LOCUS       NM_006794               2094 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens G protein-coupled receptor 75 (GPR75), mRNA.
ACCESSION   NM_006794
VERSION     NM_006794.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2094)
  AUTHORS   Dashti,M.R., Gorbanzadeh,F., Jafari-Gharabaghlou,D., Farhoudi
            Sefidan Jadid,M. and Zarghami,N.
  TITLE     G Protein-Coupled Receptor 75 (GPR75) As a Novel Molecule for
            Targeted Therapy of Cancer and Metabolic Syndrome
  JOURNAL   Asian Pac J Cancer Prev 24 (5), 1817-1825 (2023)
   PUBMED   37247305
  REMARK    GeneRIF: G Protein-Coupled Receptor 75 (GPR75) As a Novel Molecule
            for Targeted Therapy of Cancer and Metabolic Syndrome.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2094)
  AUTHORS   Pascale,J.V., Park,E.J., Adebesin,A.M., Falck,J.R.,
            Schwartzman,M.L. and Garcia,V.
  TITLE     Uncovering the signalling, structure and function of the
            20-HETE-GPR75 pairing: Identifying the chemokine CCL5 as a negative
            regulator of GPR75
  JOURNAL   Br J Pharmacol 178 (18), 3813-3828 (2021)
   PUBMED   33974269
  REMARK    GeneRIF: Uncovering the signalling, structure and function of the
            20-HETE-GPR75 pairing: Identifying the chemokine CCL5 as a negative
            regulator of GPR75.
REFERENCE   3  (bases 1 to 2094)
  AUTHORS   Akbari,P., Gilani,A., Sosina,O., Kosmicki,J.A., Khrimian,L.,
            Fang,Y.Y., Persaud,T., Garcia,V., Sun,D., Li,A., Mbatchou,J.,
            Locke,A.E., Benner,C., Verweij,N., Lin,N., Hossain,S.,
            Agostinucci,K., Pascale,J.V., Dirice,E., Dunn,M., Kraus,W.E.,
            Shah,S.H., Chen,Y.I., Rotter,J.I., Rader,D.J., Melander,O.,
            Still,C.D., Mirshahi,T., Carey,D.J., Berumen-Campos,J.,
            Kuri-Morales,P., Alegre-Diaz,J., Torres,J.M., Emberson,J.R.,
            Collins,R., Balasubramanian,S., Hawes,A., Jones,M., Zambrowicz,B.,
            Murphy,A.J., Paulding,C., Coppola,G., Overton,J.D., Reid,J.G.,
            Shuldiner,A.R., Cantor,M., Kang,H.M., Abecasis,G.R., Karalis,K.,
            Economides,A.N., Marchini,J., Yancopoulos,G.D., Sleeman,M.W.,
            Altarejos,J., Della Gatta,G., Tapia-Conyer,R., Schwartzman,M.L.,
            Baras,A., Ferreira,M.A.R. and Lotta,L.A.
  CONSRTM   Regeneron Genetics Center; DiscovEHR Collaboration
  TITLE     Sequencing of 640,000 exomes identifies GPR75 variants associated
            with protection from obesity
  JOURNAL   Science 373 (6550) (2021)
   PUBMED   34210852
  REMARK    GeneRIF: Sequencing of 640,000 exomes identifies GPR75 variants
            associated with protection from obesity.
REFERENCE   4  (bases 1 to 2094)
  AUTHORS   Cardenas,S., Colombero,C., Panelo,L., Dakarapu,R., Falck,J.R.,
            Costas,M.A. and Nowicki,S.
  TITLE     GPR75 receptor mediates 20-HETE-signaling and metastatic features
            of androgen-insensitive prostate cancer cells
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1865 (2), 158573 (2020)
   PUBMED   31760076
  REMARK    GeneRIF: Study results show for the first time the involvement of
            the 20-HETE-GPR75 receptor in the activation of intracellular
            signaling known to be stimulated in cell malignant transformations
            leading to the differentiation of PC-3 prostate cancer cells
            towards a more aggressive phenotype. GPR75 receptor stimulation is
            necessary for the pro-metastatic actions of 20-HETE in androgen
            insensitive prostate cancer cells.
REFERENCE   5  (bases 1 to 2094)
  AUTHORS   Dedoni,S., Campbell,L.A., Harvey,B.K., Avdoshina,V. and
            Mocchetti,I.
  TITLE     The orphan G-protein-coupled receptor 75 signaling is activated by
            the chemokine CCL5
  JOURNAL   J Neurochem 146 (5), 526-539 (2018)
   PUBMED   29772059
  REMARK    GeneRIF: This study explored the interaction of CCL5 with GPR75, an
            orphan receptor of the Gqalpha family of GPCRs, which appears to be
            expressed more abundantly in neuron-like cells than astrocytes.
REFERENCE   6  (bases 1 to 2094)
  AUTHORS   Garcia,V., Gilani,A., Shkolnik,B., Pandey,V., Zhang,F.F.,
            Dakarapu,R., Gandham,S.K., Reddy,N.R., Graves,J.P., Gruzdev,A.,
            Zeldin,D.C., Capdevila,J.H., Falck,J.R. and Schwartzman,M.L.
  TITLE     20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (Gq) to
            Affect Vascular Function and Trigger Hypertension
  JOURNAL   Circ Res 120 (11), 1776-1788 (2017)
   PUBMED   28325781
REFERENCE   7  (bases 1 to 2094)
  AUTHORS   Tarttelin,E.E., Kirschner,L.S., Bellingham,J., Baffi,J.,
            Taymans,S.E., Gregory-Evans,K., Csaky,K., Stratakis,C.A. and
            Gregory-Evans,C.Y.
  TITLE     Cloning and characterization of a novel orphan G-protein-coupled
            receptor localized to human chromosome 2p16
  JOURNAL   Biochem Biophys Res Commun 260 (1), 174-180 (1999)
   PUBMED   10381362
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK314885.1, AF072693.1 and AC008068.4.
            
            On May 17, 2019 this sequence version replaced NM_006794.3.
            
            Summary: GPR75 is a member of the G protein-coupled receptor
            family. GPRs are cell surface receptors that activate
            guanine-nucleotide binding proteins upon the binding of a
            ligand.[supplied by OMIM, Jul 2002].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.85979.1,
                                           SRR1803615.158623.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394705.3/ ENSP00000378195.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1872              AK314885.1         23-1894
            1873-2093           AF072693.1         1834-2054
            2094-2094           AC008068.4         26808-26808         c
FEATURES             Location/Qualifiers
     source          1..2094
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p16.2"
     gene            1..2094
                     /gene="GPR75"
                     /gene_synonym="GPRchr2; WI31133"
                     /note="G protein-coupled receptor 75"
                     /db_xref="GeneID:10936"
                     /db_xref="HGNC:HGNC:4526"
                     /db_xref="MIM:606704"
     exon            1..140
                     /gene="GPR75"
                     /gene_synonym="GPRchr2; WI31133"
                     /inference="alignment:Splign:2.1.0"
     exon            141..2094
                     /gene="GPR75"
                     /gene_synonym="GPRchr2; WI31133"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..1872
                     /gene="GPR75"
                     /gene_synonym="GPRchr2; WI31133"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 75"
                     /protein_id="NP_006785.1"
                     /db_xref="CCDS:CCDS1849.1"
                     /db_xref="GeneID:10936"
                     /db_xref="HGNC:HGNC:4526"
                     /db_xref="MIM:606704"
                     /translation="MNSTGHLQDAPNATSLHVPHSQEGNSTSLQEGLQDLIHTATLVT
                     CTFLLAVIFCLGSYGNFIVFLSFFDPAFRKFRTNFDFMILNLSFCDLFICGVTAPMFT
                     FVLFFSSASSIPDAFCFTFHLTSSGFIIMSLKTVAVIALHRLRMVLGKQPNRTASFPC
                     TVLLTLLLWATSFTLATLATLKTSKSHLCLPMSSLIAGKGKAILSLYVVDFTFCVAVV
                     SVSYIMIAQTLRKNAQVRKCPPVITVDASRPQPFMGVPVQGGGDPIQCAMPALYRNQN
                     YNKLQHVQTRGYTKSPNQLVTPAASRLQLVSAINLSTAKDSKAVVTCVIIVLSVLVCC
                     LPLGISLVQVVLSSNGSFILYQFELFGFTLIFFKSGLNPFIYSRNSAGLRRKVLWCLQ
                     YIGLGFFCCKQKTRLRAMGKGNLEVNRNKSSHHETNSAYMLSPKPQKKFVDQACGPSH
                     SKESMVSPKISAGHQHCGQSSSTPINTRIEPYYSIYNSSPSQEESSPCNLQPVNSFGF
                     ANSYIAMHYHTTNDLVQEYDSTSAKQIPVPSV"
ORIGIN      
        1 gtcttgccgc ggctcccggg atgcgcggag gcggtggcga tggcgatgat gcctctagtc
       61 ctgcatcatc cagagcggca ggcggagctg gggtccggac tgcgagatgg aggaggggcg
      121 gcgctgcggc cacccggcag gcttatctgt cttgggcctc ttttgtcaca tattgctcat
      181 ctgtgagctg aggccctgac tcactgagta tttttgggga gcagaagaag gagacatttc
      241 tctccgaaaa tgaactcaac aggccacctt caggatgccc ccaatgccac ctcgctccat
      301 gtgcctcact cacaggaagg aaacagcacc tctctccagg agggtcttca ggatctcatc
      361 cacacagcca ccttggtgac ctgtactttt ctactggcgg tcatcttctg cctgggttcc
      421 tatggcaact tcattgtctt cttgtccttc ttcgatccag ccttcaggaa attcagaacc
      481 aactttgatt tcatgatcct gaacctgtcc ttctgtgacc tcttcatttg tggagtgaca
      541 gcccccatgt tcacctttgt gttattcttc agctcagcca gtagtatccc ggatgctttc
      601 tgcttcactt tccatctcac cagttcaggc ttcatcatca tgtctctgaa gacagtggca
      661 gtgatcgccc tgcaccggct ccggatggtg ttggggaaac agcctaatcg cacggcctcc
      721 tttccctgca ccgtactcct caccctgctt ctctgggcca ccagtttcac ccttgccacc
      781 ttggctacct tgaaaaccag caagtcccac ctctgtcttc ccatgtccag tctgattgct
      841 ggaaaaggga aagccatttt gtctctctat gtggtcgact tcaccttctg tgttgctgtg
      901 gtctctgtct cttacatcat gattgctcag accctgcgga agaacgctca agtcagaaag
      961 tgcccccctg taatcacagt cgatgcttcc agaccacagc ctttcatggg ggtccctgtg
     1021 cagggaggtg gagatcccat ccagtgtgcc atgccggctc tgtataggaa ccagaattac
     1081 aacaaactgc agcacgttca gacccgtgga tataccaaga gtcccaacca actggtcacc
     1141 cctgcagcaa gccgactcca gctcgtatca gccatcaacc tctccactgc caaggattcc
     1201 aaagccgtgg tcacctgtgt gatcattgtg ctgtcagtcc tggtgtgctg tcttccactg
     1261 gggatttcct tggtacaggt ggttctctcc agcaatggga gcttcattct ttaccagttt
     1321 gaattgtttg gatttactct tatatttttc aagtcaggat taaacccttt tatatattct
     1381 cggaacagtg cagggctgag aaggaaagtg ctctggtgcc tccaatacat aggcctgggt
     1441 tttttctgct gcaaacaaaa gactcgactt cgagccatgg gaaaagggaa cctcgaagtc
     1501 aacagaaaca aatcctccca tcatgaaaca aactctgcct acatgttatc tccaaagcca
     1561 cagaagaaat ttgtggacca ggcttgtggc ccaagtcatt caaaagaaag tatggtgagt
     1621 cccaagatct ctgctggaca tcaacactgt ggtcagagca gctcgacccc catcaacact
     1681 cggattgaac cttactacag catctataac agcagccctt cccaggagga gagcagccca
     1741 tgtaacttac agccagtaaa ctcttttgga tttgccaatt catatattgc catgcattat
     1801 cacaccacta atgacttagt gcaggaatat gacagcactt cagccaagca gattccagtc
     1861 ccctccgttt aaagtcatgg aggctatagg atcttatgta aacagttttt gtttctgata
     1921 gtaatggact ttattctaac ttgagatcag tggcggatca aaacctacaa gattcaactg
     1981 aaaagttggc agttatggtt ttctttcatc tgatgtgtca gtatctgttg atttgctttg
     2041 tagtttgttg acatcttaag atttgatgtg aaagttttag attttttacc ctgc
//
