LOCUS       NM_005299               2734 bp    mRNA    linear   PRI 07-DEC-2024
DEFINITION  Homo sapiens G protein-coupled receptor 31 (GPR31), mRNA.
ACCESSION   NM_005299
VERSION     NM_005299.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2734)
  AUTHORS   Oguro-Igashira,E., Murakami,M., Mori,R., Kuwahara,R., Kihara,T.,
            Kohara,M., Fujiwara,M., Motooka,D., Okuzaki,D., Arase,M.,
            Toyota,H., Peng,S., Ogino,T., Kitabatake,Y., Morii,E., Hirota,S.,
            Ikeuchi,H., Umemoto,E., Kumanogoh,A. and Takeda,K.
  TITLE     The pyruvate-GPR31 axis promotes transepithelial dendrite formation
            in human intestinal dendritic cells
  JOURNAL   Proc Natl Acad Sci U S A 121 (44), e2318767121 (2024)
   PUBMED   39432783
  REMARK    GeneRIF: The pyruvate-GPR31 axis promotes transepithelial dendrite
            formation in human intestinal dendritic cells.
REFERENCE   2  (bases 1 to 2734)
  AUTHORS   Forch,A., Wallner,S., Zeman,F., Ettl,T., Brochhausen,C. and
            Schreml,S.
  TITLE     Expression of Proton-Sensitive GPR31, GPR151, TASK1 and TASK3 in
            Common Skin Tumors
  JOURNAL   Cells 11 (1), 27 (2021)
   PUBMED   35011589
  REMARK    GeneRIF: Expression of Proton-Sensitive GPR31, GPR151, TASK1 and
            TASK3 in Common Skin Tumors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2734)
  AUTHORS   Cartwright,I.M., Dowdell,A.S., Lanis,J.M., Brink,K.R., Mu,A.,
            Kostelecky,R.E., Schaefer,R.E.M., Welch,N., Onyiah,J.C.,
            Hall,C.H.T., Gerich,M.E., Tabor,J.J. and Colgan,S.P.
  TITLE     Mucosal acidosis elicits a unique molecular signature in epithelia
            and intestinal tissue mediated by GPR31-induced CREB
            phosphorylation
  JOURNAL   Proc Natl Acad Sci U S A 118 (20) (2021)
   PUBMED   33972436
  REMARK    GeneRIF: Mucosal acidosis elicits a unique molecular signature in
            epithelia and intestinal tissue mediated by GPR31-induced CREB
            phosphorylation.
REFERENCE   4  (bases 1 to 2734)
  AUTHORS   Mendioroz,M., Puebla-Guedea,M., Montero-Marin,J.,
            Urdanoz-Casado,A., Blanco-Luquin,I., Roldan,M., Labarga,A. and
            Garcia-Campayo,J.
  TITLE     Telomere length correlates with subtelomeric DNA methylation in
            long-term mindfulness practitioners
  JOURNAL   Sci Rep 10 (1), 4564 (2020)
   PUBMED   32165663
  REMARK    GeneRIF: Telomere length correlates with subtelomeric DNA
            methylation in long-term mindfulness practitioners.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2734)
  AUTHORS   Mashiko,M., Kurosawa,A., Tani,Y., Tsuji,T. and Takeda,S.
  TITLE     GPR31 and GPR151 are activated under acidic conditions
  JOURNAL   J Biochem 166 (4), 317-322 (2019)
   PUBMED   31119277
REFERENCE   6  (bases 1 to 2734)
  AUTHORS   Honn,K.V., Guo,Y., Cai,Y., Lee,M.J., Dyson,G., Zhang,W. and
            Tucker,S.C.
  TITLE     12-HETER1/GPR31, a high-affinity 12(S)-hydroxyeicosatetraenoic acid
            receptor, is significantly up-regulated in prostate cancer and
            plays a critical role in prostate cancer progression
  JOURNAL   FASEB J 30 (6), 2360-2369 (2016)
   PUBMED   26965684
  REMARK    GeneRIF: The data implicate 12-HETER1 in a critical new role in the
            regulation of prostate cancer progression and offer a novel
            alternative target for therapeutic intervention.
REFERENCE   7  (bases 1 to 2734)
  AUTHORS   Jones,R.M., Cadby,G., Melton,P.E., Abraham,L.J., Whitehouse,A.J.
            and Moses,E.K.
  TITLE     Genome-wide association study of autistic-like traits in a general
            population study of young adults
  JOURNAL   Front Hum Neurosci 7, 658 (2013)
   PUBMED   24133439
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2734)
  AUTHORS   Guo,Y., Zhang,W., Giroux,C., Cai,Y., Ekambaram,P., Dilly,A.K.,
            Hsu,A., Zhou,S., Maddipati,K.R., Liu,J., Joshi,S., Tucker,S.C.,
            Lee,M.J. and Honn,K.V.
  TITLE     Identification of the orphan G protein-coupled receptor GPR31 as a
            receptor for 12-(S)-hydroxyeicosatetraenoic acid
  JOURNAL   J Biol Chem 286 (39), 33832-33840 (2011)
   PUBMED   21712392
  REMARK    GeneRIF: 12-HETER represents the first identified high affinity
            receptor for the 12-(S)-HETE hydroxyl fatty acids.
REFERENCE   9  (bases 1 to 2734)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   10 (bases 1 to 2734)
  AUTHORS   Zingoni,A., Rocchi,M., Storlazzi,C.T., Bernardini,G., Santoni,A.
            and Napolitano,M.
  TITLE     Isolation and chromosomal localization of GPR31, a human gene
            encoding a putative G protein-coupled receptor
  JOURNAL   Genomics 42 (3), 519-523 (1997)
   PUBMED   9205127
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121935.17.
            
            On Nov 22, 2019 this sequence version replaced NM_005299.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC095537.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366834.2/ ENSP00000355799.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2734              AL121935.17        54348-57081         c
FEATURES             Location/Qualifiers
     source          1..2734
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q27"
     gene            1..2734
                     /gene="GPR31"
                     /gene_synonym="12-HETER; HETER; HETER1"
                     /note="G protein-coupled receptor 31"
                     /db_xref="GeneID:2853"
                     /db_xref="HGNC:HGNC:4486"
                     /db_xref="MIM:602043"
     exon            1..2734
                     /gene="GPR31"
                     /gene_synonym="12-HETER; HETER; HETER1"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1109
                     /gene="GPR31"
                     /gene_synonym="12-HETER; HETER; HETER1"
                     /note="probable G-protein coupled receptor 31; bA517H2.2
                     (G protein-coupled receptor 31);
                     12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE)
                     receptor; 12-(S)-HETE acid receptor;
                     hydroxyeicosatetraenoic (HETE) acid receptor 1;
                     12-(S)-HETE receptor; GPR31/12-HETER"
                     /codon_start=1
                     /product="12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid
                     receptor"
                     /protein_id="NP_005290.2"
                     /db_xref="CCDS:CCDS5299.1"
                     /db_xref="GeneID:2853"
                     /db_xref="HGNC:HGNC:4486"
                     /db_xref="MIM:602043"
                     /translation="MPFPNCSAPSTVVATAVGVLLGLECGLGLLGNAVALWTFLFRVR
                     VWKPYAVYLLNLALADLLLAACLPFLAAFYLSLQAWHLGRVGCWALHFLLDLSRSVGM
                     AFLAAVALDRYLRVVHPRLKVNLLSPQAALGVSGLVWLLMVALTCPGLLISEAAQNST
                     RCHSFYSRADGSFSIIWQEALSCLQFVLPFGLIVFCNAGIIRALQKRLREPEKQPKLQ
                     RAQALVTLVVVLFALCFLPCFLARVLMHIFQNLGSCRALCAVAHTSDVTGSLTYLHSV
                     LNPVVYCFSSPTFRSSYRRVFHTLRGKGQAAEPPDFNPRDSYS"
     regulatory      2119..2124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR31"
                     /gene_synonym="12-HETER; HETER; HETER1"
                     /note="hexamer: GATAAA"
     polyA_site      2139
                     /gene="GPR31"
                     /gene_synonym="12-HETER; HETER; HETER1"
                     /note="major polyA site"
     regulatory      2714..2719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR31"
                     /gene_synonym="12-HETER; HETER; HETER1"
                     /note="hexamer: AATAAA"
     polyA_site      2734
                     /gene="GPR31"
                     /gene_synonym="12-HETER; HETER; HETER1"
                     /note="major polyA site"
ORIGIN      
        1 attctgctga ggaactgttc ttgttgggca aatgtagatc ttgtctactc tgtggcagga
       61 aaaggccttt tctttcattt tgtaagaaag agcacagagt tcctcctgta cctgctccag
      121 ctgtgcctgc agcccctcac ggccgggtga tgccattccc aaactgctca gcccccagca
      181 ctgtggtggc cacagctgtg ggtgtcttgc tggggctgga gtgtgggctg ggtctgctgg
      241 gcaacgcggt ggcgctgtgg accttcctgt tccgggtcag ggtgtggaag ccgtacgctg
      301 tctacctgct caacctggcc ctggctgacc tgctgttggc tgcgtgcctg cctttcctgg
      361 ccgccttcta cctgagcctc caggcttggc atctgggccg tgtgggctgc tgggccctgc
      421 acttcctgct ggacctcagc cgcagcgtgg ggatggcctt cctggccgcc gtggctttgg
      481 accggtacct ccgtgtggtc caccctcggc ttaaggtcaa cctgctgtct cctcaggcgg
      541 ccctgggggt ctcgggcctc gtctggctcc tgatggtcgc cctcacctgc ccgggcttgc
      601 tcatctctga ggccgcccag aactccacca ggtgccacag tttctactcc agggcagacg
      661 gctccttcag catcatctgg caggaagcac tctcctgcct tcagtttgtc ctcccctttg
      721 gcctcatcgt gttctgcaat gcaggcatca tcagggctct ccagaaaaga ctccgggagc
      781 ctgagaaaca gcccaagctt cagcgggccc aggcactggt caccttggtg gtggtgctgt
      841 ttgctctgtg ctttctgccc tgcttcctgg ccagagtcct gatgcacatc ttccagaatc
      901 tggggagctg cagggccctt tgtgcagtgg ctcatacctc ggatgtcacg ggcagcctca
      961 cctacctgca cagtgtgctc aaccccgtgg tatactgctt ctccagcccc accttcagga
     1021 gctcctatcg gagggtcttc cacaccctcc gaggcaaagg gcaggcagca gagcccccag
     1081 atttcaaccc cagagactcc tattcctgac aacagccagc gtcctcaacg cccgtgttta
     1141 tggaactacc tgcgacctaa ataataatta ctcctacttt gggattctgg aagaagaaga
     1201 agtcttaaga ctgcaataca aggatcagag cataaacatg ggcacagttg ctgcaggtgt
     1261 ggtcttatac tttgttgacc agggtggtcc tctgtgattt taccttgtag agtggcaaat
     1321 caaaatgaac aagctagaac ctcctcctac ccaactatga tgcagattca gttgctgaac
     1381 tgaaaagtcg ggcagctact ccatctccac acttgaagaa atgtaatttg ctaaatcagt
     1441 gaaggaagag aagaaagccg ggtgatggca tctttccaac tcttacttgg tctcagcaag
     1501 tcattttcat ttattatgct tcagttttaa atacaaaaaa aaaactatgt tttcttccca
     1561 cctgctgtgc agactgggga tgaccgacat cagaaagtgc cctggttcta aaaagagact
     1621 ctgctgtata taaggtactg tcgtacatgc tagcctttat ttggaacata acatttttgt
     1681 tttcataaaa ttttgcttca tttttctaga ttatacatta tgttaaggaa aatgtagtga
     1741 gttccctagt ttactgtaag aaatgctttc ctgatacgtt tctggaattt gcctctagag
     1801 ctgtttttta agtttgaatg tctaaaaggc ttttgaaatg tactttgctt cccccgatgt
     1861 gaaaaaaagg tcacagaact ttatgcctcc tgcgagaagt gcacaatgta agctatcacg
     1921 tggtgtttga aatggtcatt tccaaccccg ctggcacagc tggtggacaa tggtgctcgg
     1981 gacatgccag ggctccatgg gccacagtgt gaaggtgggc aggcgtccag ccccagcctc
     2041 tggatgccgt tacaacagct gccatctttt catctcattc cttgtaaatt gtattccaaa
     2101 actgagtctc acgatgatga taaaagattt tcaaagtcac tttccttgtt gccttatctc
     2161 tcattctctg ctcaaaccta aaagtttgct tagggccaaa aagcagtcac caccatgccc
     2221 agaggaggcg ggaggcctgc cttgtcacga catgggcctg gtgagctgcc cctcagcctc
     2281 cctggagctg cactcatgtt attcgtgtgc agaaactatt ctttatctcc taacacgata
     2341 aaacactttt gtactaaata tcagttctgt ggtgttttga tgccttcaat tatcccacag
     2401 gggtggtccc aagctttctg tcaaattcga ggtcaaaaat gatggctcta ggcaacagaa
     2461 aatggcaagt ctcccatctg cagagctgac agcctgccag ggaggttcct tatcagaacc
     2521 aaatttgaaa tgtgggagtg agttccacct gttctgctaa ggaagggtgt aaaaatctgc
     2581 ccaacgaaag gagtataatt tggaattcta ccagcattac tttgctactg tctgaggttt
     2641 tatttcctcc taagtgaata gaatttcaaa gggctaagaa gggaacagtg accagatagt
     2701 tgtgaaatgt ctgaataaaa ttctttaatg tgga
//
