LOCUS       NM_001348195            1665 bp    mRNA    linear   PRI 29-OCT-2022
DEFINITION  Homo sapiens G protein-coupled receptor 42 (GPR42), mRNA.
ACCESSION   NM_001348195
VERSION     NM_001348195.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1665)
  AUTHORS   Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
            R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
            Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
            Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
            Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
            Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
            Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
            Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
            Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
            Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
            Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
            D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
            Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
            Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
            Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
            MA.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1665)
  AUTHORS   Puhl HL 3rd, Won YJ, Lu VB and Ikeda SR.
  TITLE     Human GPR42 is a transcribed multisite variant that exhibits copy
            number polymorphism and is functional when heterologously expressed
  JOURNAL   Sci Rep 5, 12880 (2015)
   PUBMED   26260360
  REMARK    GeneRIF: Our data suggest that GPR42 be reclassified as a
            functioning gene and that recognition of sequence and copy number
            polymorphism of the FFAR3/GPR42 complex be considered during
            genetic and pharmacological investigation of these receptors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1665)
  AUTHORS   Liaw CW and Connolly DT.
  TITLE     Sequence polymorphisms provide a common consensus sequence for
            GPR41 and GPR42
  JOURNAL   DNA Cell Biol 28 (11), 555-560 (2009)
   PUBMED   19630535
  REMARK    GeneRIF: Study presents evidence showing that the six amino acid
            differences, including that R/W174 are polymorphisms rather than
            gene-specific differences between GPR41 and GPR42.
REFERENCE   4  (bases 1 to 1665)
  AUTHORS   Ichimura A, Hirasawa A, Hara T and Tsujimoto G.
  TITLE     Free fatty acid receptors act as nutrient sensors to regulate
            energy homeostasis
  JOURNAL   Prostaglandins Other Lipid Mediat 89 (3-4), 82-88 (2009)
   PUBMED   19460454
  REMARK    Review article
REFERENCE   5  (bases 1 to 1665)
  AUTHORS   Brown AJ, Jupe S and Briscoe CP.
  TITLE     A family of fatty acid binding receptors
  JOURNAL   DNA Cell Biol 24 (1), 54-61 (2005)
   PUBMED   15684720
  REMARK    Review article
REFERENCE   6  (bases 1 to 1665)
  AUTHORS   Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J,
            Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A,
            Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel
            S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA,
            Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J,
            Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M,
            Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W,
            Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V,
            Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready
            P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S,
            Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer
            J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D,
            Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo
            N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS,
            DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA,
            Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM and Lucas
            SM.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   7  (bases 1 to 1665)
  AUTHORS   Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels
            D, Muir AI, Wigglesworth MJ, Kinghorn I, Fraser NJ, Pike NB, Strum
            JC, Steplewski KM, Murdock PR, Holder JC, Marshall FH, Szekeres PG,
            Wilson S, Ignar DM, Foord SM, Wise A and Dowell SJ.
  TITLE     The Orphan G protein-coupled receptors GPR41 and GPR43 are
            activated by propionate and other short chain carboxylic acids
  JOURNAL   J Biol Chem 278 (13), 11312-11319 (2003)
   PUBMED   12496283
REFERENCE   8  (bases 1 to 1665)
  AUTHORS   Sawzdargo M, George SR, Nguyen T, Xu S, Kolakowski LF and O'Dowd
            BF.
  TITLE     A cluster of four novel human G protein-coupled receptor genes
            occurring in close proximity to CD22 gene on chromosome 19q13.1
  JOURNAL   Biochem Biophys Res Commun 239 (2), 543-547 (1997)
   PUBMED   9344866
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002511.1.
            
            On May 3, 2021 this sequence version replaced NM_001348195.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000454971.3/ ENSP00000410925.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AC002511.1         17635-17685
            52-1665             AC002511.1         17916-19529
FEATURES             Location/Qualifiers
     source          1..1665
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..1665
                     /gene="GPR42"
                     /gene_synonym="FFAR1L; FFAR3L; GPR41L; GPR42P"
                     /note="G protein-coupled receptor 42"
                     /db_xref="GeneID:2866"
                     /db_xref="HGNC:HGNC:4500"
                     /db_xref="MIM:603822"
     exon            1..51
                     /gene="GPR42"
                     /gene_synonym="FFAR1L; FFAR3L; GPR41L; GPR42P"
                     /inference="alignment:Splign:2.1.0"
     exon            52..1665
                     /gene="GPR42"
                     /gene_synonym="FFAR1L; FFAR3L; GPR41L; GPR42P"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1103
                     /gene="GPR42"
                     /gene_synonym="FFAR1L; FFAR3L; GPR41L; GPR42P"
                     /note="G protein-coupled receptor 42 pseudogene; G-protein
                     coupled receptor"
                     /codon_start=1
                     /product="G-protein coupled receptor 42"
                     /protein_id="NP_001335124.1"
                     /db_xref="CCDS:CCDS12460.1"
                     /db_xref="GeneID:2866"
                     /db_xref="HGNC:HGNC:4500"
                     /db_xref="MIM:603822"
                     /translation="MDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKLR
                     CRPVAVDVLLLNLTASDLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLT
                     ALFLAAVSIERFLSVAHPLWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGDIS
                     HSQGTNGTCYLEFWKDQLAILLPVRLEMAVVLFVVPLIITSYCYSRLVWILGRGGSHR
                     RQRRVAGLVAATLLNFLVCFGPYNVSHVVGYICGESPVWRIYVTLLSTLNSCVDPFVY
                     YFSSSGFQADFHELLRRLCGLWGQWQQESSMELKEQKGGEEQRADRPAERKTSEHSQG
                     CGTGGQVACAEN"
ORIGIN      
        1 agagacagca aggtgctgtg cggcagagca tttggggtct caaagaagca gtggccacca
       61 ccatggatac aggccccgac cagtcctact tctccggcaa tcactggttc gtcttctcgg
      121 tgtaccttct cactttcctg gtggggctcc ccctcaacct gctggccctg gtggtcttcg
      181 tgggcaagct gcggtgccgc ccggtggccg tggacgtgct cctgctcaac ctgaccgcct
      241 cggacctgct cctgctgctg ttcctgcctt tccgcatggt ggaggcagcc aatggcatgc
      301 actggcccct gcccttcatc ctctgcccac tctctggatt catcttcttc accaccatct
      361 atctcaccgc cctcttcctg gcagctgtga gcattgaacg cttcctgagt gtggcccacc
      421 cactgtggta caagacccgg ccgaggctgg ggcaggcagg tctggtgagt gtggcctgct
      481 ggctgttggc ctctgctcac tgcagcgtgg tctacgtcat agaattctca ggggacatct
      541 cccacagcca gggcaccaat gggacctgct acctggagtt ctggaaggac cagctagcca
      601 tcctcctgcc cgtgcggctg gagatggctg tggtcctctt tgtggtcccg ctgatcatca
      661 ccagctactg ctacagccgc ctggtgtgga tcctcggcag agggggcagc caccgccggc
      721 agaggagggt ggcggggctg gtggcggcca cgctgctcaa cttccttgtc tgctttgggc
      781 cctacaacgt gtcccatgtc gtgggctata tctgcggtga aagcccggtg tggaggatct
      841 acgtgacgct tctcagcacc ctgaactcct gtgtcgaccc ctttgtctac tacttctcct
      901 cctccgggtt ccaagccgac tttcatgagc tgctgaggag gttgtgtggg ctctggggcc
      961 agtggcagca ggagagcagc atggagctga aggagcagaa gggaggggag gagcagagag
     1021 cggaccgacc agctgaaaga aagaccagtg aacactcaca gggctgtgga actggtggcc
     1081 aggtggcctg tgctgaaaac taggtcctcc gggggaggag ggtgtagctg gcgtgtcatc
     1141 ctcagggcgc ttcctcgctc acgccaggag ggacttggag tggcgagctg gggcccgatg
     1201 gggcttgggg gcagagtaga catctagcct ccctaagggt atgcgcgcta aagcccagct
     1261 ctcgatctca cctccatccc catccaccca cacactatgg attgggctct gggaaggggt
     1321 cagggtgaga ggctgctctg gagaacaatg aggtcctcat agcagcaggc agctcctgtg
     1381 ttttcttgag ggtggcagag gagctaagag cagtgcccag gtctgagggg gctgcccagt
     1441 gagtggcagg ggcaggagag gggagaaccc catcctcaga gctgctccca gccagcgagt
     1501 caggagcggg ggagacaggg ctccagggat gaggccgcat tctgctccca cagtgccttt
     1561 tccagaaagt tcccattgct caataaatgt ggatcatcag agacatttat gaacaatgac
     1621 agaagaaaaa ttacccaaat aaatgtggaa gcaagcaaaa gagaa
//
