LOCUS       NM_005284               1783 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens G protein-coupled receptor 6 (GPR6), transcript
            variant 2, mRNA.
ACCESSION   NM_005284 XM_005266933
VERSION     NM_005284.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1783)
  AUTHORS   Isawi,I.H., Morales,P., Sotudeh,N., Hurst,D.P., Lynch,D.L. and
            Reggio,P.H.
  TITLE     GPR6 Structural Insights: Homology Model Construction and Docking
            Studies
  JOURNAL   Molecules 25 (3), 725 (2020)
   PUBMED   32046081
  REMARK    GeneRIF: GPR6 Structural Insights: Homology Model Construction and
            Docking Studies.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1783)
  AUTHORS   Collins,A.G. and Frank,M.J.
  TITLE     How much of reinforcement learning is working memory, not
            reinforcement learning? A behavioral, computational, and
            neurogenetic analysis
  JOURNAL   Eur J Neurosci 35 (7), 1024-1035 (2012)
   PUBMED   22487033
  REMARK    GeneRIF: The GPR6 gene influences the reinforcement learning rate
            in a computational, neurogenetic model.
REFERENCE   3  (bases 1 to 1783)
  AUTHORS   Shimada,M., Miyagawa,T., Kawashima,M., Tanaka,S., Honda,Y.,
            Honda,M. and Tokunaga,K.
  TITLE     An approach based on a genome-wide association study reveals
            candidate loci for narcolepsy
  JOURNAL   Hum Genet 128 (4), 433-441 (2010)
   PUBMED   20677014
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1783)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   5  (bases 1 to 1783)
  AUTHORS   Uhlenbrock,K., Huber,J., Ardati,A., Busch,A.E. and Kostenis,E.
  TITLE     Fluid shear stress differentially regulates gpr3, gpr6, and gpr12
            expression in human umbilical vein endothelial cells
  JOURNAL   Cell Physiol Biochem 13 (2), 75-84 (2003)
   PUBMED   12649592
  REMARK    GeneRIF: control of gene expression in vascular endothelial cells
            in the presence of fluid shear stress and determines that it is not
            a sphingosine 1-phosphate receptor
REFERENCE   6  (bases 1 to 1783)
  AUTHORS   Song,Z.H., Modi,W. and Bonner,T.I.
  TITLE     Molecular cloning and chromosomal localization of human genes
            encoding three closely related G protein-coupled receptors
  JOURNAL   Genomics 28 (2), 347-349 (1995)
   PUBMED   8530049
REFERENCE   7  (bases 1 to 1783)
  AUTHORS   Heiber,M., Docherty,J.M., Shah,G., Nguyen,T., Cheng,R., Heng,H.H.,
            Marchese,A., Tsui,L.C., Shi,X., George,S.R. et al.
  TITLE     Isolation of three novel human genes encoding G protein-coupled
            receptors
  JOURNAL   DNA Cell Biol 14 (1), 25-35 (1995)
   PUBMED   7832990
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA205492.1, DA260869.1, BC043414.2 and AL591076.5.
            
            On Jun 2, 2019 this sequence version replaced NM_005284.4.
            
            Transcript Variant: This variant (2) lacks a portion of the 5' UTR
            and 5' coding region, and initiates translation at a downstream
            in-frame start codon, compared to variant 1. The encoded isoform
            (b) is shorter at the N-terminus, compared to isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.272803.1, DA260869.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000275169.5/ ENSP00000275169.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 DA205492.1         56-63
            9-567               DA260869.1         9-567
            568-1520            BC043414.2         411-1363
            1521-1521           AL591076.5         75319-75319
            1522-1783           BC043414.2         1365-1626
FEATURES             Location/Qualifiers
     source          1..1783
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..1783
                     /gene="GPR6"
                     /note="G protein-coupled receptor 6"
                     /db_xref="GeneID:2830"
                     /db_xref="HGNC:HGNC:4515"
                     /db_xref="MIM:600553"
     exon            1..157
                     /gene="GPR6"
                     /inference="alignment:Splign:2.1.0"
     exon            158..1783
                     /gene="GPR6"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1264
                     /gene="GPR6"
                     /note="isoform b is encoded by transcript variant 2;
                     sphingosine 1-phosphate receptor GPR6"
                     /codon_start=1
                     /product="G-protein coupled receptor 6 isoform b"
                     /protein_id="NP_005275.1"
                     /db_xref="CCDS:CCDS5079.1"
                     /db_xref="GeneID:2830"
                     /db_xref="HGNC:HGNC:4515"
                     /db_xref="MIM:600553"
                     /translation="MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAAL
                     GAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPA
                     LRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLL
                     AITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSV
                     VRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRK
                     GVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQ
                     EIQRALWLLLCGCFQSKVPFRSRSPSEV"
     regulatory      1760..1765
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR6"
                     /note="hexamer: AATAAA"
     polyA_site      1783
                     /gene="GPR6"
                     /note="major polyA site"
ORIGIN      
        1 actcgcggag ccggcacagc gacaggcgcc ccgcgcttgc ctcctccccg gcccggccgc
       61 ctcctgcagg cagctgctct gtttgcgcgg ggagctcagc ccggcgcccc gcctcggcgc
      121 ccatgaccag cgacttccag aagtcctgac gccccagggt gcaaatccgg ccgcgatgaa
      181 cgcgagcgcc gcctcgctca acgactccca ggtggtggta gtggcggccg aaggagcggc
      241 ggcggcggcc acagcagcag gggggccgga cacgggcgaa tggggacccc ctgctgcggc
      301 ggctctagga gccggcggcg gagctaatgg gtctctggag ctgtcctcgc agctgtcggc
      361 tgggccaccg ggactcctgc tgccagcggt gaatccgtgg gacgtgctcc tgtgcgtgtc
      421 ggggacagtg atcgctggag aaaacgcgct ggtggtggcg ctcatcgcgt ccactccggc
      481 gctgcgcacg cccatgttcg tgctggtagg cagcctggcc accgctgacc tgttggcggg
      541 ctgtggcctc atcttgcact ttgtgttcca gtacttggtg ccctcggaga ctgtgagtct
      601 gctcacggtg ggcttcctcg tggcctcctt cgccgcctct gtcagcagcc tgctggccat
      661 tacggtggac cgctacctgt ccctgtataa cgcgctcacc tattactcgc gccggaccct
      721 gttgggcgtg cacctcctgc ttgccgccac ttggaccgtg tccctaggcc tggggctgct
      781 gcccgtgctg ggctggaact gcctggcaga gcgcgccgcc tgcagcgtgg tgcgcccgct
      841 ggcgcgcagc cacgtggctc tgctctccgc cgccttcttc atggtcttcg gcatcatgct
      901 gcacctgtac gtgcgcatct gccaggtggt ctggcgccac gcgcaccaga tcgcgctgca
      961 gcagcactgc ctggcgccac cccatctcgc tgccaccaga aagggtgtgg gtacactggc
     1021 tgtggtgctg ggcactttcg gcgccagctg gctgcccttc gccatctatt gcgtggtggg
     1081 cagccatgag gacccggcgg tctacactta cgccaccctg ctgcccgcca cctacaactc
     1141 catgatcaat cccatcatct atgccttccg caaccaggag atccagcgcg ccctgtggct
     1201 cctgctctgt ggctgtttcc agtccaaagt gccctttcgt tccaggtctc ccagcgaggt
     1261 ctgaagggct cgccccgtgt cctctcacca acaccacacc ccaacaagcc agcctttggt
     1321 aagctcggtg cctgctgacg aactctgaga tcccaatggt gtgagtctga ctttggaaag
     1381 aaaaagggac taaagagaaa tgtaacaaac ttacaaggac aaagaggctt gttggcactt
     1441 tacatataca gtgtatacat gtgtacatat atatacaaat atttgtatct tctggaggtg
     1501 ttcaggatgt ggagcttcct attctgtgaa aaaccaagaa aaagatatgg ttgtatactc
     1561 aaattgtaca tcacgtttgt caaacgaaga cattccaata ctgcttaatt atagcacttt
     1621 atttttagct gctgaactgc caaaacagtg ttgccatttt caagggcagg gaaaagggag
     1681 taaaaggtgt atttttgtcg tatgtgatag aatattttgc tgcacatgca tcaacaaatt
     1741 acaacatgtt ttgtacacga ataaacccat tacaagaatg taa
//
