LOCUS       NM_005294               1571 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens G protein-coupled receptor 21 (GPR21), mRNA.
ACCESSION   NM_005294
VERSION     NM_005294.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1571)
  AUTHORS   Lin,X., Chen,B., Wu,Y., Han,Y., Qi,A., Wang,J., Yang,Z., Wei,X.,
            Zhao,T., Wu,L., Xie,X., Sun,J., Zheng,J., Zhao,S. and Xu,F.
  TITLE     Cryo-EM structures of orphan GPR21 signaling complexes
  JOURNAL   Nat Commun 14 (1), 216 (2023)
   PUBMED   36639690
  REMARK    GeneRIF: Cryo-EM structures of orphan GPR21 signaling complexes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1571)
  AUTHORS   Bordano,V., Kinsella,G.K., Cannito,S., Dianzani,C., Gigliotti,C.L.,
            Stephens,J.C., Monge,C., Bocca,C., Rosa,A.C., Miglio,G.,
            Dianzani,U., Findlay,J.B.C. and Benetti,E.
  TITLE     G protein-coupled receptor 21 in macrophages: An in vitro study
  JOURNAL   Eur J Pharmacol 926, 175018 (2022)
   PUBMED   35537492
  REMARK    GeneRIF: G protein-coupled receptor 21 in macrophages: An in vitro
            study.
REFERENCE   3  (bases 1 to 1571)
  AUTHORS   Riddy,D.M., Kammoun,H.L., Murphy,A.J., Bosnyak-Gladovic,S., De la
            Fuente Gonzalez,R., Merlin,J., Ziemann,M., Fabb,S., Pierce,T.L.,
            Diepenhorst,N., Rueda,P., El-Osta,A., Gautier,J.F., Venteclef,N.,
            Charman,W.N., Christopoulos,A., Sexton,P.M., Summers,R.J.,
            Febbraio,M.A., Delerive,P. and Langmead,C.J.
  TITLE     Deletion of GPR21 improves glucose homeostasis and inhibits the
            CCL2-CCR2 axis by divergent mechanisms
  JOURNAL   BMJ Open Diabetes Res Care 9 (2) (2021)
   PUBMED   34782333
  REMARK    GeneRIF: Deletion of GPR21 improves glucose homeostasis and
            inhibits the CCL2-CCR2 axis by divergent mechanisms.
REFERENCE   4  (bases 1 to 1571)
  AUTHORS   Leonard,S., Kinsella,G.K., Benetti,E. and Findlay,J.B.C.
  TITLE     Regulating the effects of GPR21, a novel target for type 2 diabetes
  JOURNAL   Sci Rep 6, 27002 (2016)
   PUBMED   27243589
  REMARK    GeneRIF: GPR21 is up-regulated in type 2 diabetes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1571)
  AUTHORS   Bresnick,J.N., Skynner,H.A., Chapman,K.L., Jack,A.D., Zamiara,E.,
            Negulescu,P., Beaumont,K., Patel,S. and McAllister,G.
  TITLE     Identification of signal transduction pathways used by orphan g
            protein-coupled receptors
  JOURNAL   Assay Drug Dev Technol 1 (2), 239-249 (2003)
   PUBMED   15090189
REFERENCE   6  (bases 1 to 1571)
  AUTHORS   O'Dowd,B.F., Nguyen,T., Jung,B.P., Marchese,A., Cheng,R.,
            Heng,H.H., Kolakowski,L.F. Jr., Lynch,K.R. and George,S.R.
  TITLE     Cloning and chromosomal mapping of four putative novel human
            G-protein-coupled receptor genes
  JOURNAL   Gene 187 (1), 75-81 (1997)
   PUBMED   9073069
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DN989991.1, DA792401.1,
            BC066885.1 and AK299686.1.
            
            On May 20, 2020 this sequence version replaced NM_005294.2.
            
            Summary: This gene encodes a member of the G-protein-coupled
            receptor 1 family. G-protein coupled receptors are membrane
            proteins which activate signaling cascades as a response to
            extracellular stress. The encoded protein activates a Gq signal
            transduction pathway which mobilizes calcium. [provided by RefSeq,
            Nov 2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK299686.1, AK313539.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000616002.3/ ENSP00000482287.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DN989991.1         33-34
            3-472               DA792401.1         1-470
            473-1522            BC066885.1         1-1050
            1523-1571           AK299686.1         1517-1565
FEATURES             Location/Qualifiers
     source          1..1571
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.2"
     gene            1..1571
                     /gene="GPR21"
                     /note="G protein-coupled receptor 21"
                     /db_xref="GeneID:2844"
                     /db_xref="HGNC:HGNC:4476"
                     /db_xref="MIM:601909"
     exon            1..76
                     /gene="GPR21"
                     /inference="alignment:Splign:2.1.0"
     exon            77..1571
                     /gene="GPR21"
                     /inference="alignment:Splign:2.1.0"
     CDS             473..1522
                     /gene="GPR21"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 21"
                     /protein_id="NP_005285.1"
                     /db_xref="CCDS:CCDS6849.1"
                     /db_xref="GeneID:2844"
                     /db_xref="HGNC:HGNC:4476"
                     /db_xref="MIM:601909"
                     /translation="MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLIIS
                     GNIIVIFVFHCAPLLNHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLTC
                     QIFGFVVSVLKSVSMASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYSTLV
                     FLPSFFHWGKPGYHGDVFQWCAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRIC
                     QQHTKDISERQARFSSQSGETGEVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLES
                     STGHSNRFASFLTTWLAISNSFCNCVIYSLSNSVFQRGLKRLSGAMCTSCASQTTAND
                     PYTVRSKGPLNGCHI"
ORIGIN      
        1 acattcctgc tttgcaaggc tttctgctaa ggatgtattg tggcttttgt ttggattgca
       61 gcatgcagaa ttacagctgt tcagaggaga ctcattacaa ctcctgctga agctcctaat
      121 cttcttccct tctcttctac cctttccccc taccctcact tggcctgaag acgttctccc
      181 cagagtttac cttgctcccc tggtgctatg tgtatggtga acctggcact atggccgcgt
      241 ctgggactgg ccagacaact gctgctggct ctccttattc caggaaggat ttaaagggga
      301 attgcactgc aggcaatgca ccagagcagc agcatcagga gcttggggag taaggctcct
      361 ctggcattat tacacacatg caaagctgac cgcaatgaca gcagctgctt ctttgaactg
      421 ttggcagcag ccaagcggca gcatgaagtg acagatcact cctgagctca agatgaactc
      481 caccttggat ggtaatcaga gcagccaccc tttttgcctc ttggcatttg gctatttgga
      541 aactgtcaat ttttgccttt tggaagtatt gattattgtc tttctaactg tattgattat
      601 ttctggcaac atcattgtga tttttgtatt tcactgtgca cctttgttga accatcacac
      661 tacaagttat tttatccaga ctatggcata tgctgacctt tttgttgggg tgagctgcgt
      721 ggtcccttct ttatcactcc tccatcaccc ccttccagta gaggagtcct tgacttgcca
      781 gatatttggt tttgtagtat cagttctgaa gagcgtctcc atggcttctc tggcctgtat
      841 cagcattgat agatacattg ccattactaa acctttaacc tataatactc tggttacacc
      901 ctggagacta cgcctgtgta ttttcctgat ttggctatac tcgaccctgg tcttcctgcc
      961 ttcctttttc cactggggca aacctggata tcatggagat gtgtttcagt ggtgtgcgga
     1021 gtcctggcac accgactcct acttcaccct gttcatcgtg atgatgttat atgccccagc
     1081 agcccttatt gtctgcttca cctatttcaa catcttccgc atctgccaac agcacacaaa
     1141 ggatatcagc gaaaggcaag cccgcttcag cagccagagt ggggagactg gggaagtgca
     1201 ggcctgtcct gataagcgct atgccatggt cctgtttcga atcactagtg tattttacat
     1261 cctctggttg ccatatatca tctacttctt gttggaaagc tccactggcc acagcaaccg
     1321 cttcgcatcc ttcttgacca cctggcttgc tattagtaac agtttctgca actgtgtaat
     1381 ttatagtctc tccaacagtg tattccaaag aggactaaag cgcctctcag gggctatgtg
     1441 tacttcttgt gcaagtcaga ctacagccaa cgacccttac acagttagaa gcaaaggccc
     1501 tcttaatgga tgtcatatct gaagtggctc agttacgggg ttcccgtgtg tgtgtgtgtg
     1561 tgtgtgtgtg t
//
