LOCUS       NM_005293               1564 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens G protein-coupled receptor 20 (GPR20), mRNA.
ACCESSION   NM_005293
VERSION     NM_005293.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1564)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   2  (bases 1 to 1564)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1564)
  AUTHORS   Hase,M., Yokomizo,T., Shimizu,T. and Nakamura,M.
  TITLE     Characterization of an orphan G protein-coupled receptor, GPR20,
            that constitutively activates Gi proteins
  JOURNAL   J Biol Chem 283 (19), 12747-12755 (2008)
   PUBMED   18347022
  REMARK    GeneRIF: GPR20 constitutively activates G(i) proteins without
            ligand stimulation
REFERENCE   4  (bases 1 to 1564)
  AUTHORS   O'Dowd,B.F., Nguyen,T., Jung,B.P., Marchese,A., Cheng,R.,
            Heng,H.H., Kolakowski,L.F. Jr., Lynch,K.R. and George,S.R.
  TITLE     Cloning and chromosomal mapping of four putative novel human
            G-protein-coupled receptor genes
  JOURNAL   Gene 187 (1), 75-81 (1997)
   PUBMED   9073069
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100803.11, DR006873.1, AB209066.1 and AA601037.1.
            
            On May 17, 2019 this sequence version replaced NM_005293.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.240271.1,
                                           DRR138518.303696.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377741.4/ ENSP00000366970.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC100803.11        58605-58625         c
            22-363              DR006873.1         28-369
            364-1534            AB209066.1         1-1171
            1535-1549           AA601037.1         3-17                c
            1550-1564           AC100803.11        47809-47823         c
FEATURES             Location/Qualifiers
     source          1..1564
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..1564
                     /gene="GPR20"
                     /note="G protein-coupled receptor 20"
                     /db_xref="GeneID:2843"
                     /db_xref="HGNC:HGNC:4475"
                     /db_xref="MIM:601908"
     exon            1..86
                     /gene="GPR20"
                     /inference="alignment:Splign:2.1.0"
     exon            87..1564
                     /gene="GPR20"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1187
                     /gene="GPR20"
                     /note="CTD-3064M3.3"
                     /codon_start=1
                     /product="G-protein coupled receptor 20"
                     /protein_id="NP_005284.2"
                     /db_xref="CCDS:CCDS34949.1"
                     /db_xref="GeneID:2843"
                     /db_xref="HGNC:HGNC:4475"
                     /db_xref="MIM:601908"
                     /translation="MPSVSPAGPSAGAVPNATAVTTVRTNASGLEVPLFHLFARLDEE
                     LHGTFPGLWLALMAVHGAIFLAGLVLNGLALYVFCCRTRAKTPSVIYTINLVVTDLLV
                     GLSLPTRFAVYYGARGCLRCAFPHVLGYFLNMHCSILFLTCICVDRYLAIVRPEGSRR
                     CRQPACARAVCAFVWLAAGAVTLSVLGVTGSRPCCRVFALTVLEFLLPLLVISVFTGR
                     IMCALSRPGLLHQGRQRRVRAMQLLLTVLIIFLVCFTPFHARQVAVALWPDMPHHTSL
                     VVYHVAVTLSSLNSCMDPIVYCFVTSGFQATVRGLFGQHGEREPSSGDVVSMHRSSKG
                     SGRHHILSAGPHALTQALANGPEA"
ORIGIN      
        1 gtcaggccgt aggaaggcga ggtccgggct gcatgcagag ctgagagctg aggactccca
       61 tctccagcct gcccgggtga agcgcggcct ggggtgtgct ggctgccgtc atgccctctg
      121 tgtctccagc ggggccctcg gccggggcag tccccaatgc caccgcagtg acaacagtgc
      181 ggaccaatgc cagcgggctg gaggtgcccc tgttccacct gtttgcccgg ctggacgagg
      241 agctgcatgg caccttccca ggcctgtggc tggcgctgat ggcggtgcac ggagccatct
      301 tcctggcagg gctggtgctc aacgggctgg cgctgtacgt cttctgctgc cgcacccggg
      361 ccaagacacc ctcagtcatc tacaccatca acctggtggt gaccgatcta ctggtagggc
      421 tgtccctgcc cacgcgcttc gctgtgtact acggcgccag gggctgcctg cgctgtgcct
      481 tcccgcacgt cctcggttac ttcctcaaca tgcactgctc catcctcttc ctcacctgca
      541 tctgcgtgga ccgctacctg gccatcgtgc ggcccgaagg ctcccgccgc tgccgccagc
      601 ctgcctgtgc cagggccgtg tgcgccttcg tgtggctggc cgccggtgcc gtcaccctgt
      661 cggtgctggg cgtgacaggc agccggccct gctgccgtgt ctttgcgctg actgtcctgg
      721 agttcctgct gcccctgctg gtcatcagcg tgtttaccgg ccgcatcatg tgtgcactgt
      781 cgcggccggg tctgctccac cagggtcgcc agcgccgcgt gcgggccatg cagctcctgc
      841 tcacggtgct catcatcttt ctcgtctgct tcacgccctt ccacgcccgc caagtggccg
      901 tggcgctgtg gcccgacatg ccacaccaca cgagcctcgt ggtctaccac gtggccgtga
      961 ccctcagcag cctcaacagc tgcatggacc ccatcgtcta ctgcttcgtc accagtggct
     1021 tccaggccac cgtccgaggc ctcttcggcc agcacggaga gcgtgagccc agcagcggtg
     1081 acgtggtcag catgcacagg agctccaagg gctcaggccg tcatcacatc ctcagtgccg
     1141 gccctcacgc cctcacccag gccctggcta atgggcccga ggcttagtca gcagggctct
     1201 gccaggggcc gaaggtcagg actcatctgg gcatgccagc gtggacaccc accatgccag
     1261 gggtggcaat cggttccatc tcgattgatt ggtgatggct acccagagca ccgcattgag
     1321 cgtctaaggc cactgtgctg tggttgatta gcaatgtctg ccactggctc cgatgggatg
     1381 tggtggcctg aatgccggtg atttgctgtt cctggggtat agcacgtcca ctgaaaactc
     1441 acaggggtag ccgggagctg ctcctcactt tggccagttt gtctccagaa ggagttcctc
     1501 agaaaaaagg gcacagtgga ttccattgat tagaaggatg agatgaaaaa gaaaaaagaa
     1561 aaaa
//
