LOCUS       NM_005281               2137 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens G protein-coupled receptor 3 (GPR3), mRNA.
ACCESSION   NM_005281
VERSION     NM_005281.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2137)
  AUTHORS   Ren,S., Zhang,F., Shang,L., Yang,X., Pan,Y., Zhang,X. and Wu,Y.
  TITLE     Rare variants in GPR3 in POI patients: a case series with review of
            literature
  JOURNAL   J Ovarian Res 16 (1), 210 (2023)
   PUBMED   37919810
  REMARK    GeneRIF: Rare variants in GPR3 in POI patients: a case series with
            review of literature.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2137)
  AUTHORS   Iorio,C., Rourke,J.L., Wells,L., Sakamaki,J.I., Moon,E., Hu,Q.,
            Kin,T. and Screaton,R.A.
  TITLE     Silencing the G-protein coupled receptor 3-salt inducible kinase 2
            pathway promotes human beta cell proliferation
  JOURNAL   Commun Biol 4 (1), 907 (2021)
   PUBMED   34302056
  REMARK    GeneRIF: Silencing the G-protein coupled receptor 3-salt inducible
            kinase 2 pathway promotes human beta cell proliferation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2137)
  AUTHORS   Sveidahl Johansen,O., Ma,T., Hansen,J.B., Markussen,L.K.,
            Schreiber,R., Reverte-Salisa,L., Dong,H., Christensen,D.P., Sun,W.,
            Gnad,T., Karavaeva,I., Nielsen,T.S., Kooijman,S., Cero,C.,
            Dmytriyeva,O., Shen,Y., Razzoli,M., O'Brien,S.L., Kuipers,E.N.,
            Nielsen,C.H., Orchard,W., Willemsen,N., Jespersen,N.Z., Lundh,M.,
            Sustarsic,E.G., Hallgren,C.M., Frost,M., McGonigle,S., Isidor,M.S.,
            Broholm,C., Pedersen,O., Hansen,J.B., Grarup,N., Hansen,T.,
            Kjaer,A., Granneman,J.G., Babu,M.M., Calebiro,D., Nielsen,S.,
            Ryden,M., Soccio,R., Rensen,P.C.N., Treebak,J.T., Schwartz,T.W.,
            Emanuelli,B., Bartolomucci,A., Pfeifer,A., Zechner,R., Scheele,C.,
            Mandrup,S. and Gerhart-Hines,Z.
  TITLE     Lipolysis drives expression of the constitutively active receptor
            GPR3 to induce adipose thermogenesis
  JOURNAL   Cell 184 (13), 3502-3518 (2021)
   PUBMED   34048700
  REMARK    GeneRIF: Lipolysis drives expression of the constitutively active
            receptor GPR3 to induce adipose thermogenesis.
REFERENCE   4  (bases 1 to 2137)
  AUTHORS   Ayukawa,K., Suzuki,C., Ogasawara,H., Kinoshita,T., Furuno,M. and
            Suzuki,G.
  TITLE     Development of a High-Throughput Screening-Compatible Assay for
            Discovery of GPR3 Inverse Agonists Using a cAMP Biosensor
  JOURNAL   SLAS Discov 25 (3), 287-298 (2020)
   PUBMED   31516076
  REMARK    GeneRIF: Development of a High-Throughput Screening-Compatible
            Assay for Discovery of GPR3 Inverse Agonists Using a cAMP
            Biosensor.
REFERENCE   5  (bases 1 to 2137)
  AUTHORS   Capaldi,S., Suku,E., Antolini,M., Di Giacobbe,M., Giorgetti,A. and
            Buffelli,M.
  TITLE     Allosteric sodium binding cavity in GPR3: a novel player in
            modulation of Abeta production
  JOURNAL   Sci Rep 8 (1), 11102 (2018)
   PUBMED   30038319
  REMARK    GeneRIF: these results suggest an important role of the allosteric
            sodium binding site for GPR3 activity and open a possible avenue
            for the modulation of Abeta production in the Alzheimer's Disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2137)
  AUTHORS   Uhlenbrock,K., Huber,J., Ardati,A., Busch,A.E. and Kostenis,E.
  TITLE     Fluid shear stress differentially regulates gpr3, gpr6, and gpr12
            expression in human umbilical vein endothelial cells
  JOURNAL   Cell Physiol Biochem 13 (2), 75-84 (2003)
   PUBMED   12649592
  REMARK    GeneRIF: control of gene expression in vascular endothelial cells
            in the presence of fluid shear stress and classifies it as a
            sphingosine 1-phosphate receptor.
REFERENCE   7  (bases 1 to 2137)
  AUTHORS   Eggerickx,D., Denef,J.F., Labbe,O., Hayashi,Y., Refetoff,S.,
            Vassart,G., Parmentier,M. and Libert,F.
  TITLE     Molecular cloning of an orphan G-protein-coupled receptor that
            constitutively activates adenylate cyclase
  JOURNAL   Biochem J 309 (Pt 3) (Pt 3), 837-843 (1995)
   PUBMED   7639700
REFERENCE   8  (bases 1 to 2137)
  AUTHORS   Song,Z.H., Modi,W. and Bonner,T.I.
  TITLE     Molecular cloning and chromosomal localization of human genes
            encoding three closely related G protein-coupled receptors
  JOURNAL   Genomics 28 (2), 347-349 (1995)
   PUBMED   8530049
REFERENCE   9  (bases 1 to 2137)
  AUTHORS   Iismaa,T.P., Kiefer,J., Liu,M.L., Baker,E., Sutherland,G.R. and
            Shine,J.
  TITLE     Isolation and chromosomal localization of a novel human
            G-protein-coupled receptor (GPR3) expressed predominantly in the
            central nervous system
  JOURNAL   Genomics 24 (2), 391-394 (1994)
   PUBMED   7698767
REFERENCE   10 (bases 1 to 2137)
  AUTHORS   Marchese,A., Docherty,J.M., Nguyen,T., Heiber,M., Cheng,R.,
            Heng,H.H., Tsui,L.C., Shi,X., George,S.R. and O'Dowd,B.F.
  TITLE     Cloning of human genes encoding novel G protein-coupled receptors
  JOURNAL   Genomics 23 (3), 609-618 (1994)
   PUBMED   7851889
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from FO393419.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005281.3.
            
            Summary: This gene is a member of the G protein-coupled receptor
            family and is found in the cell membrane. G protein-coupled
            receptors, characterized by a seven transmembrane domain motif, are
            involved in translating outside signals into G protein mediated
            intracellular effects. The encoded protein activates adenylate
            cyclase and modulates amyloid-beta production in a mouse model,
            suggesting that it may play a role in Alzheimer's disease.
            [provided by RefSeq, Oct 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.284479.1,
                                           SRR3476690.1119222.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374024.4/ ENSP00000363136.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               FO393419.1         68506-68621         c
            117-2137            FO393419.1         65429-67449         c
FEATURES             Location/Qualifiers
     source          1..2137
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..2137
                     /gene="GPR3"
                     /gene_synonym="ACCA"
                     /note="G protein-coupled receptor 3"
                     /db_xref="GeneID:2827"
                     /db_xref="HGNC:HGNC:4484"
                     /db_xref="MIM:600241"
     exon            1..116
                     /gene="GPR3"
                     /gene_synonym="ACCA"
                     /inference="alignment:Splign:2.1.0"
     exon            117..2137
                     /gene="GPR3"
                     /gene_synonym="ACCA"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1114
                     /gene="GPR3"
                     /gene_synonym="ACCA"
                     /note="adenylate cyclase constitutive activator; ACCA
                     orphan receptor"
                     /codon_start=1
                     /product="G-protein coupled receptor 3"
                     /protein_id="NP_005272.1"
                     /db_xref="CCDS:CCDS303.1"
                     /db_xref="GeneID:2827"
                     /db_xref="HGNC:HGNC:4484"
                     /db_xref="MIM:600241"
                     /translation="MMWGAGSPLAWLSAGSGNVNVSSVGPAEGPTGPAAPLPSPKAWD
                     VVLCISGTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAAVFC
                     IGSAEMSLVLVGVLAMAFTASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALV
                     WGGALGLGLLPVLAWNCLDGLTTCGVVYPLSKNHLVVLAIAFFMVFGIMLQLYAQICR
                     IVCRHAQQIALQRHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVYCLLGDAHSPP
                     LYTYLTLLPATYNSMINPIIYAFRNQDVQKVLWAVCCCCSSSKIPFRSRSPSDV"
     regulatory      2114..2119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR3"
                     /gene_synonym="ACCA"
                     /note="hexamer: AATAAA"
     polyA_site      2137
                     /gene="GPR3"
                     /gene_synonym="ACCA"
                     /note="major polyA site"
ORIGIN      
        1 gtgactcacg ccgcttctcc cgcggccgcg ggggcttctc ggggtccacg cacgccctgc
       61 gccgccagga cccgagcgga gcctccccgc ggcccggccg cgcctggtcc tgagcggtac
      121 catgatgtgg ggtgcaggca gccctctggc ctggctctca gctggctcag gcaacgtgaa
      181 tgtaagcagc gtgggcccag cagaggggcc cacaggtcca gccgcaccac tgccctcgcc
      241 taaggcctgg gatgtggtgc tctgcatctc aggcaccctg gtgtcctgcg agaatgcgct
      301 agtggtggcc atcatcgtgg gcactcctgc cttccgtgcc cccatgttcc tgctggtggg
      361 cagcctggcc gtggcagacc tgctggcagg cctgggcctg gtcctgcact ttgctgctgt
      421 cttctgcatc ggctcagcgg agatgagcct ggtgctggtt ggcgtgctgg caatggcctt
      481 taccgccagc atcggcagtc tactggccat cactgtcgac cgctaccttt ctctgtacaa
      541 tgccctcacc tactattcag agacaacagt gacacggacc tatgtgatgc tggccttagt
      601 gtggggaggt gccctgggcc tggggctgct gcctgtgctg gcctggaact gcctggatgg
      661 cctgaccaca tgtggcgtgg tttatccact ctccaagaac catctggtag ttctggccat
      721 tgccttcttc atggtgtttg gcatcatgct gcagctctac gcccaaatct gccgcatcgt
      781 ctgccgccat gcccagcaga ttgcccttca gcggcacctg ctgcctgcct cccactatgt
      841 ggccacccgc aagggcattg ccacactggc cgtggtgctt ggagcctttg ccgcctgctg
      901 gttgcccttc actgtctact gcctgctggg tgatgcccac tctccacctc tctacaccta
      961 tcttaccttg ctccctgcca cctacaactc catgatcaac cctatcatct acgccttccg
     1021 caaccaggat gtgcagaaag tgctgtgggc tgtctgctgc tgctgttcct cttccaagat
     1081 ccccttccga tcccgctccc ccagtgatgt ctagctgagt cttcatgacc cttcaaccct
     1141 gattactaca gaattccaga atgttaggct ctccagggct tctttccaaa cccccagctc
     1201 cacacccccc agacccagct ggttctggag ttctaggaca ttgggtgttt caaggttctg
     1261 ttcagatccc tatgggggcc cagctggctc cacggttcca gaatgttcag gtggtcagtg
     1321 ttctactcag aaatgtctca cagcccagct gggttgcaat tccagaatgc tgggagtttt
     1381 acagtgccat tccaagtccc agatgtccct cttcccccaa acttgacctt gaccatgtca
     1441 ctttatgttt gaatttctga gctaaagagt cagagagatt agtcacatag ttgcctaaat
     1501 aggagagaga aagattatat atgcacatat acaaagacag tgtctattta tgattgattt
     1561 atttatttat aaatttactt atgggtggta aggggcaaaa aagaggccca caccttgata
     1621 tccaggccat accagggtat cccttgtccc ttcaccccca tttctgacct cagttcctgg
     1681 aggggggaaa gggtgaaaga gaaaccacgt attttgttat tattttggat tattttttat
     1741 cgaagagatc atagaaacca gagccttctc cccaggcctg ccctcctcgg gtttggaagg
     1801 ggaacacacc agcctctggt tttttatttt tttaagaagc catcacctga gcaaccaaaa
     1861 attcctctgc gctggggtcc gactgccctc tggtggccat ttggggaaaa ctgcagcccg
     1921 gccaggcagc tgggaccaga atgcaacccc agctccactc cagcctggcg tccagggcca
     1981 cagccatggc ctgggggcca agcctcaccc tgcggtgccc taaaggaggg ggggcacgag
     2041 ccaacacccc acccctctgc caaccggggt atggccccca gtgcattccc tgttcccgtc
     2101 tccaacccaa ctcaataaaa aatgattttg tcataaa
//
