LOCUS       NM_004951               1685 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens G protein-coupled receptor 183 (GPR183), mRNA.
ACCESSION   NM_004951
VERSION     NM_004951.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1685)
  AUTHORS   Guigues,A., Gimenez,S., Mettling,C., Maurel,D., Doumazane,E.,
            Prezeau,L., Francois,V. and Corbeau,P.
  TITLE     The EBI2 receptor is coexpressed with CCR5 in CD4 + T cells and
            boosts HIV-1 R5 replication
  JOURNAL   AIDS 38 (10), 1449-1459 (2024)
   PUBMED   38770825
  REMARK    GeneRIF: The EBI2 receptor is coexpressed with CCR5 in CD4 + T
            cells and boosts HIV-1 R5 replication.
REFERENCE   2  (bases 1 to 1685)
  AUTHORS   Hu,L., An,K., Zhang,Y. and Bai,C.
  TITLE     Exploring the Activation Mechanism of the GPR183 Receptor
  JOURNAL   J Phys Chem B 128 (25), 6071-6081 (2024)
   PUBMED   38877985
  REMARK    GeneRIF: Exploring the Activation Mechanism of the GPR183 Receptor.
REFERENCE   3  (bases 1 to 1685)
  AUTHORS   Zhang,F., Zhang,B., Ding,H., Li,X., Wang,X., Zhang,X., Liu,Q.,
            Feng,Q., Han,M., Chen,L., Qi,L., Yang,D., Li,X., Zhu,X., Zhao,Q.,
            Qiu,J., Zhu,Z., Tang,H., Shen,N., Wang,H. and Wei,B.
  TITLE     The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to
            Limit IFN Response and Systemic Lupus Erythematosus
  JOURNAL   Adv Sci (Weinh) 10 (27), e2207108 (2023)
   PUBMED   37469011
  REMARK    GeneRIF: The Oxysterol Receptor EBI2 Links Innate and Adaptive
            Immunity to Limit IFN Response and Systemic Lupus Erythematosus.
REFERENCE   4  (bases 1 to 1685)
  AUTHORS   Zhao,M., Mei,Y., Zhao,Z., Cao,P., Xin,Y., Guo,Y., Yang,M. and Wu,H.
  TITLE     Abnormal lower expression of GPR183 in peripheral blood T and B
            cell subsets of systemic lupus erythematosus patients
  JOURNAL   Autoimmunity 55 (7), 429-442 (2022)
   PUBMED   35875859
  REMARK    GeneRIF: Abnormal lower expression of GPR183 in peripheral blood T
            and B cell subsets of systemic lupus erythematosus patients.
REFERENCE   5  (bases 1 to 1685)
  AUTHORS   Copperi,F., Schleis,I., Roumain,M., Muccioli,G.G., Casola,S.,
            Klingenspor,M., Pfeifer,A. and Gnad,T.
  TITLE     EBI2 is a negative modulator of brown adipose tissue energy
            expenditure in mice and human brown adipocytes
  JOURNAL   Commun Biol 5 (1), 280 (2022)
   PUBMED   35351968
  REMARK    GeneRIF: EBI2 is a negative modulator of brown adipose tissue
            energy expenditure in mice and human brown adipocytes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1685)
  AUTHORS   Benned-Jensen,T., Smethurst,C., Holst,P.J., Page,K.R., Sauls,H.,
            Sivertsen,B., Schwartz,T.W., Blanchard,A., Jepras,R. and
            Rosenkilde,M.M.
  TITLE     Ligand modulation of the Epstein-Barr virus-induced
            seven-transmembrane receptor EBI2: identification of a potent and
            efficacious inverse agonist
  JOURNAL   J Biol Chem 286 (33), 29292-29302 (2011)
   PUBMED   21673108
REFERENCE   7  (bases 1 to 1685)
  AUTHORS   Norregaard,K., Benned-Jensen,T. and Rosenkilde,M.M.
  TITLE     EBI2, GPR18 and GPR17--three structurally related, but biologically
            distinct 7TM receptors
  JOURNAL   Curr Top Med Chem 11 (6), 618-628 (2011)
   PUBMED   21261596
  REMARK    GeneRIF: REVIEW: functional properties and in vivo biology
            Review article
REFERENCE   8  (bases 1 to 1685)
  AUTHORS   Benned-Jensen,T. and Rosenkilde,M.M.
  TITLE     Structural motifs of importance for the constitutive activity of
            the orphan 7TM receptor EBI2: analysis of receptor activation in
            the absence of an agonist
  JOURNAL   Mol Pharmacol 74 (4), 1008-1021 (2008)
   PUBMED   18628402
  REMARK    GeneRIF: Structural motifs of importance for the constitutive
            activity of EBI2: analysis of receptor activation in the absence of
            an agonist.
REFERENCE   9  (bases 1 to 1685)
  AUTHORS   Rosenkilde,M.M., Benned-Jensen,T., Andersen,H., Holst,P.J.,
            Kledal,T.N., Luttichau,H.R., Larsen,J.K., Christensen,J.P. and
            Schwartz,T.W.
  TITLE     Molecular pharmacological phenotyping of EBI2. An orphan
            seven-transmembrane receptor with constitutive activity
  JOURNAL   J Biol Chem 281 (19), 13199-13208 (2006)
   PUBMED   16540462
  REMARK    GeneRIF: Based on the constitutive signaling and cellular
            expression pattern of EBI2, it is suggested that it may function in
            conjunction with BILF1 in the reprogramming of the cell during EBV
            infection
REFERENCE   10 (bases 1 to 1685)
  AUTHORS   Birkenbach,M., Josefsen,K., Yalamanchili,R., Lenoir,G. and Kieff,E.
  TITLE     Epstein-Barr virus-induced genes: first lymphocyte-specific G
            protein-coupled peptide receptors
  JOURNAL   J Virol 67 (4), 2209-2220 (1993)
   PUBMED   8383238
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313443.1, BC020752.1 and
            AW574697.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004951.4.
            
            Summary: This gene was identified by the up-regulation of its
            expression upon Epstein-Barr virus infection of primary B
            lymphocytes. This gene is predicted to encode a G protein-coupled
            receptor that is most closely related to the thrombin receptor.
            Expression of this gene was detected in B-lymphocyte cell lines and
            lymphoid tissues but not in T-lymphocyte cell lines or peripheral
            blood T lymphocytes. The function of this gene is unknown.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223390.1, BC020752.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149004, SAMEA2154361
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376414.5/ ENSP00000365596.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-613               AK313443.1         97-709
            614-1680            BC020752.1         614-1680
            1681-1685           AW574697.1         21-25               c
FEATURES             Location/Qualifiers
     source          1..1685
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q32.3"
     gene            1..1685
                     /gene="GPR183"
                     /gene_synonym="EBI2; hEBI2"
                     /note="G protein-coupled receptor 183"
                     /db_xref="GeneID:1880"
                     /db_xref="HGNC:HGNC:3128"
                     /db_xref="MIM:605741"
     exon            1..60
                     /gene="GPR183"
                     /gene_synonym="EBI2; hEBI2"
                     /inference="alignment:Splign:2.1.0"
     exon            61..1685
                     /gene="GPR183"
                     /gene_synonym="EBI2; hEBI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1164
                     /gene="GPR183"
                     /gene_synonym="EBI2; hEBI2"
                     /note="Epstein-Barr virus induced gene 2
                     (lymphocyte-specific G protein-coupled receptor);
                     EBV-induced G-protein coupled receptor 2; epstein-Barr
                     virus-induced G-protein coupled receptor 2"
                     /codon_start=1
                     /product="G-protein coupled receptor 183"
                     /protein_id="NP_004942.1"
                     /db_xref="CCDS:CCDS9492.1"
                     /db_xref="GeneID:1880"
                     /db_xref="HGNC:HGNC:3128"
                     /db_xref="MIM:605741"
                     /translation="MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFII
                     GLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDA
                     LCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVF
                     AQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQ
                     ICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSN
                     FLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSA
                     VKSAPEENSREMTETQMMIHSKSSNGK"
     regulatory      1663..1668
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR183"
                     /gene_synonym="EBI2; hEBI2"
                     /note="hexamer: AATAAA"
     polyA_site      1685
                     /gene="GPR183"
                     /gene_synonym="EBI2; hEBI2"
                     /note="major polyA site"
ORIGIN      
        1 acttcagttt ggacaactac tcacagctac tacacagaga cccgaacgag tcactgatat
       61 acacctggac caccaccaat ggatatacaa atggcaaaca attttactcc gccctctgca
      121 actcctcagg gaaatgactg tgacctctat gcacatcaca gcacggccag gatagtaatg
      181 cctctgcatt acagcctcgt cttcatcatt gggctcgtgg gaaacttact agccttggtc
      241 gtcattgttc aaaacaggaa aaaaatcaac tctaccaccc tctattcaac aaatttggtg
      301 atttctgata tactttttac caccgctttg cctacacgaa tagcctacta tgcaatgggc
      361 tttgactgga gaatcggaga tgccttgtgt aggataactg cgctagtgtt ttacatcaac
      421 acatatgcag gtgtgaactt tatgacctgc ctgagtattg accgcttcat tgctgtggtg
      481 caccctctac gctacaacaa gataaaaagg attgaacatg caaaaggcgt gtgcatattt
      541 gtctggattc tagtatttgc tcagacactc ccactcctca tcaaccctat gtcaaagcag
      601 gaggctgaaa ggattacatg catggagtat ccaaactttg aagaaactaa atctcttccc
      661 tggattctgc ttggggcatg tttcatagga tatgtacttc cacttataat cattctcatc
      721 tgctattctc agatctgctg caaactcttc agaactgcca aacaaaaccc actcactgag
      781 aaatctggtg taaacaaaaa ggctctcaac acaattattc ttattattgt tgtgtttgtt
      841 ctctgtttca caccttacca tgttgcaatt attcaacata tgattaagaa gcttcgtttc
      901 tctaatttcc tggaatgtag ccaaagacat tcgttccaga tttctctgca ctttacagta
      961 tgcctgatga acttcaattg ctgcatggac ccttttatct acttctttgc atgtaaaggg
     1021 tataagagaa aggttatgag gatgctgaaa cggcaagtca gtgtatcgat ttctagtgct
     1081 gtgaagtcag cccctgaaga aaattcacgt gaaatgacag aaacgcagat gatgatacat
     1141 tccaagtctt caaatggaaa gtgaaatgga ttgtattttg gtttatagtg acgtaaactg
     1201 tatgacaaac tttgcaggac ttcccttata aagcaaaata attgttcagc ttccaattag
     1261 tattctttta tatttctttc attgggcact ttcccatctc caactcggaa gtaagcccaa
     1321 gagaacaaca taaagcaaac aacataaagc acaataaaaa tgcaaataaa tatttcattt
     1381 ttatttgtaa acgaatacac caaaaggagg cgctcttaat aactcccaat gtaaaaagtt
     1441 ttgttttaat aaaaaattta attattattt cttgccaaca aatggctaga aaggactgaa
     1501 tagattatat attgccagat gttaatactg taacatactt tttaaataac atatttctta
     1561 aatccaaatt tctctcaatg ttagatttaa ttccctcaat aacaccaatg ttttgttttg
     1621 tttcgttctg ggtcataaaa ctttgttaag gaactctttt ggaataaaga gcaggatgct
     1681 gcaaa
//
