LOCUS       NM_030784               5967 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens G protein-coupled receptor 63 (GPR63), transcript
            variant 2, mRNA.
ACCESSION   NM_030784
VERSION     NM_030784.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5967)
  AUTHORS   Zeng,S., Liang,Y., Hu,H., Wang,F. and Liang,L.
  TITLE     Endothelial cell-derived S1P promotes migration and stemness by
            binding with GPR63 in colorectal cancer
  JOURNAL   Pathol Res Pract 240, 154197 (2022)
   PUBMED   36371997
  REMARK    GeneRIF: Endothelial cell-derived S1P promotes migration and
            stemness by binding with GPR63 in colorectal cancer.
REFERENCE   2  (bases 1 to 5967)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   3  (bases 1 to 5967)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   4  (bases 1 to 5967)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   5  (bases 1 to 5967)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   6  (bases 1 to 5967)
  AUTHORS   Niedernberg,A., Tunaru,S., Blaukat,A., Ardati,A. and Kostenis,E.
  TITLE     Sphingosine 1-phosphate and dioleoylphosphatidic acid are low
            affinity agonists for the orphan receptor GPR63
  JOURNAL   Cell Signal 15 (4), 435-446 (2003)
   PUBMED   12618218
REFERENCE   7  (bases 1 to 5967)
  AUTHORS   Lee,D.K., George,S.R., Cheng,R., Nguyen,T., Liu,Y., Brown,M.,
            Lynch,K.R. and O'Dowd,B.F.
  TITLE     Identification of four novel human G protein-coupled receptors
            expressed in the brain
  JOURNAL   Brain Res Mol Brain Res 86 (1-2), 13-22 (2001)
   PUBMED   11165367
REFERENCE   8  (bases 1 to 5967)
  AUTHORS   Kawasawa,Y., Kume,K., Izumi,T. and Shimizu,T.
  TITLE     Mammalian PSP24s (alpha and beta isoforms) are not responsive to
            lysophosphatidic acid in mammalian expression systems
  JOURNAL   Biochem Biophys Res Commun 276 (3), 957-964 (2000)
   PUBMED   11027575
REFERENCE   9  (bases 1 to 5967)
  AUTHORS   Kawasawa,Y., Kume,K., Nakade,S., Haga,H., Izumi,T. and Shimizu,T.
  TITLE     Brain-specific expression of novel G-protein-coupled receptors,
            with homologies to Xenopus PSP24 and human GPR45
  JOURNAL   Biochem Biophys Res Commun 276 (3), 952-956 (2000)
   PUBMED   11027574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA242987.1, AK313535.1, AK289839.1, AL033379.2 and AI208851.1.
            
            On Nov 22, 2018 this sequence version replaced NM_030784.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289839.1, SRR1660809.53507.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229955.4/ ENSP00000229955.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DA242987.1         1-32
            33-195              AK313535.1         1-163
            196-1999            AK289839.1         196-1999
            2000-2000           AL033379.2         105406-105406       c
            2001-2080           AK289839.1         2001-2080
            2081-5530           AL033379.2         101876-105325       c
            5531-5967           AI208851.1         4-440               c
FEATURES             Location/Qualifiers
     source          1..5967
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q16.1"
     gene            1..5967
                     /gene="GPR63"
                     /gene_synonym="PSP24(beta); PSP24B"
                     /note="G protein-coupled receptor 63"
                     /db_xref="GeneID:81491"
                     /db_xref="HGNC:HGNC:13302"
                     /db_xref="MIM:606915"
     exon            1..210
                     /gene="GPR63"
                     /gene_synonym="PSP24(beta); PSP24B"
                     /inference="alignment:Splign:2.1.0"
     exon            211..5967
                     /gene="GPR63"
                     /gene_synonym="PSP24(beta); PSP24B"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..1620
                     /gene="GPR63"
                     /gene_synonym="PSP24(beta); PSP24B"
                     /note="brain expressed G-protein-coupled receptor PSP24
                     beta; PSP24-2; PSP24-beta"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 63"
                     /protein_id="NP_110411.1"
                     /db_xref="CCDS:CCDS5036.1"
                     /db_xref="GeneID:81491"
                     /db_xref="HGNC:HGNC:13302"
                     /db_xref="MIM:606915"
                     /translation="MVFSAVLTAFHTGTSNTTFVVYENTYMNITLPPPFQHPDLSPLL
                     RYSFETMAPTGLSSLTVNSTAVPTTPAAFKSLNLPLQITLSAIMIFILFVSFLGNLVV
                     CLMVYQKAAMRSAINILLASLAFADMLLAVLNMPFALVTILTTRWIFGKFFCRVSAMF
                     FWLFVIEGVAILLIISIDRFLIIVQRQDKLNPYRAKVLIAVSWATSFCVAFPLAVGNP
                     DLQIPSRAPQCVFGYTTNPGYQAYVILISLISFFIPFLVILYSFMGILNTLRHNALRI
                     HSYPEGICLSQASKLGLMSLQRPFQMSIDMGFKTRAFTTILILFAVFIVCWAPFTTYS
                     LVATFSKHFYYQHNFFEISTWLLWLCYLKSALNPLIYYWRIKKFHDACLDMMPKSFKF
                     LPQLPGHTKRRIRPSAVYVCGEHRTVV"
     regulatory      1784..1789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR63"
                     /gene_synonym="PSP24(beta); PSP24B"
                     /note="hexamer: AATAAT"
     polyA_site      1806
                     /gene="GPR63"
                     /gene_synonym="PSP24(beta); PSP24B"
                     /note="major polyA site"
     regulatory      5460..5465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR63"
                     /gene_synonym="PSP24(beta); PSP24B"
                     /note="hexamer: AATAAA"
     polyA_site      5487
                     /gene="GPR63"
                     /gene_synonym="PSP24(beta); PSP24B"
                     /note="major polyA site"
     regulatory      5922..5927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR63"
                     /gene_synonym="PSP24(beta); PSP24B"
                     /note="hexamer: AAGAAA"
     regulatory      5945..5950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR63"
                     /gene_synonym="PSP24(beta); PSP24B"
                     /note="hexamer: AATAAA"
     polyA_site      5946
                     /gene="GPR63"
                     /gene_synonym="PSP24(beta); PSP24B"
     polyA_site      5967
                     /gene="GPR63"
                     /gene_synonym="PSP24(beta); PSP24B"
ORIGIN      
        1 actttcagct ccagctcccg ccaccgccgc ctgtatcgcc gccgccgcca ccacctcctc
       61 ttcgttgtcc tccttcctcc tccgcctggc agcgttgttc tctgcagcgg aggagagaag
      121 tgctatgtca ggaaagttcc gggagggact acatggagcc atgctccctg ggctcttccg
      181 cgggcgcccg cgcgctgccc ttcgcttgag gcaaaaggac tcttgtggaa gatggaactc
      241 attgtccatt ttccagaatg tatttccaag cccatcaatg ggacctgata ctgctgttct
      301 gtgttgaaat gcttgaagaa ctcctgcatc tctgcttgca tcttccatcc tactgaaacc
      361 atggtcttct cggcagtgtt gactgcgttc cataccggga catccaacac aacatttgtc
      421 gtgtatgaaa acacctacat gaatattaca ctccctccac cattccagca tcctgacctc
      481 agtccattgc ttagatatag ttttgaaacc atggctccca ctggtttgag ttccttgacc
      541 gtgaatagta cagctgtgcc cacaacacca gcagcattta agagcctaaa cttgcctctt
      601 cagatcaccc tttctgctat aatgatattc attctgtttg tgtcttttct tgggaacttg
      661 gttgtttgcc tcatggttta ccaaaaagct gccatgaggt ctgcaattaa catcctcctt
      721 gccagcctag cttttgcaga catgttgctt gcagtgctga acatgccctt tgccctggta
      781 actattctta ctacccgatg gatttttggg aaattcttct gtagggtatc tgctatgttt
      841 ttctggttat ttgtgataga aggagtagcc atcctgctca tcattagcat agataggttc
      901 cttattatag tccagaggca ggataagcta aacccatata gagctaaggt tctgattgca
      961 gtttcttggg caacttcctt ttgtgtagct tttcctttag ccgtaggaaa ccccgacctg
     1021 cagatacctt cccgagctcc ccagtgtgtg tttgggtaca caaccaatcc aggctaccag
     1081 gcttatgtga ttttgatttc tctcatttct ttcttcatac ccttcctggt aatactgtac
     1141 tcatttatgg gcatactcaa cacccttcgg cacaatgcct tgaggatcca tagctaccct
     1201 gaaggtatat gcctcagcca ggccagcaaa ctgggtctca tgagtctgca gagacctttc
     1261 cagatgagca ttgacatggg ctttaaaaca cgtgccttca ccactatttt gattctcttt
     1321 gctgtcttca ttgtctgctg ggccccattc accacttaca gccttgtggc aacattcagt
     1381 aagcactttt actatcagca caactttttt gagattagca cctggctact gtggctctgc
     1441 tacctcaagt ctgcattgaa tccgctgatc tactactgga ggattaagaa attccatgat
     1501 gcttgcctgg acatgatgcc taagtccttc aagtttttgc cgcagctccc tggtcacaca
     1561 aagcgacgga tacgtcctag tgctgtctat gtgtgtgggg aacatcggac ggtggtgtga
     1621 atattggaac tggctgacat tttgggtgat gcttgttctt tattgacatt gaattctctt
     1681 tctcatagcc tctccacttt attttttttt atagggtttg tgtatgtatg tgtgtgagca
     1741 gtgtaaagaa agaatggtaa ttatagttct gttaccaaga ataaataata ggaaagtgat
     1801 tacaaatatt acctccaggg ttcaatagaa atcctcaatt tagggtgagg agactttttt
     1861 ttggttttgg ggtttttcct tgattgattt tgttttcata gtgggaatca ggattgtgct
     1921 ttattgagcc tgcagttaca ttgaattgta ggtgtttcgt gtgctgctaa ggtatgctta
     1981 tttgagttta tcaagacttt ttttttctgg aagacactgc tgcttttacc atcacattgg
     2041 agccaaacat ctcaatcaat atatatttag ttttatttta aaaactaacc caggaaggtt
     2101 agcgacattt taagggtcat tactatttac tttggtgcac tttaagagat aatgtacaaa
     2161 ttaattcagt cttatttttc agaattgttt ttatacatga tatgtgcttt aggaaatgtg
     2221 cattatcatt tatgggaaga tagttttaag aaatgtttta tctgcatgta cagttgtaaa
     2281 agagaacata aaatgtagat acttttctaa gcacaatagc aactcttcaa gcaatagcgc
     2341 aaaatctagg agacaggatc cttgcaaatt taaaaggtga atgtagtgag ggggatggca
     2401 agtggctggt acaggctgtg gtgattcctt ttactcaagg gtttttgtgg agtataggga
     2461 gaaggggttg atatttatgg acacctatgt gtcaggcact gtgcatcatt ttatccttac
     2521 aggatgttgt gaggtaggta ttattgtttt catttttaca ggtgaagaaa gcaggtctca
     2581 gagggactaa aatcctgccc aaggttagtg gtagagctgg gatccaaaaa tctgtcagaa
     2641 tcctgagact gcgctgttcc actgtgccac gcagacagtt cattcagttt agatgtcaca
     2701 tagtcaagag ggaactctat gcatccttta attttttaga ctatgatatt ctttttaaaa
     2761 attagccttt attttctaac taccaaaaga aatatgaaag cattacagaa acactggaaa
     2821 atagaaaaga aaaaataaaa tcacttacaa ccactttttg ttttttggag tctcgctttg
     2881 ccacccaggc tggagtgcag tggtgtgatc atggctcatt gtagcctcaa cctcccaggc
     2941 tcaggtaatc ctcctgtctc agcctcctga atagctggaa ccacacacac acacgcacac
     3001 acaggtgtgt gccaccacac ccagctattt ttttgtattt tcttttgtaa agacaaggtt
     3061 tcaccatgtt gcccaggctg gtctcagagt cctgagctca aacgatctgc ctgccttggc
     3121 ctcccaaaat gttgggatta caggcatgag ccaccacatc tgacctacaa ccacttttta
     3181 atgtgagact taaaaatctt agataaataa ggctgtgaag caaaaccagt gatttttttt
     3241 tttgtttttg atttgcaaaa caagtgactg acaattattg agaaattaaa gatagctatg
     3301 tgtaggtctt gcccctgcgg gtttggaggt ttccagttgt ccatctgtgt tagttgtaag
     3361 tgttctgggc agaatagtat tgttgcccca atgcttgccc tagcagagct ggagtttgtg
     3421 aacgtgctca gatgtgtgtc tcctacaaag aagggaaaat gaaccctcgt ctgagcctag
     3481 aacaagtttt aatagggcat gtctgacatt tcaaattgtt tttctcttgc tgacagtctg
     3541 cccccaggtg catctagggc cttggtcagc ttctctgtta ccagtggctc actttataaa
     3601 acagcccaca gggataaggg ctgaaaatat agccacttgg ctacatcatt gactaattaa
     3661 gtaagttaac tgtggattta tagcatcttt tcaggatgtt agtgttttgt gagccagtgg
     3721 aaaaaataag cttctatttc ttcatttgta aaaccagaga gttggattag atgaatctct
     3781 aacgtcctgt ccagctcaaa tgtgctttcc tctatactag ggtatagatt tttgaagagc
     3841 ctagctgact tcagcatcac ctcacccttt ggtctccagt attacttctt tacattttac
     3901 ttcattagct atttcttaat attaaatgtc tgaagagtgt ggcactgtat caggagttgg
     3961 ggcattgaaa ggttgaagac atcatgaaat atctgggaaa ctctgctctt aaggaaattg
     4021 caccgatgtt ggaactcatt gtccagttaa agagctcttt ggggactcaa gcatattatt
     4081 caacatgttg ttttgggatt atcttcaaat gatagtcacc tacctctttc atttctaatt
     4141 tttattcaca ggtaaaattg tttttgtcca tagggatttt ataggacata agcactgtag
     4201 tagatactag tagcattttg aagtgtatta tgctctccat tttccatata aactagattt
     4261 caagcagata ttgataagga cattttttat tagacttttc tctgaggaaa gtcagcatga
     4321 tctgtattca tcttacatat tgataggtca tgaagactcc tttttggctg gaggtgaaac
     4381 tgagctttgt tttctttgtt cctgttttat gggcagtctt taggtacttt catgctgctt
     4441 aataggcagt gcctcatttg gtgagagctc tggagtgcct gccgagacgc tccctgtttg
     4501 tgaacaaaga ttatgaaggg gtctttgtga gaattcagca gcaacactga acagcagttc
     4561 tttttacact ggattatctt gatctgatga gagtttacaa atcattttga acatttttat
     4621 tatgtataca ttgtgaaagc tttaaaaata agtactatgg agcacctttg agaaacgtag
     4681 gtgcaaaatc atatgttgcc tattccccca tattttcttg aggcagggaa agataccact
     4741 actaattctc actgcttaca ggcataatca gaaatggttt tttgtttgcc tgtttttcct
     4801 tctggctagt aagaagcgta aaagagataa tgaaatattt gtggtcaaaa gaaagatgca
     4861 agggaaattc caaatagtat ggagtaacat tatttaaact ttaatacatg tttaagcatc
     4921 cccaagggag cttgttaaca gtacagattc ctgggcctcc agagggtctg tggttgagcc
     4981 caggaatgtg catttttatt ttattgagca ctctgcctga ctctggctca ggtagtccct
     5041 gggaaactct tcaggaaaca ttcctgtaga aaatatatct atttaaatat catctgtttt
     5101 atcccacaat gtttgtttcg tgttgcaagc cattatcttc taggcatggg taatccacat
     5161 tgagaggaaa atccacacaa cattgtgcct gatttgctgc cacctgtgtt tgtgctggat
     5221 cttgccagtg ttagctttat tttctttcaa ctggcaaaat tctgataaag catatagctt
     5281 cacagtagag caaaatgggt gacttaattg aaagtcatga ctttcagcag tctaattatg
     5341 ctcatatttt attttcttat agagagctgt ctttattgtg tgtaattccc ggaagaatgt
     5401 aaagatttat ctaattccta ttgctctgcc agttgtgttc aatgcaagca ttgaagtaaa
     5461 ataaaaataa cctttttaat atgtgtattt ctgttgccca caaagatatt taattttttt
     5521 cttgatcttt gtttttgttt atgtgaaaat atttacatat gtatcatttc tgtatatatc
     5581 acagaaaagt tttcacttgc ttgacatttt attctacaat gatttttagt ttaagtttaa
     5641 agaatggcta cattcagatt tattttcaca actatagtcc tgctaaactg ccttcattga
     5701 aaactcagtt tttatgataa aaaatatcaa agcacaagtt tgttattgga ggtaaattat
     5761 acatttctta gatatctatt ggtactagac ctttgtaatt aaaattaatt tattttacaa
     5821 tagtaactga cctgtatgga aaaaaaaaca accttgaatt atgggttcta atatttaaat
     5881 atcgaaaaat atggttattt gtgcatattc ttattacaac caagaaaaga actcctgata
     5941 agaaaataaa taaatattta acatttc
//
