LOCUS       NM_004767               6529 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens G protein-coupled receptor 37 like 1 (GPR37L1), mRNA.
ACCESSION   NM_004767
VERSION     NM_004767.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6529)
  AUTHORS   Breitwieser,G.E., Cippitelli,A., Wang,Y., Pelletier,O., Dershem,R.,
            Wei,J., Toll,L., Fakhoury,B., Brunori,G., Metpally,R., Carey,D.J.
            and Robishaw,J.
  CONSRTM   Regeneron Genetics Center
  TITLE     Rare GPR37L1 Variants Reveal Potential Association between GPR37L1
            and Disorders of Anxiety and Migraine
  JOURNAL   J Neurosci 44 (19), e1226232024 (2024)
   PUBMED   38569927
  REMARK    GeneRIF: Rare GPR37L1 Variants Reveal Potential Association between
            GPR37L1 and Disorders of Anxiety and Migraine.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6529)
  AUTHORS   Bang,S., Jiang,C., Xu,J., Chandra,S., McGinnis,A., Luo,X., He,Q.,
            Li,Y., Wang,Z., Ao,X., Parisien,M., Fernandes de Araujo,L.O.,
            Jahangiri Esfahani,S., Zhang,Q., Tonello,R., Berta,T.,
            Diatchenko,L. and Ji,R.R.
  TITLE     Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium
            channel signaling and pain homeostasis
  JOURNAL   J Clin Invest 134 (9), e173537 (2024)
   PUBMED   38530364
  REMARK    GeneRIF: Satellite glial GPR37L1 and its ligand maresin 1 regulate
            potassium channel signaling and pain homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6529)
  AUTHORS   Armando,I., Cuevas,S., Fan,C., Kumar,M., Izzi,Z., Jose,P.A. and
            Konkalmatt,P.R.
  TITLE     G Protein-Coupled Receptor 37L1 Modulates Epigenetic Changes in
            Human Renal Proximal Tubule Cells
  JOURNAL   Int J Mol Sci 23 (22), 14456 (2022)
   PUBMED   36430934
  REMARK    GeneRIF: G Protein-Coupled Receptor 37L1 Modulates Epigenetic
            Changes in Human Renal Proximal Tubule Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6529)
  AUTHORS   Mouat,M.A., Coleman,J.L.J., Wu,J., Dos Remedios,C.G., Feneley,M.P.,
            Graham,R.M. and Smith,N.J.
  TITLE     Involvement of GPR37L1 in murine blood pressure regulation and
            human cardiac disease pathophysiology
  JOURNAL   Am J Physiol Heart Circ Physiol 321 (4), H807-H817 (2021)
   PUBMED   34533400
  REMARK    GeneRIF: Involvement of GPR37L1 in murine blood pressure regulation
            and human cardiac disease pathophysiology.
REFERENCE   5  (bases 1 to 6529)
  AUTHORS   Alonso-Gardon,M., Elorza-Vidal,X., Castellanos,A., La Sala,G.,
            Armand-Ugon,M., Gilbert,A., Di Pietro,C., Pla-Casillanis,A.,
            Ciruela,F., Gasull,X., Nunes,V., Martinez,A., Schulte,U.,
            Cohen-Salmon,M., Marazziti,D. and Estevez,R.
  TITLE     Identification of the GlialCAM interactome: the G protein-coupled
            receptors GPRC5B and GPR37L1 modulate megalencephalic
            leukoencephalopathy proteins
  JOURNAL   Hum Mol Genet 30 (17), 1649-1665 (2021)
   PUBMED   34100078
  REMARK    GeneRIF: Identification of the GlialCAM interactome: the G
            protein-coupled receptors GPRC5B and GPR37L1 modulate
            megalencephalic leukoencephalopathy proteins.
REFERENCE   6  (bases 1 to 6529)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   7  (bases 1 to 6529)
  AUTHORS   Zhao,X., Southwick,K., Cardasis,H.L., Du,Y., Lassman,M.E., Xie,D.,
            El-Sherbeini,M., Geissler,W.M., Pryor,K.D., Verras,A.,
            Garcia-Calvo,M., Shen,D.M., Yates,N.A., Pinto,S. and
            Hendrickon,R.C.
  TITLE     Peptidomic profiling of human cerebrospinal fluid identifies
            YPRPIHPA as a novel substrate for prolylcarboxypeptidase
  JOURNAL   Proteomics 10 (15), 2882-2886 (2010)
   PUBMED   20517885
REFERENCE   8  (bases 1 to 6529)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 6529)
  AUTHORS   Arking,D.E., Reinier,K., Post,W., Jui,J., Hilton,G., O'Connor,A.,
            Prineas,R.J., Boerwinkle,E., Psaty,B.M., Tomaselli,G.F., Rea,T.,
            Sotoodehnia,N., Siscovick,D.S., Burke,G.L., Marban,E.,
            Spooner,P.M., Chakravarti,A. and Chugh,S.S.
  TITLE     Genome-wide association study identifies GPC5 as a novel genetic
            locus protective against sudden cardiac arrest
  JOURNAL   PLoS One 5 (3), e9879 (2010)
   PUBMED   20360844
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 6529)
  AUTHORS   Valdenaire,O., Giller,T., Breu,V., Ardati,A., Schweizer,A. and
            Richards,J.G.
  TITLE     A new family of orphan G protein-coupled receptors predominantly
            expressed in the brain
  JOURNAL   FEBS Lett 424 (3), 193-196 (1998)
   PUBMED   9539149
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592300.16, AK222639.1 and AL050068.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004767.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050334.1, SRR14038193.781317.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367282.6/ ENSP00000356251.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL592300.16        6000-6001
            3-1558              AK222639.1         1-1556
            1559-5571           AL592300.16        11705-15717
            5572-6525           AL050068.1         1-954
            6526-6529           AL592300.16        16672-16675
FEATURES             Location/Qualifiers
     source          1..6529
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..6529
                     /gene="GPR37L1"
                     /gene_synonym="ET(B)R-LP-2; ETBR-LP-2; ETBRLP2"
                     /note="G protein-coupled receptor 37 like 1"
                     /db_xref="GeneID:9283"
                     /db_xref="HGNC:HGNC:14923"
                     /db_xref="MIM:617630"
     exon            1..677
                     /gene="GPR37L1"
                     /gene_synonym="ET(B)R-LP-2; ETBR-LP-2; ETBRLP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1493
                     /gene="GPR37L1"
                     /gene_synonym="ET(B)R-LP-2; ETBR-LP-2; ETBRLP2"
                     /note="endothelin type b receptor-like protein 2;
                     endothelin B receptor-like protein 2; prosaposin receptor
                     GPR37L1"
                     /codon_start=1
                     /product="G-protein coupled receptor 37-like 1 precursor"
                     /protein_id="NP_004758.3"
                     /db_xref="CCDS:CCDS1420.1"
                     /db_xref="GeneID:9283"
                     /db_xref="HGNC:HGNC:14923"
                     /db_xref="MIM:617630"
                     /translation="MRWLWPLAVSLAVILAVGLSRVSGGAPLHLGRHRAETQEQQSRS
                     KRGTEDEEAKGVQQYVPEEWAEYPRPIHPAGLQPTKPLVATSPNPGKDGGTPDSGQEL
                     RGNLTGAPGQRLQIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIVWHSYY
                     LKSAWNSILASLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTT
                     FSLCALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMTLAVPELLLWQLAQEP
                     APTMGTLDSCIMKPSASLPESLYSLVMTYQNARMWWYFGCYFCLPILFTVTCQLVTWR
                     VRGPPGRKSECRASKHEQCESQLNSTVVGLTVVYAFCTLPENVCNIVVAYLSTELTRQ
                     TLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASEASAANG
                     SDNKLKTEVSSSIYFHKPRESPPLLPLGTPC"
     exon            678..6529
                     /gene="GPR37L1"
                     /gene_synonym="ET(B)R-LP-2; ETBR-LP-2; ETBRLP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2425..2430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR37L1"
                     /gene_synonym="ET(B)R-LP-2; ETBR-LP-2; ETBRLP2"
                     /note="hexamer: AATAAA"
     polyA_site      2443
                     /gene="GPR37L1"
                     /gene_synonym="ET(B)R-LP-2; ETBR-LP-2; ETBRLP2"
                     /note="major polyA site"
     regulatory      4342..4347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR37L1"
                     /gene_synonym="ET(B)R-LP-2; ETBR-LP-2; ETBRLP2"
                     /note="hexamer: CATAAA"
     polyA_site      4369
                     /gene="GPR37L1"
                     /gene_synonym="ET(B)R-LP-2; ETBR-LP-2; ETBRLP2"
     regulatory      6506..6511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR37L1"
                     /gene_synonym="ET(B)R-LP-2; ETBR-LP-2; ETBRLP2"
                     /note="hexamer: AACAAA"
     polyA_site      6529
                     /gene="GPR37L1"
                     /gene_synonym="ET(B)R-LP-2; ETBR-LP-2; ETBRLP2"
ORIGIN      
        1 gcactcacct gctcttcctg ggctggctgt ctcctgctca tccagccatg cggtggctgt
       61 ggcccctggc tgtctctctt gctgtgattt tggctgtggg gctaagcagg gtctctgggg
      121 gtgcccccct gcacctgggc aggcacagag ccgagaccca ggagcagcag agccgatcca
      181 agaggggcac cgaggatgag gaggccaagg gcgtgcagca gtatgtgcct gaggagtggg
      241 cggagtaccc ccggcccatt caccctgctg gcctgcagcc aaccaagccc ttggtggcca
      301 ccagccctaa ccccggcaag gatgggggca ccccagacag tgggcaggaa ctgaggggca
      361 atctgacagg agcaccaggg cagaggctac agatccagaa ccccctgtat ccggtgaccg
      421 agagctccta cagtgcctat gccatcatgc ttctggcgct ggtggtgttt gcggtgggca
      481 ttgtgggcaa cctgtcggtc atgtgcatcg tgtggcacag ctactacctg aagagtgcct
      541 ggaactccat ccttgccagc ctggccctct gggattttct ggtcctcttt ttctgcctcc
      601 ctattgtcat cttcaacgag atcaccaagc agaggctact gggtgacgtt tcttgtcgtg
      661 ccgtgccctt catggaggtc tcctctctgg gagtcacgac tttcagcctc tgtgccctgg
      721 gcattgaccg cttccacgtg gccaccagca ccctgcccaa ggtgaggccc atcgagcggt
      781 gccaatccat cctggccaag ttggctgtca tctgggtggg ctccatgacg ctggctgtgc
      841 ctgagctcct gctgtggcag ctggcacagg agcctgcccc caccatgggc accctggact
      901 catgcatcat gaaaccctca gccagcctgc ccgagtccct gtattcactg gtgatgacct
      961 accagaacgc ccgcatgtgg tggtactttg gctgctactt ctgcctgccc atcctcttca
     1021 cagtcacctg ccagctggtg acatggcggg tgcgaggccc tccagggagg aagtcagagt
     1081 gcagggccag caagcacgag cagtgtgaga gccagctcaa cagcaccgtg gtgggcctga
     1141 ccgtggtcta cgccttctgc accctcccag agaacgtctg caacatcgtg gtggcctacc
     1201 tctccaccga gctgacccgc cagaccctgg acctcctggg cctcatcaac cagttctcca
     1261 ccttcttcaa gggcgccatc accccagtgc tgctcctttg catctgcagg ccgctgggcc
     1321 aggccttcct ggactgctgc tgctgctgct gctgtgagga gtgcggcggg gcttcggagg
     1381 cctctgctgc caatgggtcg gacaacaagc tcaagaccga ggtgtcctct tccatctact
     1441 tccacaagcc cagggagtca cccccactcc tgcccctggg cacaccttgc tgaggcccca
     1501 gtaggggtgg ggagggaggg agaggccgcc acccccgccg gtgtctgctg ttctttcccc
     1561 ataggtcttg ctttgttgcc tgtcttgctg tctagggatg gacttggttc ctcttgtcaa
     1621 ggtttgggaa tgtcaaagcc ccctccccac acagggcctt tcctgtccct tgtggggcct
     1681 tccaaccctg tcctttccac tggtgggcgg tgatgcttct aggtccttag aactgcccag
     1741 aaactctgag tcccagcagc tgggagccag aactttgcct gccctccctt ggttccagtc
     1801 tctcttctct ctctctgcct tggaacctga ccatacttta gttgtgccct tcccaggcat
     1861 catcctccta ccaccaacct ggggccccat cttggaatgg gggctccttg gggccagccc
     1921 agtgtggctc accacactct tctttttttt tttttttttt tttgagatgg agtcttgctc
     1981 tgttgcccag gctggagtac atttgcctga tgtcagctcc ctgcaacctc cgcctcctgg
     2041 gttcaagcga ttctcctgcc tcagcctcct gagtagctgg gattacaggt gtgcaccaac
     2101 acacccggct aatttttgta tttgtagaag aggcggggtt tcaccatgtt ggccaggctg
     2161 gtgttgaact cctgacctca agtgatctgc ctgccttggc ctcccaaagt gctgggatta
     2221 caggtgtgag ctgccacgcc cagccccagt acactcttct ctggaccaga tctgtcccag
     2281 tcctggatgc ctcctcctac tggtgccttc ttttcttcca gaggatttct ctctccttcc
     2341 tcctcctttc tttgggatcc ctgggttgcc ctgtcccaac ctccttgtta ggtgctttcc
     2401 cataggaggc ccttcttgag aaacaataaa ctaggtagaa ctacccctat gcccatccac
     2461 tttcttgtgc cacattctgg cagggcccag atgcagctgg gccttcctgg cctggcagtg
     2521 cctaggagaa tttctcctga cctggcctgg cctgtggctg atgttcagaa cagccttgtg
     2581 gccgatgttc agaacagcct tgtggccctg gcgactccaa gggttttatg gcttttgagg
     2641 gacagagagg atggagggct tggggagccg gaggacctaa gtcctcatcc tggcctaaac
     2701 cccatgctcc ttgggaagtc aaaagcctgg aaaatatctc ctctggagcc ttcatctctg
     2761 ctatgccctc tctccacaaa gccccccttg gagggagtcc agtggtcttt cctctgtgag
     2821 ccccagggct tcccagcctt tgtcactctg agagctgctc ttgttcagtt tcttagaatg
     2881 gactgttttg cctgtagacg gcccagctgc ctgccctggc ctgcccccac ccagccccca
     2941 ctgcaccacc cttcccgcca gagctcccac tgcccccggc agacccttca tgcagcttct
     3001 cctgtggggt cttgcccttg aagtgccact tcccccagcc ccacctctgg tcccttccag
     3061 agggcaccct tagccttgta ggtccctggg aagctggcac agcatcaacc agaagtgatg
     3121 cctcagccag gccaccagtc gctccccgcc tgggagctca gctttcctca gaaccacccc
     3181 ccctgtctga agctctgtcc tgggtcccac cagacttctg cccaccaggc ctacctacag
     3241 catccacatg gggcctcagg aagggccccg ggggcccagg gatgggcagg ggcagggttt
     3301 ccaagcgcct ggggctccat tctcctctgt ccacccaccc acaccccttg gcctcagcct
     3361 gccctgtacc caagcttccc tccccctctc ctggggatct taacggcctt gttctctctc
     3421 cctggcaccc acccccaggg cgggtgatgc cgccaagaga gagggaggcc gttgctaggt
     3481 gatggcgccg ccatgcacac accctttgtg ctggggagtg acacccaccc gtttctcagc
     3541 agacctgttg ccacggtgac tgaagccccc agctctgtct gtagaaactt cagatgggtg
     3601 ggggagcagg ttggagaggg gaccaaaggc aggcctgtcg tgctgaagct cttggggacc
     3661 gtttcctcgg catttcccca actccttctc cacccccctg ccaggcccgg aagtaccacc
     3721 agcttcctaa gggatgcagg aaggggccgg gtgaactgag gtgaagtcca gggcagggga
     3781 gtcagacccc tcaacatcct gtttaggggt cctcctccac aaagggtgcc ctccacctct
     3841 ccctcctgct ggttggccgg ctcagagatg aagggggaga gatggtggct ccaaggctct
     3901 gccaccgcca cctcccaagc ctgccaacgt gaatggcttg cagaatcagt cagcaggcca
     3961 gcggccttgg gaaagagcca ctgtcctcgc agcctgggcc agctggggga acaatgtagg
     4021 gtttgttgct taggggtccc aggcttgcgg gggggttggc acatggtggg cagtggactt
     4081 gagctgggat ggtctgaggg ggcactgaca cgctcacccg agggcagact tcagaccagc
     4141 cctcagatcc tgatgccagg ttacagggct gaggggagcc tgaaatccac tgggtctccc
     4201 tgctccactt gggagtcacc ttctcatcac ctatcctgga actgaatgca attacttaaa
     4261 ctcagtctca gcttcctcat ctgtaaaatg ggaataatct gtccttcaca gaggattatg
     4321 gtcatttaat gagacaagat acataaagca ctttgcatgg tgccccgaac cttttattcc
     4381 ttcctctcct ttgggaattc aattctctag tgttaggagc aggcttggcc cagggattct
     4441 taaatgcatc caggttttgg catcaaaggg ccccaaacat gacaatttac ctatactcat
     4501 ggtctgttcc cattcaactt taataggtta tgtgtgtttt ttttttctta agagctgggt
     4561 gggggggtct cactatgttg cccaggctgg ctttgaactc ctgggctcaa gcagtcctcc
     4621 tgtctcagcc tcctgagtag ctgggactac aagtgtgtac caccatgcct ggctgaacac
     4681 tttttttttt ttgagacaag atcccactca gtcactcaag ctgagtgctg tggtgtgatc
     4741 acagctcatt gcagcctcca cttcctgggc tcaagcgatt ctcctgcctc agcttcctga
     4801 gtagctggga ctacaggtgc gcactaccac gcctgtctaa tttttgatta tttgtagaga
     4861 tagggtctca ctattttgcc caggctggtc tcaaactccc agactcaagt cattctccta
     4921 cctcgggctc ccaaagtact gggattacag gcatgagcac ctggcccctg aacaaattct
     4981 ttaagtcata ttagcacctg ctgcacgccg gcactgtgga aggaggatgc ttgcttgctt
     5041 cctggtaacc agctctctta tctcaaacct caatcctcag tgaggatcac aggatctgag
     5101 aaaggcacct tggcctggaa acagccccag atgagtgaga ttgctggtcc tctcccggga
     5161 tcccaggccc aggaaaacct agccatgctt gcagtcagga gagggcaggg gatagagccc
     5221 tggctcccat tcaacctcct tagccaggag gacatgtccc attttgctta ggagttggga
     5281 ggtaccctag aatcacttag cttcagatgc caaattccat ccacattctt tcctccaact
     5341 ctctggcagt ggggaactgc ctctccaggc agggaactgc tctgacaggt ctgatgactg
     5401 cctccaggag gaagccctgg gcaccaatga aggtgagggg ctggagggcc caggacgggg
     5461 agtcaaggtc cccactccca ggactaaggg acagtttggc tcctttttcc tgcagtggga
     5521 ggggtgagaa gggctggggt gttctgcaag ggcctgctcc attttccagg gtgaaggaga
     5581 ggccgaggga ggtggagcgg gaggaggtgg ggcttactgt gaaactgggt caagatggcc
     5641 tcggatttga gcaggcaggg tcaccaggct ctgaggcagc agctgtgagc agtgccgagg
     5701 gaggaccagc tctgacggtg aggtcgggtg ggggactaga atccagcaga ggagcgaggg
     5761 cagggctcct accaggaaac ccatagcatt gacactaact gagaggcagc aaaggcggtg
     5821 acactccccc aggctctgtg ggcccagccc tacccctgaa gcacagttaa ctggttctgg
     5881 ggtaggaact gggggccgga gggacagggt tctggttctg gctcaacctt ggctgctggt
     5941 gagatccagg gcctgggaaa gaggggctga ggcctgaact gggcctaagg agagtgcagc
     6001 tcagttcgca cacaacagca cccagccctg tccccttgct gcctctaccc agccctgggc
     6061 agttccctca acagagctct gcagccccaa gtggcagctg ctggctcaaa gctgggacta
     6121 catgaaagtc tgaaaagaga atgagaagga ggtggcgcaa gagcctggac gcacgtgtgg
     6181 gaggccgttt tgtgcagcgc cattgtgctc cccgggcggg catgtgctcg cgctccgtgg
     6241 ctctgttggt gcccagcgtg cgggggtgtg ctggtggccc tgtgggcctg tagggcaacc
     6301 catgccaact gcggaaaagt aaccagcacc atacaccccc cccaacacaa aactggtcat
     6361 ttattttttt tgttgtcatt gttattagga agcaaaaaaa tgtacagtta caagaatcat
     6421 tttccaaaca gaggttaaat atgagctgaa aagtgtaaaa aaggaagagg aacatcactt
     6481 tacaaatcat taaattaaac aaataaacaa acagaaccca aagaaccaa
//
