LOCUS       NM_005301               3300 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens G protein-coupled receptor 35 (GPR35), transcript
            variant 1, mRNA.
ACCESSION   NM_005301
VERSION     NM_005301.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3300)
  AUTHORS   Wu,Y., Zhang,P., Fan,H., Zhang,C., Yu,P., Liang,X. and Chen,Y.
  TITLE     GPR35 acts a dual role and therapeutic target in inflammation
  JOURNAL   Front Immunol 14, 1254446 (2023)
   PUBMED   38035084
  REMARK    GeneRIF: GPR35 acts a dual role and therapeutic target in
            inflammation.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3300)
  AUTHORS   Mackiewicz,T., Wlodarczyk,J., Zielinska,M., Wlodarczyk,M.,
            Durczynski,A., Hogendorf,P., Dziki,L. and Fichna,J.
  TITLE     Increased GPR35 expression in human colorectal and pancreatic
            cancer samples: A preliminary clinical validation of a new
            biomarker
  JOURNAL   Adv Clin Exp Med 32 (7), 783-789 (2023)
   PUBMED   36637186
  REMARK    GeneRIF: Increased GPR35 expression in human colorectal and
            pancreatic cancer samples: A preliminary clinical validation of a
            new biomarker.
REFERENCE   3  (bases 1 to 3300)
  AUTHORS   Im,D.S.
  TITLE     Recent advances in GPR35 pharmacology; 5-HIAA serotonin metabolite
            becomes a ligand
  JOURNAL   Arch Pharm Res 46 (6), 550-563 (2023)
   PUBMED   37227682
  REMARK    GeneRIF: Recent advances in GPR35 pharmacology; 5-HIAA serotonin
            metabolite becomes a ligand.
            Review article
REFERENCE   4  (bases 1 to 3300)
  AUTHORS   Li,Y., Liu,A., Liu,S., Yan,L., Yuan,Y. and Xu,Q.
  TITLE     Involvement of CXCL17 and GPR35 in Gastric Cancer Initiation and
            Progression
  JOURNAL   Int J Mol Sci 24 (1), 615 (2022)
   PUBMED   36614059
  REMARK    GeneRIF: Involvement of CXCL17 and GPR35 in Gastric Cancer
            Initiation and Progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3300)
  AUTHORS   Wyant,G.A., Yu,W., Doulamis,I.P., Nomoto,R.S., Saeed,M.Y.,
            Duignan,T., McCully,J.D. and Kaelin,W.G. Jr.
  TITLE     Mitochondrial remodeling and ischemic protection by G
            protein-coupled receptor 35 agonists
  JOURNAL   Science 377 (6606), 621-629 (2022)
   PUBMED   35926043
  REMARK    GeneRIF: Mitochondrial remodeling and ischemic protection by G
            protein-coupled receptor 35 agonists.
REFERENCE   6  (bases 1 to 3300)
  AUTHORS   Wang,J., Simonavicius,N., Wu,X., Swaminath,G., Reagan,J., Tian,H.
            and Ling,L.
  TITLE     Kynurenic acid as a ligand for orphan G protein-coupled receptor
            GPR35
  JOURNAL   J Biol Chem 281 (31), 22021-22028 (2006)
   PUBMED   16754668
REFERENCE   7  (bases 1 to 3300)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 3300)
  AUTHORS   Okumura,S., Baba,H., Kumada,T., Nanmoku,K., Nakajima,H., Nakane,Y.,
            Hioki,K. and Ikenaka,K.
  TITLE     Cloning of a G-protein-coupled receptor that shows an activity to
            transform NIH3T3 cells and is expressed in gastric cancer cells
  JOURNAL   Cancer Sci 95 (2), 131-135 (2004)
   PUBMED   14965362
REFERENCE   9  (bases 1 to 3300)
  AUTHORS   O'Dowd,B.F., Nguyen,T., Marchese,A., Cheng,R., Lynch,K.R.,
            Heng,H.H., Kolakowski,L.F. Jr. and George,S.R.
  TITLE     Discovery of three novel G-protein-coupled receptor genes
  JOURNAL   Genomics 47 (2), 310-313 (1998)
   PUBMED   9479505
REFERENCE   10 (bases 1 to 3300)
  AUTHORS   Fauci,A.S., Balow,J.E. and Pratt,K.R.
  TITLE     Human bone marrow lymphocytes. Cytotoxic effector cells in the bone
            marrow of normal individuals
  JOURNAL   J Clin Invest 57 (4), 826-835 (1976)
   PUBMED   947955
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124862.4.
            
            On May 3, 2021 this sequence version replaced NM_005301.4.
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the shorter isoform (a, also known as
            GPR35a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314002.1, SRR14038196.2733261.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407714.2/ ENSP00000384263.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AC124862.4         9839-9927           c
            90-3300             AC124862.4         2248-5458           c
FEATURES             Location/Qualifiers
     source          1..3300
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..3300
                     /gene="GPR35"
                     /note="G protein-coupled receptor 35"
                     /db_xref="GeneID:2859"
                     /db_xref="HGNC:HGNC:4492"
                     /db_xref="MIM:602646"
     exon            1..89
                     /gene="GPR35"
                     /inference="alignment:Splign:2.1.0"
     exon            90..3300
                     /gene="GPR35"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1023
                     /gene="GPR35"
                     /note="isoform a is encoded by transcript variant 1; KYNA
                     receptor; kynurenic acid receptor"
                     /codon_start=1
                     /product="G-protein coupled receptor 35 isoform a"
                     /protein_id="NP_005292.2"
                     /db_xref="CCDS:CCDS2541.1"
                     /db_xref="GeneID:2859"
                     /db_xref="HGNC:HGNC:4492"
                     /db_xref="MIM:602646"
                     /translation="MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWV
                     FCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYM
                     SISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGG
                     FCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARM
                     VWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICY
                     YYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA"
     regulatory      1371..1376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR35"
                     /note="hexamer: AATAAA"
     polyA_site      1394
                     /gene="GPR35"
                     /note="major polyA site"
     regulatory      3276..3281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR35"
                     /note="hexamer: ATTAAA"
     polyA_site      3300
                     /gene="GPR35"
                     /note="major polyA site"
ORIGIN      
        1 acttccccca gcccttctca gacagccact gtgcaggctt tggcagcggg ggtcacacac
       61 tccacccggg aggccaaagc tgcctgcagg accatgaatg gcacctacaa cacctgtggc
      121 tccagcgacc tcacctggcc cccagcgatc aagctgggct tctacgccta cttgggcgtc
      181 ctgctggtgc taggcctgct gctcaacagc ctggcgctct gggtgttctg ctgccgcatg
      241 cagcagtgga cggagacccg catctacatg accaacctgg cggtggccga cctctgcctg
      301 ctgtgcacct tgcccttcgt gctgcactcc ctgcgagaca cctcagacac gccgctgtgc
      361 cagctctccc agggcatcta cctgaccaac aggtacatga gcatcagcct ggtcacggcc
      421 atcgccgtgg accgctatgt ggccgtgcgg cacccgctgc gtgcccgcgg gctgcggtcc
      481 cccaggcagg ctgcggccgt gtgcgcggtc ctctgggtgc tggtcatcgg ctccctggtg
      541 gctcgctggc tcctggggat tcaggagggc ggcttctgct tcaggagcac ccggcacaat
      601 ttcaactcca tggcgttccc gctgctggga ttctacctgc ccctggccgt ggtggtcttc
      661 tgctccctga aggtggtgac tgccctggcc cagaggccac ccaccgacgt ggggcaggca
      721 gaggccaccc gcaaggctgc ccgcatggtc tgggccaacc tcctggtgtt cgtggtctgc
      781 ttcctgcccc tgcacgtggg gctgacagtg cgcctcgcag tgggctggaa cgcctgtgcc
      841 ctcctggaga cgatccgtcg cgccctgtac ataaccagca agctctcaga tgccaactgc
      901 tgcctggacg ccatctgcta ctactacatg gccaaggagt tccaggaggc gtctgcactg
      961 gccgtggctc ccagtgctaa ggcccacaaa agccaggact ctctgtgcgt gaccctcgcc
     1021 taagaggcgt gctgtgggcg ctgtgggcca ggtctcgggg gctccgggag gtgctgcctg
     1081 ccaggggaag ctggaaccag tagcaaggag cccgagatca gccctgaact cactgtgtat
     1141 tctcttggag ccttgggtgg gcagggacgg cccaggtacc tgctctcttg ggaagagaga
     1201 gggacaggga caagggcaag aggactgagg ccagagcaag gccaatgtca gagacccccg
     1261 ggatggggcc tcacacttgc cacccccaga accagctcac ctggccagag tgggttcctg
     1321 ctggccaggg tgcagccttg atgacacctg ccgctgcccc tcggggctgg aataaaactc
     1381 cccacccaga gtcagtccta gtggggccct ctgtgtttcg cactcgtgtg gtgggaggca
     1441 gggagggagc gcgtggctca gagggctggc ggacatcttc cagggaccct tcggggctct
     1501 tcactttgag gtcccccttg gaccctttca ccccttccca cccccaccca cctggagcgt
     1561 gagcaggggc tgttggaagc tcctggcagg accacagtag aggcccccag cccaggtttc
     1621 cttgctcaag acagggctgg gagcagctga tctccatgta ggggctgcac agcggtgcaa
     1681 gggggggtga ccaaggtcaa gcaggtgagg gtgggttggg gtgggtggca gtgaaggggg
     1741 tggccagggt ctgtcaagga acccagccct cttctccttc cttcagggaa aggctggaaa
     1801 ccatgtctgg caggggcagg ggttgggtgc ccactcaggt aaaggcacga tgtcctgctg
     1861 gtttctgcct ctcctgtact cctgcatgga gggcatctcg aaacccaagc tggaaggaca
     1921 gggcactcca gagacctcct gtgagtgtgg gccagcacgg cctgggctca aaccccatcc
     1981 tgtcatccca tattgcatgt ccacaggcac cgccccaccc tgttccatgt tccacaggac
     2041 tggagagaga tggcagtcat gttctggcag ggacatggca caagcatgcg gctgatggca
     2101 tctcacagga cccaggctcc ggagggccca tgcccaggag agccccataa gggctctgtg
     2161 cctaaaaggg tgcatgccca ggtgggccca tgcccaggaa ggtccatgcc caggatggtc
     2221 catgagcagg agggcctcat tcccaggagg gtcccgtgcc caggagggct ctatgcccaa
     2281 aagggtccca tgtccgggag ggtccatacg caagggtgtc catgcctggt tggggggggt
     2341 ctatgtccag gagggtccca tgcctggaag ggtccatgct caggagggtt catgcccagg
     2401 agagtttatg ccctggaggg ccccatgccc gggagagtca cgtgcacaga gggccctgtg
     2461 ctcaggagga tacatgtcca ggagtgtccc tgtccaggag gctccatgcc caggaggctc
     2521 catgtcaaga aagattcatg cctaggaggg ttcatgccca ggagtgtccc tgcctaggaa
     2581 gatccattac cagaagggcc catgtcaagg agcgttcatg cccaggaagg tccagcccag
     2641 gagggtccat gtcaaggagg ttccatgccc aggagggtcc atgctgaggt gggtccatgc
     2701 ccaggagggt tcatgtccag aaaggtccat gcctaggagg gcccatacac aacagagccc
     2761 tgtgcccagg aaggaccatg tcaaggagaa ccccatgccc atgagggtcc atgcccagta
     2821 agggccatgc ccatgagatc ctcatgccca ggaaggccca tgcccaggag ggtccatgcc
     2881 caggccagtt catgcacagg agggccccat gcctaaaagt gtccatgccc aggaaggtcc
     2941 atgtccagaa gagtccatac ccaggagggc tgatatggtt aggctttgtg tctccaccca
     3001 aatctcatct tgaattgtaa tccctataat aaccatagtc cccatgtgtc aagggagaga
     3061 ccaggtggag gcaattggat catgggggct gtttcccaca tgctgttctc atgatagtga
     3121 gtgagttctc atgagatctg atggttttat aaggggctct tcccttcact tctccttcct
     3181 actgtcttat gaagaaggtt ccttgcttcc ccttcacctt ctgccatgat tgtaagtttc
     3241 ctgaggcctc cctagccatg ctgaagtgtg agtcaattaa acctctttcc tttaaaatta
//
