LOCUS       NM_004224               2020 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens G protein-coupled receptor 50 (GPR50), mRNA.
ACCESSION   NM_004224
VERSION     NM_004224.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2020)
  AUTHORS   Ahmad,R., Lahuna,O., Sidibe,A., Daulat,A., Zhang,Q., Luka,M.,
            Guillaume,J.L., Gallet,S., Guillonneau,F., Hamroune,J., Polo,S.,
            Prevot,V., Delagrange,P., Dam,J. and Jockers,R.
  TITLE     GPR50-Ctail cleavage and nuclear translocation: a new signal
            transduction mode for G protein-coupled receptors
  JOURNAL   Cell Mol Life Sci 77 (24), 5189-5205 (2020)
   PUBMED   31900622
  REMARK    GeneRIF: GPR50-Ctail cleavage and nuclear translocation: a new
            signal transduction mode for G protein-coupled receptors.
REFERENCE   2  (bases 1 to 2020)
  AUTHORS   Saha,S.K., Choi,H.Y., Yang,G.M., Biswas,P.K., Kim,K., Kang,G.H.,
            Gil,M. and Cho,S.G.
  TITLE     GPR50 Promotes Hepatocellular Carcinoma Progression via the Notch
            Signaling Pathway through Direct Interaction with ADAM17
  JOURNAL   Mol Ther Oncolytics 17, 332-349 (2020)
   PUBMED   32405532
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2020)
  AUTHORS   Chen,W., Ji,H., Li,L., Xu,C., Zou,T., Cui,W., Xu,S., Zhou,X.,
            Duan,S. and Wang,Q.
  TITLE     Significant association between GPR50 hypomethylation and AD in
            males
  JOURNAL   Mol Med Rep 20 (2), 1085-1092 (2019)
   PUBMED   31173244
  REMARK    GeneRIF: GPR50 promoter methylation level was decreased in the male
            Alzheimer's disease group compared with the male control group.
REFERENCE   4  (bases 1 to 2020)
  AUTHORS   Wojciech,S., Ahmad,R., Belaid-Choucair,Z., Journe,A.S., Gallet,S.,
            Dam,J., Daulat,A., Ndiaye-Lobry,D., Lahuna,O., Karamitri,A.,
            Guillaume,J.L., Do Cruzeiro,M., Guillonneau,F., Saade,A.,
            Clement,N., Courivaud,T., Kaabi,N., Tadagaki,K., Delagrange,P.,
            Prevot,V., Hermine,O., Prunier,C. and Jockers,R.
  TITLE     The orphan GPR50 receptor promotes constitutive TGFbeta receptor
            signaling and protects against cancer development
  JOURNAL   Nat Commun 9 (1), 1216 (2018)
   PUBMED   29572483
  REMARK    GeneRIF: GPR50 is a TbetaRI co-receptor with potential impact on
            cancer development
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2020)
  AUTHORS   Elliott,S.E., Parchim,N.F., Kellems,R.E., Xia,Y., Soffici,A.R. and
            Daugherty,P.S.
  TITLE     A pre-eclampsia-associated Epstein-Barr virus antibody cross-reacts
            with placental GPR50
  JOURNAL   Clin Immunol 168, 64-71 (2016)
   PUBMED   27181993
  REMARK    GeneRIF: Pre-eclampsia (PE) plasma IgG1 anti-Epstein-Barr virus
            nuclear antigen 1 (EBNA-1) antibody cross-reacts with placental
            protein G protein-coupled receptor 50 (GPR50).
REFERENCE   6  (bases 1 to 2020)
  AUTHORS   Bhattacharyya,S., Luan,J., Challis,B., Keogh,J., Montague,C.,
            Brennand,J., Morten,J., Lowenbeim,S., Jenkins,S., Farooqi,I.S.,
            Wareham,N.J. and O'Rahilly,S.
  TITLE     Sequence variants in the melatonin-related receptor gene (GPR50)
            associate with circulating triglyceride and HDL levels
  JOURNAL   J Lipid Res 47 (4), 761-766 (2006)
   PUBMED   16436372
  REMARK    GeneRIF: Results describe sequence variants in the
            melatonin-related receptor gene (GPR50) that associate with
            circulating triglyceride and HDL levels.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2020)
  AUTHORS   Thomson,P.A., Wray,N.R., Thomson,A.M., Dunbar,D.R., Grassie,M.A.,
            Condie,A., Walker,M.T., Smith,D.J., Pulford,D.J., Muir,W.,
            Blackwood,D.H. and Porteous,D.J.
  TITLE     Sex-specific association between bipolar affective disorder in
            women and GPR50, an X-linked orphan G protein-coupled receptor
  JOURNAL   Mol Psychiatry 10 (5), 470-478 (2005)
   PUBMED   15452587
  REMARK    GeneRIF: Polymorphisms in GPR50 were compared in bipolar affective
            disorder (BD), major depressive disorder (MDD), schizophrenia (SCZ)
            and controls. GPR50(Delta502-505) or a variant is a sex-specific
            risk factor for susceptibility to BD and SCZ.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2020)
  AUTHORS   Slominski,A., Pisarchik,A., Zbytek,B., Tobin,D.J., Kauser,S. and
            Wortsman,J.
  TITLE     Functional activity of serotoninergic and melatoninergic systems
            expressed in the skin
  JOURNAL   J Cell Physiol 196 (1), 144-153 (2003)
   PUBMED   12767050
REFERENCE   9  (bases 1 to 2020)
  AUTHORS   Gubitz,A.K. and Reppert,S.M.
  TITLE     Assignment of the melatonin-related receptor to human chromosome X
            (GPR50) and mouse chromosome X (Gpr50)
  JOURNAL   Genomics 55 (2), 248-251 (1999)
   PUBMED   9933574
REFERENCE   10 (bases 1 to 2020)
  AUTHORS   Reppert,S.M., Weaver,D.R., Ebisawa,T., Mahle,C.D. and
            Kolakowski,L.F. Jr.
  TITLE     Cloning of a melatonin-related receptor from human pituitary
  JOURNAL   FEBS Lett 386 (2-3), 219-224 (1996)
   PUBMED   8647286
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP245442.1, BC105683.1,
            BC105684.1 and U52219.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 14, 2010 this sequence version replaced NM_004224.2.
            
            Summary: This gene product belongs to the G-protein coupled
            receptor 1 family. Even though this protein shares similarity with
            the melatonin receptors, it does not bind melatonin, however, it
            inhibits melatonin receptor 1A function through heterodimerization.
            Polymorphic variants of this gene have been associated with bipolar
            affective disorder in women. [provided by RefSeq, Jan 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U52219.1, BC103696.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2149876
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000218316.4/ ENSP00000218316.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-581               BP245442.1         1-581
            582-1953            BC105683.1         492-1863
            1954-2013           BC105684.1         1852-1911
            2014-2020           U52219.1           1933-1939
FEATURES             Location/Qualifiers
     source          1..2020
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..2020
                     /gene="GPR50"
                     /gene_synonym="H9; Mel1c"
                     /note="G protein-coupled receptor 50"
                     /db_xref="GeneID:9248"
                     /db_xref="HGNC:HGNC:4506"
                     /db_xref="MIM:300207"
     exon            1..325
                     /gene="GPR50"
                     /gene_synonym="H9; Mel1c"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1992
                     /gene="GPR50"
                     /gene_synonym="H9; Mel1c"
                     /codon_start=1
                     /product="melatonin-related receptor"
                     /protein_id="NP_004215.2"
                     /db_xref="CCDS:CCDS44012.1"
                     /db_xref="GeneID:9248"
                     /db_xref="HGNC:HGNC:4506"
                     /db_xref="MIM:300207"
                     /translation="MGPTLAVPTPYGCIGCKLPQPEYPPALIIFMFCAMVITIVVDLI
                     GNSMVILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQ
                     MVGFITGLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAV
                     LPNMYIGTIEYDPRTYTCIFNYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAA
                     RDPAGQNPDNQLAEVRNFLTMFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLY
                     LAAYFIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEART
                     LARARAHARDQAREQDRAHACPAVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSRS
                     SSAYRKSASTHHKSVFSHSKAASGHLKPVSGHSKPASGHPKSATVYPKPASVHFKADS
                     VHFKGDSVHFKPDSVHFKPASSNPKPITGHHVSAGSHSKSAFSAATSHPKPTTGHIKP
                     ATSHAEPTTADYPKPATTSHPKPTAADNPELSASHCPEIPAIAHPVSDDSDLPESASS
                     PAAGPTKPAASQLESDTIADLPDPTVVTTSTNDYHDVVVIDVEDDPDEMAV"
     exon            326..2020
                     /gene="GPR50"
                     /gene_synonym="H9; Mel1c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtcattt gctctctgac tctcagagag ggaggcacgc tttcctggag ctcctggtga
       61 cagaacaggt gtttgctgtc tggacctggc tgctgatcct gagcctgctg ggagatctta
      121 acgatcccca ggagcaacat ggggcccacc ctagcggttc ccacccccta tggctgtatt
      181 ggctgtaagc taccccagcc agaataccca ccggctctaa tcatctttat gttctgcgcg
      241 atggttatca ccatcgttgt agacctaatc ggcaactcca tggtcatttt ggctgtgacg
      301 aagaacaaga agctccggaa ttctggcaac atcttcgtgg tcagtctctc tgtggccgat
      361 atgctggtgg ccatctaccc ataccctttg atgctgcatg ccatgtccat tgggggctgg
      421 gatctgagcc agttacagtg ccagatggtc gggttcatca cagggctgag tgtggtcggc
      481 tccatcttca acatcgtggc aatcgctatc aaccgttact gctacatctg ccacagcctc
      541 cagtacgaac ggatcttcag tgtgcgcaat acctgcatct acctggtcat cacctggatc
      601 atgaccgtcc tggctgtcct gcccaacatg tacattggca ccatcgagta cgatcctcgc
      661 acctacacct gcatcttcaa ctatctgaac aaccctgtct tcactgttac catcgtctgc
      721 atccacttcg tcctccctct cctcatcgtg ggtttctgct acgtgaggat ctggaccaaa
      781 gtgctggcgg cccgtgaccc tgcagggcag aatcctgaca accaacttgc tgaggttcgc
      841 aattttctaa ccatgtttgt gatcttcctc ctctttgcag tgtgctggtg ccctatcaac
      901 gtgctcactg tcttggtggc tgtcagtccg aaggagatgg caggcaagat ccccaactgg
      961 ctttatcttg cagcctactt catagcctac ttcaacagct gcctcaacgc tgtgatctac
     1021 gggctcctca atgagaattt ccgaagagaa tactggacca tcttccatgc tatgcggcac
     1081 cctatcatat tcttctctgg cctcatcagt gatattcgtg agatgcagga ggcccgtacc
     1141 ctggcccgcg cccgtgccca tgctcgcgac caagctcgtg aacaagaccg tgcccatgcc
     1201 tgtcctgctg tggaggaaac cccgatgaat gtccggaatg ttccattacc tggtgatgct
     1261 gcagctggcc accccgaccg tgcctctggc caccctaagc cccattccag atcctcctct
     1321 gcctatcgca aatctgcctc tacccaccac aagtctgtct ttagccactc caaggctgcc
     1381 tctggtcacc tcaagcctgt ctctggccac tccaagcctg cctctggtca ccccaagtct
     1441 gccactgtct accctaagcc tgcctctgtc catttcaagg ctgactctgt ccatttcaag
     1501 ggtgactctg tccatttcaa gcctgactct gttcatttca agcctgcttc cagcaacccc
     1561 aagcccatca ctggccacca tgtctctgct ggcagccact ccaagtctgc cttcagtgct
     1621 gccaccagcc accctaaacc caccactggc cacatcaagc cagctaccag ccatgctgag
     1681 cccaccactg ctgactatcc caagcctgcc actaccagcc accctaagcc cactgctgct
     1741 gacaaccctg agctctctgc ctcccattgc cccgagatcc ctgccattgc ccaccctgtg
     1801 tctgacgaca gtgacctccc tgagtcggcc tctagccctg ccgctgggcc caccaagcct
     1861 gctgccagcc agctggagtc tgacaccatc gctgaccttc ctgaccctac tgtagtcact
     1921 accagtacca atgattacca tgatgtcgtg gttattgatg ttgaagatga tcctgatgaa
     1981 atggctgtgt gaaaaatgct ctcgtaggtg gccaggcagt
//
