LOCUS       NM_080819               4343 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens G protein-coupled receptor 78 (GPR78), transcript
            variant 1, mRNA.
ACCESSION   NM_080819
VERSION     NM_080819.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4343)
  AUTHORS   Tanaka,T., Guimaro,M.C., Nakamura,H., Perez,P., Ji,Y.,
            Michael,D.G., Afione,S.A., Zheng,C., Goldsmith,C., Swaim,W.D.,
            Pedersen,A.M.L. and Chiorini,J.A.
  TITLE     Association of G protein-coupled receptor 78 with salivary
            dysfunction in male Sjogren's patients
  JOURNAL   Oral Dis 30 (3), 1173-1182 (2024)
   PUBMED   36652502
  REMARK    GeneRIF: Association of G protein-coupled receptor 78 with salivary
            dysfunction in male Sjogren's patients.
REFERENCE   2  (bases 1 to 4343)
  AUTHORS   Cai,M.N., Chen,D.M., Xiao,L.X., Li,S.S., Liao,C.H., Li,J.,
            Huang,Z.X., Wang,J.L., Gu,Y.R., Gu,L., Huang,Y.H. and Lian,Y.F.
  TITLE     COLEC10 Induces Endoplasmic Reticulum Stress by Occupying GRP78 and
            Inhibits Hepatocellular Carcinoma
  JOURNAL   Lab Invest 103 (7), 100130 (2023)
   PUBMED   36925047
  REMARK    GeneRIF: COLEC10 Induces Endoplasmic Reticulum Stress by Occupying
            GRP78 and Inhibits Hepatocellular Carcinoma.
REFERENCE   3  (bases 1 to 4343)
  AUTHORS   Deelen,J., Evans,D.S., Arking,D.E., Tesi,N., Nygaard,M., Liu,X.,
            Wojczynski,M.K., Biggs,M.L., van der Spek,A., Atzmon,G., Ware,E.B.,
            Sarnowski,C., Smith,A.V., Seppala,I., Cordell,H.J., Dose,J.,
            Amin,N., Arnold,A.M., Ayers,K.L., Barzilai,N., Becker,E.J.,
            Beekman,M., Blanche,H., Christensen,K., Christiansen,L.,
            Collerton,J.C., Cubaynes,S., Cummings,S.R., Davies,K.,
            Debrabant,B., Deleuze,J.F., Duncan,R., Faul,J.D., Franceschi,C.,
            Galan,P., Gudnason,V., Harris,T.B., Huisman,M., Hurme,M.A.,
            Jagger,C., Jansen,I., Jylha,M., Kahonen,M., Karasik,D.,
            Kardia,S.L.R., Kingston,A., Kirkwood,T.B.L., Launer,L.J.,
            Lehtimaki,T., Lieb,W., Lyytikainen,L.P., Martin-Ruiz,C., Min,J.,
            Nebel,A., Newman,A.B., Nie,C., Nohr,E.A., Orwoll,E.S., Perls,T.T.,
            Province,M.A., Psaty,B.M., Raitakari,O.T., Reinders,M.J.T.,
            Robine,J.M., Rotter,J.I., Sebastiani,P., Smith,J., Sorensen,T.I.A.,
            Taylor,K.D., Uitterlinden,A.G., van der Flier,W., van der Lee,S.J.,
            van Duijn,C.M., van Heemst,D., Vaupel,J.W., Weir,D., Ye,K.,
            Zeng,Y., Zheng,W., Holstege,H., Kiel,D.P., Lunetta,K.L.,
            Slagboom,P.E. and Murabito,J.M.
  TITLE     A meta-analysis of genome-wide association studies identifies
            multiple longevity genes
  JOURNAL   Nat Commun 10 (1), 3669 (2019)
   PUBMED   31413261
  REMARK    GeneRIF: rs7676745, located near GPR78, associates with lower odds
            of surviving to the 90th percentile age. [Meta-analysis]
            Erratum:[Nat Commun. 2021 Apr 23;12(1):2463. doi:
            10.1038/s41467-021-22613-2.. PMID: 33893282]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4343)
  AUTHORS   Stan,R.C., Silva,R.L. and de Camargo,M.M.
  TITLE     Human GRP78 affinity towards its signaling partners Ire1alpha and
            PERK is differently modulated by an unfolded protein client
  JOURNAL   Biochem Biophys Res Commun 487 (2), 375-380 (2017)
   PUBMED   28416388
  REMARK    GeneRIF: We reveal distinct binding affinities between the binary
            and ternary complexes thus formed, that suggest a preference for
            the PERK signaling branch under stress, and a predilection for the
            GRP78-UPR sensor complex formation upon stressor removal. These
            results imply a gated UPR mechanism that tunes the overall cellular
            behavior to the accumulation of unfolded proteins.
            Erratum:[Biochem Biophys Res Commun. 2017 Aug 12;490(1):69. doi:
            10.1016/j.bbrc.2017.06.004.. PMID: 28601239]
REFERENCE   5  (bases 1 to 4343)
  AUTHORS   Dong,D.D., Zhou,H. and Li,G.
  TITLE     GPR78 promotes lung cancer cell migration and metastasis by
            activation of Galphaq-Rho GTPase pathway
  JOURNAL   BMB Rep 49 (11), 623-628 (2016)
   PUBMED   27697106
  REMARK    GeneRIF: Knockdown of GPR78 in lung cancer cells suppressed cell
            migration and GPR78 modulated the formation of actin stress fibers
            in A549 cells, in a RhoA- and Rac1-dependent manner.
REFERENCE   6  (bases 1 to 4343)
  AUTHORS   Ijuin,T., Hatano,N. and Takenawa,T.
  TITLE     Glucose-regulated protein 78 (GRP78) binds directly to PIP3
            phosphatase SKIP and determines its localization
  JOURNAL   Genes Cells 21 (5), 457-465 (2016)
   PUBMED   26940976
REFERENCE   7  (bases 1 to 4343)
  AUTHORS   Yang,J.F., Cao,J.G., Tian,L. and Liu,F.
  TITLE     5, 7-Dimethoxyflavone sensitizes TRAIL-induced apoptosis through
            DR5 upregulation in hepatocellular carcinoma cells
  JOURNAL   Cancer Chemother Pharmacol 69 (1), 195-206 (2012)
   PUBMED   21660448
REFERENCE   8  (bases 1 to 4343)
  AUTHORS   Jones,P.G., Nawoschik,S.P., Sreekumar,K., Uveges,A.J., Tseng,E.,
            Zhang,L., Johnson,J., He,L., Paulsen,J.E., Bates,B. and Pausch,M.H.
  TITLE     Tissue distribution and functional analyses of the constitutively
            active orphan G protein coupled receptors, GPR26 and GPR78
  JOURNAL   Biochim Biophys Acta 1770 (6), 890-901 (2007)
   PUBMED   17363172
REFERENCE   9  (bases 1 to 4343)
  AUTHORS   Underwood,S.L., Christoforou,A., Thomson,P.A., Wray,N.R.,
            Tenesa,A., Whittaker,J., Adams,R.A., Le Hellard,S., Morris,S.W.,
            Blackwood,D.H., Muir,W.J., Porteous,D.J. and Evans,K.L.
  TITLE     Association analysis of the chromosome 4p-located G protein-coupled
            receptor 78 (GPR78) gene in bipolar affective disorder and
            schizophrenia
  JOURNAL   Mol Psychiatry 11 (4), 384-394 (2006)
   PUBMED   16389273
  REMARK    GeneRIF: Two haplotypes remained significant in both the female
            bipolar affective disorder individuals and in the full sample of
            affected female individuals. Results provide preliminary evidence
            for involvement of GPR78 in susceptibility to BPAD and SCZ.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 4343)
  AUTHORS   Lee,D.K., Nguyen,T., Lynch,K.R., Cheng,R., Vanti,W.B., Arkhitko,O.,
            Lewis,T., Evans,J.F., George,S.R. and O'Dowd,B.F.
  TITLE     Discovery and mapping of ten novel G protein-coupled receptor genes
  JOURNAL   Gene 275 (1), 83-91 (2001)
   PUBMED   11574155
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105345.3, AK128807.1,
            BC057778.1 and BE645298.1.
            
            On Nov 23, 2018 this sequence version replaced NM_080819.4.
            
            Summary: The protein encoded by this gene belongs to the G
            protein-coupled receptor family, which contain 7 transmembrane
            domains and transduce extracellular signals through heterotrimeric
            G proteins. This is an orphan receptor, which displays significant
            level of constitutive activity. Association analysis shows
            preliminary evidence for the involvement of this gene in
            susceptibility to bipolar affective disorder and schizophrenia.
            Alternatively spliced transcript variants have been found for this
            gene. [provided by RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the supported protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128807.1, BC057778.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153307, SAMEA2162568
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382487.5/ ENSP00000371927.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                AC105345.3         128576-128673
            99-394              AK128807.1         1-296
            395-2113            BC057778.1         221-1939
            2114-4306           AC105345.3         135978-138170
            4307-4343           BE645298.1         18-54               c
FEATURES             Location/Qualifiers
     source          1..4343
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.1"
     gene            1..4343
                     /gene="GPR78"
                     /note="G protein-coupled receptor 78"
                     /db_xref="GeneID:27201"
                     /db_xref="HGNC:HGNC:4528"
                     /db_xref="MIM:606921"
     exon            1..1259
                     /gene="GPR78"
                     /inference="alignment:Splign:2.1.0"
     CDS             592..1683
                     /gene="GPR78"
                     /codon_start=1
                     /product="G-protein coupled receptor 78"
                     /protein_id="NP_543009.2"
                     /db_xref="CCDS:CCDS3403.1"
                     /db_xref="GeneID:27201"
                     /db_xref="HGNC:HGNC:4528"
                     /db_xref="MIM:606921"
                     /translation="MGPGEALLAGLLVMVLAVALLSNALVLLCCAYSAELRTRASGVL
                     LVNLSLGHLLLAALDMPFTLLGVMRGRTPSAPGACQVIGFLDTFLASNAALSVAALSA
                     DQWLAVGFPLRYAGRLRPRYAGLLLGCAWGQSLAFSGAALGCSWLGYSSAFASCSLRL
                     PPEPERPRFAAFTATLHAVGFVLPLAVLCLTSLQVHRVARRHCQRMDTVTMKALALLA
                     DLHPSVRQRCLIQQKRRRHRATRKIGIAIATFLICFAPYVMTRLAELVPFVTVNAQWG
                     ILSKCLTYSKAVADPFTYSLLRRPFRQVLAGMVHRLLKRTPRPASTHDSSLDVAGMVH
                     QLLKRTPRPASTHNGSVDTENDSCLQQTH"
     exon            1260..1373
                     /gene="GPR78"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..4343
                     /gene="GPR78"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4325..4330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR78"
                     /note="hexamer: AATAAA"
     polyA_site      4343
                     /gene="GPR78"
                     /note="major polyA site"
ORIGIN      
        1 aagccaccag gtcgctccag tttggtgcca gcgcctggag ggagaggcgt ggcgagggct
       61 gtgctgccta ggatccactg agtggctctt gctggcgtgt cagctgcgcg cgaaccaggg
      121 ctgggaggct cggctggagg tgtgaccagg gcagggactg acctggcccg gaacagaagc
      181 gcgcagagtc ccatcctgcc acgccacgag gagagaagaa ggaaagatac agtgttagga
      241 aagagacctc cctcgcccct acgccccgcg cccctgcgcc tcgcttcagc ctcaggacag
      301 tcctgccggg acggtgagcg cattcagcac cctggacagc accgcggttg cgctgcctcc
      361 agggcggccc cgggctgctc ctgctccgca gagctacgcc ctccccccgg gtgccccgga
      421 ccctgcactt gccgccgctt tcctcgcgct gctctggacc ttgctagccg gctctgcacc
      481 tcccagaagc cgtgggcgcg ccgctcagct gctccatcgc ctcactttcc caggctcgcg
      541 cccgaagcag agccatgaga accccagggt gcctggcgag ccgctagcgc catgggcccc
      601 ggcgaggcgc tgctggcggg tctcctggtg atggtactgg ccgtggcgct gctatccaac
      661 gcactggtgc tgctttgttg cgcctacagc gctgagctcc gcactcgagc ctcaggcgtc
      721 ctcctggtga atctgtctct gggccacctg ctgctggcgg cgctggacat gcccttcacg
      781 ctgctcggtg tgatgcgcgg gcggacaccg tcggcgcccg gcgcatgcca agtcattggc
      841 ttcctggaca ccttcctggc gtccaacgcg gcgctgagcg tggcggcgct gagcgcagac
      901 cagtggctgg cagtgggctt cccactgcgc tacgccggac gcctgcgacc gcgctatgcc
      961 ggcctgctgc tgggctgtgc ctggggacag tcgctggcct tctcaggcgc tgcacttggc
     1021 tgctcgtggc ttggctacag cagcgccttc gcgtcctgtt cgctgcgcct gccgcccgag
     1081 cctgagcgtc cgcgcttcgc agccttcacc gccacgctcc atgccgtggg cttcgtgctg
     1141 ccgctggcgg tgctctgcct cacctcgctc caggtgcacc gggtggcacg cagacactgc
     1201 cagcgcatgg acaccgtcac catgaaggcg ctcgcgctgc tcgccgacct gcaccccagt
     1261 gtgcggcagc gctgcctcat ccagcagaag cggcgccgcc accgcgccac caggaagatt
     1321 ggcattgcta ttgcgacctt cctcatctgc tttgccccgt atgtcatgac caggctggcg
     1381 gagctcgtgc ccttcgtcac cgtgaacgcc cagtggggca tcctcagcaa gtgcctgacc
     1441 tacagcaagg cggtggccga cccgttcacg tactctctgc tccgccggcc gttccgccaa
     1501 gtcctggccg gcatggtgca ccggctgctg aagagaaccc cgcgcccagc atccacccat
     1561 gacagctctc tggatgtggc cggcatggtg caccagctgc tgaagagaac cccgcgccca
     1621 gcgtccaccc acaacggctc tgtggacaca gagaatgatt cctgcctgca gcagacacac
     1681 tgagggcctg gcagggctca tcgcccccac cttctaagaa gccctgtgga aagggcactg
     1741 gccctgccac agagatgcca ctggggaccc ccagacacca gtggcttgac tttgagctaa
     1801 ggctgaagta caggaggagg aggaggagag ggccggatgt gggtgtggac agcagtagtg
     1861 gcggaggaga gctcggggct gggctgcctg gctgctgggt ggccccggga cagtggcttt
     1921 tcctctctga accttagctt cctcaccctt gttctggggt catggcgatg cttcgagaca
     1981 gtgggtaggg aagtgccctg tgtggcatat ggtactcgtg ggcgtgctat aagtgactgc
     2041 tgttcatgtg ggtgaggtgg tcactcttgc tcagggtctg ttgtgcagcc cagatggaca
     2101 cctgtttctc caacctggtt attagcattg ttccgatttg ttctcggcat tgcccaggtt
     2161 tgggagataa atgccggggc ggagtctggt tgggggctcc cagagttcac atctgatagt
     2221 ctgtggtcag gacctggcag gcacgggcag tccctgggac atgcccatct ctggaagcct
     2281 aggggtcccc agctccaggc ctgtccgctg tgactgcctg tgtgggcacg cagatggagc
     2341 ctgtctcctg ccttcctttc catggtttgc caggggtttg gcatcttgac tgcggaagct
     2401 gtggagtctg tgtgctcaga gccttttctg gtgaagatat catcagagca tgtgacctct
     2461 gtttcctccc cctgaaggcc accgctgggc ctctggatct tagacatgag acggtcaaga
     2521 gattgaagta gtagccaggg cccaggtgtc cagagagggt ggcctgggat ggggagggcc
     2581 cttgctcccc aacagcagtg ctgggggagc caagagaagg tggagcatcc ctgagtagtg
     2641 gtgtgcatca cccccagttt agtaatcacg gggtgccatt ccccggtggg agcacccacc
     2701 atcaatgtca ttgaatgtcc ccatgggaca gtgttgagga cttttgtgac atctgtccta
     2761 tttcacagct cagggaaagg tgcacagtgc acacgggcac ccggtggaga ggtgtgtgtg
     2821 tgaatgagtg agcgagtgaa tgaatggaca cgattctctc ttcagcctct gtcattgctg
     2881 ttttcttcaa ggcccagggc catcccctgc agaggtaggg tgggctgcaa gacctcaggc
     2941 ccctgcctca tgggactctc tgatgggctt caaccgtggg ctcttgcagg catggagcct
     3001 gtatcatgac accttacacc caaggccagc aatgcaagga gagtatggac atcaaattct
     3061 ttccttccag aggctgaatt cttcaaagac acacgcggtc gtcacttgct cttggcatta
     3121 acggtggaga acccagctga ggtggcttca cagattcttc cccaaaaaca caggtgttat
     3181 tattatactt ttaaaaaact ttttgagaca gggtctgact ctgttgccta ggctagagtg
     3241 cagtggtgca atctcagctc actgcagcct ccacctccca tgctcaagcc atcctcccac
     3301 ctcagcctcc tgagtagttg aggacacagg cacgggacac catgcctggc taatttttgt
     3361 attttttttt gtagagatgg cggtctcact ttgttgccca ggctggtctt gaattcctga
     3421 gcttaagtga tcctcccacc tcagcctccc aaagtgctgg gattacaggt gtgagccacc
     3481 acacccagcc aaaaccaggt gttatttgct gactcaccaa tgcctccccc aaaaggataa
     3541 atttaaaggt gtgtataacc catgaagtgt aattcaaata aaacaaatta tcgtttggaa
     3601 taataacaac tataggtatg tggtcaggaa gcagttaaaa acattaaaat acagacctgg
     3661 ccagttcaat ccaacccagg ggttccaagc aggaggtggg gcaggtgggc gtcatgccct
     3721 gattcacaga gggcacaggt gggtgtcatg ccctggttca cagagggcac gtgaactcga
     3781 gaccgtgctg caccccggtg cccctgtgct tataagggag ggcacgtgca cagcagaagc
     3841 aggttgttcc ccatttaaag ttctggagcc caggctgtga gctccttggc tgagccctct
     3901 cctgtccctg ggagctcccc aggtgcgagg agcctgccag ccagtggggc ctacactctg
     3961 tgttattgca tctccgccag gctaaaagcc ttggtcacta ctttagagcc actcaaggaa
     4021 acgcgtgcac cctgccctgc tggaaggcac catggttaga gggaggcaca ctgtttctta
     4081 gagacgggga ctgcttgctg tcatgtttcg ccttcctcgg cagctccatg gaatgttctg
     4141 gagcaggcat cttagggcat tccctccgca cttctctgcc agcccatgtg gctcccacac
     4201 tgggctatcc cttgccttag gcttgtggcc tttttttttt tttttttttt aatttgaaaa
     4261 atatttttca tgtgcactta aacgtgttgt ggaatgatgc tgggtctcaa gaatgctgtg
     4321 aatcaataaa cattttattc aga
//
