LOCUS       NM_020370               1509 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens G protein-coupled receptor 84 (GPR84), mRNA.
ACCESSION   NM_020370
VERSION     NM_020370.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1509)
  AUTHORS   Aktar,R., Rondinelli,S. and Peiris,M.
  TITLE     GPR84 in physiology-Many functions in many tissues
  JOURNAL   Br J Pharmacol 181 (10), 1524-1535 (2024)
   PUBMED   37533166
  REMARK    GeneRIF: GPR84 in physiology-Many functions in many tissues.
            Review article
REFERENCE   2  (bases 1 to 1509)
  AUTHORS   Marsango,S. and Milligan,G.
  TITLE     Regulation of the pro-inflammatory G protein-coupled receptor GPR84
  JOURNAL   Br J Pharmacol 181 (10), 1500-1508 (2024)
   PUBMED   37085331
  REMARK    GeneRIF: Regulation of the pro-inflammatory G protein-coupled
            receptor GPR84.
            Review article
REFERENCE   3  (bases 1 to 1509)
  AUTHORS   Forsman,H., Dahlgren,C., Martensson,J., Bjorkman,L. and
            Sundqvist,M.
  TITLE     Function and regulation of GPR84 in human neutrophils
  JOURNAL   Br J Pharmacol 181 (10), 1536-1549 (2024)
   PUBMED   36869866
  REMARK    GeneRIF: Function and regulation of GPR84 in human neutrophils.
            Review article
REFERENCE   4  (bases 1 to 1509)
  AUTHORS   Luscombe,V.B., Baena-Lopez,L.A., Bataille,C.J.R., Russell,A.J. and
            Greaves,D.R.
  TITLE     Kinetic insights into agonist-dependent signalling bias at the
            pro-inflammatory G-protein coupled receptor GPR84
  JOURNAL   Eur J Pharmacol 956, 175960 (2023)
   PUBMED   37543157
  REMARK    GeneRIF: Kinetic insights into agonist-dependent signalling bias at
            the pro-inflammatory G-protein coupled receptor GPR84.
REFERENCE   5  (bases 1 to 1509)
  AUTHORS   Peters,A., Rabe,P., Liebing,A.D., Krumbholz,P., Nordstrom,A.,
            Jager,E., Kraft,R. and Staubert,C.
  TITLE     Hydroxycarboxylic acid receptor 3 and GPR84 - Two
            metabolite-sensing G protein-coupled receptors with opposing
            functions in innate immune cells
  JOURNAL   Pharmacol Res 176, 106047 (2022)
   PUBMED   34968686
  REMARK    GeneRIF: Hydroxycarboxylic acid receptor 3 and GPR84 - Two
            metabolite-sensing G protein-coupled receptors with opposing
            functions in innate immune cells.
REFERENCE   6  (bases 1 to 1509)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   7  (bases 1 to 1509)
  AUTHORS   Ichimura,A., Hirasawa,A., Hara,T. and Tsujimoto,G.
  TITLE     Free fatty acid receptors act as nutrient sensors to regulate
            energy homeostasis
  JOURNAL   Prostaglandins Other Lipid Mediat 89 (3-4), 82-88 (2009)
   PUBMED   19460454
  REMARK    Review article
REFERENCE   8  (bases 1 to 1509)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
REFERENCE   9  (bases 1 to 1509)
  AUTHORS   Yousefi,S., Cooper,P.R., Potter,S.L., Mueck,B. and Jarai,G.
  TITLE     Cloning and expression analysis of a novel G-protein-coupled
            receptor selectively expressed on granulocytes
  JOURNAL   J Leukoc Biol 69 (6), 1045-1052 (2001)
   PUBMED   11404393
REFERENCE   10 (bases 1 to 1509)
  AUTHORS   Wittenberger,T., Schaller,H.C. and Hellebrand,S.
  TITLE     An expressed sequence tag (EST) data mining strategy succeeding in
            the discovery of new G-protein coupled receptors
  JOURNAL   J Mol Biol 307 (3), 799-813 (2001)
   PUBMED   11273702
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP303386.1, BC020614.1 and CD366881.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020370.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.93800.1, BC020614.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267015.4/ ENSP00000267015.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BP303386.1         1-8
            9-1505              BC020614.1         7-1503
            1506-1509           CD366881.1         17-20               c
FEATURES             Location/Qualifiers
     source          1..1509
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..1509
                     /gene="GPR84"
                     /gene_synonym="EX33; GPCR4"
                     /note="G protein-coupled receptor 84"
                     /db_xref="GeneID:53831"
                     /db_xref="HGNC:HGNC:4535"
                     /db_xref="MIM:606383"
     exon            1..94
                     /gene="GPR84"
                     /gene_synonym="EX33; GPCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            95..1509
                     /gene="GPR84"
                     /gene_synonym="EX33; GPCR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1293
                     /gene="GPR84"
                     /gene_synonym="EX33; GPCR4"
                     /note="inflammation-related G protein-coupled receptor
                     EX33"
                     /codon_start=1
                     /product="G-protein coupled receptor 84"
                     /protein_id="NP_065103.1"
                     /db_xref="CCDS:CCDS8878.1"
                     /db_xref="GeneID:53831"
                     /db_xref="HGNC:HGNC:4535"
                     /db_xref="MIM:606383"
                     /translation="MWNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLA
                     LAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFA
                     SNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYI
                     LVPVVCTCSFDRIRGRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLR
                     QASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGD
                     QINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIP
                     FLLLNILDARVQAPRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSILKRGPRSF
                     HRLH"
     regulatory      1490..1495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR84"
                     /gene_synonym="EX33; GPCR4"
                     /note="hexamer: AATGAA"
     polyA_site      1509
                     /gene="GPR84"
                     /gene_synonym="EX33; GPCR4"
                     /note="major polyA site"
ORIGIN      
        1 ctgcttgaag cctaactgtc caccagaaag gactgctctt tgggtgagtt gaacttcttc
       61 cattatagaa agaattgaag gctgagaaac tcagcctcta tcatgtggaa cagctctgac
      121 gccaacttct cctgctacca tgagtctgtg ctgggctatc gttatgttgc agttagctgg
      181 ggggtggtgg tggctgtgac aggcaccgtg ggcaatgtgc tcaccctact ggccttggcc
      241 atccagccca agctccgtac ccgattcaac ctgctcatag ccaacctcac actggctgat
      301 ctcctctact gcacgctcct tcagcccttc tctgtggaca cctacctcca cctgcactgg
      361 cgcaccggtg ccaccttctg cagggtattt gggctcctcc tttttgcctc caattctgtc
      421 tccatcctga ccctctgcct catcgcactg ggacgctacc tcctcattgc ccaccctaag
      481 ctttttcccc aagttttcag tgccaagggg atagtgctgg cactggtgag cacctgggtt
      541 gtgggcgtgg ccagctttgc tcccctctgg cctatttata tcctggtacc tgtagtctgc
      601 acctgcagct ttgaccgcat ccgaggccgg ccttacacca ccatcctcat gggcatctac
      661 tttgtgcttg ggctcagcag tgttggcatc ttctattgcc tcatccaccg ccaggtcaaa
      721 cgagcagcac aggcactgga ccaatacaag ttgcgacagg caagcatcca ctccaaccat
      781 gtggccagga ctgatgaggc catgcctggt cgtttccagg agctggacag caggttagca
      841 tcaggaggac ccagtgaggg gatttcatct gagccagtca gtgctgccac cacccagacc
      901 ctggaagggg actcatcaga agtgggagac cagatcaaca gcaagagagc taagcagatg
      961 gcagagaaaa gccctccaga agcatctgcc aaagcccagc caattaaagg agccagaaga
     1021 gctccggatt cttcatcgga atttgggaag gtgactcgaa tgtgttttgc tgtgttcctc
     1081 tgctttgccc tgagctacat ccccttcttg ctgctcaaca ttctggatgc cagagtccag
     1141 gctccccggg tggtccacat gcttgctgcc aacctcacct ggctcaatgg ttgcatcaac
     1201 cctgtgctct atgcagccat gaaccgccaa ttccgccaag catatggctc cattttaaaa
     1261 agagggcccc ggagtttcca taggctccat tagaactgtg accctagtca ccagaattca
     1321 ggactgtctc ctccaggacc aaagtggcca ggtaatagga gaataggtga aataacacat
     1381 gtgggcattt tcacaacaat ctctccccag cctcccaaat caagtctctc catcacttga
     1441 tcaatgtttc agccctagac tgcccaagga gtattattaa ttattaataa atgaattctg
     1501 tgcttttaa
//
