LOCUS       NM_005683               3844 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens G protein-coupled receptor 55 (GPR55), mRNA.
ACCESSION   NM_005683
VERSION     NM_005683.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3844)
  AUTHORS   Ahmed,S., Abir,A.H., Sharmin,O., Khurshid,N., Akter,A.,
            Nakshy,N.T., Hasan,M.M., Yesmine,S. and Rahman,M.
  TITLE     Modulation of PI3K/Akt/GSK3beta signaling cascade through G
            protein-coupled receptor 55 (GPR55) activation: Prenatal
            lysophosphatidylinositol attenuates valproic acid-induced synaptic
            abnormalities and mitochondrial dysfunction
  JOURNAL   Life Sci 334, 122195 (2023)
   PUBMED   37866808
  REMARK    GeneRIF: Modulation of PI3K/Akt/GSK3beta signaling cascade through
            G protein-coupled receptor 55 (GPR55) activation: Prenatal
            lysophosphatidylinositol attenuates valproic acid-induced synaptic
            abnormalities and mitochondrial dysfunction.
REFERENCE   2  (bases 1 to 3844)
  AUTHORS   Kolbe,M.R., Hohmann,T., Hohmann,U., Maronde,E., Golbik,R.,
            Prell,J., Illert,J., Strauss,C. and Dehghani,F.
  TITLE     Elucidation of GPR55-Associated Signaling behind THC and LPI
            Reducing Effects on Ki67-Immunoreactive Nuclei in Patient-Derived
            Glioblastoma Cells
  JOURNAL   Cells 12 (22), 2646 (2023)
   PUBMED   37998380
  REMARK    GeneRIF: Elucidation of GPR55-Associated Signaling behind THC and
            LPI Reducing Effects on Ki67-Immunoreactive Nuclei in
            Patient-Derived Glioblastoma Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3844)
  AUTHORS   Wang,T., Xia,K., Qiu,T., Han,S., Chen,Z., Ma,X., Zhang,L., Zou,J.,
            Zhang,Y., Yu,B., Kong,C., Guo,J., Liu,Y., Zhou,J. and Zheng,S.
  TITLE     A comprehensive survival and prognosis analysis of GPR55 expression
            in hepatocellular carcinoma
  JOURNAL   Aging (Albany NY) 15 (17), 8930-8947 (2023)
   PUBMED   37688769
  REMARK    GeneRIF: A comprehensive survival and prognosis analysis of GPR55
            expression in hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 3844)
  AUTHORS   Shimai,R., Hanafusa,K., Nakayama,H., Oshima,E., Kato,M., Kano,K.,
            Matsuo,I., Miyazaki,T., Tokano,T., Hirabayashi,Y., Iwabuchi,K. and
            Minamino,T.
  TITLE     Lysophosphatidylglucoside/GPR55 signaling promotes foam cell
            formation in human M2c macrophages
  JOURNAL   Sci Rep 13 (1), 12740 (2023)
   PUBMED   37544935
  REMARK    GeneRIF: Lysophosphatidylglucoside/GPR55 signaling promotes foam
            cell formation in human M2c macrophages.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3844)
  AUTHORS   Ismail,H.T.H., AbdelMageed,M., Lindmark,G., Hammarstrom,M.L.,
            Hammarstrom,S. and Sitohy,B.
  TITLE     Prognostic Significance of GPR55 mRNA Expression in Colon Cancer
  JOURNAL   Int J Mol Sci 23 (9), 4556 (2022)
   PUBMED   35562947
  REMARK    GeneRIF: Prognostic Significance of GPR55 mRNA Expression in Colon
            Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3844)
  AUTHORS   McPartland,J.M., Norris,R.W. and Kilpatrick,C.W.
  TITLE     Tempo and mode in the endocannaboinoid system
  JOURNAL   J Mol Evol 65 (3), 267-276 (2007)
   PUBMED   17676365
REFERENCE   7  (bases 1 to 3844)
  AUTHORS   McPartland,J.M., Matias,I., Di Marzo,V. and Glass,M.
  TITLE     Evolutionary origins of the endocannabinoid system
  JOURNAL   Gene 370, 64-74 (2006)
   PUBMED   16434153
REFERENCE   8  (bases 1 to 3844)
  AUTHORS   Petitet,F., Donlan,M. and Michel,A.
  TITLE     GPR55 as a new cannabinoid receptor: still a long way to prove it
  JOURNAL   Chem Biol Drug Des 67 (3), 252-253 (2006)
   PUBMED   16611220
REFERENCE   9  (bases 1 to 3844)
  AUTHORS   Baker,D., Pryce,G., Davies,W.L. and Hiley,C.R.
  TITLE     In silico patent searching reveals a new cannabinoid receptor
  JOURNAL   Trends Pharmacol Sci 27 (1), 1-4 (2006)
   PUBMED   16318877
REFERENCE   10 (bases 1 to 3844)
  AUTHORS   Sawzdargo,M., Nguyen,T., Lee,D.K., Lynch,K.R., Cheng,R., Heng,H.H.,
            George,S.R. and O'Dowd,B.F.
  TITLE     Identification and cloning of three novel human G protein-coupled
            receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively
            expressed in human brain
  JOURNAL   Brain Res Mol Brain Res 64 (2), 193-198 (1999)
   PUBMED   9931487
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012507.9 and BC032694.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005683.3.
            
            Summary: This gene belongs to the G-protein-coupled receptor
            superfamily. The encoded integral membrane protein is a likely
            cannabinoid receptor. It may be involved in several physiological
            and pathological processes by activating a variety of signal
            transduction pathways. [provided by RefSeq, Aug 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.245238.1,
                                           SRR1163657.221880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000650999.1/ ENSP00000498258.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC012507.9         139608-139623       c
            17-1550             BC032694.1         1-1534
            1551-2861           AC012507.9         122692-124002       c
            2862-3114           BC032694.1         1535-1787
            3115-3844           BC032694.1         1789-2518
FEATURES             Location/Qualifiers
     source          1..3844
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..3844
                     /gene="GPR55"
                     /gene_synonym="LPIR1"
                     /note="G protein-coupled receptor 55"
                     /db_xref="GeneID:9290"
                     /db_xref="HGNC:HGNC:4511"
                     /db_xref="MIM:604107"
     exon            1..75
                     /gene="GPR55"
                     /gene_synonym="LPIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            76..3844
                     /gene="GPR55"
                     /gene_synonym="LPIR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1169
                     /gene="GPR55"
                     /gene_synonym="LPIR1"
                     /codon_start=1
                     /product="G-protein coupled receptor 55"
                     /protein_id="NP_005674.2"
                     /db_xref="CCDS:CCDS2480.1"
                     /db_xref="GeneID:9290"
                     /db_xref="HGNC:HGNC:4511"
                     /db_xref="MIM:604107"
                     /translation="MSQQNTSGDCLFDGVNELMKTLQFAVHIPTFVLGLLLNLLAIHG
                     FSTFLKNRWPDYAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPSLCTLVECLYF
                     VSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFH
                     GKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGRRDHTQDW
                     VQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCF
                     SNVNCCLDVFCYYFVIKEFRMNIRAHRPSRVQLVLQDTTISRG"
     regulatory      3826..3831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR55"
                     /gene_synonym="LPIR1"
                     /note="hexamer: AATAAA"
     polyA_site      3844
                     /gene="GPR55"
                     /gene_synonym="LPIR1"
                     /note="major polyA site"
ORIGIN      
        1 agaacaggct gacagccagg cctggaggag aaatgacatc tctcagccct ctcagctgca
       61 ccggaccacc aacagttgtg attcaatggg catgaattgc tgtgtgatgc tggggaggtg
      121 tttgtgattc ttgacaaagt catttgaatc catcacttca agagagtgaa aggagccccg
      181 tctgatctgt tggtgttgta ggaagaaaca tgagtcagca aaacaccagt ggggactgcc
      241 tgtttgacgg tgtcaacgag ctgatgaaaa ccctacagtt tgcagtccac atccccacct
      301 tcgtcctggg cctgctcctc aacctgctgg ccatccatgg cttcagcacc ttccttaaga
      361 acaggtggcc cgattatgct gccacctcca tctacatgat caacctggca gtctttgacc
      421 tgctgctggt gctctccctc ccattcaaga tggtcctgtc ccaggtacag tcccccttcc
      481 cgtccctgtg caccctggtg gagtgccttt acttcgtcag catgtacgga agcgtcttca
      541 ccatctgctt catcagcatg gaccggttct tggccatccg ttacccgcta ctggtgagcc
      601 acctccggtc ccccaggaag atctttggga tctgctgcac catctgggtc ctggtgtgga
      661 ccggaagcat ccctatctac agtttccatg ggaaagtgga aaaatacatg tgcttccaca
      721 acatgtctga tgatacctgg agcgccaagg tcttcttccc gctggaggtg tttggcttcc
      781 tccttcccat gggcatcatg ggcttctgct gctccaggag catccacatc ctgctgggcc
      841 gccgagacca cacccaggac tgggtgcagc agaaagcctg catctacagc atcgcagcca
      901 gcctggctgt cttcgtggtc tccttcctcc cagtccacct ggggttcttc ctgcagttcc
      961 tggtgagaaa cagctttatc gtagagtgca gagccaagca gagcatcagc ttcttcttgc
     1021 aattgtccat gtgtttctcc aacgtcaact gctgcctgga tgttttctgc tactactttg
     1081 tcatcaaaga attccgcatg aacatcaggg cccaccggcc ttccagggtc cagctggtcc
     1141 tgcaggacac cacgatctcc cggggctaac ggaaggacat cctgttcagg ggaagaaagc
     1201 cctggccctg aattctggta acggatatcg cgttccaggg ttttgatgtg gtgggatgat
     1261 ccgcaccatc ttcactgatg tgcttccctt tgatgcccat tgagtgccag ctttgctcat
     1321 tataccccaa agaccttttt tccactgccc agacagctta taccacccag tgttcaggga
     1381 tctctgaaga acccacagac caggtgaatt actgatttct aagtccaaaa actatagagc
     1441 agaagaattg agaaagagaa tgagaccatg tcaacaaggc tgtttccaac tctccccatt
     1501 ttcctgttcg actgggaggt tctggaaaga aagagagaga gagaaaagag gtaaaggagg
     1561 gagccaagag agtcagttat tggggagagt gtcttgggca gaggtggggt ggtagggatg
     1621 agtgaagtcc ctttttagtt tgggtgtccc agaacagagc agacttgcat tttccagtcc
     1681 cttctggaac tgtgttgcca aaagcctcac tgagatgaca gcaagaaggg gtggtgttgg
     1741 ggctgggcaa gtagcatgga tcaccccaag tttccagtga gcctcagaaa ggtgaaggaa
     1801 gccagccaca cctttccgtg cccgtgagaa gactgcaaaa tgactgagtg gggtgttgat
     1861 gacatccaag agccatgagg ggggagagga aaggacactt ctggggaagg aagaagacag
     1921 gcccagggct ggaagcacac agcccctccc ctatcaccat cagggtgtcc acagcacgga
     1981 gtgttggtgc tggcccaggg tgaagagaga cagtgagaga cggcctggga gcggggagac
     2041 cccgacctgc tttctatctt aaacagactg ggaagttgct cattacagct agcttccttg
     2101 aaaacaatgg caaagaatca ggcctgcctt ggttccacca taggagggtg gaggaggtgc
     2161 tgtcttactc acctgcatcc tggctgggca gctggcaccc gtggcactgc ccatggagcc
     2221 gtccctccct ggcagctggg agggagatga ggcagctagg cacaagggtg tggccttgag
     2281 aaagaaggca agggggggtc cctgctggtc ccaggaaact gtaaacaatt gagtcacgcc
     2341 tggatggctt ctcaacggat ctggaggagg agtgcaagtg acagcggaag cctcccaatg
     2401 actcagctgc tccggagagt gaaatgatga gaaggatcca ttgtggggtg gttttgcatg
     2461 acagagcgag tgggatgagg agtaactgat gagacttcat gtgagcaagg tcttcaggag
     2521 gaaaagcaac tgaggtctac ttgtaggatc tgggctcagt gggggctgaa gggcttggga
     2581 ggggtggtga cctgagggga agaagagaag catttggata aacctggacc tgtggggagg
     2641 aggaggagga agaggaagag gaaaaggagg ggaagctgag ccgtggccct aggcttgaag
     2701 cctgcaggga gtgcagggtg ggtggggaac ctggctgagc tgcttcctgc ctgagagctt
     2761 tcccagctgg cctaagagcc atggacggac aggagtcgcc ttctcaggag cagctcccgc
     2821 tgttgctgtg ttcaagtggc accctgtaca cctcctccta ggtggatgga gggaagggtg
     2881 aggaagagag cgtcaatgaa ggggtggaag tggatgtgga ggagtgacca gaccagacca
     2941 gaccagacca gagggatcgg aggctcaggc cccctgagct gggcctctaa gaaccacagc
     3001 cacagagtca ggctctgcag acccagaggt aaggctgcct ggctgcccca aaccccagac
     3061 actcctctcc ttgcctgcag gctgccctct cccatggcca ccctagacag agacccaccc
     3121 gtgatactct gagggagcca gactttcaca tgcaacgggg catttggggc tggttcgggt
     3181 cagtgtctac gggtggtgga tttagtgacc accctcctcc cacttctttc tctgcacgag
     3241 gagttgggag cctgcctggt ggagttgagt gatgcccgtc atgtgcactt gggtctacca
     3301 atgtgcttaa ggccagatgg gcttcctaag agacaagggt gggtggacct aaccaactat
     3361 catccccagc gatgttcaaa cataaaatct tatctatgtg cagcatgact ctctccaggt
     3421 gacagaaagg gctctagaca gctgagagga cctgatcatg tagggaggga cggggagggg
     3481 agccaggacc caggagctgc atggctgtaa gaggaaggtc cttggagggt atcagcagtc
     3541 tcagtgtgat gtgacaacta tggacctgtg ggtgtgccct ggggacccct gacccatccc
     3601 aaaacactgt ggaaagaagg gcctcttctc cgtggggacc cgtgtctgtg ggagcgggca
     3661 caggtccatg ctgcaggcca ctacggctgc tcggcaggag ggccgagagt ttggacccac
     3721 atagctgcaa cccaagctgg cccataatca gcagtggggc ccagcagcac aggaggggcg
     3781 gacggttagc tttggaaaaa atgacttgat taatctgatt cgccaaataa atagattcat
     3841 gtga
//
