LOCUS       NM_005302               5298 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens G protein-coupled receptor 37 (GPR37), mRNA.
ACCESSION   NM_005302
VERSION     NM_005302.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5298)
  AUTHORS   Zhou,J., Xu,W., Wu,Y., Wang,M., Zhang,N., Wang,L., Feng,Y.,
            Zhang,T., Wang,L. and Mao,A.
  TITLE     GPR37 promotes colorectal cancer liver metastases by enhancing the
            glycolysis and histone lactylation via Hippo pathway
  JOURNAL   Oncogene 42 (45), 3319-3330 (2023)
   PUBMED   37749229
  REMARK    GeneRIF: GPR37 promotes colorectal cancer liver metastases by
            enhancing the glycolysis and histone lactylation via Hippo pathway.
REFERENCE   2  (bases 1 to 5298)
  AUTHORS   Liu,H., Zhu,Y., Niu,H., Jie,J., Hua,S., Bai,X., Wang,S. and Song,L.
  TITLE     Activation of PI3K/Akt pathway by G protein-coupled receptor 37
            promotes resistance to cisplatin-induced apoptosis in non-small
            cell lung cancer
  JOURNAL   Cancer Med 12 (19), 19777-19793 (2023)
   PUBMED   37732632
  REMARK    GeneRIF: Activation of PI3K/Akt pathway by G protein-coupled
            receptor 37 promotes resistance to cisplatin-induced apoptosis in
            non-small cell lung cancer.
REFERENCE   3  (bases 1 to 5298)
  AUTHORS   Xie,X., Cai,X., Zhou,F., Li,Y., Liu,Q., Cai,L., Zhu,W., Wei,J.,
            Jin,C., Liu,Z., Jiang,C., Zhao,H., Yang,L., Zhao,C. and Huang,X.
  TITLE     GPR37 promotes cancer growth by binding to CDK6 and represents a
            new theranostic target in lung adenocarcinoma
  JOURNAL   Pharmacol Res 183, 106389 (2022)
   PUBMED   35934193
  REMARK    GeneRIF: GPR37 promotes cancer growth by binding to CDK6 and
            represents a new theranostic target in lung adenocarcinoma.
            Erratum:[Pharmacol Res. 2024 Oct;208:107391. doi:
            10.1016/j.phrs.2024.107391.. PMID: 39242215]
REFERENCE   4  (bases 1 to 5298)
  AUTHORS   Morato,X., Garcia-Esparcia,P., Argerich,J., Llorens,F., Zerr,I.,
            Paslawski,W., Borras,E., Sabido,E., Petaja-Repo,U.E.,
            Fernandez-Duenas,V., Ferrer,I., Svenningsson,P. and Ciruela,F.
  TITLE     Ecto-GPR37: a potential biomarker for Parkinson's disease
  JOURNAL   Transl Neurodegener 10 (1), 8 (2021)
   PUBMED   33637132
  REMARK    GeneRIF: Ecto-GPR37: a potential biomarker for Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5298)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 5298)
  AUTHORS   Imai,Y., Soda,M., Hatakeyama,S., Akagi,T., Hashikawa,T.,
            Nakayama,K.I. and Takahashi,R.
  TITLE     CHIP is associated with Parkin, a gene responsible for familial
            Parkinson's disease, and enhances its ubiquitin ligase activity
  JOURNAL   Mol Cell 10 (1), 55-67 (2002)
   PUBMED   12150907
REFERENCE   7  (bases 1 to 5298)
  AUTHORS   Imai,Y., Soda,M., Inoue,H., Hattori,N., Mizuno,Y. and Takahashi,R.
  TITLE     An unfolded putative transmembrane polypeptide, which can lead to
            endoplasmic reticulum stress, is a substrate of Parkin
  JOURNAL   Cell 105 (7), 891-902 (2001)
   PUBMED   11439185
REFERENCE   8  (bases 1 to 5298)
  AUTHORS   Donohue,P.J., Shapira,H., Mantey,S.A., Hampton,L.L., Jensen,R.T.
            and Battey,J.F.
  TITLE     A human gene encodes a putative G protein-coupled receptor highly
            expressed in the central nervous system
  JOURNAL   Brain Res Mol Brain Res 54 (1), 152-160 (1998)
   PUBMED   9526070
REFERENCE   9  (bases 1 to 5298)
  AUTHORS   Marazziti,D., Golini,E., Gallo,A., Lombardi,M.S., Matteoni,R. and
            Tocchini-Valentini,G.P.
  TITLE     Cloning of GPR37, a gene located on chromosome 7 encoding a
            putative G-protein-coupled peptide receptor, from a human frontal
            brain EST library
  JOURNAL   Genomics 45 (1), 68-77 (1997)
   PUBMED   9339362
REFERENCE   10 (bases 1 to 5298)
  AUTHORS   Zeng,Z., Su,K., Kyaw,H. and Li,Y.
  TITLE     A novel endothelin receptor type-B-like gene enriched in the brain
  JOURNAL   Biochem Biophys Res Commun 233 (2), 559-567 (1997)
   PUBMED   9144577
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004925.1 and AF017262.1.
            
            On May 17, 2019 this sequence version replaced NM_005302.4.
            
            Summary: This gene is a member of the G protein-coupled receptor
            family. The encoded protein contains seven transmembrane domains
            and is found in cell and endoplasmic reticulum membranes. G
            protein-coupled receptors are involved in translating outside
            signals into G protein mediated intracellular effects. This gene
            product interacts with Parkin and is involved in juvenile Parkinson
            disease. [provided by RefSeq, Oct 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.136430.1,
                                           SRR1803611.188468.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303921.3/ ENSP00000306449.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-799               AC004925.1         84020-84818
            800-1665            AF017262.1         1-866
            1666-1666           AC004925.1         85685-85685
            1667-2663           AF017262.1         868-1864
            2664-5298           AC004925.1         103293-105927
FEATURES             Location/Qualifiers
     source          1..5298
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.33"
     gene            1..5298
                     /gene="GPR37"
                     /gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
                     /note="G protein-coupled receptor 37"
                     /db_xref="GeneID:2861"
                     /db_xref="HGNC:HGNC:4494"
                     /db_xref="MIM:602583"
     exon            1..1839
                     /gene="GPR37"
                     /gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
                     /inference="alignment:Splign:2.1.0"
     CDS             817..2658
                     /gene="GPR37"
                     /gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
                     /note="Parkin-associated endothelin receptor-like
                     receptor; G protein-coupled receptor 37 (endothelin
                     receptor type B-like); probable G-protein coupled receptor
                     37; ETBR-LP-1; endothelin B receptor-like protein 1;
                     prosaposin receptor GPR37"
                     /codon_start=1
                     /product="prosaposin receptor GPR37 precursor"
                     /protein_id="NP_005293.1"
                     /db_xref="CCDS:CCDS5792.1"
                     /db_xref="GeneID:2861"
                     /db_xref="HGNC:HGNC:4494"
                     /db_xref="MIM:602583"
                     /translation="MRAPGALLARMSRLLLLLLLKVSASSALGVAPASRNETCLGESC
                     APTVIQRRGRDAWGPGNSARDVLRARAPREEQGAAFLAGPSWDLPAAPGRDPAAGRGA
                     EASAAGPPGPPTRPPGPWRWKGARGQEPSETLGRGNPTALQLFLQISEEEEKGPRGAG
                     ISGRSQEQSVKTVPGASDLFYWPRRAGKLQGSHHKPLSKTANGLAGHEGWTIALPGRA
                     LAQNGSLGEGIHEPGGPRRGNSTNRRVRLKNPFYPLTQESYGAYAVMCLSVVIFGTGI
                     IGNLAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLEDFSC
                     KIVPYIEVASLGVTTFTLCALCIDRFRAATNVQMYYEMIENCSSTTAKLAVIWVGALL
                     LALPEVVLRQLSKEDLGFSGRAPAERCIIKISPDLPDTIYVLALTYDSARLWWYFGCY
                     FCLPTLFTITCSLVTARKIRKAEKACTRGNKRQIQLESQMNCTVVALTILYGFCIIPE
                     NICNIVTAYMATGVSQQTMDLLNIISQFLLFFKSCVTPVLLFCLCKPFSRAFMECCCC
                     CCEECIQKSSTVTSDDNDNEYTTELELSPFSTIRREMSTFASVGTHC"
     exon            1840..5298
                     /gene="GPR37"
                     /gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2756
                     /gene="GPR37"
                     /gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
                     /note="major polyA site"
     regulatory      3105..3110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR37"
                     /gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
                     /note="hexamer: ATTACA"
     polyA_site      3123
                     /gene="GPR37"
                     /gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
                     /note="major polyA site"
     regulatory      3156..3161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR37"
                     /gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
                     /note="hexamer: AATAAA"
     polyA_site      3183
                     /gene="GPR37"
                     /gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
     regulatory      3608..3613
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR37"
                     /gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
                     /note="hexamer: AATAAA"
     polyA_site      3627
                     /gene="GPR37"
                     /gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
     regulatory      3737..3742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR37"
                     /gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
                     /note="hexamer: AATAAA"
     polyA_site      3767
                     /gene="GPR37"
                     /gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
     regulatory      4072..4077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR37"
                     /gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
                     /note="hexamer: ATTAAA"
     polyA_site      4102
                     /gene="GPR37"
                     /gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
     regulatory      5154..5159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR37"
                     /gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
                     /note="hexamer: TATAAA"
     polyA_site      5174
                     /gene="GPR37"
                     /gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
ORIGIN      
        1 agtgactagc tcccgcggct agcggcactg tccaccgacg agcggcgccc tcttctcccc
       61 cttctcccca cgatttcctt ctctgcggcg gcacgccgtc cagcagcctg cttcgccccg
      121 tcgtcaactt tgagctggag gagaagcaac tttggcagtg gccgcggggt tggaatcccg
      181 cttctcctcg gcagcagtag gctcgcaagt cgctggggtt aggtggggca agagtttcgc
      241 cggcgcatca gcgctgcttc ggactgtttg caacgtgttt ccagcgagct gggagcgggg
      301 ttgtgactgc gagtcgtctg ggggaggggg acttgttttt cttttcctct agagacctcg
      361 gcttgcaact ggatcaaacg ctgtcgaaag gatgtaaata ggcagagcaa ctgttaccaa
      421 gaaggccacc acccccaccc aaaggcagtg aggagtgtgg ggcttcgtct gggctccccc
      481 gagtctcaac agtaatcaac agtcaggtgt tgattgcaac ttttcaaggt cagccaccgg
      541 gagtagccta ttccctctag gaaccttgga gggcatacct tgctgggact caacttggct
      601 gagaaatgca caagatgcca aaggaggaag gattataggg ggcgtgtgtg tgacccccaa
      661 gaccgatctt ccgctatcac cctaatctcc ggttccccgc tacccgggcg ggggtgagta
      721 tgtgacatgt gcctaactct cagcagcaac ttcggcagca ggtgtcgatc ctaactaagc
      781 aggagctgcg gctgccgggt gtgccctcac caagccatgc gagccccggg cgcgcttctc
      841 gcccgcatgt cgcggctact gcttctgcta ctgctcaagg tgtctgcctc ttctgccctc
      901 ggggtcgccc ctgcgtccag aaacgaaact tgtctggggg agagctgtgc acctacagtg
      961 atccagcgcc gcggcaggga cgcctgggga ccgggaaatt ctgcaagaga cgttctgcga
     1021 gcccgagcac ccagggagga gcagggggca gcgtttcttg cgggaccctc ctgggacctg
     1081 ccggcggccc cgggccgtga cccggctgca ggcagagggg cggaggcgtc ggcagccgga
     1141 cccccgggac ctccaaccag gccacctggc ccctggaggt ggaaaggtgc tcggggtcag
     1201 gagccttctg aaactttggg gagagggaac cccacggccc tccagctctt ccttcagatc
     1261 tcagaggagg aagagaaggg tcccagaggc gctggcattt ccgggcgtag ccaggagcag
     1321 agtgtgaaga cagtccccgg agccagcgat cttttttact ggccaaggag agccgggaaa
     1381 ctccagggtt cccaccacaa gcccctgtcc aagacggcca atggactggc ggggcacgaa
     1441 gggtggacaa ttgcactccc gggccgggcg ctggcccaga atggatcctt gggtgaagga
     1501 atccatgagc ctgggggtcc ccgccgggga aacagcacga accggcgtgt gagactgaag
     1561 aaccccttct acccgctgac ccaggagtcc tatggagcct acgcggtcat gtgtctgtcc
     1621 gtggtgatct tcgggaccgg catcattggc aacctggcgg tgatgtgcat cgtgtgccac
     1681 aactactaca tgcggagcat ctccaactcc ctcttggcca acctggcctt ctgggacttt
     1741 ctcatcatct tcttctgcct tccgctggtc atcttccacg agctgaccaa gaagtggctg
     1801 ctggaggact tctcctgcaa gatcgtgccc tatatagagg tcgcttctct gggagtcacc
     1861 actttcacct tatgtgctct gtgcatagac cgcttccgtg ctgccaccaa cgtacagatg
     1921 tactacgaaa tgatcgaaaa ctgttcctca acaactgcca aacttgctgt tatatgggtg
     1981 ggagctctat tgttagcact tccagaagtt gttctccgcc agctgagcaa ggaggatttg
     2041 gggtttagtg gccgagctcc ggcagaaagg tgcattatta agatctctcc tgatttacca
     2101 gacaccatct atgttctagc cctcacctac gacagtgcga gactgtggtg gtattttggc
     2161 tgttactttt gtttgcccac gcttttcacc atcacctgct ctctagtgac tgcgaggaaa
     2221 atccgcaaag cagagaaagc ctgtacccga gggaataaac ggcagattca actagagagt
     2281 cagatgaact gtacagtagt ggcactgacc attttatatg gattttgcat tattcctgaa
     2341 aatatctgca acattgttac tgcctacatg gctacagggg tttcacagca gacaatggac
     2401 ctccttaata tcatcagcca gttccttttg ttctttaagt cctgtgtcac cccagtcctc
     2461 cttttctgtc tctgcaaacc cttcagtcgg gccttcatgg agtgctgctg ctgttgctgt
     2521 gaggaatgca ttcagaagtc ttcaacggtg accagtgatg acaatgacaa cgagtacacc
     2581 acggaactcg aactctcgcc tttcagtacc atacgccgtg aaatgtccac ttttgcttct
     2641 gtcggaactc attgctgaag gacagtactt ggttgggtca gatttatttg tttgattttc
     2701 atatcccgtg aaagttttta attcatattt ttccttatag ggaaaaatgc aaaaaagaaa
     2761 caataaagaa agaaatatta actactgtag aactgatttt acaaattaat atttgtgctt
     2821 tgaaaaaaag tttctattta gttatttaag aagaatgaga aggccaatag ttttagatta
     2881 ttttatctgg tatggtgcta atattttatt tgaaaaaagt tactgcaact taacttaaaa
     2941 ttgctaacgt tttttcttct tttaaaaata caattattgt atattgatta tagcaatgtg
     3001 attttgtagg ttattttata tttgagttgt gattgaaagt atgttgtata tggtattgtg
     3061 agatgatttg tacttggaag cattcacaaa gtagcaccaa ataaattaca ctttattctt
     3121 taatgtcatt gtcaatctac ttttaaccaa tattcaataa atcttctaat tgccttaaag
     3181 atacaattac tggttctatg cacaatttaa aaccggcctt actgttttat aacgtatttt
     3241 cttttaaggc aggtaatcat tatgttataa agaagttttt ctaatagcag tattttatat
     3301 gcatgattca taaaactatg ttgtatgtta aaacaaagct gtatttttaa tattcaggta
     3361 tagatgtcaa attacttctg aatacttata aaatatgaat aaatagcaga gtaggaagaa
     3421 agtttctttt ttaaaaaatt cacctctgaa ctagcacata gagctacaga ttttcccttg
     3481 gggaattatg ggcagaatca agaattttaa aatgcagttg tcatctgatt tcctctgaac
     3541 actgaccttt gaagctttgt gaatcctacg taaagcactc tgagttctaa tttttctcct
     3601 tttgaaaaat aaacttgatg aaatctatac aacttaattt ctttaagtgc aatgaaagta
     3661 taggagtgga ataataaaat atttatatat ttttattaga acattctacc tttaacttga
     3721 tacttcataa actctgaata aaaaaaccta acctcctcca ttgggaatat ttgaatcccc
     3781 tcttttgcct cttctggagt ttaaaatgca gcagttgtgt aggatgcttg ctgtgtggga
     3841 cacatgtcta actcaggtgg cagagaccat gacctagtga cacagtgata tttaaaagct
     3901 accaaagaag atgtgtagtt ggatgtcttt gtcttcagaa aaatcttgtt atagagaacc
     3961 cagttttctt gctgggaaaa cgtagtttct gcttgttgat ttctgttcta ctcggcataa
     4021 gtaagtcagt attccttttt ccaaattata acatgatgtt atttaaaaat cattaaagag
     4081 attggtgcag gtgaaactta aatggcagtg cccaggctat ctcctttttc ccagtccaat
     4141 acttttcaaa ggggtttttc cctccattgt gtgtattctg tgggatctgc aggagaattc
     4201 aaacaaggtg cccttgtctt cttgtagatc cctgtaatag gtctttggaa aatttctcaa
     4261 gaggacacct gagctaggtt ttggctgctg agcagaacag caactgtgat tccatagtgt
     4321 ctctcctgat atttagtcac tttataaatc aaggaacaat tgagcatgtc atgtggaaaa
     4381 gattctatcc tattacctga gtaactaaag gtaaataggt cacagcctca gaccttacag
     4441 aatcaggcag ggatgacatg gatgggaagg aataaaataa atacatagac aactatgata
     4501 taagctgggg cttgttaggt gcctcaggaa gatgtgaagt tctgcgatac tttggaatag
     4561 agggaatgct tatagggtta gaagagagca tgaaaggctt tatgagataa ctggatgagt
     4621 gggcttttag aaggagctga tgaaagatgg tgtgaggagt ggacacttca ggaggagaga
     4681 gctaatttat aaaggaatag aagaagaaat cagtgggtgt gattgaagaa taaacagccc
     4741 agtttgactt ctgtgctacg tgtgcatagc agccttgtgg gaaatattaa agaaaatatg
     4801 caccaaggcc atctaataat aggaccatgt tttgaaagat gtttacatgg tggtgcttca
     4861 ggaaatgggg ctttgctttt aaggtttttg agtatggaga aatagtatcc cagctctgca
     4921 ataggaagat caacttgcaa acagtttaaa taggctggta ggggacagtc tgatcatgaa
     4981 aaagcaacta ggaagctatt ataagagatt gaaccacaat ggaggcagca ggaacttaaa
     5041 tttctttttt catttatact tgcctttcaa ctttttgtag ttgcaacatg tactttctta
     5101 ttgaatccta cctctgtcaa agtggaaact ttgataactc aaattgtccc aagtataaag
     5161 tgatttcaaa gttttctcat agtcgtcttg tgtttttcac aaaaaccaat ttctataata
     5221 tacttttaaa aaattgttaa tcatttctgt tcaacatttc ttcagtctgg atcttatcca
     5281 atgtcttacg ctcctcgt
//
