LOCUS       NM_018971               2642 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens G protein-coupled receptor 27 (GPR27), mRNA.
ACCESSION   NM_018971
VERSION     NM_018971.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2642)
  AUTHORS   Cai,C., Hu,L., Wu,K. and Liu,Y.
  TITLE     GPR27 expression correlates with prognosis and tumor progression in
            gliomas
  JOURNAL   PeerJ 12, e17024 (2024)
   PUBMED   38638156
  REMARK    GeneRIF: GPR27 expression correlates with prognosis and tumor
            progression in gliomas.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2642)
  AUTHORS   Pan,J. and Gao,Y.
  TITLE     Prognostic significance and immune characteristics of GPR27 in
            gastric cancer
  JOURNAL   Aging (Albany NY) 15 (17), 9144-9166 (2023)
   PUBMED   37702614
  REMARK    GeneRIF: Prognostic significance and immune characteristics of
            GPR27 in gastric cancer.
REFERENCE   3  (bases 1 to 2642)
  AUTHORS   Matsumoto,M., Saito,T., Takasaki,J., Kamohara,M., Sugimoto,T.,
            Kobayashi,M., Tadokoro,M., Matsumoto,S., Ohishi,T. and Furuichi,K.
  TITLE     An evolutionarily conserved G-protein coupled receptor family,
            SREB, expressed in the central nervous system
  JOURNAL   Biochem Biophys Res Commun 272 (2), 576-582 (2000)
   PUBMED   10833454
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC096970.2.
            
            On May 17, 2019 this sequence version replaced NM_018971.2.
            
            Summary: GPR27 is a member of the G protein-coupled receptors
            (GPCRs), a large family of receptors that have a similar structure
            characterized by 7 transmembrane domains. Activation of GPCRs by
            extracellular stimuli such as neurotransmitters, hormones, or light
            induces an intracellular signaling cascade mediated by
            heterotrimeric GTP-binding proteins, or G proteins.[supplied by
            OMIM, May 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: HQ709187.1, AB040799.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304411.3/ ENSP00000303149.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2642              AC096970.2         156799-159440       c
FEATURES             Location/Qualifiers
     source          1..2642
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p13"
     gene            1..2642
                     /gene="GPR27"
                     /gene_synonym="SREB1"
                     /note="G protein-coupled receptor 27"
                     /db_xref="GeneID:2850"
                     /db_xref="HGNC:HGNC:4482"
                     /db_xref="MIM:605187"
     exon            1..2642
                     /gene="GPR27"
                     /gene_synonym="SREB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1323
                     /gene="GPR27"
                     /gene_synonym="SREB1"
                     /note="super conserved receptor expressed in brain 1"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 27"
                     /protein_id="NP_061844.1"
                     /db_xref="CCDS:CCDS2915.1"
                     /db_xref="GeneID:2850"
                     /db_xref="HGNC:HGNC:4482"
                     /db_xref="MIM:605187"
                     /translation="MANASEPGGSGGGEAAALGLKLATLSLLLCVSLAGNVLFALLIV
                     RERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLA
                     ALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPVL
                     DGGGDDEDAPCALEQRPDGAPGALGFLLLLAVVVGATHLVYLRLLFFIHDRRKMRPAR
                     LVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEEF
                     KTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGIN
                     PVVCFLFNRELRDCFRAQFPCCQSPRTTQATHPCDLKGIGL"
     regulatory      2618..2623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR27"
                     /gene_synonym="SREB1"
                     /note="hexamer: AATATA"
     polyA_site      2642
                     /gene="GPR27"
                     /gene_synonym="SREB1"
                     /note="major polyA site"
ORIGIN      
        1 attcctgaga tggcggcggc ggcacagcgg cggctcgggg agcccaggag gggccggccg
       61 ggagcgggct gagccccgca ggacggggag ctcgcccagg gccggcggag cggcggagct
      121 cgggccgggc ggcctgcggg agcggcgagg caggggacgg ccccggggcg gagcgcacgg
      181 cctggtgagg ccgcgatggc gaacgcgagc gagccgggtg gcagcggcgg cggcgaggcg
      241 gccgccctgg gcctcaagct ggccacgctc agcctgctgc tgtgcgtgag cctagcgggc
      301 aacgtgctgt tcgcgctgct gatcgtgcgg gagcgcagcc tgcaccgcgc cccgtactac
      361 ctgctgctcg acctgtgcct ggccgacggg ctgcgcgcgc tcgcctgcct cccggccgtc
      421 atgctggcgg cgcggcgtgc ggcggccgcg gcgggggcgc cgccgggcgc gctgggctgc
      481 aagctgctcg ccttcctggc cgcgctcttc tgcttccacg ccgccttcct gctgctgggc
      541 gtgggcgtca cccgctacct ggccatcgcg caccaccgct tctatgcaga gcgcctggcc
      601 ggctggccgt gcgccgccat gctggtgtgc gccgcctggg cgctggcgct ggccgcggcc
      661 ttcccgccag tgctggacgg cggtggcgac gacgaggacg cgccgtgcgc cctggagcag
      721 cggcccgacg gcgcccccgg cgcgctgggc ttcctgctgc tgctggccgt ggtggtgggc
      781 gccacgcacc tcgtctacct ccgcctgctc ttcttcatcc acgaccgccg caagatgcgg
      841 cccgcgcgcc tggtgcccgc cgtcagccac gactggacct tccacggccc gggcgccacc
      901 ggccaggcgg ccgccaactg gacggcgggc ttcggccgcg ggcccacgcc gcccgcgctt
      961 gtgggcatcc ggcccgcagg gccgggccgc ggcgcgcgcc gcctcctcgt gctggaagaa
     1021 ttcaagacgg agaagaggct gtgcaagatg ttctacgccg tcacgctgct cttcctgctc
     1081 ctctgggggc cctacgtcgt ggccagctac ctgcgggtcc tggtgcggcc cggcgccgtc
     1141 ccccaggcct acctgacggc ctccgtgtgg ctgaccttcg cgcaggccgg catcaacccc
     1201 gtcgtgtgct tcctcttcaa cagggagctg agggactgct tcagggccca gttcccctgc
     1261 tgccagagcc cccggaccac ccaggcgacc catccctgcg acctgaaagg cattggttta
     1321 tgagggaggc cccgccacat agacccccaa cccagccttt ccctttggct cggacggtga
     1381 cgttgtatct tttccttctg gcccctgttt aattttctaa gctgccttca aaatgactcg
     1441 aagtggacag acacttggat tgtactgact cctttggggg tggggtgggt gaggagtagg
     1501 atgctcagcc cactccagct ccgcacattc gtcctcctaa ctcgactttc ttcctgacaa
     1561 taggccctgc agtctttttg tagcggtact gacgtctttt attccatgtg tggttccttt
     1621 ttttcttttt ctataaaggc tgtactaatt ttcttcatgc aacgtttcct aaagaccatg
     1681 gccagttttc tacagaagct atttttgaca acctcaagtg gcattacatt ttgcagtgaa
     1741 gtagaggaac ctagggggac ttcttcacaa gttagatttc ttgaggatct tctgttggaa
     1801 gcaggagaaa gtggggggtg gggggaagtt gtccgaaatg ccctctgaat tgccggctgc
     1861 agggtccttg tgctgcgctg gttctttgaa agtctcagtg ttgatattga acttaaagag
     1921 cagagatgga gatcagtagc aaggcagtca tttttttaaa gcagtaagta acaagtaaga
     1981 tttggttccc ggtttacttt ctgctgctaa aaaccacgtc agtgacaact gctctctgta
     2041 ttatagcaat cttgaatgga aacatttctg tcaagttgta agttttaaaa gagtaaagtg
     2101 ttttggttag taatgatgtg gagaaaaata cagtattgca tgtgttcgtg tgtatagatt
     2161 gtggttcgag gattgggagg gctctgagaa gcagagtact acatcaaaat tgttttaagt
     2221 attttttgcc aataaaaaat taattttatg gaaatggctt gtgctttgag aagcccagtt
     2281 ttattctgtc ttatgaaact aatttccact ttgaaaattg ttcttctgtt gtttatggta
     2341 taaatgaatg gaatataatg atatcctcct tctaggaaac aaagcatttc cttaaaatgt
     2401 ttgctaggtt aagctgtgct gttctactga tggttgtttt aaattaataa tgagaactat
     2461 aatttaaata atatttcttt gttagacatt ataatgttaa actgaaagac taaattctgc
     2521 aagtactata taatattttt ggcttataat gctacatttt tattaatgta ccttccgttt
     2581 tgaggattta tatctgtatt tctctttgca ttatacaaat ataccagtat tttcattctg
     2641 ga
//
