LOCUS       NM_023915               1493 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens G protein-coupled receptor 87 (GPR87), mRNA.
ACCESSION   NM_023915
VERSION     NM_023915.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1493)
  AUTHORS   Heinzelmann,K., Hu,Q., Hu,Y., Dobrinskikh,E., Ansari,M.,
            Melo-Narvaez,M.C., Ulke,H.M., Leavitt,C., Mirita,C., Trudeau,T.,
            Saal,M.L., Rice,P., Gao,B., Janssen,W.J., Yang,I.V., Schiller,H.B.,
            Vladar,E.K., Lehmann,M. and Konigshoff,M.
  TITLE     Single-cell RNA sequencing identifies G-protein coupled receptor 87
            as a basal cell marker expressed in distal honeycomb cysts in
            idiopathic pulmonary fibrosis
  JOURNAL   Eur Respir J 59 (6), 2102373 (2022)
   PUBMED   35604813
  REMARK    GeneRIF: Single-cell RNA sequencing identifies G-protein coupled
            receptor 87 as a basal cell marker expressed in distal honeycomb
            cysts in idiopathic pulmonary fibrosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1493)
  AUTHORS   Ceylan,S., Bahadori,F. and Akbas,F.
  TITLE     Engineering of siRNA loaded PLGA Nano-Particles for highly
            efficient silencing of GPR87 gene as a target for pancreatic cancer
            treatment
  JOURNAL   Pharm Dev Technol 25 (7), 855-864 (2020)
   PUBMED   32188321
  REMARK    GeneRIF: Engineering of siRNA loaded PLGA Nano-Particles for highly
            efficient silencing of GPR87 gene as a target for pancreatic cancer
            treatment.
REFERENCE   3  (bases 1 to 1493)
  AUTHORS   Wang,L., Zhou,W., Zhong,Y., Huo,Y., Fan,P., Zhan,S., Xiao,J.,
            Jin,X., Gou,S., Yin,T., Wu,H. and Liu,T.
  TITLE     Overexpression of G protein-coupled receptor GPR87 promotes
            pancreatic cancer aggressiveness and activates NF-kappaB signaling
            pathway
  JOURNAL   Mol Cancer 16 (1), 61 (2017)
   PUBMED   28288630
  REMARK    GeneRIF: we reported that GPR87 expression was significantly
            upregulated in pancreatic cancer, and higher GPR87 correlated with
            shorter overall survival of patients with pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1493)
  AUTHORS   Niss Arfelt,K., Fares,S., Sparre-Ulrich,A.H., Hjorto,G.M.,
            Gasbjerg,L.S., Molleskov-Jensen,A.S., Benned-Jensen,T. and
            Rosenkilde,M.M.
  TITLE     Signaling via G proteins mediates tumorigenic effects of GPR87
  JOURNAL   Cell Signal 30, 9-18 (2017)
   PUBMED   27865873
  REMARK    GeneRIF: the basal activity of GPR87 was investigated.
REFERENCE   5  (bases 1 to 1493)
  AUTHORS   Zhang,X., Liu,D., Hayashida,Y., Okazoe,H., Hashimoto,T., Ueda,N.,
            Sugimoto,M. and Kakehi,Y.
  TITLE     G Protein-Coupled Receptor 87 (GPR87) Promotes Cell Proliferation
            in Human Bladder Cancer Cells
  JOURNAL   Int J Mol Sci 16 (10), 24319-24331 (2015)
   PUBMED   26473854
  REMARK    GeneRIF: knockdown of GPR87 led to a p53-dependent signal
            transduction and caused apoptosis in the bladder cancer cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1493)
  AUTHORS   Glatt,S., Halbauer,D., Heindl,S., Wernitznig,A., Kozina,D.,
            Su,K.C., Puri,C., Garin-Chesa,P. and Sommergruber,W.
  TITLE     hGPR87 contributes to viability of human tumor cells
  JOURNAL   Int J Cancer 122 (9), 2008-2016 (2008)
   PUBMED   18183596
  REMARK    GeneRIF: Human GPR87 mRNA transcript was preferentially
            overexpressed in squamous cell carcinomas. Up-regulation of both,
            transcript and protein, was detected in samples of SCC of the lung,
            cervix, skin and head and neck (pharynx, larynx and epiglottis).
REFERENCE   7  (bases 1 to 1493)
  AUTHORS   Gugger,M., White,R., Song,S., Waser,B., Cescato,R., Riviere,P. and
            Reubi,J.C.
  TITLE     GPR87 is an overexpressed G-protein coupled receptor in squamous
            cell carcinoma of the lung
  JOURNAL   Dis Markers 24 (1), 41-50 (2008)
   PUBMED   18057535
  REMARK    GeneRIF: G-protein coupled receptor(GPR87) stands out as a
            candidate for further target validation due to its marked
            overexpression and correlation on a mutation-based level to
            squamous cell carcinoma
REFERENCE   8  (bases 1 to 1493)
  AUTHORS   Tabata,K., Baba,K., Shiraishi,A., Ito,M. and Fujita,N.
  TITLE     The orphan GPCR GPR87 was deorphanized and shown to be a
            lysophosphatidic acid receptor
  JOURNAL   Biochem Biophys Res Commun 363 (3), 861-866 (2007)
   PUBMED   17905198
  REMARK    GeneRIF: Results suggest that the GPR87 is a LPA receptor which
            evolved from a common ancestor of P2Y receptors.
REFERENCE   9  (bases 1 to 1493)
  AUTHORS   Lee,D.K., Nguyen,T., Lynch,K.R., Cheng,R., Vanti,W.B., Arkhitko,O.,
            Lewis,T., Evans,J.F., George,S.R. and O'Dowd,B.F.
  TITLE     Discovery and mapping of ten novel G protein-coupled receptor genes
  JOURNAL   Gene 275 (1), 83-91 (2001)
   PUBMED   11574155
REFERENCE   10 (bases 1 to 1493)
  AUTHORS   Wittenberger,T., Schaller,H.C. and Hellebrand,S.
  TITLE     An expressed sequence tag (EST) data mining strategy succeeding in
            the discovery of new G-protein coupled receptors
  JOURNAL   J Mol Biol 307 (3), 799-813 (2001)
   PUBMED   11273702
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP226924.1, BC117565.1 and AF345566.1.
            
            On May 17, 2019 this sequence version replaced NM_023915.3.
            
            Summary: This gene encodes a G protein-coupled receptor and is
            located in a cluster of G protein-couple receptor genes on
            chromosome 3. The encoded protein has been shown to be
            overexpressed in lung squamous cell carcinoma (PMID:18057535) and
            regulated by p53 (PMID:19602589). [provided by RefSeq, Nov 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC117565.1, AK027784.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260843.5/ ENSP00000260843.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               BP226924.1         133-266
            135-1471            BC117565.1         72-1408
            1472-1493           AF345566.1         1178-1199
FEATURES             Location/Qualifiers
     source          1..1493
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.1"
     gene            1..1493
                     /gene="GPR87"
                     /gene_synonym="FKSG78; GPR95; KPG_002"
                     /note="G protein-coupled receptor 87"
                     /db_xref="GeneID:53836"
                     /db_xref="HGNC:HGNC:4538"
                     /db_xref="MIM:606379"
     exon            1..235
                     /gene="GPR87"
                     /gene_synonym="FKSG78; GPR95; KPG_002"
                     /inference="alignment:Splign:2.1.0"
     exon            236..367
                     /gene="GPR87"
                     /gene_synonym="FKSG78; GPR95; KPG_002"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..1410
                     /gene="GPR87"
                     /gene_synonym="FKSG78; GPR95; KPG_002"
                     /note="orphan GPCR 87; G-protein coupled receptor 95"
                     /codon_start=1
                     /product="G-protein coupled receptor 87"
                     /protein_id="NP_076404.3"
                     /db_xref="CCDS:CCDS3157.1"
                     /db_xref="GeneID:53836"
                     /db_xref="HGNC:HGNC:4538"
                     /db_xref="MIM:606379"
                     /translation="MGFNLTLAKLPNNELHGQESHNSGNRSDGPGKNTTLHNEFDTIV
                     LPVLYLIIFVASILLNGLAVWIFFHIRNKTSFIFYLKNIVVADLIMTLTFPFRIVHDA
                     GFGPWYFKFILCRYTSVLFYANMYTSIVFLGLISIDRYLKVVKPFGDSRMYSITFTKV
                     LSVCVWVIMAVLSLPNIILTNGQPTEDNIHDCSKLKSPLGVKWHTAVTYVNSCLFVAV
                     LVILIGCYIAISRYIHKSSRQFISQSSRKRKHNQSIRVVVAVFFTCFLPYHLCRIPFT
                     FSHLDRLLDESAQKILYYCKEITLFLSACNVCLDPIIYFFMCRSFSRRLFKKSNIRTR
                     SESIRSLQSVRRSEVRIYYDYTDV"
     exon            368..1493
                     /gene="GPR87"
                     /gene_synonym="FKSG78; GPR95; KPG_002"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1451..1456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR87"
                     /gene_synonym="FKSG78; GPR95; KPG_002"
                     /note="hexamer: AATAAA"
     polyA_site      1471
                     /gene="GPR87"
                     /gene_synonym="FKSG78; GPR95; KPG_002"
                     /note="major polyA site"
ORIGIN      
        1 agtagtcgcc tggcaggaga atttgaaagg gtgccccaaa ggacaatctc taaaggggta
       61 agggagatac ctaccttgtc tggtagggga gatgtttcgt tttcatgctt taccagaaaa
      121 tccacttccc tgccgacctt agtttcaaag cttattctta attagagaca agaaacctgt
      181 ttcaacttga agacaccgta tgaggtgaat ggacagccag ccaccacaat gaaagaaatc
      241 aaaccaggaa taacctatgc tgaacccacg cctcaatcgt ccccaagtgt ttcctgacac
      301 gcatctttgc ttacagtgca tcacaactga agaatggggt tcaacttgac gcttgcaaaa
      361 ttaccaaata acgagctgca cggccaagag agtcacaatt caggcaacag gagcgacggg
      421 ccaggaaaga acaccaccct tcacaatgaa tttgacacaa ttgtcttgcc ggtgctttat
      481 ctcattatat ttgtggcaag catcttgctg aatggtttag cagtgtggat cttcttccac
      541 attaggaata aaaccagctt catattctat ctcaaaaaca tagtggttgc agacctcata
      601 atgacgctga catttccatt tcgaatagtc catgatgcag gatttggacc ttggtacttc
      661 aagtttattc tctgcagata cacttcagtt ttgttttatg caaacatgta tacttccatc
      721 gtgttccttg ggctgataag cattgatcgc tatctgaagg tggtcaagcc atttggggac
      781 tctcggatgt acagcataac cttcacgaag gttttatctg tttgtgtttg ggtgatcatg
      841 gctgttttgt ctttgccaaa catcatccta acaaatggtc agccaacaga ggacaatatc
      901 catgactgct caaaacttaa aagtcctttg ggggtcaaat ggcatacggc agtcacctat
      961 gtgaacagct gcttgtttgt ggccgtgctg gtgattctga tcggatgtta catagccata
     1021 tccaggtaca tccacaaatc cagcaggcaa ttcataagtc agtcaagccg aaagcgaaaa
     1081 cataaccaga gcatcagggt tgttgtggct gtgtttttta cctgctttct accatatcac
     1141 ttgtgcagaa ttccttttac ttttagtcac ttagacaggc ttttagatga atctgcacaa
     1201 aaaatcctat attactgcaa agaaattaca cttttcttgt ctgcgtgtaa tgtttgcctg
     1261 gatccaataa tttacttttt catgtgtagg tcattttcaa gaaggctgtt caaaaaatca
     1321 aatatcagaa ccaggagtga aagcatcaga tcactgcaaa gtgtgagaag atcggaagtt
     1381 cgcatatatt atgattacac tgatgtgtag gccttttatt gtttgttgga atcgatatgt
     1441 acaaagtgta aataaatgtt tcttttcatt atccttgctt gagcccatca aaa
//
