LOCUS       NM_001097612            2124 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens G protein-coupled receptor 89A (GPR89A), transcript
            variant 1, mRNA.
ACCESSION   NM_001097612 XM_001133508 XM_001133516 XM_927869
VERSION     NM_001097612.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2124)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2124)
  AUTHORS   Pandey,S., Nelson,D.C. and Assmann,S.M.
  TITLE     Two novel GPCR-type G proteins are abscisic acid receptors in
            Arabidopsis
  JOURNAL   Cell 136 (1), 136-148 (2009)
   PUBMED   19135895
REFERENCE   3  (bases 1 to 2124)
  AUTHORS   Maeda,Y., Ide,T., Koike,M., Uchiyama,Y. and Kinoshita,T.
  TITLE     GPHR is a novel anion channel critical for acidification and
            functions of the Golgi apparatus
  JOURNAL   Nat Cell Biol 10 (10), 1135-1145 (2008)
   PUBMED   18794847
REFERENCE   4  (bases 1 to 2124)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   5  (bases 1 to 2124)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC349534.1, AB097025.1, BC003187.1 and AC242845.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001097612.1.
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.186675.1,
                                           SRR1803613.223066.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313835.14/ ENSP00000319673.9
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DC349534.1         29-59
            32-1934             AB097025.1         1-1903
            1935-1938           BC003187.1         1866-1869
            1939-2124           AC242845.1         125876-126061
FEATURES             Location/Qualifiers
     source          1..2124
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.1"
     gene            1..2124
                     /gene="GPR89A"
                     /gene_synonym="GPHR; GPR89; GPR89B; SH120; UNQ192"
                     /note="G protein-coupled receptor 89A"
                     /db_xref="GeneID:653519"
                     /db_xref="HGNC:HGNC:31984"
                     /db_xref="MIM:612821"
     exon            1..188
                     /gene="GPR89A"
                     /gene_synonym="GPHR; GPR89; GPR89B; SH120; UNQ192"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1514
                     /gene="GPR89A"
                     /gene_synonym="GPHR; GPR89; GPR89B; SH120; UNQ192"
                     /note="isoform 1 is encoded by transcript variant 1; Golgi
                     pH regulator A; protein GPR89; putative MAPK-activating
                     protein PM01; putative NF-kappa-B-activating protein 90"
                     /codon_start=1
                     /product="Golgi pH regulator A isoform 1"
                     /protein_id="NP_001091081.1"
                     /db_xref="CCDS:CCDS72857.1"
                     /db_xref="GeneID:653519"
                     /db_xref="HGNC:HGNC:31984"
                     /db_xref="MIM:612821"
                     /translation="MSFLIDSSIMITSQILFFGFGWLFFMRQLFKDYEIRQYVVQVIF
                     SVTFAFSCTMFELIIFEILGVLNSSSRYFHWKMNLCVILLILVFMVPFYIGYFIVSNI
                     RLLHKQRLLFSCLLWLTFMYFFWKLGDPFPILSPKHGILSIEQLISRVGVIGVTLMAL
                     LSGFGAVNCPYTYMSYFLRNVTDTDILALERRLLQTMDMIISKKKRMAMARRTMFQKG
                     EVHNKPSGFWGMIKSVTTSASGSENLTLIQQEVDALEELSRQLFLETADLYATKERIE
                     YSKTFKGKYFNFLGYFFSIYCVWKIFMATINIVFDRVGKTDPVTRGIEITVNYLGIQF
                     DVKFWSQHISFILVGIIIVTSIRGLLITLTKFFYAISSSKSSNVIVLLLAQIMGMYFV
                     SSVLLIRMSMPLEYRTIITEVLGELQFNFYHRWFDVIFLVSALSSILFLYLAHKQAPE
                     KQMAP"
     exon            189..248
                     /gene="GPR89A"
                     /gene_synonym="GPHR; GPR89; GPR89B; SH120; UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            249..352
                     /gene="GPR89A"
                     /gene_synonym="GPHR; GPR89; GPR89B; SH120; UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            353..459
                     /gene="GPR89A"
                     /gene_synonym="GPHR; GPR89; GPR89B; SH120; UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            460..561
                     /gene="GPR89A"
                     /gene_synonym="GPHR; GPR89; GPR89B; SH120; UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            562..682
                     /gene="GPR89A"
                     /gene_synonym="GPHR; GPR89; GPR89B; SH120; UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            683..763
                     /gene="GPR89A"
                     /gene_synonym="GPHR; GPR89; GPR89B; SH120; UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            764..873
                     /gene="GPR89A"
                     /gene_synonym="GPHR; GPR89; GPR89B; SH120; UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            874..962
                     /gene="GPR89A"
                     /gene_synonym="GPHR; GPR89; GPR89B; SH120; UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1055
                     /gene="GPR89A"
                     /gene_synonym="GPHR; GPR89; GPR89B; SH120; UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1151
                     /gene="GPR89A"
                     /gene_synonym="GPHR; GPR89; GPR89B; SH120; UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1241
                     /gene="GPR89A"
                     /gene_synonym="GPHR; GPR89; GPR89B; SH120; UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1307
                     /gene="GPR89A"
                     /gene_synonym="GPHR; GPR89; GPR89B; SH120; UNQ192"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..2124
                     /gene="GPR89A"
                     /gene_synonym="GPHR; GPR89; GPR89B; SH120; UNQ192"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2042..2047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR89A"
                     /gene_synonym="GPHR; GPR89; GPR89B; SH120; UNQ192"
                     /note="hexamer: ATTAAA"
     polyA_site      2061
                     /gene="GPR89A"
                     /gene_synonym="GPHR; GPR89; GPR89B; SH120; UNQ192"
                     /note="major polyA site"
     regulatory      2104..2109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR89A"
                     /gene_synonym="GPHR; GPR89; GPR89B; SH120; UNQ192"
                     /note="hexamer: AATAGA"
     polyA_site      2124
                     /gene="GPR89A"
                     /gene_synonym="GPHR; GPR89; GPR89B; SH120; UNQ192"
                     /note="major polyA site"
ORIGIN      
        1 gcagcttgat ggcgtcgggc tggagagccg cagtcccggc tgcagcacct gggagaaggc
       61 agaccgtgtg agggggcctg tggccccagc gtgctgtggc ctcggggagt gggaagtgga
      121 ggcaggagcc ttccttacac ttcgccatga gtttcctcat cgactccagc atcatgatta
      181 cctcccagat actatttttt ggatttgggt ggcttttctt catgcgccaa ttgtttaaag
      241 actatgagat acgtcagtat gttgtacagg tgatcttctc cgtgacgttt gcattttctt
      301 gcaccatgtt tgagctcatc atctttgaaa tcttaggagt attgaatagc agctcccgtt
      361 attttcactg gaaaatgaac ctgtgtgtaa ttctgctgat cctggttttc atggtgcctt
      421 tttacattgg ctattttatt gtgagcaata tccgactact gcataaacaa cgactgcttt
      481 tttcctgtct cttatggctg acctttatgt atttcttctg gaaactagga gatccctttc
      541 ccattctcag cccaaaacat gggatcttat ccatagaaca gctcatcagc cgggttggtg
      601 tgattggagt gactctcatg gctcttcttt ctggatttgg tgctgtcaac tgcccataca
      661 cttacatgtc ttacttcctc aggaatgtga ctgacacgga tattctagcc ctggaacggc
      721 gactgctgca aaccatggat atgatcataa gcaaaaagaa aaggatggca atggcacgga
      781 gaacaatgtt ccagaagggg gaagtgcata acaaaccatc aggtttctgg ggaatgataa
      841 aaagtgttac cacttcagca tcaggaagtg aaaatcttac tcttattcaa caggaagtgg
      901 atgctttgga agaattaagc aggcagcttt ttctggaaac agctgatcta tatgctacca
      961 aggagagaat agaatactcc aaaaccttca aggggaaata ttttaatttt cttggttact
     1021 ttttctctat ttactgtgtt tggaaaattt tcatggctac catcaatatt gtttttgatc
     1081 gagttgggaa aacggatcct gtcacaagag gcattgagat cactgtgaat tatctgggaa
     1141 tccaatttga tgtgaagttt tggtcccaac acatttcctt cattcttgtt ggaataatca
     1201 tcgtcacatc catcagagga ttgctgatca ctcttaccaa gttcttttat gccatctcta
     1261 gcagtaagtc ctccaatgtc attgtcctgc tattagcaca gataatgggc atgtactttg
     1321 tctcctctgt gctgctgatc cgaatgagta tgcctttaga ataccgcacc ataatcactg
     1381 aagtccttgg agaactgcag ttcaacttct atcaccgttg gtttgatgtg atcttcctgg
     1441 tcagcgctct ctctagcata ctcttcctct atttggctca caaacaggca ccagagaagc
     1501 aaatggcacc ttgaacttaa gcctactaca gactgttaga ggccagtggt ttcaaaattt
     1561 agatataaga ggggggaaaa atggaaccag ggcctgacat tttataaaca aacaaaatgc
     1621 tatggtagca tttttcacct tcatagcata ctccttcccc gtcaggtgat actatgacca
     1681 tgagtagcat cagccagaac atgagaggga gaactaactc aagacaatac tcagcagaga
     1741 gcatcccgtg tggatatgag gctggtgtag aggcggagag gagccaagaa actaaaggtg
     1801 aaaaatacac tggaactctg gggcaagaca tgtctatggt agctgagcca aacacgtagg
     1861 atttccgttt taaggttcac atggaaaagg ttatagcttt gccttgagat tgactcatta
     1921 aaatcagaga ctgtaacact tttgccttac gttcatttta tcaagcatag cttggtattt
     1981 attatgcttg tgtgatctaa catcagttag catcccacac ctcctcatct gatcctgccc
     2041 cattaaaata accaagaaag aggttatctg ttcttttccg ggaaaggggt ggtatgcacc
     2101 tgaaatagat tttaccaaaa gaga
//
