LOCUS       NM_001506               1269 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens G protein-coupled receptor 32 (GPR32), mRNA.
ACCESSION   NM_001506
VERSION     NM_001506.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1269)
  AUTHORS   Arnardottir,H., Thul,S., Pawelzik,S.C., Karadimou,G., Artiach,G.,
            Gallina,A.L., Mysdotter,V., Carracedo,M., Tarnawski,L.,
            Caravaca,A.S., Baumgartner,R., Ketelhuth,D.F., Olofsson,P.S.,
            Paulsson-Berne,G., Hansson,G.K. and Back,M.
  TITLE     The resolvin D1 receptor GPR32 transduces inflammation resolution
            and atheroprotection
  JOURNAL   J Clin Invest 131 (24) (2021)
   PUBMED   34699386
  REMARK    GeneRIF: The resolvin D1 receptor GPR32 transduces inflammation
            resolution and atheroprotection.
REFERENCE   2  (bases 1 to 1269)
  AUTHORS   Dos Santos,H.T., Nam,K., Hunt,J.P., Buchmann,L.O., Monroe,M.M. and
            Baker,O.J.
  TITLE     SPM Receptor Expression and Localization in Irradiated Salivary
            Glands
  JOURNAL   J Histochem Cytochem 69 (8), 523-534 (2021)
   PUBMED   34339312
  REMARK    GeneRIF: SPM Receptor Expression and Localization in Irradiated
            Salivary Glands.
REFERENCE   3  (bases 1 to 1269)
  AUTHORS   Zheng,S., Wang,Q., D'Souza,V., Bartis,D., Dancer,R., Parekh,D.,
            Gao,F., Lian,Q., Jin,S. and Thickett,D.R.
  TITLE     ResolvinD1 stimulates epithelial wound repair and inhibits
            TGF-beta-induced EMT whilst reducing fibroproliferation and
            collagen production
  JOURNAL   Lab Invest 98 (1), 130-140 (2018)
   PUBMED   29083412
  REMARK    GeneRIF: Data suggest that resolvin D1/RVDR1 signaling (1) promotes
            epithelial wound repair, (2) inhibits TGFB-induced
            epithelial-mesenchymal transition in type II alveolar cells, (3)
            inhibits fibroproliferation and apoptosis, (4) reduces effects of
            TGFB on primary lung fibroblast collagen production, and (5)
            inhibits myofibroblast differentiation. (TGFB = transforming growth
            factor beta)
REFERENCE   4  (bases 1 to 1269)
  AUTHORS   Taylan,A., Gurler,O., Toprak,B., Sisman,A.R., Yalcin,H., Colak,A.
            and Sari,I.
  TITLE     S1000A12, Chitotriosidase, and Resolvin D1 as Potential Biomarkers
            of Familial Mediterranean Fever
  JOURNAL   J Korean Med Sci 30 (9), 1241-1245 (2015)
   PUBMED   26339162
  REMARK    GeneRIF: Our findings indicate that chitotriosidase and S10012A are
            useful in diagnosis and detection of subclinical inflammation
            and/or assessment of disease activity in FMF patients.
REFERENCE   5  (bases 1 to 1269)
  AUTHORS   Zhao,X.W., Bao,J.J., Hu,C., Ding,H., Liu,X.C., Mei,Q. and Xu,J.M.
  TITLE     Effect of diclofenac on the levels of lipoxin A4 and Resolvin D1
            and E1 in the post-ERCP pancreatitis
  JOURNAL   Dig Dis Sci 59 (12), 2992-2996 (2014)
   PUBMED   25030943
  REMARK    GeneRIF: The effects of diclofenac on the incidence of pancreatitis
            following endoscopic retrograde cholangiopancreatography via
            lipoxin A4 and resolvin D1 and E1 levels is reported.
REFERENCE   6  (bases 1 to 1269)
  AUTHORS   Hsiao,H.M., Thatcher,T.H., Levy,E.P., Fulton,R.A., Owens,K.M.,
            Phipps,R.P. and Sime,P.J.
  TITLE     Resolvin D1 attenuates polyinosinic-polycytidylic acid-induced
            inflammatory signaling in human airway epithelial cells via TAK1
  JOURNAL   J Immunol 193 (10), 4980-4987 (2014)
   PUBMED   25320283
  REMARK    GeneRIF: Resolvin D1 attenuates the viral mimic-induced
            inflammatory signaling in human airway epithelial cells via TAK1.
REFERENCE   7  (bases 1 to 1269)
  AUTHORS   Lee,H.J., Park,M.K., Lee,E.J. and Lee,C.H.
  TITLE     Resolvin D1 inhibits TGF-beta1-induced epithelial mesenchymal
            transition of A549 lung cancer cells via lipoxin A4 receptor/formyl
            peptide receptor 2 and GPR32
  JOURNAL   Int J Biochem Cell Biol 45 (12), 2801-2807 (2013)
   PUBMED   24120851
  REMARK    GeneRIF: Results suggest that resolvin D1 inhibited
            TGF-beta1-induced EMT via ALX/FPR2 and GPR32 by reducing the
            expression of ZEB1.
REFERENCE   8  (bases 1 to 1269)
  AUTHORS   Im,D.S.
  TITLE     Omega-3 fatty acids in anti-inflammation (pro-resolution) and GPCRs
  JOURNAL   Prog Lipid Res 51 (3), 232-237 (2012)
   PUBMED   22542696
  REMARK    Review article
REFERENCE   9  (bases 1 to 1269)
  AUTHORS   Krishnamoorthy,S., Recchiuti,A., Chiang,N., Yacoubian,S., Lee,C.H.,
            Yang,R., Petasis,N.A. and Serhan,C.N.
  TITLE     Resolvin D1 binds human phagocytes with evidence for proresolving
            receptors
  JOURNAL   Proc Natl Acad Sci U S A 107 (4), 1660-1665 (2010)
   PUBMED   20080636
  REMARK    GeneRIF: results indicate that RvD1 specifically interacts with
            both ALX and GPR32 on phagocytes.
REFERENCE   10 (bases 1 to 1269)
  AUTHORS   Marchese,A., Nguyen,T., Malik,P., Xu,S., Cheng,R., Xie,Z.,
            Heng,H.H., George,S.R., Kolakowski,L.F. Jr. and O'Dowd,B.F.
  TITLE     Cloning genes encoding receptors related to chemoattractant
            receptors
  JOURNAL   Genomics 50 (2), 281-286 (1998)
   PUBMED   9653656
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC095544.1 and AC010325.7.
            
            On Dec 1, 2012 this sequence version replaced NM_001506.1.
            
            Summary: This gene is intronless and encodes a member of the
            G-protein coupled receptor 1 family. The encoded protein binds to
            resolvin D1 and lipoxin A4 and has been linked to pulmonary
            inflammation. A related pseudogene has been identified on
            chromosome 19. [provided by RefSeq, Nov 2012].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC095544.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270590.4/ ENSP00000270590.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               BC095544.1         2-136
            136-150             AC010325.7         103264-103278
            151-1269            BC095544.1         152-1270
FEATURES             Location/Qualifiers
     source          1..1269
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1269
                     /gene="GPR32"
                     /gene_synonym="DRV1; RVDR1"
                     /note="G protein-coupled receptor 32"
                     /db_xref="GeneID:2854"
                     /db_xref="HGNC:HGNC:4487"
                     /db_xref="MIM:603195"
     exon            1..1269
                     /gene="GPR32"
                     /gene_synonym="DRV1; RVDR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1208
                     /gene="GPR32"
                     /gene_synonym="DRV1; RVDR1"
                     /note="resolvin D1 receptor"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 32"
                     /protein_id="NP_001497.1"
                     /db_xref="CCDS:CCDS12801.1"
                     /db_xref="GeneID:2854"
                     /db_xref="HGNC:HGNC:4487"
                     /db_xref="MIM:603195"
                     /translation="MNGVSEGTRGCSDRQPGVLTRDRSCSRKMNSSGCLSEEVGSLRP
                     LTVVILSASIVVGVLGNGLVLWMTVFRMARTVSTVCFFHLALADFMLSLSLPIAMYYI
                     VSRQWLLGEWACKLYITFVFLSYFASNCLLVFISVDRCISVLYPVWALNHRTVQRASW
                     LAFGVWLLAAALCSAHLKFRTTRKWNGCTHCYLAFNSDNETAQIWIEGVVEGHIIGTI
                     GHFLLGFLGPLAIIGTCAHLIRAKLLREGWVHANRPKRLLLVLVSAFFIFWSPFNVVL
                     LVHLWRRVMLKEIYHPRMLLILQASFALGCVNSSLNPFLYVFVGRDFQEKFFQSLTSA
                     LARAFGEEEFLSSCPRGNAPRE"
ORIGIN      
        1 tcttgagcct aggaggtgga ggctgcagtg atctgtgatt gtacctttgc actccagcct
       61 gggtgacaga gcatgacgct gtctctaaaa gaataataat aataagcatt ccataaaaat
      121 tatggaatgg agaaatcatg aatggggtct cggaggggac cagaggctgc agtgacaggc
      181 aacctggggt cctgacacgt gatcgctctt gttccaggaa gatgaactct tccggatgcc
      241 tgtctgagga ggtggggtcc ctccgcccac tgactgtggt tatcctgtct gcgtccattg
      301 tcgtcggagt gctgggcaat gggctggtgc tgtggatgac tgtcttccgt atggcacgca
      361 cggtctccac cgtctgcttc ttccacctgg cccttgccga tttcatgctc tcactgtctc
      421 tgcccattgc catgtactat attgtctcca ggcagtggct cctcggagag tgggcctgca
      481 aactctacat cacctttgtg ttcctcagct actttgccag taactgcctc cttgtcttca
      541 tctctgtgga ccgttgcatc tctgtcctct accccgtctg ggccctgaac caccgcactg
      601 tgcagcgggc gagctggctg gcctttgggg tgtggctcct ggccgccgcc ttgtgctctg
      661 cgcacctgaa attccggaca accagaaaat ggaatggctg tacgcactgc tacttggcgt
      721 tcaactctga caatgagact gcccagattt ggattgaagg ggtcgtggag ggacacatta
      781 tagggaccat tggccacttc ctgctgggct tcctggggcc cttagcaatc ataggcacct
      841 gcgcccacct catccgggcc aagctcttgc gggagggctg ggtccatgcc aaccggccca
      901 agaggctgct gctggtgctg gtgagcgctt tctttatctt ctggtccccg tttaacgtgg
      961 tgctgttggt ccatctgtgg cgacgggtga tgctcaagga aatctaccac ccccggatgc
     1021 tgctcatcct ccaggctagc tttgccttgg gctgtgtcaa cagcagcctc aaccccttcc
     1081 tctacgtctt cgttggcaga gatttccaag aaaagttttt ccagtctttg acttctgccc
     1141 tggcgagggc gtttggagag gaggagtttc tgtcatcctg tccccgtggc aacgcccccc
     1201 gggaatgatg gaagacttca gctggaagct ggaagccgtc cttcttagtt tgcttgtggc
     1261 ctcttacct
//
