LOCUS       NM_007227               1725 bp    mRNA    linear   PRI 30-JUL-2024
DEFINITION  Homo sapiens G protein-coupled receptor 45 (GPR45), mRNA.
ACCESSION   NM_007227
VERSION     NM_007227.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1725)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1725)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   3  (bases 1 to 1725)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   4  (bases 1 to 1725)
  AUTHORS   Kawasawa,Y., Kume,K., Izumi,T. and Shimizu,T.
  TITLE     Mammalian PSP24s (alpha and beta isoforms) are not responsive to
            lysophosphatidic acid in mammalian expression systems
  JOURNAL   Biochem Biophys Res Commun 276 (3), 957-964 (2000)
   PUBMED   11027575
REFERENCE   5  (bases 1 to 1725)
  AUTHORS   Kawasawa,Y., Kume,K., Nakade,S., Haga,H., Izumi,T. and Shimizu,T.
  TITLE     Brain-specific expression of novel G-protein-coupled receptors,
            with homologies to Xenopus PSP24 and human GPR45
  JOURNAL   Biochem Biophys Res Commun 276 (3), 952-956 (2000)
   PUBMED   11027574
REFERENCE   6  (bases 1 to 1725)
  AUTHORS   Marchese,A., Sawzdargo,M., Nguyen,T., Cheng,R., Heng,H.H.,
            Nowak,T., Im,D.S., Lynch,K.R., George,S.R. and O'dowd,B.F.
  TITLE     Discovery of three novel orphan G-protein-coupled receptors
  JOURNAL   Genomics 56 (1), 12-21 (1999)
   PUBMED   10036181
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC066880.1 and AC012360.7.
            
            On May 27, 2003 this sequence version replaced NM_007227.2.
            
            Summary: This intronless gene encodes a member of the G
            protein-coupled receptor (GPCR) family. Members of this protein
            family contain seven putative transmembrane domains and may mediate
            signaling processes to the interior of the cell via activation of
            heterotrimeric G proteins. This protein may function in the central
            nervous system. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258456.3/ ENSP00000258456.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1307              BC066880.1         1-1307
            1308-1725           AC012360.7         127520-127937       c
FEATURES             Location/Qualifiers
     source          1..1725
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q12.1"
     gene            1..1725
                     /gene="GPR45"
                     /gene_synonym="PSP24; PSP24(ALPHA); PSP24-1; PSP24-alpha;
                     PSP24A"
                     /note="G protein-coupled receptor 45"
                     /db_xref="GeneID:11250"
                     /db_xref="HGNC:HGNC:4503"
                     /db_xref="MIM:604838"
     exon            1..1725
                     /gene="GPR45"
                     /gene_synonym="PSP24; PSP24(ALPHA); PSP24-1; PSP24-alpha;
                     PSP24A"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1235
                     /gene="GPR45"
                     /gene_synonym="PSP24; PSP24(ALPHA); PSP24-1; PSP24-alpha;
                     PSP24A"
                     /note="high-affinity lysophosphatidic acid receptor"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 45"
                     /protein_id="NP_009158.3"
                     /db_xref="CCDS:CCDS2066.1"
                     /db_xref="GeneID:11250"
                     /db_xref="HGNC:HGNC:4503"
                     /db_xref="MIM:604838"
                     /translation="MACNSTSLEAYTYLLLNTSNASDSGSTQLPAPLRISLAIVMLLM
                     TVVGFLGNTVVCIIVYQRPAMRSAINLLLATLAFSDIMLSLCCMPFTAVTLITVRWHF
                     GDHFCRLSATLYWFFVLEGVAILLIISVDRFLIIVQRQDKLNPRRAKVIIAVSWVLSF
                     CIAGPSLTGWTLVEVPARAPQCVLGYTELPADRAYVVTLVVAVFFAPFGVMLCAYMCI
                     LNTVRKNAVRVHNQSDSLDLRQLTRAGLRRLQRQQQVSVDLSFKTKAFTTILILFVGF
                     SLCWLPHSVYSLLSVFSQRFYCGSSFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREA
                     CIELLPQTFQILPKVPERIRRRIQPSTVYVCNENQSAV"
ORIGIN      
        1 cagaggtcca cagacatcca ggaagatgca gccagcagac aaagaatggc agccacccaa
       61 gtgctgaggg gagccctccc ggccatttct gtcccagctc caagggtctc tccacgatgg
      121 cctgcaacag cacgtccctt gaggcttaca catacctgct gctgaacacc agcaacgcct
      181 cagactcggg gtccacccag ttgcccgcac ccctcaggat ctccttggcc atagtgatgc
      241 tgctgatgac cgtggtgggg ttcctgggca acactgtggt ctgcatcatc gtgtaccaga
      301 ggccggctat gcgctcggcc atcaacctgc tgctggccac cctggccttc tccgacatca
      361 tgctgtccct ctgctgcatg cccttcaccg ccgtcaccct catcaccgtg cgctggcact
      421 ttggggacca cttctgccgc ctctcagcca cgctctactg gttttttgtc ctggagggcg
      481 tggccatcct gctcatcatc agcgtggacc gcttcctcat catcgtccag cgccaggaca
      541 agctgaaccc gcgcagggcc aaggtgatca tcgcggtctc ctgggtgctg tccttctgca
      601 tcgcggggcc ctcgctcacg ggctggacgc tggtggaggt gccggcgcgg gccccacagt
      661 gcgtgctggg ctacacggag ctccccgctg accgcgccta cgtggtcacc ttggtggtgg
      721 ccgtgttctt cgcgcccttt ggcgtcatgc tgtgcgccta catgtgcatc ctcaacacgg
      781 tccgcaagaa cgccgtgcgc gtgcacaacc agtcggacag cctggacctg cggcagctca
      841 ccagggcggg cctgcggcgc ctgcagcggc agcaacaggt cagcgtggac ttgagcttca
      901 agaccaaggc cttcaccacc atcctgatcc tcttcgtggg cttctccctc tgctggctgc
      961 cccactccgt ctacagcctc ctgtctgtgt ttagccagcg cttttactgc ggttcctcct
     1021 tctacgccac cagcacctgc gtcctgtggc tcagttacct caagtccgtc ttcaacccca
     1081 tcgtctactg ctggagaatc aaaaaattcc gcgaggcctg catagagttg ctgccccaga
     1141 ccttccaaat cctccccaaa gtgcctgagc ggatccgaag gagaatccag ccaagcacag
     1201 tctacgtgtg caatgaaaac cagtctgcgg tttagggggt cagggggcca cagagaaggg
     1261 gcagctgagc cccagtccca gggtggatct gtcctgctct gttccctggc atgttggtca
     1321 tagtctgcac tttgtggtgg caatttaagc acaaaggtac tcatttgtaa tcagatgagc
     1381 tgcagctccc aaatttcaaa ttttggcacg atgaattatt tttgtttctc tttgcagaga
     1441 gccaaatatg gggctgatgg gaactgcaac gtcattaagt caaaaatgga gtgggctggg
     1501 gagtgcagaa gttgggcaga aagggaggag gagggcaaca gggaatgaag ctggttgagt
     1561 gtggggcagg aggactggtc agtcacaaga gcttcaacct gccctgcgag ccctctctgc
     1621 acctgctcaa gagaaaccct gagaaacccc agtaggtgtg agctcctggg tgttcattca
     1681 ttttgtttga caccagggtt cttcagctat tgatgtttgt ggtgt
//
