LOCUS       NM_080817               3318 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens G protein-coupled receptor 82 (GPR82), mRNA.
ACCESSION   NM_080817
VERSION     NM_080817.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3318)
  AUTHORS   Tarpey,P.S., Smith,R., Pleasance,E., Whibley,A., Edkins,S.,
            Hardy,C., O'Meara,S., Latimer,C., Dicks,E., Menzies,A.,
            Stephens,P., Blow,M., Greenman,C., Xue,Y., Tyler-Smith,C.,
            Thompson,D., Gray,K., Andrews,J., Barthorpe,S., Buck,G., Cole,J.,
            Dunmore,R., Jones,D., Maddison,M., Mironenko,T., Turner,R.,
            Turrell,K., Varian,J., West,S., Widaa,S., Wray,P., Teague,J.,
            Butler,A., Jenkinson,A., Jia,M., Richardson,D., Shepherd,R.,
            Wooster,R., Tejada,M.I., Martinez,F., Carvill,G., Goliath,R., de
            Brouwer,A.P., van Bokhoven,H., Van Esch,H., Chelly,J., Raynaud,M.,
            Ropers,H.H., Abidi,F.E., Srivastava,A.K., Cox,J., Luo,Y.,
            Mallya,U., Moon,J., Parnau,J., Mohammed,S., Tolmie,J.L.,
            Shoubridge,C., Corbett,M., Gardner,A., Haan,E., Rujirabanjerd,S.,
            Shaw,M., Vandeleur,L., Fullston,T., Easton,D.F., Boyle,J.,
            Partington,M., Hackett,A., Field,M., Skinner,C., Stevenson,R.E.,
            Bobrow,M., Turner,G., Schwartz,C.E., Gecz,J., Raymond,F.L.,
            Futreal,P.A. and Stratton,M.R.
  TITLE     A systematic, large-scale resequencing screen of X-chromosome
            coding exons in mental retardation
  JOURNAL   Nat Genet 41 (5), 535-543 (2009)
   PUBMED   19377476
REFERENCE   2  (bases 1 to 3318)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
REFERENCE   3  (bases 1 to 3318)
  AUTHORS   Lee,D.K., Nguyen,T., Lynch,K.R., Cheng,R., Vanti,W.B., Arkhitko,O.,
            Lewis,T., Evans,J.F., George,S.R. and O'Dowd,B.F.
  TITLE     Discovery and mapping of ten novel G protein-coupled receptor genes
  JOURNAL   Gene 275 (1), 83-91 (2001)
   PUBMED   11574155
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC070180.1 and AL627402.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_080817.4.
            
            Summary: The protein encoded by this gene is an orphan G
            protein-coupled receptor of unknown function. The encoded protein
            is a member of a family of proteins that contain seven
            transmembrane domains and transduce extracellular signals through
            heterotrimeric G proteins. [provided by RefSeq, Sep 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313702.1, AL832460.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302548.5/ ENSP00000303549.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1152              BC070180.1         27-1178
            1153-3318           AL627402.10        123182-125347
FEATURES             Location/Qualifiers
     source          1..3318
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.4"
     gene            1..3318
                     /gene="GPR82"
                     /note="G protein-coupled receptor 82"
                     /db_xref="GeneID:27197"
                     /db_xref="HGNC:HGNC:4533"
                     /db_xref="MIM:300748"
     exon            1..109
                     /gene="GPR82"
                     /inference="alignment:Splign:2.1.0"
     exon            110..180
                     /gene="GPR82"
                     /inference="alignment:Splign:2.1.0"
     exon            181..3318
                     /gene="GPR82"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1225
                     /gene="GPR82"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 82"
                     /protein_id="NP_543007.1"
                     /db_xref="CCDS:CCDS14259.1"
                     /db_xref="GeneID:27197"
                     /db_xref="HGNC:HGNC:4533"
                     /db_xref="MIM:300748"
                     /translation="MNNNTTCIQPSMISSMALPIIYILLCIVGVFGNTLSQWIFLTKI
                     GKKTSTHIYLSHLVTANLLVCSAMPFMSIYFLKGFQWEYQSAQCRVVNFLGTLSMHAS
                     MFVSLLILSWIAISRYATLMQKDSSQETTSCYEKIFYGHLLKKFRQPNFARKLCIYIW
                     GVVLGIIIPVTVYYSVIEATEGEESLCYNRQMELGAMISQIAGLIGTTFIGFSFLVVL
                     TSYYSFVSHLRKIRTCTSIMEKDLTYSSVKRHLLVIQILLIVCFLPYSIFKPIFYVLH
                     QRDNCQQLNYLIETKNILTCLASARSSTDPIIFLLLDKTFKKTLYNLFTKSNSAHMQS
                     YG"
     regulatory      3295..3300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR82"
                     /note="hexamer: AATAAA"
     polyA_site      3318
                     /gene="GPR82"
                     /note="major polyA site"
ORIGIN      
        1 acactgacta aagatattgg aagagtgaag atcagagaat tttaagtctg aaatttggca
       61 tcactgccct gaacaatata accttagttg gcataaacta ctcatacaga caaaggcatt
      121 atccatcaca ataagtaact ttttgtcttt atttcaaccg gacaatcgtg attagaaaag
      181 ctcctgtgac aaaattcaag aaaacctgac ataaatgaac aacaatacaa catgtattca
      241 accatctatg atctcttcca tggctttacc aatcatttac atcctccttt gtattgttgg
      301 tgtttttgga aacactctct ctcaatggat atttttaaca aaaataggta aaaaaacatc
      361 aacgcacatc tacctgtcac accttgtgac tgcaaactta cttgtgtgca gtgccatgcc
      421 tttcatgagt atctatttcc tgaaaggttt ccaatgggaa tatcaatctg ctcaatgcag
      481 agtggtcaat tttctgggaa ctctatccat gcatgcaagt atgtttgtca gtctcttaat
      541 tttaagttgg attgccataa gccgctatgc taccttaatg caaaaggatt cctcgcaaga
      601 gactacttca tgctatgaga aaatatttta tggccattta ctgaaaaaat ttcgccagcc
      661 caactttgct agaaaactat gcatttacat atggggagtt gtactgggca taatcattcc
      721 agttaccgta tactactcag tcatagaggc tacagaagga gaagagagcc tatgctacaa
      781 tcggcagatg gaactaggag ccatgatctc tcagattgca ggtctcattg gaaccacatt
      841 tattggattt tcctttttag tagtactaac atcatactac tcttttgtaa gccatctgag
      901 aaaaataaga acctgtacgt ccattatgga gaaagatttg acttacagtt ctgtgaaaag
      961 acatcttttg gtcatccaga ttctactaat agtttgcttc cttccttata gtatttttaa
     1021 acccattttt tatgttctac accaaagaga taactgtcag caattgaatt atttaataga
     1081 aacaaaaaac attctcacct gtcttgcttc ggccagaagt agcacagacc ccattatatt
     1141 tcttttatta gataaaacat tcaagaagac actatataat ctctttacaa agtctaattc
     1201 agcacatatg caatcatatg gttgactttt gaatggaaaa ccccacaata ttaagaaaag
     1261 cattcatgtg actttattag ggacactaaa ctacatcatt aacatgtcac agcttggttg
     1321 acaataatca ccaagaaaat ctctttggtt tttaaaaata aataaacata tattcataaa
     1381 actcaaaaaa cagttatact gaacgttgag atggcagaaa ctttcagaag caaaaattaa
     1441 gcatattgaa aggatcccac tcatatgaaa ctaacaggct gttttctgtt taaactcaac
     1501 tgtcagtgct tctgttcaga acacgttatt tcatgactag gataaagaag caaatggttt
     1561 atgacttgtc tgctttctgg tagttagaat acaagggtca atctatggct agtgtttatt
     1621 ggtaatttta aaatctttaa aaataagtag ctgggcacag tggcttacgc ctgtaatccc
     1681 agcactttgg gaggctgagg tgggtggatc attttgaggt caggagttca agaccagcct
     1741 gggcaacatg gtgaaaccct gtctctacta aaaatacaaa aatcagctgg acatggtggt
     1801 gggcgcctgt aatcccagct actcgggagg ctgaggcagg agaatcgctt gagcccggga
     1861 cggaggttgc agtgagcgga gatcgtgcca ctgcactaca gcctgggagg cagagcgaga
     1921 ctctgtctca taaaacaaaa caaaaaaata aaaataagta aaaaaataaa taagaaatat
     1981 cctcattcac atcttaccta aatgcatgaa taatacagtg aaaaaaatcc aaggttttat
     2041 aaacatatta tttatttgaa attatctggc tcatgttatt ggggagaagc aatattcatt
     2101 gactatattt ttaaagcaga tgatacttat aaaaatgctt aaatatttgg attaggcttt
     2161 gtcaaagtaa aaagctatgt cattatatgc ccatcttcat cacattgtgc atattttctt
     2221 ctgtattcaa tataaataat gttattagtg acaaacagta cctggcagtt aattttttgt
     2281 gaaataaatg aatgaataat aagggagtgt aatagtattg cagttaagag attgatctct
     2341 gaagttatac ttcttgggtt caatctggct ctacttttta tttagctgga caatcttagg
     2401 caaattaact tatcctctgt acgtgttaat ttcttcattt gtagagcaga aaatactatc
     2461 ttatttacag atcctattat taaatcagct gttactatta tgagtagcta acgcttagta
     2521 agcacttgct gtttgccaag cattctactt atatgcttta catatattat tttaatcacc
     2581 acaactctaa agtatactaa tttactgatg aaaatattga agtgggctgg gtgcggtggc
     2641 tcatgcctgt aatcccagca ctctgggagg ccgaggtggg cagatcacct gaggtcagga
     2701 gttcgagact agcctggcca acatggcgaa acccacctct actaaaaata caaaaattag
     2761 ctgggcgtgg tggtgtgtgc ctgtagtccc agctacttgg gaggctgagg cagaagaatc
     2821 acttgaactc gggaggctga ggcaggagaa tcacttgaac tcaggaggcg gaggttgcag
     2881 tgagccaaga tcatgccatt gcactccagc ctgggcgaca gagtgagact ctgtctcaaa
     2941 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa tatatatata tatatatata tatatgtatg
     3001 tatgtatgta tatgtgcata gttaagtaaa tcaccccaat tttttctaat atttaagtga
     3061 acatttaaag ataagcattt cttaatgtta atttcttttc tttcatgtaa tcttgtcagt
     3121 agacaaatga tggtgactat attctgtaat aagtacatat attatgatta aaaaaaaaag
     3181 cgtgtactat ctgcccaaag agatcataag cactttggag ctataaactt cttgtctatt
     3241 tctacttcca tggtactgat attctcttct cagataacca aacaaaaaca gctgaataaa
     3301 atcaaccatt aatagtaa
//
