LOCUS       NM_005295               2970 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens G protein-coupled receptor 22 (GPR22), mRNA.
ACCESSION   NM_005295
VERSION     NM_005295.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2970)
  AUTHORS   Chang,C.C., Chen,C.H., Hsu,S.Y. and Leu,S.
  TITLE     Cardiomyocyte-specific overexpression of GPR22 ameliorates cardiac
            injury in mice with acute myocardial infarction
  JOURNAL   BMC Cardiovasc Disord 24 (1), 287 (2024)
   PUBMED   38816768
  REMARK    GeneRIF: Cardiomyocyte-specific overexpression of GPR22 ameliorates
            cardiac injury in mice with acute myocardial infarction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2970)
  AUTHORS   Evangelou,E., Valdes,A.M., Kerkhof,H.J., Styrkarsdottir,U., Zhu,Y.,
            Meulenbelt,I., Lories,R.J., Karassa,F.B., Tylzanowski,P., Bos,S.D.,
            Akune,T., Arden,N.K., Carr,A., Chapman,K., Cupples,L.A., Dai,J.,
            Deloukas,P., Doherty,M., Doherty,S., Engstrom,G., Gonzalez,A.,
            Halldorsson,B.V., Hammond,C.L., Hart,D.J., Helgadottir,H.,
            Hofman,A., Ikegawa,S., Ingvarsson,T., Jiang,Q., Jonsson,H.,
            Kaprio,J., Kawaguchi,H., Kisand,K., Kloppenburg,M., Kujala,U.M.,
            Lohmander,L.S., Loughlin,J., Luyten,F.P., Mabuchi,A., McCaskie,A.,
            Nakajima,M., Nilsson,P.M., Nishida,N., Ollier,W.E.,
            Panoutsopoulou,K., van de Putte,T., Ralston,S.H., Rivadeneira,F.,
            Saarela,J., Schulte-Merker,S., Shi,D., Slagboom,P.E., Sudo,A.,
            Tamm,A., Tamm,A., Thorleifsson,G., Thorsteinsdottir,U., Tsezou,A.,
            Wallis,G.A., Wilkinson,J.M., Yoshimura,N., Zeggini,E., Zhai,G.,
            Zhang,F., Jonsdottir,I., Uitterlinden,A.G., Felson,D.T., van
            Meurs,J.B., Stefansson,K., Ioannidis,J.P. and Spector,T.D.
  CONSRTM   arcOGEN Consortium; Translation Research in Europe Applied
            Technologies for Osteoarthritis (TreatOA)
  TITLE     Meta-analysis of genome-wide association studies confirms a
            susceptibility locus for knee osteoarthritis on chromosome 7q22
  JOURNAL   Ann Rheum Dis 70 (2), 349-355 (2011)
   PUBMED   21068099
  REMARK    GeneRIF: Meta-analysis and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   3  (bases 1 to 2970)
  AUTHORS   Kerkhof,H.J., Lories,R.J., Meulenbelt,I., Jonsdottir,I.,
            Valdes,A.M., Arp,P., Ingvarsson,T., Jhamai,M., Jonsson,H.,
            Stolk,L., Thorleifsson,G., Zhai,G., Zhang,F., Zhu,Y., van der
            Breggen,R., Carr,A., Doherty,M., Doherty,S., Felson,D.T.,
            Gonzalez,A., Halldorsson,B.V., Hart,D.J., Hauksson,V.B., Hofman,A.,
            Ioannidis,J.P., Kloppenburg,M., Lane,N.E., Loughlin,J.,
            Luyten,F.P., Nevitt,M.C., Parimi,N., Pols,H.A., Rivadeneira,F.,
            Slagboom,E.P., Styrkarsdottir,U., Tsezou,A., van de Putte,T.,
            Zmuda,J., Spector,T.D., Stefansson,K., Uitterlinden,A.G. and van
            Meurs,J.B.
  TITLE     A genome-wide association study identifies an osteoarthritis
            susceptibility locus on chromosome 7q22
  JOURNAL   Arthritis Rheum 62 (2), 499-510 (2010)
   PUBMED   20112360
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   4  (bases 1 to 2970)
  AUTHORS   Adams,J.W., Wang,J., Davis,J.R., Liaw,C., Gaidarov,I., Gatlin,J.,
            Dalton,N.D., Gu,Y., Ross,J. Jr., Behan,D., Chien,K. and Connolly,D.
  TITLE     Myocardial expression, signaling, and function of GPR22: a
            protective role for an orphan G protein-coupled receptor
  JOURNAL   Am J Physiol Heart Circ Physiol 295 (2), H509-H521 (2008)
   PUBMED   18539757
  REMARK    GeneRIF: Demonstrate GRR22 expression in human heart.
REFERENCE   5  (bases 1 to 2970)
  AUTHORS   Lee,J., Hever,A., Willhite,D., Zlotnik,A. and Hevezi,P.
  TITLE     Effects of RNA degradation on gene expression analysis of human
            postmortem tissues
  JOURNAL   FASEB J 19 (10), 1356-1358 (2005)
   PUBMED   15955843
REFERENCE   6  (bases 1 to 2970)
  AUTHORS   O'Dowd,B.F., Nguyen,T., Jung,B.P., Marchese,A., Cheng,R.,
            Heng,H.H., Kolakowski,L.F. Jr., Lynch,K.R. and George,S.R.
  TITLE     Cloning and chromosomal mapping of four putative novel human
            G-protein-coupled receptor genes
  JOURNAL   Gene 187 (1), 75-81 (1997)
   PUBMED   9073069
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA519131.1, AK122621.1,
            BC107128.2, U66581.1 and AC002381.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005295.2.
            
            Summary: This gene is a member of the G-protein coupled receptor 1
            family and encodes a multi-pass membrane protein. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.61439.1,
                                           SRR1660807.64017.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304402.6/ ENSP00000302676.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DA519131.1         1-3
            4-1529              AK122621.1         1-1526
            1530-2648           BC107128.2         184-1302
            2649-2939           AK122621.1         2646-2936
            2940-2966           U66581.1           1831-1857
            2967-2970           AC002381.1         81179-81182
FEATURES             Location/Qualifiers
     source          1..2970
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.3"
     gene            1..2970
                     /gene="GPR22"
                     /note="G protein-coupled receptor 22"
                     /db_xref="GeneID:2845"
                     /db_xref="HGNC:HGNC:4477"
                     /db_xref="MIM:601910"
     exon            1..389
                     /gene="GPR22"
                     /inference="alignment:Splign:2.1.0"
     exon            390..1320
                     /gene="GPR22"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..2970
                     /gene="GPR22"
                     /inference="alignment:Splign:2.1.0"
     CDS             1347..2648
                     /gene="GPR22"
                     /note="probable G-protein coupled receptor 22"
                     /codon_start=1
                     /product="G-protein coupled receptor 22"
                     /protein_id="NP_005286.2"
                     /db_xref="CCDS:CCDS5744.1"
                     /db_xref="GeneID:2845"
                     /db_xref="HGNC:HGNC:4477"
                     /db_xref="MIM:601910"
                     /translation="MCFSPILEINMQSESNITVRDDIDDINTNMYQPLSYPLSFQVSL
                     TGFLMLEIVLGLGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCIPLTIVI
                     LLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKPANRILTMGRAVML
                     MISIWIFSFFSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEYYTELGMYYHLLVQIP
                     IFFFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLTTQHEATDMSQSSG
                     GRNVVFGVRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTPISVLNT
                     TILCLGPSDLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQKVLKSKMKKRVVSIVEA
                     DPLPNNAVIHNSWIDPKRNKKITFEDSEIREKCLVPQVVTD"
     regulatory      2927..2932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR22"
                     /note="hexamer: AATACA"
     polyA_site      2970
                     /gene="GPR22"
                     /note="major polyA site"
ORIGIN      
        1 gtcattctgc aaaagctgcc cgaacaggct ttcctctgaa aagcagtgcc gttccttttt
       61 agaaagactg aatctaaatg ttgtctctgg agacaagaag ccttcagtat gttaaattac
      121 tttcattatg tattttcaga tgcttattga ttccacagta ggaagagtga gagactgcag
      181 cagcctctaa gcagcactac atgttccata cattagcagt actgctgaaa caatggcaca
      241 ctacagacac atattttcat taaggtcatt ttcgaagaga tgtttatgac cctcttcccc
      301 cagtcctcta ctaacaagtg aacaaaatga atcaatccaa actggaaatg cttcaactac
      361 atcaagaatt tatcaaatct ttagcagagg gccaatagca gctaattcag tatttacaac
      421 tgacaatatg aagaatgcaa ttgactgagc atctccctag ctgtctgaac tacgaactgc
      481 aagatgttct tgtaacacga ctttaagaca ttaaggagtt aaaaccaggg aataggtcta
      541 cattactgat ggaatataaa aaatcaactg tatcctaaga agatgctaca taaaataacc
      601 acaaaaagaa aaacaatata actgtaaaag cctgaaaaga atttttaaaa ggggaagttt
      661 atactttcat ataccagaat tgtggaagtt actgattctg gaagacataa tgaaacatga
      721 atttccaaaa agaaaagaaa atactttatc agcacacaaa aggaagattt aggaagtgtt
      781 ttctgcacta aatattcaga tattcatatc aattggtatg actaatggat ttttctatct
      841 gacttttatg accaattatg tatcctcttc taatgaaaac aaacaaaatt aaacagcaga
      901 tggtttttat caaaaggaca tggcctggat ttataatata aagcaagtta tgtgatcaag
      961 aaatcatttc aaaatagtga gcactgctat taaaaacaga tttacaatgg taacaaaagg
     1021 atgtctaaat atattttaga agctacaaac gttatgtttc cttttttgtt ttcacatatt
     1081 ctggaaaata aagaaatatt atcatgtact ccatcaaagg gaaacataat tcctatcatc
     1141 tgaggaaatt cctcttggcc gtgacttttt aaagcaaaac aaatacaaat attatgtact
     1201 gttctttaga aatccatcag ccaactaaat ctcataatgc atgcagttga agtattggag
     1261 agaaaacgaa agaattccta caagacatga aataaaacac agctacttca ctgttgtcag
     1321 ggaaaaaaac caactgctcc aaaagaatgt gtttttctcc cattctggaa atcaacatgc
     1381 agtctgaatc taacattaca gtgcgagatg acattgatga catcaacacc aatatgtacc
     1441 aaccactatc atatccgtta agctttcaag tgtctctcac cggatttctt atgttagaaa
     1501 ttgtgttggg acttggcagc aacctcactg tattggtact ttactgcatg aaatccaact
     1561 taatcaactc tgtcagtaac attattacaa tgaatcttca tgtacttgat gtaataattt
     1621 gtgtgggatg tattcctcta actatagtta tccttctgct ttcactggag agtaacactg
     1681 ctctcatttg ctgtttccat gaggcttgtg tatcttttgc aagtgtctca acagcaatca
     1741 acgtttttgc tatcactttg gacagatatg acatctctgt aaaacctgca aaccgaattc
     1801 tgacaatggg cagagctgta atgttaatga tatccatttg gattttttct tttttctctt
     1861 tcctgattcc ttttattgag gtaaattttt tcagtcttca aagtggaaat acctgggaaa
     1921 acaagacact tttatgtgtc agtacaaatg aatactacac tgaactggga atgtattatc
     1981 acctgttagt acagatccca atattctttt tcactgttgt agtaatgtta atcacataca
     2041 ccaaaatact tcaggctctt aatattcgaa taggcacaag attttcaaca gggcagaaga
     2101 agaaagcaag aaagaaaaag acaatttctc taaccacaca acatgaggct acagacatgt
     2161 cacaaagcag tggtgggaga aatgtagtct ttggtgtaag aacttcagtt tctgtaataa
     2221 ttgccctccg gcgagctgtg aaacgacacc gtgaacgacg agaaagacaa aagagagtct
     2281 tcaggatgtc tttattgatt atttctacat ttcttctctg ctggacacca atttctgttt
     2341 taaataccac cattttatgt ttaggcccaa gtgacctttt agtaaaatta agattgtgtt
     2401 ttttagtcat ggcttatgga acaactatat ttcaccctct attatatgca ttcactagac
     2461 aaaaatttca aaaggtcttg aaaagtaaaa tgaaaaagcg agttgtttct atagtagaag
     2521 ctgatcccct gcctaataat gctgtaatac acaactcttg gatagatcct aaaagaaaca
     2581 aaaaaattac ctttgaagat agtgaaataa gagaaaaatg tttagtgcct caggttgtca
     2641 cagactagag aaaagtctca gtttcaccaa atccacattc aaatgagttt taaatttaaa
     2701 ttgtaaaaac tgatattact gccaaatata agaaaaatat tttaagtatt ggttatgttg
     2761 taaattttca atgtgaatgt caattagata ggtcatatat attcaatttc ttcattactt
     2821 aatgtatttg ttgcatggca gtttgttaaa gtactatcat gtgtatattt tgtcaatatt
     2881 atgtccaaca gaaaatattc atgtaagtca tattttttaa ggaataaata catagcctta
     2941 aaacagtgta taactttaaa atgtaactga
//
