LOCUS       NM_153442              10306 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens G protein-coupled receptor 26 (GPR26), mRNA.
ACCESSION   NM_153442
VERSION     NM_153442.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10306)
  AUTHORS   Meng,L., Jiang,Y.P., Zhu,J. and Li,B.
  TITLE     MiR-188-3p/GPR26 modulation functions as a potential regulator in
            manipulating glioma cell properties
  JOURNAL   Neurol Res 42 (3), 222-227 (2020)
   PUBMED   32024457
  REMARK    GeneRIF: MiR-188-3p/GPR26 modulation functions as a potential
            regulator in manipulating glioma cell properties.
REFERENCE   2  (bases 1 to 10306)
  AUTHORS   Mori,F., Tanji,K., Miki,Y., Toyoshima,Y., Yoshida,M., Kakita,A.,
            Takahashi,H., Utsumi,J., Sasaki,H. and Wakabayashi,K.
  TITLE     G protein-coupled receptor 26 immunoreactivity in intranuclear
            inclusions associated with polyglutamine and intranuclear inclusion
            body diseases
  JOURNAL   Neuropathology 36 (1), 50-55 (2016)
   PUBMED   26303144
  REMARK    GeneRIF: GPR26 may have a common role in the formation or
            degradation of intranuclear inclusions in several neurodegenerative
            diseases
REFERENCE   3  (bases 1 to 10306)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   4  (bases 1 to 10306)
  AUTHORS   Yu,B., Barbalic,M., Brautbar,A., Nambi,V., Hoogeveen,R.C., Tang,W.,
            Mosley,T.H., Rotter,J.I., deFilippi,C.R., O'Donnell,C.J.,
            Kathiresan,S., Rice,K., Heckbert,S.R., Ballantyne,C.M., Psaty,B.M.
            and Boerwinkle,E.
  CONSRTM   CARDIoGRAM Consortium
  TITLE     Association of genome-wide variation with highly sensitive cardiac
            troponin-T levels in European Americans and Blacks: a meta-analysis
            from atherosclerosis risk in communities and cardiovascular health
            studies
  JOURNAL   Circ Cardiovasc Genet 6 (1), 82-88 (2013)
   PUBMED   23247143
REFERENCE   5  (bases 1 to 10306)
  AUTHORS   Boulay,J.L., Ionescu,M.C., Sivasankaran,B., Labuhn,M.,
            Dolder-Schlienger,B., Taylor,E., Morin,P. Jr., Hemmings,B.A.,
            Lino,M.M., Jones,G., Maier,D. and Merlo,A.
  TITLE     The 10q25.3-26.1 G protein-coupled receptor gene GPR26 is
            epigenetically silenced in human gliomas
  JOURNAL   Int J Oncol 35 (5), 1123-1131 (2009)
   PUBMED   19787267
  REMARK    GeneRIF: epigenetic silencing is a common mechanism in malignant
            gliomas that simultaneously inactivates MGMT and GPR26
REFERENCE   6  (bases 1 to 10306)
  AUTHORS   Carter,A.N., Cole,C.L., Playle,A.G., Ramsay,E.J. and
            Shervington,A.A.
  TITLE     GPR26: a marker for primary glioblastoma?
  JOURNAL   Mol Cell Probes 22 (2), 133-137 (2008)
   PUBMED   18037267
  REMARK    GeneRIF: Study has identified GPR26 to be a genetic indicator of
            primary glioblastoma, suggesting that it could be a suppressor of
            primary glioblastoma development.
REFERENCE   7  (bases 1 to 10306)
  AUTHORS   Jones,P.G., Nawoschik,S.P., Sreekumar,K., Uveges,A.J., Tseng,E.,
            Zhang,L., Johnson,J., He,L., Paulsen,J.E., Bates,B. and Pausch,M.H.
  TITLE     Tissue distribution and functional analyses of the constitutively
            active orphan G protein coupled receptors, GPR26 and GPR78
  JOURNAL   Biochim Biophys Acta 1770 (6), 890-901 (2007)
   PUBMED   17363172
REFERENCE   8  (bases 1 to 10306)
  AUTHORS   Salim,K., Fenton,T., Bacha,J., Urien-Rodriguez,H., Bonnert,T.,
            Skynner,H.A., Watts,E., Kerby,J., Heald,A., Beer,M., McAllister,G.
            and Guest,P.C.
  TITLE     Oligomerization of G-protein-coupled receptors shown by selective
            co-immunoprecipitation
  JOURNAL   J Biol Chem 277 (18), 15482-15485 (2002)
   PUBMED   11854302
REFERENCE   9  (bases 1 to 10306)
  AUTHORS   Lee,D.K., Lynch,K.R., Nguyen,T., Im,D.S., Cheng,R., Saldivia,V.R.,
            Liu,Y., Liu,I.S., Heng,H.H., Seeman,P., George,S.R., O'Dowd,B.F.
            and Marchese,A.
  TITLE     Cloning and characterization of additional members of the G
            protein-coupled receptor family
  JOURNAL   Biochim Biophys Acta 1490 (3), 311-323 (2000)
   PUBMED   10684976
REFERENCE   10 (bases 1 to 10306)
  AUTHORS   Adams,M.D., Soares,M.B., Kerlavage,A.R., Fields,C. and Venter,J.C.
  TITLE     Rapid cDNA sequencing (expressed sequence tags) from a
            directionally cloned human infant brain cDNA library
  JOURNAL   Nat Genet 4 (4), 373-380 (1993)
   PUBMED   8401585
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009987.17, AJ505757.1,
            AK091093.1 and AI076749.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_153442.3.
            
            Summary: This gene encodes a G protein-couple receptor protein.
            G-protein-coupled receptors are a large family of membrane proteins
            that are involved in cellular responses to environmental stimuli,
            neurotransmitters, and hormones. The encoded protein may play a
            role in neurodegenerative diseases. Epigenetic silencing of this
            gene has been observed in gliomas. [provided by RefSeq, Sep 2016].
            
            Sequence Note: Sequence Note: This RefSeq record was created from
            transcript and genomic sequence data because no single transcript
            was available for the full length of the gene. The extent of this
            transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ505757.1, SRR1803615.25394.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284674.2/ ENSP00000284674.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-695               AC009987.17        159746-160440       c
            696-5768            AJ505757.1         695-5767
            5769-5769           AC009987.17        133933-133933       c
            5770-7514           AJ505757.1         5768-7512
            7515-8092           AC009987.17        131610-132187       c
            8093-10302          AK091093.1         1-2210
            10303-10306         AI076749.1         11-14               c
FEATURES             Location/Qualifiers
     source          1..10306
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     gene            1..10306
                     /gene="GPR26"
                     /note="G protein-coupled receptor 26"
                     /db_xref="GeneID:2849"
                     /db_xref="HGNC:HGNC:4481"
                     /db_xref="MIM:604847"
     exon            1..721
                     /gene="GPR26"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1067
                     /gene="GPR26"
                     /codon_start=1
                     /product="G-protein coupled receptor 26"
                     /protein_id="NP_703143.1"
                     /db_xref="CCDS:CCDS7636.1"
                     /db_xref="GeneID:2849"
                     /db_xref="HGNC:HGNC:4481"
                     /db_xref="MIM:604847"
                     /translation="MNSWDAGLAGLLVGTMGVSLLSNALVLLCLLHSADIRRQAPALF
                     TLNLTCGNLLCTVVNMPLTLAGVVAQRQPAGDRLCRLAAFLDTFLAANSMLSMAALSI
                     DRWVAVVFPLSYRAKMRLRDAALMVAYTWLHALTFPAAALALSWLGFHQLYASCTLCS
                     RRPDERLRFAVFTGAFHALSFLLSFVVLCCTYLKVLKVARFHCKRIDVITMQTLVLLV
                     DLHPSVRERCLEEQKRRRQRATKKISTFIGTFLVCFAPYVITRLVELFSTVPIGSHWG
                     VLSKCLAYSKAASDPFVYSLLRHQYRKSCKEILNRLLHRRSIHSSGLTGDSHSQNILP
                     VSE"
     exon            722..835
                     /gene="GPR26"
                     /inference="alignment:Splign:2.1.0"
     exon            836..10306
                     /gene="GPR26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2341..2346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR26"
                     /note="hexamer: AATAAA"
     polyA_site      2361
                     /gene="GPR26"
                     /note="major polyA site"
     regulatory      10285..10290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR26"
                     /note="hexamer: AATAAA"
     polyA_site      10306
                     /gene="GPR26"
                     /note="major polyA site"
ORIGIN      
        1 cgccatggcg gcgccgggtt gcggaccctg agcgccggcg cggggcgcgc accatgaact
       61 cgtgggacgc gggcctggcg gggctactgg tgggcacgat gggcgtctcg ctgctgtcca
      121 acgcgctggt gctgctctgc ctgctgcaca gcgcggacat ccgccgccag gcgccggcgc
      181 tcttcaccct gaacctcacg tgcgggaacc tgctgtgcac cgtggtcaac atgccgctca
      241 cgctggccgg cgtcgtggcg cagcggcagc cggcgggcga ccgcctgtgc cgcctggctg
      301 ccttcctcga caccttcctg gctgccaact ccatgctcag catggccgcg ctcagcatcg
      361 accgctgggt ggccgtggtc ttcccgctga gctaccgggc caagatgcgc ctccgcgacg
      421 cggcgctcat ggtggcctac acgtggctgc acgcgctcac cttcccagcc gccgcgctcg
      481 ccctgtcctg gctcggcttc caccagctgt acgcctcgtg cacgctgtgc agccggcggc
      541 cagacgagcg cctgcgcttc gccgtcttca ctggcgcctt ccacgctctc agcttcctgc
      601 tctccttcgt cgtgctctgc tgcacgtacc tcaaggtgct caaggtggcc cgcttccatt
      661 gcaagcgcat cgacgtgatc accatgcaga cgctggtgct gctggtggac ctgcacccca
      721 gtgtgcggga acgctgtctg gaggagcaga agcggaggcg acagcgagcc accaagaaga
      781 tcagcacctt catagggacc ttccttgtgt gcttcgcgcc ctatgtgatc accaggctag
      841 tggagctctt ctccacggtg cccatcggct cccactgggg ggtgctgtcc aagtgcttgg
      901 cgtacagcaa ggccgcatcc gacccctttg tgtactcctt actgcgacac cagtaccgca
      961 aaagctgcaa ggagattctg aacaggctcc tgcacagacg ctccatccac tcctctggcc
     1021 tcacaggcga ctctcacagc cagaacattc tgccggtgtc tgagtgaagg accgcgctcc
     1081 tgctgaagag tttagaatga ggcagcggtg agaagaaggg tgggagggcg tgggggcccc
     1141 tgggtggaca ccaccagcca ccagtccctg gcatgcccag tgatcctggt tccctggctt
     1201 gtaggggctc cagagcctgc ttcctggttc ctcaagggca gatattggac actccttatt
     1261 tgtcaccaaa ggatgactgt aggccgtgtg ctggcctttc tttctaagaa gctgctttga
     1321 gctcctggac tcacctgagg ctccctgggg gatgacactc agttctgtca ctgtcaagga
     1381 tgcagagagc tggtggtagg tgggaagcat ggtgtccacc tgcctgctga ccactggacg
     1441 ctgctccatg ctgaagaaaa gtgacagtct ccaggggaca tttcagccat gctgaaaggg
     1501 aggctggcag tggtcatttg gcccggatct aacatggcac ctcgtctcca cagggtagtg
     1561 gtggctgctt caacccaaat attattcagc tggtactaac gacattgtgc ccagctggga
     1621 ctcttgggct ctgtgcctga gggaaaatgt ttcacaacta gtggctgccc aattgctgct
     1681 gaccagttgt cttagaaatg gtcaattgga ttcaacttta gtcctctcct tccccctaaa
     1741 agcgaatgtt tgtgtgtgca gacaatctta gcatgaaaat ggtttaaata ggctggtcct
     1801 acatgtatta ggttctttca agtttgactg ggaggtcacc tttttctgat ttacaagtcc
     1861 taattgttgg agctcagtaa aggtaggagg aaggtggctg gttggtcctc ccttccccct
     1921 gtttgtgacc tgaatttaca ggaagtgttt caacttgtct tatgcatctt atctggcatg
     1981 tcctgggaga tggatgggca agaactggcc tgagcaggga tttttgcctt gattttaagt
     2041 cactgggttc cattgtcctg gcacctccat ttccttagtt tctgtaagcc tgttaacaga
     2101 aagtagaggc tattcaaggt tatcaagaaa gtgccctgtg ctaatgatga gacagtgaat
     2161 tttttttttt tttcgagatg ggagtttcac tcttattgcc caggctagag tgcaatggtg
     2221 cgatctaggc tcaccacaac ctctgccttc caggttcaag tgattagaga cagtgaaatt
     2281 tttatggaat actgcaccta taaaacacat gccaatctgt tagcagtcct gacttgattt
     2341 aataaaaacc aaggagagcc acccctgctt tctggccatc tcttctttgt ctaccatttc
     2401 aaattgactt gtgaatactc agagcagtta tttttcaatc ctccactcta agtgattcct
     2461 ccagggtggg aagcacgggg agcaatggaa tcagatggct cattctctcc ttccagctct
     2521 ttacatccta actttggagg tatagaagga aggatgtggt ccaacgggaa ggaagtgaag
     2581 agtctattgg tttttacttc taggcagtcc caatttttaa aggcagagaa gtatctgcat
     2641 ctttatttga aaagacgtct tattaactct tagctcctca gttagaaaac aattcacctg
     2701 gcttagtctt gtctagtttc aaagttacca tggagactag aatggagaca ggtgtagctt
     2761 ccaaggaggc cttggcatct tgcagttgct gtcagagatg ggctcatatc tgcttgggga
     2821 agccaatggg gcacaatcct tcccaatttc atgatctggg gcatcatgtc ggtagctgaa
     2881 gtcagccacg gtgggagtgt ttataccatg aaaatcagca agtgctgtaa atcaggcctt
     2941 ttgccccaca gagagctgat tgtgaaacat ctactagcac accactgcca gacatgactg
     3001 tgtgtgtccc tgaaacaaaa ttgctctggc tcagagctcc tttggccact catattacaa
     3061 tagcaacaga catttgcttc ctggtggcaa gtaactgtgc accctccaac atcccaaccc
     3121 cagaggaacc agtgggattg aaaaccagca gaagccaaga caggatgcac agctgaattg
     3181 gaggagagta gctcccttct cacacaaacg ctttcaaagt tgggcaaaag tggcccagtg
     3241 cgtgaggtca gtcaacagcc aaattccagc agcaaaatac attttcatca atatcacttt
     3301 gggagaataa ctgtggcaca tgctctttct gctttctctg tactgtatag gcaacatgtt
     3361 gtactcccag tagcaactag atctctttta cctcttcttt agccaagaag caagatctgt
     3421 cacccacaac accacatatc ttgaaaagat gcttttcata attttcacta tacctctaaa
     3481 accaattgta ccgacatcac gtagacaaaa actccagata aatccattga ttgggtattt
     3541 tcattattat ttggacacat gaattaaatc ccaagggaaa gtgagaagaa aattaatgta
     3601 ttagcaacca gtgttagcca actctgctgt aattaccttt agataaatgt ttattttcat
     3661 ctctatacag tctatcaaat ttgccccctg gctttattac tcccaattga attatctacc
     3721 tcattttgtt aatttaattt atcaaaggta acattgtttt ctcaggtata acacatagaa
     3781 acaccaagat tttcagcatc tgaatcaaac taaaattact tgcttgactt cactccaggg
     3841 tgagacttga cctttaaggc ccaaactctg gtgaactgtt ggactgggta gaaatctttc
     3901 aagaagcttg aaaataaggc cataaaggag gggctttcaa attcctaaat ccacatatag
     3961 ggctgagttc ctagtcctac acaatcagaa tttgcctttt taagtcacgc tgcaactatt
     4021 ccggcttttt atatggcacc tttctgaggg aggggatttt acagccgagg gacctccaaa
     4081 gggaacgtcc atttgcatgt gtgccctggt atttagggtt tgtctcatgg tcagctcgcc
     4141 tctcaaagat ggctcaccaa tcacctgcct gtttttactt agaaagcagg cttgggcagg
     4201 aggggaaatg gatttgaacc atctcagacc aactctatct cttctagcac tcagctcagc
     4261 ctcctgtccc catgagcaat aaaactctct ccttatgtct gtgaaattcg ttttcttttt
     4321 catggtgcct ttctttctaa gaaaagatag aaagaatggg gccaggttca tgtcccagtt
     4381 gtcacccttt tacatgcttg ggtgcaggta gatgaggcct tcccatggct acagtgtgac
     4441 ccttggagga accaaaggct gtgcattgtt agaatttagc ccagatgcag gataaactag
     4501 cttgcctgag tttaatgagg atattatatc aggtgccagg aatcccttgg gtcagctcct
     4561 atcctctgga cggggagcat catgggaaaa agaggtccga gtcatattta gggcttcatg
     4621 tgtctggaag ggagccatta gctcttaaat tattcacaga agtcaccacg gaaggttgtt
     4681 taagatgcag attccagcat cccctcctca gagatcaatt tcagcagggc caggcaggac
     4741 ctgggtttcc gcacttttaa tcatcgatgc ccaggtaact gataggagtt ttcttcaaac
     4801 catcccctaa ggagaaatga tcttagacac ttggataaac tctatagaaa attgagtgtt
     4861 tctattaata actatctagg tttcaattgt cttgtatctt tccctaattc tccaaacagt
     4921 tcaatctcca gctttattca atggctgggc cattttgttc ttggagggac aaaattgacc
     4981 tctccatgaa attgcaaaaa cccatcttca ttccttttta tggggctcca ggtcataagg
     5041 atgagatata tttggggtac tggcagagga tggcagagct ggctggctct gagccaggaa
     5101 gccttgttag aggaaggaac tctggcattc agaggtgtcc ccttgggggc acttgcttgg
     5161 gtcttggatc aaactctact ggggcagcct ggctgtggga ggtgatgaca tctgccacct
     5221 ctgccactac ccagagcttg tcctgccctc ttcccagcca gcctcacaca caggagctga
     5281 gccaggctga ggcaaggtca gcgagagaca gttctccatg ccagtatctg ggtgtgggtc
     5341 tcttgttggc tcccagctca tcccgtgtgg ctgacccttc caggtcactt ggagcagcca
     5401 gtaatgacag tgtcctaaca gctggtgggt atggaggaaa gactagacat caggctatgg
     5461 actcacatgg agggccctgg tgttggctct gggacctggg ctgggccgga cctggggaga
     5521 gggtgggtgg agcttggcct ctgcagtttg cgcttgcagg ttcaggggag aaagttgttt
     5581 gagatcaggg tttaggggta gtgtttccca ttaatcttca tcataatctt ttgatgtagg
     5641 tgctgttatt atctctacgt tacacatctg ggaggatttg aaagtcctgg agacagggag
     5701 gttttgggga gaatgcaaaa cagggcaggg ctctcaagga gggtggacca gtgaccatgg
     5761 ggaaactgag tgtttctatt aataagtatc taagtttcaa ttgtcttgta tctttcccta
     5821 attctccaaa cggttcaatc tccagtttta ttcagggact gggccatttt gttctcagag
     5881 ggacaaaact gatctctcca tgaaatcccc tgcacctcac tctgggcagc tctaggctca
     5941 gcagatgttt ttctgccatt aggaaacagc cccttactct cagctcctgt gctaacaccc
     6001 atacccacca gctgggcgtt gggacctctc ccgtcatatg gctgccactt gcttgggaag
     6061 gaattctcca gactcctttt actttgtatg tgtttctagg ggaattctga gggaagaagc
     6121 tttgcagcaa cctctgtgcc cagaacatac ggctcacaag tcctttgtgc cgacagggaa
     6181 tctatctaat tgttttagtg tgtgaggctc attgtcagcc tagatttccc tgaaactctg
     6241 ggccagcagc ccccaggagc atcagtagga cccagcattt cccctggcac caaagtggac
     6301 ctctttgcac cttgcagccg ggagaactga cttagagggc cctggtgttg gctctggaac
     6361 ctgggctgag atggattcgg ggagaggctg ggtggagctt ggcctctacg gtctgttctt
     6421 gcagattcag gagagaaagt ggtatgagag cagtgtggtt tgtaagttcc ccaacttccc
     6481 cgctggctca cactgtctcc ccagaccaat ggcctattag cccccaaaaa gttagtccaa
     6541 ccccaggcca gctgcctttg ctctgctgtg gcctaagttc tggcctggtc aaaggaaggt
     6601 ggcaggaact ccaggcttgc tcctgcctcc tcacacctca ttccacaaat gcggagtgaa
     6661 agagcaggag ccagacacat ttgggggttg actgtctaga aaggaggaat cagaggtccc
     6721 aaggaacaca atcgtgcaac ttcctaggga atctgcatca ggagaaagaa gcggctagga
     6781 cacacagtgg cttcgctcag cctggccacg acatcactgt gcagaagaag agatctgtca
     6841 ggggtccaga ggagcggagt cctggagcct ctgggagggt ggcatgtggc agctgcaggc
     6901 tgtggtccag aactatgagc agacttgcct gtcactctcc aaacatttac tgaacaccta
     6961 ctgtgtgcca ggccctgtgc tttgtcaggc tctgggggag acaggtcatt actctgcagt
     7021 gtgggaagcg gggctgccct ggaagtgtgt actcagtgct gtgggggtac agagggaggg
     7081 ctggagaact tagctggtgg gaaaggaggg ttctggaagg cttctcagag gtagtggcat
     7141 tgggccagaa cttacagtag ggaagagcat gtggcaaggc acagaggaga tgggagcctg
     7201 cctggtgagg ggtccagtgg tgacagagct cagtgtgggt ccagagatgg tgtcaggtga
     7261 gggctgagag gggagggcaa gtgccccttg agatgggctg aacgtgatga tgatctgtgg
     7321 ccagtgggag atgatagaag tcttgaggtt gggaatataa gaattaggtc tcttttagaa
     7381 agagaggaca tggagaaaat ccatatattt ttagctacca aaaaagagaa ggaagaaaga
     7441 aaagaaataa gaagagaagc aagacagaaa agaaggaaga gagaaggaag aatggcaaag
     7501 gaaggaagaa ggagagaagg aaggaaaaac aaaggaagga gaaaaaggga aggaaagaag
     7561 aaaggaagga aaaaaggaag gagggagggg aggaaggaaa agaaaaagaa ggaaggaagg
     7621 agtcctagcc acttctttct cctgatgcag attccctagg aagttgaacg aagaaggaag
     7681 gaaggaagaa aggagagaaa ggaggaagga aaatgaatct cattcatttt gaggggcatc
     7741 ttcattacac agcgtgggga gggaagcata attcactctt aagaaaccaa ccacaccagc
     7801 cagggcccat cttctgacaa tatcctgaag ggttcgaatg tttgtcttcg gtagggagtg
     7861 ccacacattt aatatcaatg cagggtcctg atgggcactg ccacataccc ccaggacaaa
     7921 cggaaaaatc cacacagcag aaacaagcag ttggcaaaag ctgtcctcat gctacttggc
     7981 aattcaatca ccctcccttc actcccacac ctatctccgg gtgttgcccg tacagtgtgt
     8041 catgtaaata gcatctagca tttaaaggtc aaatttgatg agtctaatca atcttagcag
     8101 tgttccagtt catcacgtat acccatattt aaggactttt aaagtaattt ggatttttaa
     8161 ctcaaaagac gatgtgtacc ccttggggca tgcgtgtgtt cttaggaaca ccagcgtgtg
     8221 gtatttcctg tgtcctctca tgcatgctca gcatgtcact gttgtactca ttccctggca
     8281 cggaagaatt gttgcacatc tttaatagaa gccaaagccc atgatttgat ggtttcaaga
     8341 gcctaaaatc tgtatttgga gagaggaagt ctactcttaa ctgtgagagt taagagtatc
     8401 accatcaagg cgcaaggctt cagtcttatc ccggacaatc ctcagggatt gggtttgatg
     8461 tcgggggagc attggatgcc atcacgttga cactcaattg attgggtgac ccaagatggt
     8521 cagtttccta aggaccagac catagtgact gctcatgcat cggctgaaat accaaacacc
     8581 ctgcaccaaa agactcagct tgacattgct ttgcactcaa ctcatgtatt accaaatctt
     8641 tgcttgaatt attaatagta accaaactct ctgctctaac aaccttcgaa tgtcaagttc
     8701 ccttgcaagc tgaaattgtt ccaaacctca acactcctgt tttacaacaa acatgtaaat
     8761 acaacctctt ttggagtgca gaaacatttg cggagtctgg tgtgccacca accccatcag
     8821 gatttcccca ggggaaaatg gctaactctg gatcacaaac agcacaaatt aaaaaggtgc
     8881 cttgcctgat gcccattacc acctggggtg gtttttctag acaccagaat aggccagatt
     8941 taattttcac aggctcatct gggagaagga tcaaatcctg ccatctggat gtgcattatt
     9001 aatgctggtg tttggtgagg aagctcctag gaatgcatag atctctcctt ctgccatagt
     9061 atgtcgtgtg tagtggatgc cagtagacaa ctttagccac tcctgtccgt ccttcttcat
     9121 ggaacacact catttcgcca cacggaggct ttactctgcc cagtgtccaa tgggagaacc
     9181 atcccttccc tttagtgaga ggacagctgg ctaaatgcta tcctcagtcc tcctggaggc
     9241 tcctagtaat gagggcactg aacaccaatt ctttacattc cttgaatttt catagattct
     9301 atttttttca tgtctgtgaa aagtggggtg gggaactcac accaaccata gcttggggca
     9361 tccagagagt ggctagtaga tgatagaagg gagtccagtt aaggaaacct aaggtatgtg
     9421 ccagctggtt tagcattcaa tatggaaatg cactttatat ttatttgcac acatcaagaa
     9481 tacttttgga aaccaggatt tagaaaaata aaagatattt ctttcctggg gacaaagtga
     9541 cctgcaaatg attggcttct gtacaatgtt gcaatccctt aatgtcagac tcttaggaaa
     9601 atgggtggga catctgtgtg tttgtgttgg agtgaatgtg cccataaccc tgtgctccca
     9661 taagtctgtg tgcccgtgat catatgcata tgggtgaatg tttgtgtgcc catgatttta
     9721 tgcatatagg tgaatatttg tgtgcccatg agcatatgca tatgggtgaa tgtttgtgtg
     9781 cccatgagta tatgcatacg ggtgaatgtt tgtgtgccca tgagtatatg catatgggta
     9841 tatgtttgtg tgcccgtgat tatatgcata tgggtgaatg tttgtgtgcc cgtgattata
     9901 tgcatgtggg tgaatgttca tgaacacaaa cagctacact cggagtagaa aacaaatgaa
     9961 gcaaaagttt agcatcctct catgtgtgtc aacattgtag ttttacattt actttcttct
    10021 aatctattaa acataagtat ggctccattt ttttagtatt accagaagcc ctcccaatac
    10081 ggcaatatta ccttctgtgt aatccacttg ccaacagctg ttttctgttg aaatgggact
    10141 caagaatttt gaatccaagg ccaatgctgc ctgctctgtt tacaatggtt tgtgttttgt
    10201 ggatacatat caaatgctgt aatatatttt tatgatagaa ttgatggtta atacagggaa
    10261 aaagtatata ttgtgattct gtccaataaa gcctcctgtt ataaaa
//
