LOCUS       NM_001195381            4150 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens G protein-coupled receptor 35 (GPR35), transcript
            variant 2, mRNA.
ACCESSION   NM_001195381
VERSION     NM_001195381.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4150)
  AUTHORS   Wu,Y., Zhang,P., Fan,H., Zhang,C., Yu,P., Liang,X. and Chen,Y.
  TITLE     GPR35 acts a dual role and therapeutic target in inflammation
  JOURNAL   Front Immunol 14, 1254446 (2023)
   PUBMED   38035084
  REMARK    GeneRIF: GPR35 acts a dual role and therapeutic target in
            inflammation.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4150)
  AUTHORS   Mackiewicz,T., Wlodarczyk,J., Zielinska,M., Wlodarczyk,M.,
            Durczynski,A., Hogendorf,P., Dziki,L. and Fichna,J.
  TITLE     Increased GPR35 expression in human colorectal and pancreatic
            cancer samples: A preliminary clinical validation of a new
            biomarker
  JOURNAL   Adv Clin Exp Med 32 (7), 783-789 (2023)
   PUBMED   36637186
  REMARK    GeneRIF: Increased GPR35 expression in human colorectal and
            pancreatic cancer samples: A preliminary clinical validation of a
            new biomarker.
REFERENCE   3  (bases 1 to 4150)
  AUTHORS   Im,D.S.
  TITLE     Recent advances in GPR35 pharmacology; 5-HIAA serotonin metabolite
            becomes a ligand
  JOURNAL   Arch Pharm Res 46 (6), 550-563 (2023)
   PUBMED   37227682
  REMARK    GeneRIF: Recent advances in GPR35 pharmacology; 5-HIAA serotonin
            metabolite becomes a ligand.
            Review article
REFERENCE   4  (bases 1 to 4150)
  AUTHORS   Li,Y., Liu,A., Liu,S., Yan,L., Yuan,Y. and Xu,Q.
  TITLE     Involvement of CXCL17 and GPR35 in Gastric Cancer Initiation and
            Progression
  JOURNAL   Int J Mol Sci 24 (1), 615 (2022)
   PUBMED   36614059
  REMARK    GeneRIF: Involvement of CXCL17 and GPR35 in Gastric Cancer
            Initiation and Progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4150)
  AUTHORS   Wyant,G.A., Yu,W., Doulamis,I.P., Nomoto,R.S., Saeed,M.Y.,
            Duignan,T., McCully,J.D. and Kaelin,W.G. Jr.
  TITLE     Mitochondrial remodeling and ischemic protection by G
            protein-coupled receptor 35 agonists
  JOURNAL   Science 377 (6606), 621-629 (2022)
   PUBMED   35926043
  REMARK    GeneRIF: Mitochondrial remodeling and ischemic protection by G
            protein-coupled receptor 35 agonists.
REFERENCE   6  (bases 1 to 4150)
  AUTHORS   Wang,J., Simonavicius,N., Wu,X., Swaminath,G., Reagan,J., Tian,H.
            and Ling,L.
  TITLE     Kynurenic acid as a ligand for orphan G protein-coupled receptor
            GPR35
  JOURNAL   J Biol Chem 281 (31), 22021-22028 (2006)
   PUBMED   16754668
REFERENCE   7  (bases 1 to 4150)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 4150)
  AUTHORS   Okumura,S., Baba,H., Kumada,T., Nanmoku,K., Nakajima,H., Nakane,Y.,
            Hioki,K. and Ikenaka,K.
  TITLE     Cloning of a G-protein-coupled receptor that shows an activity to
            transform NIH3T3 cells and is expressed in gastric cancer cells
  JOURNAL   Cancer Sci 95 (2), 131-135 (2004)
   PUBMED   14965362
REFERENCE   9  (bases 1 to 4150)
  AUTHORS   O'Dowd,B.F., Nguyen,T., Marchese,A., Cheng,R., Lynch,K.R.,
            Heng,H.H., Kolakowski,L.F. Jr. and George,S.R.
  TITLE     Discovery of three novel G-protein-coupled receptor genes
  JOURNAL   Genomics 47 (2), 310-313 (1998)
   PUBMED   9479505
REFERENCE   10 (bases 1 to 4150)
  AUTHORS   Fauci,A.S., Balow,J.E. and Pratt,K.R.
  TITLE     Human bone marrow lymphocytes. Cytotoxic effector cells in the bone
            marrow of normal individuals
  JOURNAL   J Clin Invest 57 (4), 826-835 (1976)
   PUBMED   947955
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124862.4.
            
            On May 3, 2021 this sequence version replaced NM_001195381.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and 5'
            coding region, and uses an alternate start codon, compared to
            variant 1. The resulting isoform (b, also known as GPR35b) is
            longer at the N-terminus, compared to isoform a. Variants 2-4 all
            encode the same isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853560.17595.1,
                                           SRR14038194.657781.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AC124862.4         29837-29977         c
            142-367             AC124862.4         28795-29020         c
            368-491             AC124862.4         18896-19019         c
            492-795             AC124862.4         18014-18317         c
            796-939             AC124862.4         16376-16519         c
            940-4150            AC124862.4         2248-5458           c
FEATURES             Location/Qualifiers
     source          1..4150
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..4150
                     /gene="GPR35"
                     /note="G protein-coupled receptor 35"
                     /db_xref="GeneID:2859"
                     /db_xref="HGNC:HGNC:4492"
                     /db_xref="MIM:602646"
     exon            1..141
                     /gene="GPR35"
                     /inference="alignment:Splign:2.1.0"
     exon            142..367
                     /gene="GPR35"
                     /inference="alignment:Splign:2.1.0"
     exon            368..491
                     /gene="GPR35"
                     /inference="alignment:Splign:2.1.0"
     exon            492..795
                     /gene="GPR35"
                     /inference="alignment:Splign:2.1.0"
     exon            796..939
                     /gene="GPR35"
                     /inference="alignment:Splign:2.1.0"
     CDS             851..1873
                     /gene="GPR35"
                     /note="isoform b is encoded by transcript variant 2; KYNA
                     receptor; kynurenic acid receptor"
                     /codon_start=1
                     /product="G-protein coupled receptor 35 isoform b"
                     /protein_id="NP_001182310.1"
                     /db_xref="CCDS:CCDS56174.1"
                     /db_xref="GeneID:2859"
                     /db_xref="HGNC:HGNC:4492"
                     /db_xref="MIM:602646"
                     /translation="MLSGSRAVPTPHRGSEELLKYMLHSPCVSLTMNGTYNTCGSSDL
                     TWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLC
                     TLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRS
                     PRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVV
                     VFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGW
                     NACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDS
                     LCVTLA"
     exon            940..4150
                     /gene="GPR35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2221..2226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR35"
                     /note="hexamer: AATAAA"
     polyA_site      2244
                     /gene="GPR35"
                     /note="major polyA site"
     regulatory      4126..4131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR35"
                     /note="hexamer: ATTAAA"
     polyA_site      4150
                     /gene="GPR35"
                     /note="major polyA site"
ORIGIN      
        1 cctttagtca cttccagctc caggcacagc agttggtgac tccttggtgg gagccgtgtc
       61 ccacccggtc ctgatactgc cgtcttctct ttcacagtcc tccaggcttg ggccagcctt
      121 gggggcagca gagcttctgg gctgacatgg gctcattgct ccttctccaa gccctctgag
      181 gacatcaaaa gcgtggacgc atcactttcc accatcttgc tgcccactgt ccctccatcc
      241 tgaggcctcc taagcacatg tgtggggtgg caggcacact gctgatagct gtggatgcgg
      301 ccgtgacatc cttcacccct gcccccatgg catgcatgat ccattaggga ggaccgtctg
      361 cacaaaggtc tcttgccctg tgcagcttcc tgcagactgg acttgcaaag tccagcctgt
      421 atggctggag ttcccatgcc tgccaatctc ctgtcgactg cgagtcagct ccgatacttc
      481 accagattca gccacctggg ggagctggaa gtgaatctcc tcgtagctga gccttctgat
      541 gagactgcag ccccggctga cacctggatt gcagactcat gaaagacctg aaactctacc
      601 aacagccacc tgggggagct ggaagtgaat ctcctcgtag ctgagccttc tgatgagact
      661 gcagccccgg ctgacacctg gattgcagac tcatgaaaga ccctgagcag aggacccagt
      721 ttggcagagc ccgaattcct gacccacagg aactgggaga taaaactctg tggttttaat
      781 cttctcattt tagagtgctc agtgtcctgt ggtgtgaaca cgcttcattc aacctgggcc
      841 cttgggagag atgctgagtg gttcccgggc tgtccccact ccacaccgtg gcagtgaaga
      901 gctgctgaag tacatgcttc atagtccttg cgtctctctg accatgaatg gcacctacaa
      961 cacctgtggc tccagcgacc tcacctggcc cccagcgatc aagctgggct tctacgccta
     1021 cttgggcgtc ctgctggtgc taggcctgct gctcaacagc ctggcgctct gggtgttctg
     1081 ctgccgcatg cagcagtgga cggagacccg catctacatg accaacctgg cggtggccga
     1141 cctctgcctg ctgtgcacct tgcccttcgt gctgcactcc ctgcgagaca cctcagacac
     1201 gccgctgtgc cagctctccc agggcatcta cctgaccaac aggtacatga gcatcagcct
     1261 ggtcacggcc atcgccgtgg accgctatgt ggccgtgcgg cacccgctgc gtgcccgcgg
     1321 gctgcggtcc cccaggcagg ctgcggccgt gtgcgcggtc ctctgggtgc tggtcatcgg
     1381 ctccctggtg gctcgctggc tcctggggat tcaggagggc ggcttctgct tcaggagcac
     1441 ccggcacaat ttcaactcca tggcgttccc gctgctggga ttctacctgc ccctggccgt
     1501 ggtggtcttc tgctccctga aggtggtgac tgccctggcc cagaggccac ccaccgacgt
     1561 ggggcaggca gaggccaccc gcaaggctgc ccgcatggtc tgggccaacc tcctggtgtt
     1621 cgtggtctgc ttcctgcccc tgcacgtggg gctgacagtg cgcctcgcag tgggctggaa
     1681 cgcctgtgcc ctcctggaga cgatccgtcg cgccctgtac ataaccagca agctctcaga
     1741 tgccaactgc tgcctggacg ccatctgcta ctactacatg gccaaggagt tccaggaggc
     1801 gtctgcactg gccgtggctc ccagtgctaa ggcccacaaa agccaggact ctctgtgcgt
     1861 gaccctcgcc taagaggcgt gctgtgggcg ctgtgggcca ggtctcgggg gctccgggag
     1921 gtgctgcctg ccaggggaag ctggaaccag tagcaaggag cccgagatca gccctgaact
     1981 cactgtgtat tctcttggag ccttgggtgg gcagggacgg cccaggtacc tgctctcttg
     2041 ggaagagaga gggacaggga caagggcaag aggactgagg ccagagcaag gccaatgtca
     2101 gagacccccg ggatggggcc tcacacttgc cacccccaga accagctcac ctggccagag
     2161 tgggttcctg ctggccaggg tgcagccttg atgacacctg ccgctgcccc tcggggctgg
     2221 aataaaactc cccacccaga gtcagtccta gtggggccct ctgtgtttcg cactcgtgtg
     2281 gtgggaggca gggagggagc gcgtggctca gagggctggc ggacatcttc cagggaccct
     2341 tcggggctct tcactttgag gtcccccttg gaccctttca ccccttccca cccccaccca
     2401 cctggagcgt gagcaggggc tgttggaagc tcctggcagg accacagtag aggcccccag
     2461 cccaggtttc cttgctcaag acagggctgg gagcagctga tctccatgta ggggctgcac
     2521 agcggtgcaa gggggggtga ccaaggtcaa gcaggtgagg gtgggttggg gtgggtggca
     2581 gtgaaggggg tggccagggt ctgtcaagga acccagccct cttctccttc cttcagggaa
     2641 aggctggaaa ccatgtctgg caggggcagg ggttgggtgc ccactcaggt aaaggcacga
     2701 tgtcctgctg gtttctgcct ctcctgtact cctgcatgga gggcatctcg aaacccaagc
     2761 tggaaggaca gggcactcca gagacctcct gtgagtgtgg gccagcacgg cctgggctca
     2821 aaccccatcc tgtcatccca tattgcatgt ccacaggcac cgccccaccc tgttccatgt
     2881 tccacaggac tggagagaga tggcagtcat gttctggcag ggacatggca caagcatgcg
     2941 gctgatggca tctcacagga cccaggctcc ggagggccca tgcccaggag agccccataa
     3001 gggctctgtg cctaaaaggg tgcatgccca ggtgggccca tgcccaggaa ggtccatgcc
     3061 caggatggtc catgagcagg agggcctcat tcccaggagg gtcccgtgcc caggagggct
     3121 ctatgcccaa aagggtccca tgtccgggag ggtccatacg caagggtgtc catgcctggt
     3181 tggggggggt ctatgtccag gagggtccca tgcctggaag ggtccatgct caggagggtt
     3241 catgcccagg agagtttatg ccctggaggg ccccatgccc gggagagtca cgtgcacaga
     3301 gggccctgtg ctcaggagga tacatgtcca ggagtgtccc tgtccaggag gctccatgcc
     3361 caggaggctc catgtcaaga aagattcatg cctaggaggg ttcatgccca ggagtgtccc
     3421 tgcctaggaa gatccattac cagaagggcc catgtcaagg agcgttcatg cccaggaagg
     3481 tccagcccag gagggtccat gtcaaggagg ttccatgccc aggagggtcc atgctgaggt
     3541 gggtccatgc ccaggagggt tcatgtccag aaaggtccat gcctaggagg gcccatacac
     3601 aacagagccc tgtgcccagg aaggaccatg tcaaggagaa ccccatgccc atgagggtcc
     3661 atgcccagta agggccatgc ccatgagatc ctcatgccca ggaaggccca tgcccaggag
     3721 ggtccatgcc caggccagtt catgcacagg agggccccat gcctaaaagt gtccatgccc
     3781 aggaaggtcc atgtccagaa gagtccatac ccaggagggc tgatatggtt aggctttgtg
     3841 tctccaccca aatctcatct tgaattgtaa tccctataat aaccatagtc cccatgtgtc
     3901 aagggagaga ccaggtggag gcaattggat catgggggct gtttcccaca tgctgttctc
     3961 atgatagtga gtgagttctc atgagatctg atggttttat aaggggctct tcccttcact
     4021 tctccttcct actgtcttat gaagaaggtt ccttgcttcc ccttcacctt ctgccatgat
     4081 tgtaagtttc ctgaggcctc cctagccatg ctgaagtgtg agtcaattaa acctctttcc
     4141 tttaaaatta
//
