LOCUS       NM_005298               1198 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens G protein-coupled receptor 25 (GPR25), mRNA.
ACCESSION   NM_005298
VERSION     NM_005298.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1198)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1198)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1198)
  AUTHORS   Sherva,R., Miller,M.B., Lynch,A.I., Devereux,R.B., Rao,D.C.,
            Oberman,A., Hopkins,P.N., Kitzman,D.W., Atwood,L.D. and Arnett,D.K.
  TITLE     A whole genome scan for pulse pressure/stroke volume ratio in
            African Americans: the HyperGEN study
  JOURNAL   Am J Hypertens 20 (4), 398-402 (2007)
   PUBMED   17386346
  REMARK    GeneRIF: GPR-25 is homologous to receptors involved in blood
            pressure regulation.
REFERENCE   4  (bases 1 to 1198)
  AUTHORS   Jung,B.P., Nguyen,T., Kolakowski,L.F. Jr., Lynch,K.R., Heng,H.H.,
            George,S.R. and O'Dowd,B.F.
  TITLE     Discovery of a novel human G protein-coupled receptor gene (GPR25)
            located on chromosome 1
  JOURNAL   Biochem Biophys Res Commun 230 (1), 69-72 (1997)
   PUBMED   9020062
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC126386.1.
            
            On May 17, 2019 this sequence version replaced NM_005298.3.
            
            Summary: This gene is intronless and encodes a member of the
            G-protein coupled receptor 1 family. G-protein coupled receptors
            are membrane proteins which activate signaling cascades as a
            response to extracellular stress. This gene has been linked to
            arterial stiffness. [provided by RefSeq, Nov 2012].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC126388.1, AK315339.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304244.5/ ENSP00000301917.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1198              BC126386.1         27-1224
FEATURES             Location/Qualifiers
     source          1..1198
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..1198
                     /gene="GPR25"
                     /note="G protein-coupled receptor 25"
                     /db_xref="GeneID:2848"
                     /db_xref="HGNC:HGNC:4480"
                     /db_xref="MIM:602174"
     exon            1..1198
                     /gene="GPR25"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1143
                     /gene="GPR25"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 25"
                     /protein_id="NP_005289.2"
                     /db_xref="CCDS:CCDS1405.1"
                     /db_xref="GeneID:2848"
                     /db_xref="HGNC:HGNC:4480"
                     /db_xref="MIM:602174"
                     /translation="MAPTEPWSPSPGSAPWDYSGLDGLEELELCPAGDLPYGYVYIPA
                     LYLAAFAVGLLGNAFVVWLLAGRRGPRRLVDTFVLHLAAADLGFVLTLPLWAAAAALG
                     GRWPFGDGLCKLSSFALAGTRCAGALLLAGMSVDRYLAVVKLLEARPLRTPRCALASC
                     CGVWAVALLAGLPSLVYRGLQPLPGGQDSQCGEEPSHAFQGLSLLLLLLTFVLPLVVT
                     LFCYCRISRRLRRPPHVGRARRNSLRIIFAIESTFVGSWLPFSALRAVFHLARLGALP
                     LPCPLLLALRWGLTIATCLAFVNSCANPLIYLLLDRSFRARALDGACGRTGRLARRIS
                     SASSLSRDDSSVFRCRAQAANTASASW"
ORIGIN      
        1 agagctgctg ccgcctgcgc ccagggctgc actccgcgca ggcctcatag ccaggccatg
       61 gcccccacag agccctggag ccccagcccg gggtcagcgc cctgggacta ctcggggttg
      121 gacggcctgg aggagctgga gctgtgtccg gccggggacc tgccctacgg ctacgtctac
      181 atccccgcgc tctacctggc ggccttcgcc gtgggcctgc tgggcaacgc ctttgtggtg
      241 tggctgctgg ccgggcggcg gggcccgcgg cggctggtgg ataccttcgt gctgcacctg
      301 gcggcagctg acctgggctt cgtgctcacg ctgccgctgt gggccgcggc ggcggcgcta
      361 ggcggccgct ggccgttcgg cgatggcctc tgcaagctca gcagcttcgc gctggcgggc
      421 acgcgctgcg cgggcgcgct gctgctggcg ggcatgagcg tggaccgcta cctggccgtg
      481 gtgaagctgc tcgaggcgag gccactgcgc accccgcgct gcgcgctggc ctcgtgctgc
      541 ggcgtctggg ccgtggcgct gctggccggc ctgccctccc tggtctaccg ggggttgcag
      601 cccctgcctg ggggccagga cagccagtgc ggcgaggagc cctcccacgc cttccagggc
      661 ctcagcttgc tgctgctgct gctgaccttc gtgctgcccc tggtcgtcac cctcttctgc
      721 tactgccgca tctcgcgccg cctgcgacgg ccgccgcacg tgggtcgggc ccggaggaac
      781 tcgctgcgca tcatcttcgc catcgagagc acgtttgtgg gctcctggct gcccttcagc
      841 gccctgcggg ccgtcttcca cctggcgcgt ctgggggcgc tgccgctgcc gtgccccctg
      901 ctgctggcgc tgcgctgggg cctcaccatt gccacctgcc tggccttcgt caacagctgc
      961 gccaacccgc tcatctacct cctgctggac cgctcattcc gagcccgggc gctggacggg
     1021 gcctgcgggc gcaccggccg cctggcgcga aggatcagct cagcctcctc gctctccagg
     1081 gacgacagtt ccgtgttccg ttgccgggcc caggccgcga acactgcctc ggcctcctgg
     1141 tagctgcccc gggccgctgg aggtgggcgg cagcggagca tcgagaggag gccagagg
//
