LOCUS       NM_001393907            4921 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens G protein-coupled receptor 61 (GPR61), transcript
            variant 2, mRNA.
ACCESSION   NM_001393907
VERSION     NM_001393907.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4921)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4921)
  AUTHORS   Oishi,A., Karamitri,A., Gerbier,R., Lahuna,O., Ahmad,R. and
            Jockers,R.
  TITLE     Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2
            receptor reciprocally modulate their signaling functions
  JOURNAL   Sci Rep 7 (1), 8990 (2017)
   PUBMED   28827538
  REMARK    GeneRIF: Collectively, these data show that GPR61, GPR62 and GPR135
            are unable to bind melatonin, but show a reciprocal regulatory
            interaction with MT2 receptors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4921)
  AUTHORS   Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
            Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
            King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
            Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
            Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
            Ferrucci,L., Fornage,M. and Mozaffarian,D.
  TITLE     Genome-wide association study identifies novel loci associated with
            concentrations of four plasma phospholipid fatty acids in the de
            novo lipogenesis pathway: results from the Cohorts for Heart and
            Aging Research in Genomic Epidemiology (CHARGE) consortium
  JOURNAL   Circ Cardiovasc Genet 6 (2), 171-183 (2013)
   PUBMED   23362303
REFERENCE   4  (bases 1 to 4921)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   5  (bases 1 to 4921)
  AUTHORS   Wheeler,H.E., Metter,E.J., Tanaka,T., Absher,D., Higgins,J.,
            Zahn,J.M., Wilhelmy,J., Davis,R.W., Singleton,A., Myers,R.M.,
            Ferrucci,L. and Kim,S.K.
  TITLE     Sequential use of transcriptional profiling, expression
            quantitative trait mapping, and gene association implicates MMP20
            in human kidney aging
  JOURNAL   PLoS Genet 5 (10), e1000685 (2009)
   PUBMED   19834535
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 4921)
  AUTHORS   Toyooka,M., Tujii,T. and Takeda,S.
  TITLE     The N-terminal domain of GPR61, an orphan G-protein-coupled
            receptor, is essential for its constitutive activity
  JOURNAL   J Neurosci Res 87 (6), 1329-1333 (2009)
   PUBMED   19025769
  REMARK    GeneRIF: We conclude that the N-terminal domain of GPR61 is
            required for maintaining its constitutive activity and functions as
            a tethered intramolecular ligand.
REFERENCE   7  (bases 1 to 4921)
  AUTHORS   Conner,A.C., Hay,D.L., Simms,J., Howitt,S.G., Schindler,M.,
            Smith,D.M., Wheatley,M. and Poyner,D.R.
  TITLE     A key role for transmembrane prolines in calcitonin receptor-like
            receptor agonist binding and signalling: implications for family B
            G-protein-coupled receptors
  JOURNAL   Mol Pharmacol 67 (1), 20-31 (2005)
   PUBMED   15615699
  REMARK    GeneRIF: Modeling rationalizes the effects of transmembrane proline
            mutants previously reported for another family of GPCR.
REFERENCE   8  (bases 1 to 4921)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
REFERENCE   9  (bases 1 to 4921)
  AUTHORS   Cikos,S., Gregor,P. and Koppel,J.
  TITLE     Cloning of a novel biogenic amine receptor-like G protein-coupled
            receptor expressed in human brain
  JOURNAL   Biochim Biophys Acta 1521 (1-3), 66-72 (2001)
   PUBMED   11690637
  REMARK    GeneRIF: maps to chromosome 1, is widely expressed, with expression
            highest in the brain areas associated with cognition, learning, and
            memory.
REFERENCE   10 (bases 1 to 4921)
  AUTHORS   Lee,D.K., George,S.R., Cheng,R., Nguyen,T., Liu,Y., Brown,M.,
            Lynch,K.R. and O'Dowd,B.F.
  TITLE     Identification of four novel human G protein-coupled receptors
            expressed in the brain
  JOURNAL   Brain Res Mol Brain Res 86 (1-2), 13-22 (2001)
   PUBMED   11165367
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355145.31 and AL355310.20.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene belongs to the G-protein coupled receptor 1
            family. G protein-coupled receptors contain 7 transmembrane domains
            and transduce extracellular signals through heterotrimeric G
            proteins. The protein encoded by this gene is most closely related
            to biogenic amine receptors. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290027.1, SRR1660807.22955.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000527748.5/ ENSP00000432456.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AL355145.31        67929-68010
            83-4921             AL355310.20        3475-8313
FEATURES             Location/Qualifiers
     source          1..4921
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..4921
                     /gene="GPR61"
                     /gene_synonym="BALGR; GPCR3"
                     /note="G protein-coupled receptor 61"
                     /db_xref="GeneID:83873"
                     /db_xref="HGNC:HGNC:13300"
                     /db_xref="MIM:606916"
     exon            1..82
                     /gene="GPR61"
                     /gene_synonym="BALGR; GPCR3"
                     /inference="alignment:Splign:2.1.0"
     exon            83..4921
                     /gene="GPR61"
                     /gene_synonym="BALGR; GPCR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             684..2039
                     /gene="GPR61"
                     /gene_synonym="BALGR; GPCR3"
                     /note="biogenic amine receptor-like GPCR; probable
                     G-protein coupled receptor 61; biogenic amine
                     receptor-like G-protein coupled receptor"
                     /codon_start=1
                     /product="G-protein coupled receptor 61"
                     /protein_id="NP_001380836.1"
                     /db_xref="CCDS:CCDS801.1"
                     /db_xref="GeneID:83873"
                     /db_xref="HGNC:HGNC:13300"
                     /db_xref="MIM:606916"
                     /translation="MESSPIPQSSGNSSTLGRVPQTPGPSTASGVPEVGLRDVASESV
                     ALFFMLLLDLTAVAGNAAVMAVIAKTPALRKFVFVFHLCLVDLLAALTLMPLAMLSSS
                     ALFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVA
                     SVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFL
                     LPLLLILVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTP
                     HRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCF
                     TSNPFFYGCLNRQIRGELSKQFVCFFKPAPEEELRLPSREGSIEENFLQFLQGTGCPS
                     ESWVSRPLPSPKQEPPAVDFRIPGQIAEETSEFLEQQLTSDIIMSDSYLRPAASPRLE
                     S"
     regulatory      4900..4905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR61"
                     /gene_synonym="BALGR; GPCR3"
                     /note="hexamer: AATAAA"
     polyA_site      4921
                     /gene="GPR61"
                     /gene_synonym="BALGR; GPCR3"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgcttc aggcttcagc agccttggag aagcatcagc tgagaggagc tatcacatgg
       61 gagccgggac tgctcagcaa agatggattt atgaggaaac tgaaattcag aagattcaca
      121 gagttagtaa tgcccagaac tgggactaga aactaaattt tgtgctcctt ctactcccca
      181 gcagctcttg ccattctgag gagacaagaa atcaggaaat ttacataagg aaccctaaaa
      241 ctgaggcact atcccagaga tcagcaggac cctgggaagg agaaacagga tttagaatcc
      301 ccggctaaca gttctggaaa gggtagaagg gtatggagaa caagaatggc agaaaggaga
      361 tggaaaagga agaggtgaag gccattccga aagcggagtg ttgagtgggt caggctcctg
      421 cacctctcac gtctcctgct tcttagcagt caccaaggca gaccctgcag ctacctccgg
      481 ccagaaaggg gatgagcttc tgatccttca gctgcctggc ctggcgctct gtacgcagac
      541 aaacctgccc aagaggctcc agtgggaggt gccccctacg aaaccaggaa gcctgggcct
      601 gggctcgcca tcccagggtc gctggactag gatgggggat gggcctgtga caggaggtac
      661 cctgggtgcc ctctttcggc cccatggagt cctcacccat cccccagtca tcagggaact
      721 cttccacttt ggggagggtc cctcaaaccc caggtccctc tactgccagt ggggtcccgg
      781 aggtggggct acgggatgtt gcttcggaat ctgtggccct cttcttcatg ctcctgctgg
      841 acttgactgc tgtggctggc aatgccgctg tgatggccgt gatcgccaag acgcctgccc
      901 tccgaaaatt tgtcttcgtc ttccacctct gcctggtgga cctgctggct gccctgaccc
      961 tcatgcccct ggccatgctc tccagctctg ccctctttga ccacgccctc tttggggagg
     1021 tggcctgccg cctctacttg tttctgagcg tgtgctttgt cagcctggcc atcctctcgg
     1081 tgtcagccat caatgtggag cgctactatt acgtagtcca ccccatgcgc tacgaggtgc
     1141 gcatgacgct ggggctggtg gcctctgtgc tggtgggtgt gtgggtgaag gccttggcca
     1201 tggcttctgt gccagtgttg ggaagggtct cctgggagga aggagctccc agtgtccccc
     1261 caggctgttc actccagtgg agccacagtg cctactgcca gctttttgtg gtggtctttg
     1321 ctgtccttta ctttctgttg cccctgctcc tcatacttgt ggtctactgc agcatgttcc
     1381 gagtggcccg cgtggctgcc atgcagcacg ggccgctgcc cacgtggatg gagacacccc
     1441 ggcaacgctc cgaatctctc agcagccgct ccacgatggt caccagctcg ggggcccccc
     1501 agaccacccc acaccggacg tttgggggag ggaaagcagc agtggttctc ctggctgtgg
     1561 ggggacagtt cctgctctgt tggttgccct acttctcttt ccacctctat gttgccctga
     1621 gtgctcagcc catttcaact gggcaggtgg agagtgtggt cacctggatt ggctactttt
     1681 gcttcacttc caaccctttc ttctatggat gtctcaaccg gcagatccgg ggggagctca
     1741 gcaagcagtt tgtctgcttc ttcaagccag ctccagagga ggagctgagg ctgcctagcc
     1801 gggagggctc cattgaggag aacttcctgc agttccttca ggggactggc tgtccttctg
     1861 agtcctgggt ttcccgaccc ctacccagcc ccaagcagga gccacctgct gttgactttc
     1921 gaatcccagg ccagatagct gaggagacct ctgagttcct ggagcagcaa ctcaccagcg
     1981 acatcatcat gtcagacagc tacctccgtc ctgccgcctc accccggctg gagtcatgat
     2041 gggccgctgg acactcggag ggatatgggg ctggggccag ttatgattgc aaggaccacc
     2101 ttgtgggatc accttttccc agctggctag ggctgaggct ggggtctctg cacacagctt
     2161 ttgcttagtg tttcctgggt caggaacaga gccaacagga tgaacgtgtg caaaagcctt
     2221 ggacttggct gtgatctttg actgctaggg gagggaacct gggtatggtg agacggtgac
     2281 gagagaaaag ggtcacaaag gtgaggtgaa acctctcaat tggtgaaatt tccatgcttc
     2341 cagaagcagg gaattctcta agggtaggag ttggaggata cagggcagca ggccaggttt
     2401 ggagttattc taggggccat ttaggatatt ttatttttca gtgtaattgt ccagggcagt
     2461 aattgcaccc aagcaaggta agaaaatgac ccatgttttc tcatttcctt gctaggttta
     2521 aaaagaacta aattatagcc aagtgtttcc acttgagtta atagatcatt tttctggttt
     2581 tatacctgag atttccttaa aatgagagga ccagtagggt gtattccttt actgagtttg
     2641 gccagaaaca aggcaaaata gaaattaggg tacatggagt agaagatagg aaagctgact
     2701 gcagctctct ctctcccacc cttcaggaaa agcccttctg ttctattttt ctgtctctct
     2761 cctgcacaca ggagatcaag ggtagagcct gatcttagca gagacaagaa taaggcagga
     2821 tggctttcct ctcttttagg aggaagaatt agaatgactg ggggtcagac gggcgagggt
     2881 ggaggttagc atttgaattg gtaaagtagc tggaaacaga gaggccaggt aatcagcctg
     2941 atcaataata ctgcgaatct tttctttcca ggactggcct ccctgatctc tctcctcatg
     3001 gcagcgaccc acctccagtc ccctggacaa tcgggtacaa gagacttaag gttgggcatg
     3061 ggaagggtgg ggtttccatg atccattaaa tgccttccta ctcccattca tcgctctcaa
     3121 aattagcttc agtgacaaag acttaaatct ctctcctatc tgcagcactg ggttggagag
     3181 agggcacggg agttggtctt ggctgttcat tgattgagac tgtaggaact gtgttggttg
     3241 gtattggtgg tggtattttc aacaaacagg gaataactgc aaactggaca ggacacccat
     3301 ctgggaccac ctgtccatcc tacttccctc aattgaatca ggtaacacta acggatcaag
     3361 gcagggccag agggtggtgt ggtctctatt tgaacaaatt cctggctcac tgagcatcaa
     3421 aaggggaaat gggctggtgg gagtgggata gtctcccatt taagcagcta ataaataatt
     3481 tttatgataa aaggttatac tgataacaac attgactcct ttagttcaat tcagtgcata
     3541 atagttgaac acccactagt ccctgggacc cacacagggc gtgtggtcat tgcttttaag
     3601 gagttcatag tctaagttga tgagatacct tatattttca caaagcactt tgatttgata
     3661 aagcactaca gaatgtgctt gagaaatata ttggagaata tgtccatggc tctaacttct
     3721 gagagttcag cccgtggcag caagatgcat accttgaagc ttcctgcaga ttgtggaaag
     3781 cataggggtt gtaaatgaaa ctctctaatg aagaaaaaaa attaaatgaa actgggcaaa
     3841 cagctttccc cctttgttct aggaaaattt ctaggttgtc ttcctaccac tagattatta
     3901 taccagtcta gtgcctatta cattgtggaa gttccctaaa aacatagtat atatagggag
     3961 gagagtcctt tgtgattgaa aaacatgttc acctctcctc cctattaaaa taaatgcata
     4021 cagaggaatc aatcattcct agacagggaa aaaactcttc tttcaaacac cactgatcag
     4081 ctattagatc caaggaattg ccagcaggtg gcagtgtgag cccaatggaa ggaggaaagg
     4141 cgagtgtacg tggtgggagg aggaagggga gggcattaaa cattgcctgg cagccatttt
     4201 gttaatttat tttgcctttt cctttgactt tgccctccag cccttccttc acatacatca
     4261 aagaagaaag ttttaagagc aagggtatct ttaattcagg ctgaaatttc ctgacactgt
     4321 gatctcactg gtgtttatta cagagtttga catacatggg ttcatttgcc atttattttt
     4381 ccctgtagga gtggatcatg aaggaaataa aaatttctct tttattatgc tgagaacttt
     4441 cccaacaatt tctgctatga ccaccttcca ggagttttct agtcaccaga tgccttggta
     4501 aagttcaata cgtaatcttt ggctctgaaa gctgttcctg gacaaaatct gagctaactc
     4561 actgaagaat caacagattg aggcaaccat ccggtcagtt actttttcct gcatcctgct
     4621 ggtgttgggg taactcccaa tcctagatga aaaccttaga ctttctgttg tcaggtgtcc
     4681 ccaggcaata tcctacgggg gcatgataga aaagggtaac tctggggtca gatagatgta
     4741 cttactcact gtgtgaagtt gggaaagctg cttaatttct ctgagcctac ttcctcacct
     4801 gtaaaaatgg ggatcattat tacctacctc acagggttgt tgtgaggatt aagagatggg
     4861 atgtgggagc acctagccgt atctggcaaa taggtactca ataaatactg gttttacttc
     4921 c
//
