LOCUS       NM_001164165            1920 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens GPR75-ASB3 readthrough (GPR75-ASB3), mRNA.
ACCESSION   NM_001164165
VERSION     NM_001164165.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1920)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP350378.1 and BC110915.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001164165.1.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring GPR75 (G protein-coupled
            receptor 75) and ASB3 (ankyrin repeat and SOCS box containing 3) on
            chromosome 2. The transcript includes exons from both GPR75 and
            ASB3 and translation initiates in the 5' non-coding exon of GPR75.
            The resulting protein has a novel N-terminus but is otherwise
            identical to that encoded by ASB3.[provided by RefSeq, Feb 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110915.1, SRR3476690.819866.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 10936, 51130
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BP350378.1         67-78
            13-1920             BC110915.1         1-1908
FEATURES             Location/Qualifiers
     source          1..1920
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p16.2"
     gene            1..1920
                     /gene="GPR75-ASB3"
                     /gene_synonym="ASB-3; ASB3"
                     /note="GPR75-ASB3 readthrough"
                     /db_xref="GeneID:100302652"
                     /db_xref="HGNC:HGNC:40043"
     exon            1..140
                     /gene="GPR75-ASB3"
                     /gene_synonym="ASB-3; ASB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1710
                     /gene="GPR75-ASB3"
                     /gene_synonym="ASB-3; ASB3"
                     /note="Ankyrin repeat and SOCS box protein 3"
                     /codon_start=1
                     /product="GPR75-ASB3 protein"
                     /protein_id="NP_001157637.1"
                     /db_xref="GeneID:100302652"
                     /db_xref="HGNC:HGNC:40043"
                     /translation="MAMMPLVLHHPERQAELGSGLRDGGGAALRPPGRLVKQMDFTEA
                     YADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLIN
                     ADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVEN
                     GQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGI
                     TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADP
                     DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCL
                     EILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHLAYCLK
                     YEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDPLILLCNS
                     WIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPSLTHLCRLEI
                     RSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG"
     exon            141..349
                     /gene="GPR75-ASB3"
                     /gene_synonym="ASB-3; ASB3"
                     /inference="alignment:Splign:2.1.0"
     exon            350..508
                     /gene="GPR75-ASB3"
                     /gene_synonym="ASB-3; ASB3"
                     /inference="alignment:Splign:2.1.0"
     exon            509..621
                     /gene="GPR75-ASB3"
                     /gene_synonym="ASB-3; ASB3"
                     /inference="alignment:Splign:2.1.0"
     exon            622..757
                     /gene="GPR75-ASB3"
                     /gene_synonym="ASB-3; ASB3"
                     /inference="alignment:Splign:2.1.0"
     exon            758..935
                     /gene="GPR75-ASB3"
                     /gene_synonym="ASB-3; ASB3"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1133
                     /gene="GPR75-ASB3"
                     /gene_synonym="ASB-3; ASB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1391
                     /gene="GPR75-ASB3"
                     /gene_synonym="ASB-3; ASB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1522
                     /gene="GPR75-ASB3"
                     /gene_synonym="ASB-3; ASB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1920
                     /gene="GPR75-ASB3"
                     /gene_synonym="ASB-3; ASB3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcttgccgc ggctcccggg atgcgcggag gcggtggcga tggcgatgat gcctctagtc
       61 ctgcatcatc cagagcggca ggcggagctg gggtccggac tgcgagatgg aggaggggcg
      121 gcgctgcggc cacccggcag actggtcaaa caaatggatt ttacagaggc ttacgcggac
      181 acgtgctcta cagttggact tgctgccagg gaaggcaatg ttaaagtctt aaggaaactg
      241 ctcaaaaagg gccgaagtgt cgatgttgct gataacaggg gatggatgcc aattcatgaa
      301 gcagcttatc acaactctgt agaatgtttg caaatgttaa ttaatgcaga ttcatctgaa
      361 aactacatta agatgaagac ctttgaaggt ttctgtgctt tgcatctcgc tgcaagtcaa
      421 ggacattgga aaatcgtaca gattctttta gaagctgggg cagatcctaa tgcaactact
      481 ttagaagaaa cgacaccatt gtttttagct gttgaaaatg gacagataga tgtgttaagg
      541 ctgttgcttc aacacggagc aaatgttaat ggatcccatt ctatgtgtgg atggaactcc
      601 ttgcaccagg cttcttttca ggaaaatgct gagatcataa aattgcttct tagaaaagga
      661 gcaaacaagg aatgccagga tgactttgga atcacacctt tatttgtggc tgctcagtat
      721 ggcaagctag aaagcttgag catacttatt tcatcgggtg caaatgtcaa ttgtcaagcc
      781 ttggacaaag ctacaccctt gttcattgct gctcaagagg gacacacaaa atgtgtggag
      841 cttttgctct ccagtggggc agatcctgat ctttactgta atgaggacag ttggcagtta
      901 cctattcatg cagctgcaca aatgggccat acaaaaatct tggacttgtt aataccactt
      961 actaaccggg cctgtgacac tgggctaaac aaagtaagcc ctgtttactc agcagtgttt
     1021 gggggacatg aagattgcct agaaatatta ctccggaatg gctacagccc agacgcccag
     1081 gcgtgccttg tttttggatt cagttctcct gtgtgcatgg ctttccaaaa ggactgtgag
     1141 ttctttggaa ttgtgaacat tcttttgaaa tatggagccc agataaatga acttcatttg
     1201 gcatactgcc tgaagtacga gaagttttcg atatttcgct actttttgag gaaaggttgc
     1261 tcattgggac catggaacca tatatatgaa tttgtaaatc atgcaattaa agcacaagca
     1321 aaatataagg agtggttgcc acatcttctg gttgctggat ttgacccact gattctactg
     1381 tgcaattctt ggattgactc agtcagcatt gacaccctta tcttcacttt ggagtttact
     1441 aattggaaga cacttgcacc agctgttgaa aggatgctct ctgctcgtgc ctcaaacgct
     1501 tggattctac agcaacatat tgccactgtt ccatccctga cccatctttg tcgtttggaa
     1561 attcggtcca gtctaaaatc agaacgtcta cggtctgaca gttatattag tcagctgcca
     1621 cttcccagaa gcctacataa ttatttgctc tatgaagacg ttctgaggat gtatgaagtt
     1681 ccagaactgg cagctattca agatggataa atcagtgaaa ctacttaaca cagctaattt
     1741 ttttctctga aaaatcatcg agacaaaaga gccacagagt acaagttttt atgattttat
     1801 agtcaaaaga tgattattga ttgtgagata ggttaggttt tggggggcca gtagttcagt
     1861 gagaatgttt atgtttacaa ctagccttcc cagtaaaaaa aaaaaaaaaa aaaaaaaaaa
//
