LOCUS       NM_005684               1582 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens G protein-coupled receptor 52 (GPR52), mRNA.
ACCESSION   NM_005684
VERSION     NM_005684.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1582)
  AUTHORS   Ma,M., Guo,S., Lin,X., Li,S., Wu,Y., Zeng,Y., Hu,Y., Zhao,S.,
            Xu,F., Xie,X. and Shui,W.
  TITLE     Targeted Proteomics Combined with Affinity Mass Spectrometry
            Analysis Reveals Antagonist E7 Acts As an Intracellular Covalent
            Ligand of Orphan Receptor GPR52
  JOURNAL   ACS Chem Biol 15 (12), 3275-3284 (2020)
   PUBMED   33258587
  REMARK    GeneRIF: Targeted Proteomics Combined with Affinity Mass
            Spectrometry Analysis Reveals Antagonist E7 Acts As an
            Intracellular Covalent Ligand of Orphan Receptor GPR52.
REFERENCE   2  (bases 1 to 1582)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1582)
  AUTHORS   Hatzipantelis,C.J., Lu,Y., Spark,D.L., Langmead,C.J. and
            Stewart,G.D.
  TITLE     beta-Arrestin-2-Dependent Mechanism of GPR52 Signaling in Frontal
            Cortical Neurons
  JOURNAL   ACS Chem Neurosci 11 (14), 2077-2084 (2020)
   PUBMED   32519845
  REMARK    GeneRIF: beta-Arrestin-2-Dependent Mechanism of GPR52 Signaling in
            Frontal Cortical Neurons.
REFERENCE   4  (bases 1 to 1582)
  AUTHORS   Lin,X., Li,M., Wang,N., Wu,Y., Luo,Z., Guo,S., Han,G.W., Li,S.,
            Yue,Y., Wei,X., Xie,X., Chen,Y., Zhao,S., Wu,J., Lei,M. and Xu,F.
  TITLE     Structural basis of ligand recognition and self-activation of
            orphan GPR52
  JOURNAL   Nature 579 (7797), 152-157 (2020)
   PUBMED   32076264
  REMARK    GeneRIF: high-resolution structures of human GPR52 in three states:
            a ligand-free state, a Gs-coupled self-activation state and a
            potential allosteric ligand-bound state
REFERENCE   5  (bases 1 to 1582)
  AUTHORS   Yao,Y., Cui,X., Al-Ramahi,I., Sun,X., Li,B., Hou,J., Difiglia,M.,
            Palacino,J., Wu,Z.Y., Ma,L., Botas,J. and Lu,B.
  TITLE     A striatal-enriched intronic GPCR modulates huntingtin levels and
            toxicity
  JOURNAL   Elife 4, e05449 (2015)
   PUBMED   25738228
  REMARK    GeneRIF: Data show that G protein-coupled receptor 52 (Gpr52)
            modulates huntingtin protein (Htt) levels in the striatal cells in
            vitro and in vivo.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1582)
  AUTHORS   Komatsu,H., Maruyama,M., Yao,S., Shinohara,T., Sakuma,K.,
            Imaichi,S., Chikatsu,T., Kuniyeda,K., Siu,F.K., Peng,L.S., Zhuo,K.,
            Mun,L.S., Han,T.M., Matsumoto,Y., Hashimoto,T., Miyajima,N.,
            Itoh,Y., Ogi,K., Habata,Y. and Mori,M.
  TITLE     Anatomical transcriptome of G protein-coupled receptors leads to
            the identification of a novel therapeutic candidate GPR52 for
            psychiatric disorders
  JOURNAL   PLoS One 9 (2), e90134 (2014)
   PUBMED   24587241
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1582)
  AUTHORS   Sawzdargo,M., Nguyen,T., Lee,D.K., Lynch,K.R., Cheng,R., Heng,H.H.,
            George,S.R. and O'Dowd,B.F.
  TITLE     Identification and cloning of three novel human G protein-coupled
            receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively
            expressed in human brain
  JOURNAL   Brain Res Mol Brain Res 64 (2), 193-198 (1999)
   PUBMED   9931487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL022171.1, BC095532.1, BC069460.1, DA174341.1 and DB168074.1.
            
            On May 17, 2019 this sequence version replaced NM_005684.4.
            
            Summary: Members of the G protein-coupled receptor (GPR) family
            play important roles in signal transduction from the external
            environment to the inside of the cell.[supplied by OMIM, Jul 2002].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC095532.1, SRR1803612.270767.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367685.5/ ENSP00000356658.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AL022171.1         79023-79132
            111-129             BC095532.1         2-20
            130-130             AL022171.1         79152-79152
            131-199             BC095532.1         22-90
            200-1234            BC069460.1         52-1086
            1235-1503           DA174341.1         313-581
            1504-1582           DB168074.1         428-506
FEATURES             Location/Qualifiers
     source          1..1582
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.1"
     gene            1..1582
                     /gene="GPR52"
                     /note="G protein-coupled receptor 52"
                     /db_xref="GeneID:9293"
                     /db_xref="HGNC:HGNC:4508"
                     /db_xref="MIM:604106"
     exon            1..1582
                     /gene="GPR52"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1234
                     /gene="GPR52"
                     /note="probable G-protein coupled receptor 52"
                     /codon_start=1
                     /product="G-protein coupled receptor 52"
                     /protein_id="NP_005675.3"
                     /db_xref="CCDS:CCDS30941.1"
                     /db_xref="GeneID:9293"
                     /db_xref="HGNC:HGNC:4508"
                     /db_xref="MIM:604106"
                     /translation="MNESRWTEWRILNMSSGIVNVSERHSCPLGFGHYSVVDVCIFET
                     VVIVLLTFLIIAGNLTVIFVFHCAPLLHHYTTSYFIQTMAYADLFVGVSCLVPTLSLL
                     HYSTGVHESLTCQVFGYIISVLKSVSMACLACISVDRYLAITKPLSYNQLVTPCRLRI
                     CIILIWIYSCLIFLPSFFGWGKPGYHGDIFEWCATSWLTSAYFTGFIVCLLYAPAAFV
                     VCFTYFHIFKICRQHTKEINDRRARFPSHEVDSSRETGHSPDRRYAMVLFRITSVFYM
                     LWLPYIIYFLLESSRVLDNPTLSFLTTWLAISNSFCNCVIYSLSNSVFRLGLRRLSET
                     MCTSCMCVKDQEAQEPKPRKRANSCSI"
ORIGIN      
        1 actctctggg actctcagct gtgacagaag cactgacact gtctactgaa gcaggttctg
       61 aaacactcat gtgcggtgtt taacagatgc tgggcagggc atctgcttgc tgtagccaag
      121 tctgcaggtg tctttaaatt tccaagccat gaatgaatcc aggtggactg aatggaggat
      181 cctgaacatg agcagtggca ttgtgaatgt gtccgagcgt cactcctgcc cacttggatt
      241 tggccactac agtgtggtgg atgtctgcat cttcgagaca gtggttattg tgttgctgac
      301 atttctgatc attgctggga atctaacagt tatctttgtc tttcattgtg ctccactgtt
      361 acatcattat actaccagct atttcattca gacgatggca tatgctgatc ttttcgttgg
      421 agttagctgc ttggttccta ctctgtcact tctccactac tccacaggtg tccacgagtc
      481 attgacttgc caggtttttg gatatatcat ctcagttcta aaaagtgttt ctatggcatg
      541 tcttgcttgc atcagtgtgg atcgttatct tgcaataacc aagcctcttt cctacaatca
      601 actggtcacc ccttgtcgct tgagaatttg cattattttg atctggatct actcctgcct
      661 aattttcttg ccttcctttt ttggctgggg gaaacctggt taccatggtg acatttttga
      721 atggtgtgcc acgtcttggc tcaccagtgc ctattttact ggctttattg tttgtttact
      781 ttatgctcct gctgcctttg ttgtctgctt cacttacttc cacattttca aaatttgccg
      841 tcagcacacc aaagagataa atgaccgaag agcccgattc cctagtcatg aggtagattc
      901 ttccagagag actggacaca gccctgaccg tcgctacgcc atggttttgt ttaggataac
      961 cagtgtattt tatatgctgt ggctccccta tataatttac tttcttctag aaagctcccg
     1021 ggtcttggac aatccaactc tgtccttctt aacaacctgg cttgcaataa gtaatagttt
     1081 ttgtaactgt gtaatataca gcctctccaa cagcgttttc cggctaggcc tccgaagact
     1141 gtctgagaca atgtgcacat cctgtatgtg tgtgaaggat caggaagcac aagaacccaa
     1201 acctaggaaa cgggctaatt cttgctccat ttgaagagag ctacatagta aatcaaatgt
     1261 aatctgacag tggttttgga tcatattcta gattcatctg gaaatttgcc atcagagaaa
     1321 tatttacttg aatagttgac tgtaaaatga agtatgagac taaaggtttc tctctttttt
     1381 tttctttttc atggaagaaa ctaaagggaa ggatgtatag agggttagct catgaaataa
     1441 ttatagcatg tgagtattag tgtgcagtaa taggaaaaat taagcactga gatgaaaaag
     1501 aatatctcaa atcttctgca ggacatgagc aagccccttg gctcagcatt tctgtctttc
     1561 tgtctgactg taccctgcct ct
//
