LOCUS       NM_006143               1910 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens G protein-coupled receptor 19 (GPR19), mRNA.
ACCESSION   NM_006143
VERSION     NM_006143.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1910)
  AUTHORS   Gerlach,L., Beyer,A.L., Kaemmerer,D., Sanger,J., Evert,K.,
            Schulz,S. and Lupp,A.
  TITLE     Expression of G protein-coupled receptor GPR19 in normal and
            neoplastic human tissues
  JOURNAL   Sci Rep 13 (1), 18993 (2023)
   PUBMED   37923782
  REMARK    GeneRIF: Expression of G protein-coupled receptor GPR19 in normal
            and neoplastic human tissues.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1910)
  AUTHORS   Maudsley,S., Schrauwen,C., Harputluoglu,I., Walter,D., Leysen,H.
            and McDonald,P.
  TITLE     GPR19 Coordinates Multiple Molecular Aspects of Stress Responses
            Associated with the Aging Process
  JOURNAL   Int J Mol Sci 24 (10), 8499 (2023)
   PUBMED   37239845
  REMARK    GeneRIF: GPR19 Coordinates Multiple Molecular Aspects of Stress
            Responses Associated with the Aging Process.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1910)
  AUTHORS   Rao,A. and Herr,D.R.
  TITLE     G protein-coupled receptor GPR19 regulates E-cadherin expression
            and invasion of breast cancer cells
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1864 (7), 1318-1327 (2017)
   PUBMED   28476646
  REMARK    GeneRIF: GPR19 overexpression drives MDA-MB-231 cells towards an
            epithelial phenotype.  GPR19 upregulates E-cadherin via MAPK/ERK1/2
            pathway.
REFERENCE   4  (bases 1 to 1910)
  AUTHORS   Badgandi,H.B., Hwang,S.H., Shimada,I.S., Loriot,E. and
            Mukhopadhyay,S.
  TITLE     Tubby family proteins are adapters for ciliary trafficking of
            integral membrane proteins
  JOURNAL   J Cell Biol 216 (3), 743-760 (2017)
   PUBMED   28154160
REFERENCE   5  (bases 1 to 1910)
  AUTHORS   Yang,W., Tang,H., Zhang,Y., Tang,X., Zhang,J., Sun,L., Yang,J.,
            Cui,Y., Zhang,L., Hirankarn,N., Cheng,H., Pan,H.F., Gao,J.,
            Lee,T.L., Sheng,Y., Lau,C.S., Li,Y., Chan,T.M., Yin,X., Ying,D.,
            Lu,Q., Leung,A.M., Zuo,X., Chen,X., Tong,K.L., Zhou,F., Diao,Q.,
            Tse,N.K., Xie,H., Mok,C.C., Hao,F., Wong,S.N., Shi,B., Lee,K.W.,
            Hui,Y., Ho,M.H., Liang,B., Lee,P.P., Cui,H., Guo,Q., Chung,B.H.,
            Pu,X., Liu,Q., Zhang,X., Zhang,C., Chong,C.Y., Fang,H., Wong,R.W.,
            Sun,Y., Mok,M.Y., Li,X.P., Avihingsanon,Y., Zhai,Z.,
            Rianthavorn,P., Deekajorndej,T., Suphapeetiporn,K., Gao,F.,
            Shotelersuk,V., Kang,X., Ying,S.K., Zhang,L., Wong,W.H., Zhu,D.,
            Fung,S.K., Zeng,F., Lai,W.M., Wong,C.M., Ng,I.O.,
            Garcia-Barcelo,M.M., Cherny,S.S., Shen,N., Tam,P.K., Sham,P.C.,
            Ye,D.Q., Yang,S., Zhang,X. and Lau,Y.L.
  TITLE     Meta-analysis followed by replication identifies loci in or near
            CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic
            lupus erythematosus in Asians
  JOURNAL   Am J Hum Genet 92 (1), 41-51 (2013)
   PUBMED   23273568
REFERENCE   6  (bases 1 to 1910)
  AUTHORS   Kastner,S., Voss,T., Keuerleber,S., Glockel,C., Freissmuth,M. and
            Sommergruber,W.
  TITLE     Expression of G protein-coupled receptor 19 in human lung cancer
            cells is triggered by entry into S-phase and supports G(2)-M
            cell-cycle progression
  JOURNAL   Mol Cancer Res 10 (10), 1343-1358 (2012)
   PUBMED   22912338
  REMARK    GeneRIF: G protein-coupled receptor 19 (GPR19) was found frequently
            overexpressed in tissue samples obtained from patients with small
            cell lung cancer.
REFERENCE   7  (bases 1 to 1910)
  AUTHORS   Montpetit,A. and Sinnett,D.
  TITLE     Physical mapping of the G-protein coupled receptor 19 (GPR19) in
            the chromosome 12p12.3 region frequently rearranged in cancer cells
  JOURNAL   Hum Genet 105 (1-2), 162-164 (1999)
   PUBMED   10480372
REFERENCE   8  (bases 1 to 1910)
  AUTHORS   O'Dowd,B.F., Nguyen,T., Lynch,K.R., Kolakowski,L.F. Jr.,
            Thompson,M., Cheng,R., Marchese,A., Ng,G., Heng,H.H. and
            George,S.R.
  TITLE     A novel gene codes for a putative G protein-coupled receptor with
            an abundant expression in brain
  JOURNAL   FEBS Lett 394 (3), 325-329 (1996)
   PUBMED   8830667
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008115.4.
            
            On Nov 23, 2018 this sequence version replaced NM_006143.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.674564.1, DB022290.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2153932
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651487.1/ ENSP00000498976.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AC008115.4         126034-126152       c
            120-172             AC008115.4         125428-125480       c
            173-329             AC008115.4         114320-114476       c
            330-1910            AC008115.4         90859-92439         c
FEATURES             Location/Qualifiers
     source          1..1910
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.1"
     gene            1..1910
                     /gene="GPR19"
                     /note="G protein-coupled receptor 19"
                     /db_xref="GeneID:2842"
                     /db_xref="HGNC:HGNC:4473"
                     /db_xref="MIM:602927"
     exon            1..119
                     /gene="GPR19"
                     /inference="alignment:Splign:2.1.0"
     exon            120..172
                     /gene="GPR19"
                     /inference="alignment:Splign:2.1.0"
     exon            173..329
                     /gene="GPR19"
                     /inference="alignment:Splign:2.1.0"
     exon            330..1910
                     /gene="GPR19"
                     /inference="alignment:Splign:2.1.0"
     CDS             352..1599
                     /gene="GPR19"
                     /note="GPR-NGA"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 19"
                     /protein_id="NP_006134.2"
                     /db_xref="CCDS:CCDS8652.1"
                     /db_xref="GeneID:2842"
                     /db_xref="HGNC:HGNC:4473"
                     /db_xref="MIM:602927"
                     /translation="MVFAHRMDNSKPHLIIPTLLVPLQNRSCTETATPLPSQYLMELS
                     EEHSWMSNQTDLHYVLKPGEVATASIFFGILWLFSIFGNSLVCLVIHRSRRTQSTTNY
                     FVVSMACADLLISVASTPFVLLQFTTGRWTLGSATCKVVRYFQYLTPGVQIYVLLSIC
                     IDRFYTIVYPLSFKVSREKAKKMIAASWVFDAGFVTPVLFFYGSNWDSHCNYFLPSSW
                     EGTAYTVIHFLVGFVIPSVLIILFYQKVIKYIWRIGTDGRTVRRTMNIVPRTKVKTIK
                     MFLILNLLFLLSWLPFHVAQLWHPHEQDYKKSSLVFTAITWISFSSSASKPTLYSIYN
                     ANFRRGMKETFCMSSMKCYRSNAYTITTSSRMAKKNYVGISEIPSMAKTITKDSIYDS
                     FDREAKEKKLAWPINSNPPNTFV"
     regulatory      1632..1637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR19"
                     /note="hexamer: ATTAAA"
     polyA_site      1655
                     /gene="GPR19"
                     /note="major polyA site"
     polyA_site      1739
                     /gene="GPR19"
     regulatory      1888..1893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR19"
                     /note="hexamer: CATAAA"
     polyA_site      1910
                     /gene="GPR19"
ORIGIN      
        1 ccgcctagtg agaggcggtc cgatttggcc cttggggagt gtccgtcgcg ttgatctgat
       61 ggattcacgt acacaacacc acattctatg agattttgca ggcaaaagtc cacaagctcg
      121 atatatggga cacctgcacc ggcattggat ttggccccgc aacatcttaa aggaagcagg
      181 ctgtgagcca aggggaaggc agaggacaga aatgaatgtg tttccaggct ttcctggtgg
      241 tttatggcat tctccaaact cctatgcaag ggctattcct gaccaagaag atctaaagag
      301 aacgtctctg aaatcaagtc cggatgaaga attaagagaa aaaaagtgaa tatggttttt
      361 gctcacagaa tggataacag caagccacat ttgattattc ctacacttct ggtgcccctc
      421 caaaaccgca gctgcactga aacagccaca cctctgccaa gccaatacct gatggaatta
      481 agtgaggagc acagttggat gagcaaccaa acagaccttc actatgtgct gaaacccggg
      541 gaagtggcca cagccagcat cttctttggg attctgtggt tgttttctat cttcggcaat
      601 tccctggttt gtttggtcat ccataggagt aggaggactc agtctaccac caactacttt
      661 gtggtctcca tggcatgtgc tgaccttctc atcagcgttg ccagcacgcc tttcgtcctg
      721 ctccagttca ccactggaag gtggacgctg ggtagtgcaa cgtgcaaggt tgtgcgatat
      781 tttcaatatc tcactccagg tgtccagatc tacgttctcc tctccatctg catagaccgg
      841 ttctacacca tcgtctatcc tctgagcttc aaggtgtcca gagaaaaagc caagaaaatg
      901 attgcggcat cgtgggtctt tgatgcaggc tttgtgaccc ctgtgctctt tttctatggc
      961 tccaactggg acagtcattg taactatttc ctcccctcct cttgggaagg cactgcctac
     1021 actgtcatcc acttcttggt gggctttgtg attccatctg tcctcataat tttattttac
     1081 caaaaggtca taaaatatat ttggagaata ggcacagatg gccgaacggt gaggaggaca
     1141 atgaacattg tccctcggac aaaagtgaaa actatcaaga tgttcctcat tttaaatctg
     1201 ttgtttttgc tctcctggct gccttttcat gtagctcagc tatggcaccc ccatgaacaa
     1261 gactataaga aaagttccct tgttttcaca gctatcacat ggatatcctt tagttcttca
     1321 gcctctaaac ctactctgta ttcaatttat aatgccaatt ttcggagagg gatgaaagag
     1381 actttttgca tgtcctctat gaaatgttac cgaagcaatg cctatactat cacaacaagt
     1441 tcaaggatgg ccaaaaaaaa ctacgttggc atttcagaaa tcccttccat ggccaaaact
     1501 attaccaaag actcgatcta tgactcattt gacagagaag ccaaggaaaa aaagcttgct
     1561 tggcccatta actcaaatcc accaaatact tttgtctaag ttctcattct ttcaattgtt
     1621 atgcaccaga gattaaaaag ctttaactat aaaaacagaa gctatttaca tatttgtttt
     1681 cactcaactt tccaagggaa atgttttatt ttgtaaaatg cattcatttg tttactgtag
     1741 tttttgtggg ttttatttta cttgcttttt atgttttagg aaaagcgttc actttgaact
     1801 ttagccaaca gtccttttac tattaatata ttagttacat gcataaaaaa gaaaatgctt
     1861 tcttactatt tactgttggt tcaaaaacat aaacctaagc catacacaca
//
