LOCUS       NM_001197184            1240 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens G protein-coupled receptor 33 (GPR33), transcript
            variant 1, coding, mRNA.
ACCESSION   NM_001197184
VERSION     NM_001197184.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1240)
  AUTHORS   Bohnekamp,J., Boselt,I., Saalbach,A., Tonjes,A., Kovacs,P.,
            Biebermann,H., Manvelyan,H.M., Polte,T., Gasperikova,D.,
            Lkhagvasuren,S., Baier,L., Stumvoll,M., Rompler,H. and
            Schoneberg,T.
  TITLE     Involvement of the chemokine-like receptor GPR33 in innate immunity
  JOURNAL   Biochem Biophys Res Commun 396 (2), 272-277 (2010)
   PUBMED   20399748
  REMARK    GeneRIF: These data indicate an important role of GPR33 function in
            innate immunity which became dispensable during human evolution
            most likely due to past or balancing selection.
REFERENCE   2  (bases 1 to 1240)
  AUTHORS   Rompler,H., Schulz,A., Pitra,C., Coop,G., Przeworski,M., Paabo,S.
            and Schoneberg,T.
  TITLE     The rise and fall of the chemoattractant receptor GPR33
  JOURNAL   J Biol Chem 280 (35), 31068-31075 (2005)
   PUBMED   15987686
  REMARK    GeneRIF: Cloning and analysis of more than 120 mammalian GPR33
            orthologs from 16 of 18 eutherian orders revealed an inactivation
            of this chemoattractant GPCR not only in humans, but also in
            several great ape and rodent species.
REFERENCE   3  (bases 1 to 1240)
  AUTHORS   Marchese,A., Nguyen,T., Malik,P., Xu,S., Cheng,R., Xie,Z.,
            Heng,H.H., George,S.R., Kolakowski,L.F. Jr. and O'Dowd,B.F.
  TITLE     Cloning genes encoding receptors related to chemoattractant
            receptors
  JOURNAL   Genomics 50 (2), 281-286 (1998)
   PUBMED   9653656
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL163973.1, GQ981322.1 and KF459682.2.
            
            On May 17, 2019 this sequence version replaced NM_001197184.2.
            
            Summary: This gene has been identified as an orphan chemoattractant
            G-protein-coupled receptors (GPCR) pseudogene. Studies have shown
            that the inactivated gene is present as the predominant allele in
            the human population. A small fraction of the human population has
            been found to harbor an intact allele.[provided by RefSeq, Oct
            2010].
            
            Transcript Variant: This variant (1, coding) represents the protein
            coding transcript, encoding Arg (CGA, aa 140) at the polymorphic
            site instead of the premature translation termination codon (TGA).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ981322.1, GQ981321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399285.5/ ENSP00000421557.1
            polymorphic pseudogene :: PMID: 15987686
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AL163973.1         37565-37658         c
            95-287              GQ981322.1         1-193
            288-393             AL163973.1         33341-33446         c
            394-558             KF459682.2         26-190              c
            559-1151            GQ981322.1         465-1057
            1152-1240           AL163973.1         32494-32582         c
FEATURES             Location/Qualifiers
     source          1..1240
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..1240
                     /gene="GPR33"
                     /note="G protein-coupled receptor 33"
                     /db_xref="GeneID:2856"
                     /db_xref="HGNC:HGNC:4489"
                     /db_xref="MIM:610118"
     exon            1..143
                     /gene="GPR33"
                     /inference="alignment:Splign:2.1.0"
     exon            144..1240
                     /gene="GPR33"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1151
                     /gene="GPR33"
                     /note="G protein-coupled receptor 33 pseudogene"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 33"
                     /protein_id="NP_001184113.2"
                     /db_xref="CCDS:CCDS73628.1"
                     /db_xref="GeneID:2856"
                     /db_xref="HGNC:HGNC:4489"
                     /db_xref="MIM:610118"
                     /translation="MDLINSTDYLINASTLVRNSTQFLAPASKMIIALSLYISSIIGT
                     ITNGLYLWVLRFKMKQTVNTLLFFHLILSYFISTMILPFMATSQLQDNHWNFGTALCK
                     VFNGTLSLGMFTSVFFLSAIGLDRYLLTLHPVWSQQHRTPRWASSIVLGVWISAAALS
                     IPYLIFRETHHDRKGKVTCQNNYAVSTNWESKEMQASRQWIHVACFISRFLLGFLLPF
                     FIIIFCYERVASKVKERSLFKSSKPFKVMMTAIISFFVCWMPYHIHQGLLLTTNQSLL
                     LELTLILTVLTTSFNTIFSPTLYLFVGENFKKVFKKSILALFESTFSEDSSVERTQT"
ORIGIN      
        1 agtagcatca gcaagaagaa agacatatga aatgaaggca aagtgtcact gattttgttc
       61 actctgttcc tagtgagaaa ttgatggtgt agagtcactt tggcctgctc aagaccaatc
      121 tggcatgaag atacaggtct gaggtcatta tggatctgat caactctact gattacctga
      181 tcaatgcctc tactttagta agaaacagca ctcagtttct agctcctgca tcaaaaatga
      241 ttattgccct ttctttgtac atttcatcta taattggtac catcaccaat ggcctctatc
      301 tatgggtgct aagattcaag atgaaacaga ctgtcaatac tctcttattt tttcatctca
      361 ttctctctta ttttatttca acaatgattc tgccatttat ggccacctcc caacttcaag
      421 acaatcactg gaactttgga actgccttgt gcaaggtctt caatggcact ttgtctctgg
      481 ggatgttcac ctctgttttc ttcctttcgg ccatcggtct tgatcgttac cttctcactc
      541 ttcacccagt gtggtcccag cagcaccgaa ccccgcgctg ggcttccagc attgtcctgg
      601 gagtctggat ttcagccgct gccctcagca tcccctattt gattttcaga gagacacatc
      661 atgaccgtaa aggaaaggtg acttgccaaa ataactatgc tgtgtctact aactgggaaa
      721 gcaaggagat gcaagcatca aggcagtgga ttcatgtggc ctgtttcatc agccgcttct
      781 tgctgggctt tcttctgcct ttcttcatca tcatcttttg ttatgaaaga gtagccagca
      841 aggtgaaaga gaggagcctg tttaaatcca gcaagccctt caaagttatg atgactgcca
      901 ttatctcttt ctttgtgtgt tggatgccct accatataca ccagggctta cttctcacta
      961 cgaaccagtc actactttta gagttgactt tgatacttac agtgctaacc acttctttca
     1021 atactatctt ttctcccaca ctctacttat ttgttgggga gaatttcaaa aaggtcttca
     1081 agaagtccat tcttgctctg tttgagtcaa catttagtga agattcttct gtagaaagga
     1141 cacaaaccta aactcagaag cctaaattta aattctagat tcttaagcaa acacgcactt
     1201 ggtcaattat accaatagga tataccttct gcttttgtat
//
