LOCUS       NM_001146267            3231 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens G protein-coupled receptor 85 (GPR85), transcript
            variant 4, mRNA.
ACCESSION   NM_001146267
VERSION     NM_001146267.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3231)
  AUTHORS   Fujita-Jimbo,E., Tanabe,Y., Yu,Z., Kojima,K., Mori,M., Li,H.,
            Iwamoto,S., Yamagata,T., Momoi,M.Y. and Momoi,T.
  TITLE     The association of GPR85 with PSD-95-neuroligin complex and autism
            spectrum disorder: a molecular analysis
  JOURNAL   Mol Autism 6, 17 (2015)
   PUBMED   25780553
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3231)
  AUTHORS   Radulescu,E., Sambataro,F., Mattay,V.S., Callicott,J.H.,
            Straub,R.E., Matsumoto,M., Weinberger,D.R. and Marenco,S.
  TITLE     Effect of schizophrenia risk-associated alleles in SREB2 (GPR85) on
            functional MRI phenotypes in healthy volunteers
  JOURNAL   Neuropsychopharmacology 38 (2), 341-349 (2013)
   PUBMED   22968816
  REMARK    GeneRIF: Risk-associated variants in GPR85 are associated with
            phenotypes similar to those found in patients with schizophrenia.
REFERENCE   3  (bases 1 to 3231)
  AUTHORS   Anney,R.J., Lasky-Su,J., O'Dushlaine,C., Kenny,E., Neale,B.M.,
            Mulligan,A., Franke,B., Zhou,K., Chen,W., Christiansen,H.,
            Arias-Vasquez,A., Banaschewski,T., Buitelaar,J., Ebstein,R.,
            Miranda,A., Mulas,F., Oades,R.D., Roeyers,H., Rothenberger,A.,
            Sergeant,J., Sonuga-Barke,E., Steinhausen,H., Asherson,P.,
            Faraone,S.V. and Gill,M.
  TITLE     Conduct disorder and ADHD: evaluation of conduct problems as a
            categorical and quantitative trait in the international multicentre
            ADHD genetics study
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 147B (8), 1369-1378 (2008)
   PUBMED   18951430
REFERENCE   4  (bases 1 to 3231)
  AUTHORS   Matsumoto,M., Straub,R.E., Marenco,S., Nicodemus,K.K.,
            Matsumoto,S., Fujikawa,A., Miyoshi,S., Shobo,M., Takahashi,S.,
            Yarimizu,J., Yuri,M., Hiramoto,M., Morita,S., Yokota,H.,
            Sasayama,T., Terai,K., Yoshino,M., Miyake,A., Callicott,J.H.,
            Egan,M.F., Meyer-Lindenberg,A., Kempf,L., Honea,R.,
            Vakkalanka,R.K., Takasaki,J., Kamohara,M., Soga,T., Hiyama,H.,
            Ishii,H., Matsuo,A., Nishimura,S., Matsuoka,N., Kobori,M.,
            Matsushime,H., Katoh,M., Furuichi,K. and Weinberger,D.R.
  TITLE     The evolutionarily conserved G protein-coupled receptor SREB2/GPR85
            influences brain size, behavior, and vulnerability to schizophrenia
  JOURNAL   Proc Natl Acad Sci U S A 105 (16), 6133-6138 (2008)
   PUBMED   18413613
  REMARK    GeneRIF: Theses data implicate SREB2 as a potential risk factor for
            psychiatric disorders.
REFERENCE   5  (bases 1 to 3231)
  AUTHORS   Matsumoto,M., Beltaifa,S., Weickert,C.S., Herman,M.M., Hyde,T.M.,
            Saunders,R.C., Lipska,B.K., Weinberger,D.R. and Kleinman,J.E.
  TITLE     A conserved mRNA expression profile of SREB2 (GPR85) in adult
            human, monkey, and rat forebrain
  JOURNAL   Brain Res Mol Brain Res 138 (1), 58-69 (2005)
   PUBMED   15893849
  REMARK    GeneRIF: The areas expressing high levels of SREB2 mRNA overlap
            with brain structures known to possess high levels of plasticity,
            namely, the hippocampal formation, olfactory system, and supraoptic
            and paraventricular nuclei.
REFERENCE   6  (bases 1 to 3231)
  AUTHORS   Jeon,J., Kim,C., Sun,W., Chung,H., Park,S.H. and Kim,H.
  TITLE     Cloning and localization of rgpr85 encoding rat G-protein-coupled
            receptor
  JOURNAL   Biochem Biophys Res Commun 298 (4), 613-618 (2002)
   PUBMED   12408996
REFERENCE   7  (bases 1 to 3231)
  AUTHORS   Hellebrand,S., Schaller,H.C. and Wittenberger,T.
  TITLE     The brain-specific G-protein coupled receptor GPR85 with identical
            protein sequence in man and mouse maps to human chromosome 7q31
  JOURNAL   Biochim Biophys Acta 1493 (1-2), 269-272 (2000)
   PUBMED   10978537
REFERENCE   8  (bases 1 to 3231)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 3231)
  AUTHORS   Matsumoto,M., Saito,T., Takasaki,J., Kamohara,M., Sugimoto,T.,
            Kobayashi,M., Tadokoro,M., Matsumoto,S., Ohishi,T. and Furuichi,K.
  TITLE     An evolutionarily conserved G-protein coupled receptor family,
            SREB, expressed in the central nervous system
  JOURNAL   Biochem Biophys Res Commun 272 (2), 576-582 (2000)
   PUBMED   10833454
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073346.12.
            
            On May 21, 2020 this sequence version replaced NM_001146267.1.
            
            Summary: Members of the G protein-coupled receptor (GPCR) family,
            such as GPR85, have a similar structure characterized by 7
            transmembrane domains. Activation of GPCRs by extracellular
            stimuli, such as neurotransmitters, hormones, or light, induces an
            intracellular signaling cascade mediated by heterotrimeric
            GTP-binding proteins, or G proteins (Matsumoto et al., 2000 [PubMed
            10833454]).[supplied by OMIM, Aug 2008].
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. All variants (1-4) encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.3935324.1,
                                           SRR14038193.3784705.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000424100.2/ ENSP00000396763.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-506               AC073346.12        17670-18175         c
            507-624             AC073346.12        17340-17457         c
            625-3231            AC073346.12        13633-16239         c
FEATURES             Location/Qualifiers
     source          1..3231
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.1"
     gene            1..3231
                     /gene="GPR85"
                     /gene_synonym="SREB; SREB2"
                     /note="G protein-coupled receptor 85"
                     /db_xref="GeneID:54329"
                     /db_xref="HGNC:HGNC:4536"
                     /db_xref="MIM:605188"
     exon            1..506
                     /gene="GPR85"
                     /gene_synonym="SREB; SREB2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..624
                     /gene="GPR85"
                     /gene_synonym="SREB; SREB2"
                     /inference="alignment:Splign:2.1.0"
     exon            625..3231
                     /gene="GPR85"
                     /gene_synonym="SREB; SREB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             795..1907
                     /gene="GPR85"
                     /gene_synonym="SREB; SREB2"
                     /note="super conserved receptor expressed in brain 2;
                     seven transmembrane helix receptor"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 85"
                     /protein_id="NP_001139739.1"
                     /db_xref="CCDS:CCDS5758.1"
                     /db_xref="GeneID:54329"
                     /db_xref="HGNC:HGNC:4536"
                     /db_xref="MIM:605188"
                     /translation="MANYSHAADNILQNLSPLTAFLKLTSLGFIIGVSVVGNLLISIL
                     LVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGV
                     LSCFHTAFMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDV
                     GTYSFIREEDQCTFQHRSFRANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPV
                     QFVAAVSQNWTFHGPGASGQAAANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDE
                     FKMEKRISRMFYIMTFLFLTLWGPYLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGI
                     NPFVCIFSNRELRRCFSTTLLYCRKSRLPREPYCVI"
     regulatory      3210..3215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR85"
                     /gene_synonym="SREB; SREB2"
                     /note="hexamer: TATAAA"
     polyA_site      3231
                     /gene="GPR85"
                     /gene_synonym="SREB; SREB2"
                     /note="major polyA site"
ORIGIN      
        1 gacttcctcg tgcgctgcct ttgggaagag gatgggcctg aggtcctgaa agggcctttc
       61 cagcccccca ctacaaatgc ggggagggaa aagttcagaa gcagccacga agggacaaaa
      121 gcttaatgct gccagttgga ttggacaggg cagtcaataa acccagccag ctctggagtc
      181 aggtaggggt tcctgctggt tccacagagg ctgaagcagc cccgccgccg ccctcgccac
      241 cgcagccgcc gccgccgcgg cccctgcgtt actgggggag acggtgccgc tgcgacaggg
      301 gaggacgcgg ctggagctca aggaggctcc agcgcgcagg cgccgccgag ccctgcctgg
      361 atgctcagtc aaggcactaa ggcaaaaaaa aaaaaaaaaa aaacaaaaaa caaaaaaaaa
      421 aaaaaaaaaa agaaaaagaa aaaaagaaaa aaatcagcaa tttatagaaa gaagctatag
      481 tctgtcggga tatccaacac caacagtagg gcttactgag agctccattt ctggaaagcc
      541 ttacaagact gaggaatatc agactgcgaa tcaccgggaa cggttccttt gcagcacaga
      601 agcaatctct ctccccatct tcgcatattc tgatggcaaa acaagtggaa gaaaagagga
      661 agcatgactg cagatcagat cagttctctt tgtggattat attttcagta aaatgtatgg
      721 atctatcttt tccttgttct tatatctaga tcatgagact tgactgaggc tgtatcctta
      781 tcctccatcc atctatggcg aactatagcc atgcagctga caacattttg caaaatctct
      841 cgcctctaac agcctttctg aaactgactt ccttgggttt cataatagga gtcagcgtgg
      901 tgggcaacct cctgatctcc attttgctag tgaaagataa gaccttgcat agagcacctt
      961 actacttcct gttggatctt tgctgttcag atatcctcag atctgcaatt tgtttcccat
     1021 ttgtgttcaa ctctgtcaaa aatggttcta cctggactta tgggactctg acttgcaaag
     1081 tgattgcctt tctgggggtt ttgtcctgtt tccacactgc tttcatgctc ttctgcatca
     1141 gtgtcaccag atatttagct atcgcccatc accgcttcta tacaaagagg ctgacctttt
     1201 ggacgtgtct ggctgtgatc tgtatggtgt ggactctgtc tgtggccatg gcatttcccc
     1261 cggttttaga cgtgggcact tactcattca ttagggagga agatcaatgc accttccaac
     1321 accgctcctt cagggctaat gattccttag gatttatgct gcttcttgct ctcatcctcc
     1381 tagccacaca gcttgtctac ctcaagctga tatttttcgt ccacgatcga agaaaaatga
     1441 agccagtcca gtttgtagca gcagtcagcc agaactggac ttttcatggt cctggagcca
     1501 gtggccaggc agctgccaat tggctagcag gatttggaag gggtcccaca ccacccacct
     1561 tgctgggcat caggcaaaat gcaaacacca caggcagaag aaggctattg gtcttagacg
     1621 agttcaaaat ggagaaaaga atcagcagaa tgttctatat aatgactttt ctgtttctaa
     1681 ccttgtgggg cccctacctg gtggcctgtt attggagagt ttttgcaaga gggcctgtag
     1741 taccaggggg atttctaaca gctgctgtct ggatgagttt tgcccaagca ggaatcaatc
     1801 cttttgtctg cattttctca aacagggagc tgaggcgctg tttcagcaca acccttcttt
     1861 actgcagaaa atccaggtta ccaagggaac cttactgtgt tatatgaggg agcatctgta
     1921 aatctttagc cttgtgaaaa ctaaccttct ctgctgagca attgtggccc atagccatat
     1981 tttgagaaga aattcaagaa tggaatcagc agttttaagg atttgggcaa cattctgcag
     2041 tctttgcaat agttcaccta taatcctatt ttaaatctca gagtgatcct gctgactgcc
     2101 agcaaaggtt tgtaattaag aagggactga accactgccc taagtttctt tatgtggtca
     2161 aaaactagat aatgaaagta gcaggtgcta agtatcagtg ctaaatgctc tgtatgtcac
     2221 tacatatgaa aaaacatcaa aaaacaatta gcattggaca tcttaataaa ttaagttgac
     2281 atgaggtaaa tgtgttgata aaaactaatt ttagaagttt gaagacttta aaacatttca
     2341 tactactatt gttttgcaaa gactaaaata tttggggact taaagtactg taatccacta
     2401 aagacgtgcc aatgaattat tggaatatca cactttaaaa accgccttgt aagttctggg
     2461 gagcattcca aagcagtata ttggttccaa ttagagttta ctttttttgt attaatacat
     2521 tgctatttct aaataccact ttcctcatct actagtaaga ttgctagcat tgaactgtat
     2581 tatgtggttt ttgttgattt ggtataaagt ttttccaatt catttatatt ttacaaatgc
     2641 tagatattgg tctgggaggc aacattaatg gtaccagcct gtcacaactg agcagttcta
     2701 ataatgcaga ataaatacat gttgccttaa agggttatct agtatccttc atcttattta
     2761 gcactggagc aaatagccaa gggaaatcaa atcagtaact ggtcatggtc atgcatctaa
     2821 aagtgcatgg aagatcattt attacttttt ccttttttct cacatggttt gaaacttaaa
     2881 gtgcacatca ctgaaataat gagattttct tctacggtgt gctacccttt ctaaactgtt
     2941 ctaagaagca ggcagttgat gtatgtttat attttaagtc agctgtcaag gggagaccac
     3001 agccttagta tgacatcctg cacaatttgt gaagcattta ttctactgaa ggcacagtct
     3061 tgtttatact ttctgcacat tcagtgtatt ggtaatttaa attatttcag ttttaacttg
     3121 tgaaagctta tattatgatt tctggtattt tagaaataca ttagagtctg tgagtctcat
     3181 tctttaagat acagatgtgt gaacttcaat ataaagttgc atttgccaaa a
//
