89B"
                     /gene_synonym="GPHR; GPR89; GPR89C; LINC02804; SH120;
                     UNQ192"
                     /note="hexamer: ATTATA"
     polyA_site      2160
                     /gene="GPR89B"
                     /gene_synonym="GPHR; GPR89; GPR89C; LINC02804; SH120;
                     UNQ192"
ORIGIN      
        1 gcagtcccgg ctgcagcacc tgggagaagg cagaccgtgt gagggggcct gtggccccag
       61 cgtgctgtgg cctccgggag tgggaagtgg aggcaggagc cttccttaca cttcgccatg
      121 agtttcctga tcgactccag catcatgatt acctcccaga tactattttt tggatttggg
      181 tggcttttct tcatgcgcca attgtttaaa gactatgaga tacgtcagta tgttgtacag
      241 gtgatcttct ccgtgacgtt tgcattttct tgcaccatgt ttgagctcat catctttgaa
      301 atcttaggag tattgaatag cagctcccgt tattttcact ggaaaatgaa cctgtgtgta
      361 attctgctga tcctggtttt catggtgcct ttttacattg gctattttat tgtgagcaat
      421 atccgactac tgcataaaca acgactgctt ttttcctgtc tcttatggct gacctttatg
      481 tatttcttct ggaaactagg agatcccttt cccattctca gcccaaaaca tgggatctta
      541 tccatagaac agctcatcag ccgggttggt gtgattggag tgactctcat ggctcttctt
      601 tctggatttg gtgctgtcaa ctgcccatac acttacatgt cttacttcct caggaatgtg
      661 actgacacgg atattctagc cctggaacgg cgactgctgc aaaccatgga tatgatcata
      721 agcaaaaaga aaaggatggc aatggcacgg agaacaatgt tccagaaggg ggaagtgcat
      781 aacaaaccat caggtttctg gggaatgata aaaagtgtta ccacttcagc atcaggaagt
      841 gaaaatctta ctcttattca acaggaagtg gatgctttgg aagaattaag caggcagctt
      901 tttctggaaa cagctgatct atatgctacc aaggagagaa tagaatactc caaaaccttc
      961 aaggggaaat attttaattt tcttggttac tttttctcta tttactgtgt ttggaaaatt
     1021 ttcatggcta ccatcaatat tgtttttgat cgagttggga aaacggatcc tgtcacaaga
     1081 ggcattgaga tcactgtgaa ttatctggga atccaatttg atgtgaagtt ttggtcccaa
     1141 cacatttcct tcattcttgt tggaataatc atcgtcacat ccatcagagg attgctgatc
     1201 actcttacca agttctttta tgccatctct agcagtaagt cctccaatgt cattgtcctg
     1261 ctattagcac agataatggg catgtacttt gtctcctctg tgctgctgat ccgaatgagt
     1321 atgcctttag aataccgcac cataatcact gaagtccttg gagaactgca gttcaacttc
     1381 tatcaccgtt ggtttgatgt gatcttcctg gtcagcgctc tctctagcat actcttcctc
     1441 tatttggctc acaaacaggc accagagaag caaatggcac cttgaactta agcctactac
     1501 agactgttag aggccagtgg tttcaaaatt tagatataag aggggggaaa aatggaacca
     1561 gggcctgaca ttttataaac aaacaaaatg ctatggtagc atttttcacc ttcatagcat
     1621 actccttccc cctcaggtga tactatgacc atgagtagca tcagccagaa catgagaggg
     1681 agaactaact caagacaata ctcagcagag agcatcccgt gtggatatga ggctggtgta
     1741 gaggcggaga ggagccaaga aactaaaggt gaaaaataca ctggaactct ggggcaagag
     1801 atgtctatgg tagctgagcc aaacacgtag gatttccgtt ttaaggttca catggaaaag
     1861 gttatagctt tgccttgaga ttgactcatt aaaatcagag actgtaacac ttttgcctta
     1921 cgttcatttt atcaagcata gcttggtatt tattatgctt gtgtgatcta acatgagtta
     1981 gcatcccaca cctcctcttc tgatcctgcc ccattaaaat aaccaagagg ttatctgttc
     2041 ttttccggga aaggggtggt atgcacctga aatagatttt accaaaagag agatttcagt
     2101 tatgtcattt tttcttgatt tcctgtgaac ttagtattat accctacttt caattcggta
//
