LOCUS       NM_022049               3492 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens G protein-coupled receptor 88 (GPR88), mRNA.
ACCESSION   NM_022049
VERSION     NM_022049.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3492)
  AUTHORS   Ben Hamida,S., Sengupta,S.M., Clarke,E., McNicholas,M.,
            Moroncini,E., Darcq,E., Ter-Stepanian,M., Fortier,M.E.,
            Grizenko,N., Joober,R. and Kieffer,B.L.
  TITLE     The orphan receptor GPR88 controls impulsivity and is a risk factor
            for Attention-Deficit/Hyperactivity Disorder
  JOURNAL   Mol Psychiatry 27 (11), 4662-4672 (2022)
   PUBMED   36075963
  REMARK    GeneRIF: The orphan receptor GPR88 controls impulsivity and is a
            risk factor for Attention-Deficit/Hyperactivity Disorder.
REFERENCE   2  (bases 1 to 3492)
  AUTHORS   Chen,G., Xu,J., Inoue,A., Schmidt,M.F., Bai,C., Lu,Q., Gmeiner,P.,
            Liu,Z. and Du,Y.
  TITLE     Activation and allosteric regulation of the orphan GPR88-Gi1
            signaling complex
  JOURNAL   Nat Commun 13 (1), 2375 (2022)
   PUBMED   35501348
  REMARK    GeneRIF: Activation and allosteric regulation of the orphan
            GPR88-Gi1 signaling complex.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3492)
  AUTHORS   Badgandi,H.B., Hwang,S.H., Shimada,I.S., Loriot,E. and
            Mukhopadhyay,S.
  TITLE     Tubby family proteins are adapters for ciliary trafficking of
            integral membrane proteins
  JOURNAL   J Cell Biol 216 (3), 743-760 (2017)
   PUBMED   28154160
REFERENCE   4  (bases 1 to 3492)
  AUTHORS   Jin,C., Decker,A.M., Harris,D.L. and Blough,B.E.
  TITLE     Effect of Substitution on the Aniline Moiety of the GPR88 Agonist
            2-PCCA: Synthesis, Structure-Activity Relationships, and Molecular
            Modeling Studies
  JOURNAL   ACS Chem Neurosci 7 (10), 1418-1432 (2016)
   PUBMED   27499251
  REMARK    GeneRIF: Study designed and synthesized a series of 2-PCCA
            analogues bearing a variety of substituents at the phenyl ring of
            the aniline moiety to determine the structure-activity relationship
            (SAR) in this region; SAR studies suggested that there is a
            hydrophobic pocket in the GPR88 binding site interacting with the
            aniline region of 2-PCCA
REFERENCE   5  (bases 1 to 3492)
  AUTHORS   Alkufri,F., Shaag,A., Abu-Libdeh,B. and Elpeleg,O.
  TITLE     Deleterious mutation in GPR88 is associated with chorea, speech
            delay, and learning disabilities
  JOURNAL   Neurol Genet 2 (3), e64 (2016)
   PUBMED   27123486
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3492)
  AUTHORS   Jin,C., Decker,A.M., Huang,X.P., Gilmour,B.P., Blough,B.E.,
            Roth,B.L., Hu,Y., Gill,J.B. and Zhang,X.P.
  TITLE     Synthesis, pharmacological characterization, and structure-activity
            relationship studies of small molecular agonists for the orphan
            GPR88 receptor
  JOURNAL   ACS Chem Neurosci 5 (7), 576-587 (2014)
   PUBMED   24793972
REFERENCE   7  (bases 1 to 3492)
  AUTHORS   Del Zompo,M., Deleuze,J.F., Chillotti,C., Cousin,E., Niehaus,D.,
            Ebstein,R.P., Ardau,R., Mace,S., Warnich,L., Mujahed,M.,
            Severino,G., Dib,C., Jordaan,E., Murad,I., Soubigou,S., Koen,L.,
            Bannoura,I., Rocher,C., Laurent,C., Derock,M., Faucon Biguet,N.,
            Mallet,J. and Meloni,R.
  TITLE     Association study in three different populations between the GPR88
            gene and major psychoses
  JOURNAL   Mol Genet Genomic Med 2 (2), 152-159 (2014)
   PUBMED   24689078
REFERENCE   8  (bases 1 to 3492)
  AUTHORS   Marley,A., Choy,R.W. and von Zastrow,M.
  TITLE     GPR88 reveals a discrete function of primary cilia as selective
            insulators of GPCR cross-talk
  JOURNAL   PLoS One 8 (8), e70857 (2013)
   PUBMED   23936473
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3492)
  AUTHORS   Mizushima,K., Miyamoto,Y., Tsukahara,F., Hirai,M., Sakaki,Y. and
            Ito,T.
  TITLE     A novel G-protein-coupled receptor gene expressed in striatum
  JOURNAL   Genomics 69 (3), 314-321 (2000)
   PUBMED   11056049
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099670.2 and BC036775.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_022049.2.
            
            Summary: The protein encoded by this gene is a G protein-coupled
            receptor found almost exclusively in the striatum, a brain
            structure that controls motor function and cognition. Defects in
            this gene have been associated with chorea, speech delay, and
            learning difficulties, as well as some neuropsychiatric disorders.
            [provided by RefSeq, Mar 2017].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB042410.1, BC036775.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315033.5/ ENSP00000314223.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC099670.2         152098-152130       c
            34-316              AC099670.2         151815-152097       c
            317-1507            BC036775.1         284-1474
            1508-3492           AC099670.2         148248-150232       c
FEATURES             Location/Qualifiers
     source          1..3492
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p21.2"
     gene            1..3492
                     /gene="GPR88"
                     /gene_synonym="COCPMR; STRG"
                     /note="G protein-coupled receptor 88"
                     /db_xref="GeneID:54112"
                     /db_xref="HGNC:HGNC:4539"
                     /db_xref="MIM:607468"
     exon            1..364
                     /gene="GPR88"
                     /gene_synonym="COCPMR; STRG"
                     /inference="alignment:Splign:2.1.0"
     exon            365..3492
                     /gene="GPR88"
                     /gene_synonym="COCPMR; STRG"
                     /inference="alignment:Splign:2.1.0"
     CDS             438..1592
                     /gene="GPR88"
                     /gene_synonym="COCPMR; STRG"
                     /note="probable G-protein coupled receptor 88;
                     striatum-specific G-protein coupled receptor"
                     /codon_start=1
                     /product="G protein-coupled receptor 88"
                     /protein_id="NP_071332.2"
                     /db_xref="CCDS:CCDS772.1"
                     /db_xref="GeneID:54112"
                     /db_xref="HGNC:HGNC:4539"
                     /db_xref="MIM:607468"
                     /translation="MTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIG
                     GTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPP
                     ADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAG
                     MLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRR
                     VRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRR
                     AQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPL
                     LYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW"
     regulatory      3474..3479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR88"
                     /gene_synonym="COCPMR; STRG"
                     /note="hexamer: ATTAAA"
     polyA_site      3492
                     /gene="GPR88"
                     /gene_synonym="COCPMR; STRG"
                     /note="major polyA site"
ORIGIN      
        1 gttcaccaca tcagccacca ctcctgcttc tgagcacagg gtgctctcct cttgagctca
       61 gcttctgctt ttgcagccaa gcattcttgc tgctgctgcc tgcctgccca cccgcctggg
      121 cttgcagccc gccactttac tttctccagc cctgatacca gctgagaagt ctccctgcag
      181 ctgctagttc ctgcccagga ccatgtgtgt ggatgctgct tgggagaagc gggcacttgc
      241 tcctggcact gatcccagct gagtttctcc tgttgatttc tggaccactg atgctgttgc
      301 tgaggaggta tttcccggca tccctccccc tgagacaccg gctaaggacc agcctaaacg
      361 caaggcagga cagtgtcagg atggaccgcg ctgccagaag ccgacgctag cgagggaggt
      421 gtgaagagtt ggccagaatg accaactcct cctccacatc cacctcctcc accaccggtg
      481 gctcgctgct gctgctctgc gaggaagagg agtcgtgggc gggccggcgc atcccggtgt
      541 cactcctgta ttcgggcctg gccatcgggg gcacgctggc caacggcatg gtcatctatc
      601 tcgtgtcgtc cttccgaaag ctgcagacca ccagcaacgc cttcatcgtg aacggctgcg
      661 ccgccgacct cagcgtctgc gccctctgga tgccgcagga ggcggtgctc gggctcctgc
      721 ccaccggctc tgcggagccc cccgcagact gggacggcgc tgggggcagc taccgcctgc
      781 tacggggtgg gctgctgggc ctcggactca cggtgtccct cctctcccac tgcctcgtgg
      841 ccctgaaccg ctacctgctc atcacccggg cgcccgccac ctaccaggcg ctgtaccaga
      901 ggcgccacac ggcgggcatg ctggcgctgt cctgggcgct cgccctgggc ctcgtgctgc
      961 tgctcccgcc ctgggcaccg cggcccggcg ccgcgccacc gcgagtccac tacccggcgc
     1021 tgctggccgc cgcggcgctg ctggcgcaga cagctctgct gctgcactgc tacctgggca
     1081 tcgtgcgccg cgtgcgtgtc agcgtcaagc gggtcagcgt gctcaacttc cacctgctgc
     1141 accagttgcc cggctgcgcc gccgccgccg ccgccttccc gggcgcccag cacgcgccgg
     1201 gccccggtgg cgccgcgcac ccggcgcagg cccagcccct gccgcccgcg ctgcacccgc
     1261 ggcgggcaca gcggcgtctc agcggcctgt cggtgctgct gctctgctgc gtcttcctgc
     1321 tggccacgca gccactggtg tgggtgagcc tggccagcgg cttctcgctg ccggtgccct
     1381 ggggagtgca ggcggccagc tggctcctgt gctgcgccct gtccgcgctc aatccgctgc
     1441 tctacacgtg gaggaacgag gagttccgcc gctccgtgcg ctcagtcctg ccgggcgtcg
     1501 gcgacgcggc ggccgctgcc gttgccgcca cagccgtgcc cgcagtgtcc caggcgcaac
     1561 tgggcacccg cgccgcgggc cagcactggt aacctagccg gggcccgagg gaagcggaga
     1621 tccccggctt ccgacgtcct tgggcaccgt cgcctccttc cctcctaggg catcccctgc
     1681 ctgaacgaag acttccgccg cgaagcccga tagatcgggg gaaaatgggg ccttcgaccc
     1741 cagcgggcta cctgaaccaa ggcgtctctt taagtggggc gcccgaagtc attttggacg
     1801 gccacctgat ttttaccctt tgtttctgtg ttttagagga atcctaaagt caaaacacca
     1861 gagacttgaa gaacttgcaa actggcgttt taaaataacc ggttaattta tttccacaca
     1921 gtttgttttt gaaaaagagc tttcataatg tataaccctt tccactttca tcgtcttata
     1981 tatgaagcgc cttgagtgtg catgaaccaa aggaaataac attgaagaag gaaaacaata
     2041 tgtagaaagt attttagaaa gtaacctgtc tttgatgatg cttctcttac catttagttt
     2101 ttgtatatta ccctggggca gtgaagccct aggtgtgccc accagtatga gttgccatta
     2161 agacctcaag ccctttattc ttaaaagggt ttttaataaa gtctttctca aatgaggtag
     2221 aatcttagcc agtgagaaaa aaaattattt tatgctcctt ttttttcgca ctcttaagac
     2281 tgaaaattgg cgttgagtgt tatagtgaaa attttccagt ttgataattg atggtcagag
     2341 ccagcactgg aattttgaaa acaaataagg tgattatcta ttttaggtac cgtttcacat
     2401 tttctatagc atgcacactt gttgctaccc tcattttgta accaatttat ttgccttatg
     2461 aatgtgattg cagctttgaa cattctgtac tataatggtt gctaagaaga ataagtcctt
     2521 ctgttttctc tttaacattt aaaatatctc aatgcacatg atataattaa acactaataa
     2581 taccatgact gcatagctaa tattagctgc tattgcatgc tcctagatgc tagaacttat
     2641 tgggcatgtg gtatactgaa gcaatacccg ttagacaagg atattttact tcttccagac
     2701 accagaagaa atggccttca attatttgaa aagagacaca gagacacctc tggctaccta
     2761 gagttcttcc tgtcttgacc caatttatga gaaagctccc agttgggact ttatctcaca
     2821 agtggaatca cagtcaagac ggatcaataa tatggtttgg ctcagcaaag ccagctgtgc
     2881 tcttttaggg tttaaacaag ccacacgtta gaaagcaaca ctgtttttat gtagttcata
     2941 tatattacca tgacatttaa catcaatatc gtatatgttg aaggaggtat aataaactca
     3001 gtcatatata gtgaacagtt caaatgggaa agtgttctaa aacatattat ttgagatttg
     3061 tcatattcat ctttggttta ctaaatttac ttagaaatat ttgaaatgca aaattgtgtg
     3121 aaatcacctt atcaaattaa aatgggaaga aagtaatttt aataattttt aataatcata
     3181 tgtcagcatt ctgactactt accacatcaa atctgggccc aaacagcctc agttaactgc
     3241 ataattcagg aacaaaacca gcttgctttg ttgcacgcct gggcaatttc agccaggaca
     3301 ttaggaccac ttgttgtaca tctgaataat tatggaagtt gggacatgtt aaggaaaaca
     3361 aatatgttca tcaccaacaa tcagctgtca ttttattaat ctatcccttt tgtgcatgca
     3421 ccatttctct cttactaaca gtttcatctg ttcacatttt ccttgattca aatattaaag
     3481 ttcagacaac ta
//
