LOCUS       NM_001097579            1926 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens G protein-coupled receptor 34 (GPR34), transcript
            variant 4, mRNA.
ACCESSION   NM_001097579
VERSION     NM_001097579.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1926)
  AUTHORS   Yan,J., Zhang,C., Xu,Y., Huang,Z., Ye,Q., Qian,X., Zhu,L.,
            Huang,G., Wang,X., Jiang,W. and Zhou,R.
  TITLE     GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor
            immunity
  JOURNAL   Nat Immunol 25 (11), 2057-2067 (2024)
   PUBMED   39358444
  REMARK    GeneRIF: GPR34 is a metabolic immune checkpoint for ILC1-mediated
            antitumor immunity.
            Erratum:[Nat Immunol. 2024 Nov;25(11):2167. doi:
            10.1038/s41590-024-02001-w.. PMID: 39375551]
REFERENCE   2  (bases 1 to 1926)
  AUTHORS   Izume,T., Kawahara,R., Uwamizu,A., Chen,L., Yaginuma,S., Omi,J.,
            Kawana,H., Hou,F., Sano,F.K., Tanaka,T., Kobayashi,K.,
            Okamoto,H.H., Kise,Y., Ohwada,T., Aoki,J., Shihoya,W. and Nureki,O.
  TITLE     Structural basis for lysophosphatidylserine recognition by GPR34
  JOURNAL   Nat Commun 15 (1), 902 (2024)
   PUBMED   38326347
  REMARK    GeneRIF: Structural basis for lysophosphatidylserine recognition by
            GPR34.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1926)
  AUTHORS   Liu,G., Li,X., Wang,Y., Zhang,X. and Gong,W.
  TITLE     Structural basis for ligand recognition and signaling of the
            lysophosphatidylserine receptors GPR34 and GPR174
  JOURNAL   PLoS Biol 21 (12), e3002387 (2023)
   PUBMED   38048360
  REMARK    GeneRIF: Structural basis for ligand recognition and signaling of
            the lysophosphatidylserine receptors GPR34 and GPR174.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1926)
  AUTHORS   Xia,A., Yong,X., Zhang,C., Lin,G., Jia,G., Zhao,C., Wang,X.,
            Hao,Y., Wang,Y., Zhou,P., Yang,X., Deng,Y., Wu,C., Chen,Y., Zhu,J.,
            Tang,X., Liu,J., Zhang,S., Zhang,J., Xu,Z., Hu,Q., Zhao,J., Yue,Y.,
            Yan,W., Su,Z., Wei,Y., Zhou,R., Dong,H., Shao,Z. and Yang,S.
  TITLE     Cryo-EM structures of human GPR34 enable the identification of
            selective antagonists
  JOURNAL   Proc Natl Acad Sci U S A 120 (39), e2308435120 (2023)
   PUBMED   37733739
  REMARK    GeneRIF: Cryo-EM structures of human GPR34 enable the
            identification of selective antagonists.
REFERENCE   5  (bases 1 to 1926)
  AUTHORS   Cheng,Y., Heng,X. and Feng,F.
  TITLE     G-protein Coupled Receptor 34 Promotes Gliomagenesis by Inducing
            Proliferation and Malignant Phenotype via TGF-Beta/Smad Signaling
            Pathway
  JOURNAL   Technol Cancer Res Treat 21, 15330338221105733 (2022)
   PUBMED   35770303
  REMARK    GeneRIF: G-protein Coupled Receptor 34 Promotes Gliomagenesis by
            Inducing Proliferation and Malignant Phenotype via TGF-Beta/Smad
            Signaling Pathway.
REFERENCE   6  (bases 1 to 1926)
  AUTHORS   Engemaier,E., Rompler,H., Schoneberg,T. and Schulz,A.
  TITLE     Genomic and supragenomic structure of the nucleotide-like
            G-protein-coupled receptor GPR34
  JOURNAL   Genomics 87 (2), 254-264 (2006)
   PUBMED   16338117
  REMARK    GeneRIF: data show that multiple translation initiation starts and
            alternative splicing contribute to the supragenomic diversification
            of GPR34
REFERENCE   7  (bases 1 to 1926)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 1926)
  AUTHORS   Jacobi,F.K., Broghammer,M., Pesch,K., Zrenner,E., Berger,W.,
            Meindl,A. and Pusch,C.M.
  TITLE     Physical mapping and exclusion of GPR34 as the causative gene for
            congenital stationary night blindness type 1
  JOURNAL   Hum Genet 107 (1), 89-91 (2000)
   PUBMED   10982042
REFERENCE   9  (bases 1 to 1926)
  AUTHORS   Schoneberg,T., Schulz,A., Grosse,R., Schade,R., Henklein,P.,
            Schultz,G. and Gudermann,T.
  TITLE     A novel subgroup of class I G-protein-coupled receptors
  JOURNAL   Biochim Biophys Acta 1446 (1-2), 57-70 (1999)
   PUBMED   10395919
REFERENCE   10 (bases 1 to 1926)
  AUTHORS   Marchese,A., Sawzdargo,M., Nguyen,T., Cheng,R., Heng,H.H.,
            Nowak,T., Im,D.S., Lynch,K.R., George,S.R. and O'dowd,B.F.
  TITLE     Discovery of three novel orphan G-protein-coupled receptors
  JOURNAL   Genomics 56 (1), 12-21 (1999)
   PUBMED   10036181
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK027780.1, AL627402.10, N40174.1 and BM798913.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001097579.1.
            
            Summary: G protein-coupled receptors (GPCRs), such as GPR34, are
            integral membrane proteins containing 7 putative transmembrane
            domains (TMs). These proteins mediate signals to the interior of
            the cell via activation of heterotrimeric G proteins that in turn
            activate various effector proteins, ultimately resulting in a
            physiologic response.[supplied by OMIM, Apr 2006].
            
            Transcript Variant: This variant (4) represents the longer
            transcript. Both variants 1 and 4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027780.1, SRR1660809.232105.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378142.9/ ENSP00000367384.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AK027780.1         1-211
            212-212             AL627402.10        90778-90778
            213-1592            AK027780.1         213-1592
            1593-1917           N40174.1           1-325               c
            1918-1926           BM798913.1         161-169
FEATURES             Location/Qualifiers
     source          1..1926
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.4"
     gene            1..1926
                     /gene="GPR34"
                     /gene_synonym="LPS1; LYPSR1"
                     /note="G protein-coupled receptor 34"
                     /db_xref="GeneID:2857"
                     /db_xref="HGNC:HGNC:4490"
                     /db_xref="MIM:300241"
     exon            1..112
                     /gene="GPR34"
                     /gene_synonym="LPS1; LYPSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            113..205
                     /gene="GPR34"
                     /gene_synonym="LPS1; LYPSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            206..1926
                     /gene="GPR34"
                     /gene_synonym="LPS1; LYPSR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..1430
                     /gene="GPR34"
                     /gene_synonym="LPS1; LYPSR1"
                     /note="lysophosphatidylserine receptor 1"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 34"
                     /protein_id="NP_001091048.1"
                     /db_xref="CCDS:CCDS14258.1"
                     /db_xref="GeneID:2857"
                     /db_xref="HGNC:HGNC:4490"
                     /db_xref="MIM:300241"
                     /translation="MRSHTITMTTTSVSSWPYSSHRMRFITNHSDQPPQNFSATPNVT
                     TCPMDEKLLSTVLTTSYSVIFIVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAIADLL
                     LIFCLPFRIMYHINQNKWTLGVILCKVVGTLFYMNMYISIILLGFISLDRYIKINRSI
                     QQRKAITTKQSIYVCCIVWMLALGGFLTMIILTLKKGGHNSTMCFHYRDKHNAKGEAI
                     FNFILVVMFWLIFLLIILSYIKIGKNLLRISKRRSKFPNSGKYATTARNSFIVLIIFT
                     ICFVPYHAFRFIYISSQLNVSSCYWKEIVHKTNEIMLVLSSFNSCLDPVMYFLMSSNI
                     RKIMCQLLFRRFQGEPSRSESTSEFKPGYSLHDTSVAVKIQSSSKST"
     regulatory      1903..1908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR34"
                     /gene_synonym="LPS1; LYPSR1"
                     /note="hexamer: AATAAA"
     polyA_site      1926
                     /gene="GPR34"
                     /gene_synonym="LPS1; LYPSR1"
                     /note="major polyA site"
ORIGIN      
        1 aaccaattgc accacgaccg gatggaagag cccagctgac acaaccaaga cgagtctcag
       61 tgtctaggga agcttggggt tctgctcctt ttacttcagg cgaacctgaa ctcagttaat
      121 gcaattttga agcatgccct gaatagattc agtcattatc aagtcaaact aaaaacggtg
      181 aaaggttgcg actattacca aataggaaaa atctgaagac ataagaacta cacatgagga
      241 atatgtcatt tagcactttc actttttgat ctccacagaa gacaatgaga agtcatacca
      301 taacaatgac gacaacttca gtcagcagct ggccttactc ctcccacaga atgcgcttta
      361 taaccaatca tagcgaccaa ccgccacaaa acttctcagc aacaccaaat gttactacct
      421 gtcccatgga tgaaaaattg ctatctactg tgttaaccac atcctactct gttattttca
      481 tcgtgggact ggttgggaac ataatcgccc tctatgtatt tctgggtatt caccgtaaaa
      541 gaaattccat tcaaatttat ctacttaacg tagccattgc agacctccta ctcatcttct
      601 gcctcccttt ccgaataatg tatcatatta accaaaacaa gtggacacta ggtgtgattc
      661 tgtgcaaggt tgtgggaaca ctgttttata tgaacatgta cattagcatt attttgcttg
      721 gattcatcag tttggatcgc tatataaaaa ttaatcggtc tatacagcaa cggaaggcaa
      781 taacaaccaa acaaagtatt tatgtctgtt gtatagtatg gatgcttgct cttggtggat
      841 tcctaactat gattatttta acacttaaga aaggagggca taattccaca atgtgtttcc
      901 attacagaga taagcataac gcaaaaggag aagccatttt taacttcatt cttgtggtaa
      961 tgttctggct aattttctta ctaataatcc tttcatatat taagattggg aagaatctat
     1021 tgaggatttc taaaaggagg tcaaaatttc ctaattctgg taaatatgcc actacagctc
     1081 gtaactcctt tattgtactt atcattttta ctatatgttt tgttccctat catgcctttc
     1141 gattcatcta catttcttca cagctaaatg tatcatcttg ctactggaaa gaaattgttc
     1201 acaaaaccaa tgagatcatg ctggttctct catctttcaa tagttgctta gatccagtca
     1261 tgtatttcct gatgtccagt aacattcgca aaataatgtg ccaacttctt tttagacgat
     1321 ttcaaggtga accaagtagg agtgaaagca cttcagaatt taaaccagga tactccctgc
     1381 atgatacatc tgtggcagtg aaaatacagt ctagttctaa aagtacttga ggtaaacata
     1441 ctaaaatgaa ttatataatg cagcctctta attctttgaa gaactaaaaa attaggaaac
     1501 aaagttctag catttacaaa actcagatct caaagctctg cttgtatttg tgatatttca
     1561 tttgcttaac tgtaaaccat ttcaaggtac taacttttaa atctgtatgt aaaatctttt
     1621 caaaatacat ttttaagcta atactcttaa catagattat gaagttaagt gaaatttatg
     1681 gctctaacag caaaataatt aaagtgccat agtttctcaa gtgactaaag tagttattaa
     1741 aatcaagcac ttgatactaa tttgaagtgt gtttaaaagt aaatgatttg ggaactgaca
     1801 atgtgtcaga aaatatatgt tcatttatca ttttaaaatc ttgtataatt tgccactgta
     1861 ttcatttatg cctaaatctc tataacagat gaaaagataa ttaataaaat cctaattaaa
     1921 aaatga
//
