LOCUS       NM_007264               3411 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens G protein-coupled receptor 182 (GPR182), mRNA.
ACCESSION   NM_007264
VERSION     NM_007264.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3411)
  AUTHORS   Torphy,R.J., Sun,Y., Lin,R., Caffrey-Carr,A., Fujiwara,Y., Ho,F.,
            Miller,E.N., McCarter,M.D., Lyons,T.R., Schulick,R.D., Kedl,R.M.
            and Zhu,Y.
  TITLE     GPR182 limits antitumor immunity via chemokine scavenging in mouse
            melanoma models
  JOURNAL   Nat Commun 13 (1), 97 (2022)
   PUBMED   35013216
  REMARK    GeneRIF: GPR182 limits antitumor immunity via chemokine scavenging
            in mouse melanoma models.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3411)
  AUTHORS   Le Mercier,A., Bonnavion,R., Yu,W., Alnouri,M.W., Ramas,S.,
            Zhang,Y., Jager,Y., Roquid,K.A., Jeong,H.W., Sivaraj,K.K., Cho,H.,
            Chen,X., Strilic,B., Sijmonsma,T., Adams,R., Schroeder,T.,
            Rieger,M.A. and Offermanns,S.
  TITLE     GPR182 is an endothelium-specific atypical chemokine receptor that
            maintains hematopoietic stem cell homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 118 (17) (2021)
   PUBMED   33875597
  REMARK    GeneRIF: GPR182 is an endothelium-specific atypical chemokine
            receptor that maintains hematopoietic stem cell homeostasis.
REFERENCE   3  (bases 1 to 3411)
  AUTHORS   Schmid,C.D., Schledzewski,K., Mogler,C., Waldburger,N., Kalna,V.,
            Marx,A., Randi,A.M., Geraud,C., Goerdt,S. and Koch,P.S.
  TITLE     GPR182 is a novel marker for sinusoidal endothelial differentiation
            with distinct GPCR signaling activity in vitro
  JOURNAL   Biochem Biophys Res Commun 497 (1), 32-38 (2018)
   PUBMED   29408502
  REMARK    GeneRIF: Our data demonstrate that GPR182 is an endothelial
            subtype-specific marker for human sinusoidal EC of the liver,
            spleen, lymph node and bone marrow. In addition, we provide
            evidence for GPR182-dependent downstream signaling via ERK and SRF
            pathways that may be involved in regulating endothelial
            subtype-specific sinusoidal differentiation and sinusoidal
            functions such as permeability.
REFERENCE   4  (bases 1 to 3411)
  AUTHORS   Wong,C.W., O,W.S. and Tang,F.
  TITLE     Intermedin in rat uterus: changes in gene expression and peptide
            levels across the estrous cycle and its effects on uterine
            contraction
  JOURNAL   Reprod Biol Endocrinol 11, 13 (2013)
   PUBMED   23442365
  REMARK    GeneRIF: Gene expression of adrenomedullin receptor components are
            differentially regulated in the uterus during the estrous cycle.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3411)
  AUTHORS   Ramachandran,V., Arumugam,T., Langley,R., Hwang,R.F.,
            Vivas-Mejia,P., Sood,A.K., Lopez-Berestein,G. and Logsdon,C.D.
  TITLE     The ADMR receptor mediates the effects of adrenomedullin on
            pancreatic cancer cells and on cells of the tumor microenvironment
  JOURNAL   PLoS One 4 (10), e7502 (2009)
   PUBMED   19847298
  REMARK    GeneRIF: ADMR mediates the stimulatory effects of adrenomedullin on
            cancer cells and on endothelial and stellate cells within the tumor
            microenvironment
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3411)
  AUTHORS   Kennedy,S.P., Sun,D., Oleynek,J.J., Hoth,C.F., Kong,J. and
            Hill,R.J.
  TITLE     Expression of the rat adrenomedullin receptor or a putative human
            adrenomedullin receptor does not correlate with adrenomedullin
            binding or functional response
  JOURNAL   Biochem Biophys Res Commun 244 (3), 832-837 (1998)
   PUBMED   9535752
  REMARK    GeneRIF: This putative G protein-coupled receptor remains an
            orphan, as the ability to bind and be activated by adrenomedullin
            has been refuted.  A complex of CRLR and RAMP2 or RAMP3 gives a
            functional adrenomedullin receptor.
REFERENCE   7  (bases 1 to 3411)
  AUTHORS   Martinez,A., Elsasser,T.H., Muro-Cacho,C., Moody,T.W., Miller,M.J.,
            Macri,C.J. and Cuttitta,F.
  TITLE     Expression of adrenomedullin and its receptor in normal and
            malignant human skin: a potential pluripotent role in the
            integument
  JOURNAL   Endocrinology 138 (12), 5597-5604 (1997)
   PUBMED   9389548
REFERENCE   8  (bases 1 to 3411)
  AUTHORS   Hanze,J., Dittrich,K., Dotsch,J. and Rascher,W.
  TITLE     Molecular cloning of a novel human receptor gene with homology to
            the rat adrenomedullin receptor and high expression in heart and
            immune system
  JOURNAL   Biochem Biophys Res Commun 240 (1), 183-188 (1997)
   PUBMED   9367907
REFERENCE   9  (bases 1 to 3411)
  AUTHORS   Martinez,A., Miller,M.J., Catt,K.J. and Cuttitta,F.
  TITLE     Adrenomedullin receptor expression in human lung and in pulmonary
            tumors
  JOURNAL   J Histochem Cytochem 45 (2), 159-164 (1997)
   PUBMED   9016306
REFERENCE   10 (bases 1 to 3411)
  AUTHORS   Kato,J., Kitamura,K., Kangawa,K. and Eto,T.
  TITLE     Receptors for adrenomedullin in human vascular endothelial cells
  JOURNAL   Eur J Pharmacol 289 (2), 383-385 (1995)
   PUBMED   7621913
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026120.33 and BC034761.1.
            
            On Nov 22, 2018 this sequence version replaced NM_007264.3.
            
            Summary: Adrenomedullin is a potent vasodilator peptide that exerts
            major effects on cardiovascular function. This gene encodes a
            seven-transmembrane protein that belongs to the family 1 of
            G-protein coupled receptors. Studies of the rat counterpart suggest
            that the encoded protein may function as a receptor for
            adrenomedullin. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP340154.1, BC034761.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300098.3/ ENSP00000300098.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC026120.33        96395-96473
            80-1649             BC034761.1         126-1695
            1650-3411           AC026120.33        98589-100350
FEATURES             Location/Qualifiers
     source          1..3411
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..3411
                     /gene="GPR182"
                     /gene_synonym="7TMR; ADMR; AM-R; AMR; G10D; gamrh; hrhAMR;
                     L1-R"
                     /note="G protein-coupled receptor 182"
                     /db_xref="GeneID:11318"
                     /db_xref="HGNC:HGNC:13708"
                     /db_xref="MIM:605307"
     exon            1..157
                     /gene="GPR182"
                     /gene_synonym="7TMR; ADMR; AM-R; AMR; G10D; gamrh; hrhAMR;
                     L1-R"
                     /inference="alignment:Splign:2.1.0"
     exon            158..3411
                     /gene="GPR182"
                     /gene_synonym="7TMR; ADMR; AM-R; AMR; G10D; gamrh; hrhAMR;
                     L1-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..1388
                     /gene="GPR182"
                     /gene_synonym="7TMR; ADMR; AM-R; AMR; G10D; gamrh; hrhAMR;
                     L1-R"
                     /note="adrenomedullin receptor"
                     /codon_start=1
                     /product="G-protein coupled receptor 182"
                     /protein_id="NP_009195.1"
                     /db_xref="CCDS:CCDS8927.1"
                     /db_xref="GeneID:11318"
                     /db_xref="HGNC:HGNC:13708"
                     /db_xref="MIM:605307"
                     /translation="MSVKPSWGPGPSEGVTAVPTSDLGEIHNWTELLDLFNHTLSECH
                     VELSQSTKRVVLFALYLAMFVVGLVENLLVICVNWRGSGRAGLMNLYILNMAIADLGI
                     VLSLPVWMLEVTLDYTWLWGSFSCRFTHYFYFVNMYSSIFFLVCLSVDRYVTLTSASP
                     SWQRYQHRVRRAMCAGIWVLSAIIPLPEVVHIQLVEGPEPMCLFMAPFETYSTWALAV
                     ALSTTILGFLLPFPLITVFNVLTACRLRQPGQPKSRRHCLLLCAYVAVFVMCWLPYHV
                     TLLLLTLHGTHISLHCHLVHLLYFFYDVIDCFSMLHCVINPILYNFLSPHFRGRLLNA
                     VVHYLPKDQTKAGTCASSSSCSTQHSIIITKGDSQPAAAAPHPEPSLSFQAHHLLPNT
                     SPISPTQPLTPS"
     regulatory      1625..1630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR182"
                     /gene_synonym="7TMR; ADMR; AM-R; AMR; G10D; gamrh; hrhAMR;
                     L1-R"
                     /note="hexamer: AATAAA"
     polyA_site      1645
                     /gene="GPR182"
                     /gene_synonym="7TMR; ADMR; AM-R; AMR; G10D; gamrh; hrhAMR;
                     L1-R"
                     /note="major polyA site"
     regulatory      3385..3390
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR182"
                     /gene_synonym="7TMR; ADMR; AM-R; AMR; G10D; gamrh; hrhAMR;
                     L1-R"
                     /note="hexamer: ATTAAA"
     polyA_site      3411
                     /gene="GPR182"
                     /gene_synonym="7TMR; ADMR; AM-R; AMR; G10D; gamrh; hrhAMR;
                     L1-R"
ORIGIN      
        1 agcagtgaca gctacttccc ggatgagaag ggcggccgtg aagccagcag ggaagccagc
       61 cccacagcca agggcccccc agcctcctca cagctcccca tagcctggac ctgccggccc
      121 tccctccagg accgaggggc tcccaaggga aactcaggcg tgtgctggtc ccaatgtcag
      181 tgaaacccag ctgggggcct ggcccctcgg agggggtcac cgcagtgcct accagtgacc
      241 ttggagagat ccacaactgg accgagctgc ttgacctctt caaccacact ttgtctgagt
      301 gccacgtgga gctcagccag agcaccaagc gcgtggtcct ctttgccctc tacctggcca
      361 tgtttgtggt tgggctggtg gagaacctcc tggtgatatg cgtcaactgg cgcggctcag
      421 gccgggcagg gctgatgaac ctctacatcc tcaacatggc catcgcggac ctgggcattg
      481 tcctgtctct gcccgtgtgg atgctggagg tcacgctgga ctacacctgg ctctggggca
      541 gcttctcctg ccgcttcact cactacttct actttgtcaa catgtatagc agcatcttct
      601 tcctggtgtg cctcagtgtc gaccgctatg tcaccctcac cagcgcctcc ccctcctggc
      661 agcgttacca gcaccgagtg cggcgggcca tgtgtgcagg catctgggtc ctctcggcca
      721 tcatcccgct gcctgaggtg gtccacatcc agctggtgga gggccctgag cccatgtgcc
      781 tcttcatggc accttttgaa acgtacagca cctgggccct ggcggtggcc ctgtccacca
      841 ccatcctggg cttcctgctg cccttccctc tcatcacagt cttcaatgtg ctgacagcct
      901 gccggctgcg gcagccagga caacccaaga gccggcgcca ctgcctgctg ctgtgcgcct
      961 acgtggccgt ctttgtcatg tgctggctgc cctatcatgt gaccctgctg ctgctcacac
     1021 tgcatgggac ccacatctcc ctccactgcc acctggtcca cctgctctac ttcttctatg
     1081 atgtcattga ctgcttctcc atgctgcact gtgtcatcaa ccccatcctt tacaactttc
     1141 tcagcccaca cttccggggc cggctcctga atgctgtagt ccattacctt cctaaggacc
     1201 agaccaaggc gggcacatgc gcctcctctt cctcctgttc cacccagcat tccatcatca
     1261 tcaccaaggg tgatagccag cctgctgcag cagcccccca ccctgagcca agcctgagct
     1321 ttcaggcaca ccatttgctt ccaaatactt cccccatctc tcccactcag cctcttacac
     1381 ccagctgagg tagaggccag actcctccaa cagtgaagga aaaggcacag gtgagagtat
     1441 aggtgggaga tttgggggga tgtagagggg agggtcaaag cactcgtggt caattttgaa
     1501 tctatcttaa aatactgagg tgtggagaga gagacaggat caggagcgat agagagcagg
     1561 ccctcagtgt tgtactattt gtctcggtcc ttgtgtctaa ggagcaatgc agaaaaaaag
     1621 gtgaaataaa tggaagagat agccatggac tctggatctt ttaaaaatct gcacttccag
     1681 ctgggattgg gaagggagct gaggctaaag aggtgctcgg cagaggaaac tagacacatt
     1741 catttcataa atcactctgg ctggaaacag tgaactctgc aggaacctca caaaactcct
     1801 tttgcgtttg tgagcttgtt gatcttccag ctcactatgc aggttatggg gacaagaggc
     1861 cagaggccaa ggaaccaggc ggccccagca ggacgttccc tagctgtgca tcctatgcac
     1921 agccatgata agtgaaggcg gatggggatg gcaggggtgg gggcgaagcc aaggtctgag
     1981 acctgcaccc tgcagctggg tcagcaggat ggtatctcca cccgcggcca tccaggaaac
     2041 acagctccat ttccttgctg acaccctccc ctccccgttg tccatcctgc tccctcccca
     2101 caagcaagag gagttgtccc agagtcagct cctcatagct gacctcttac cagcttcgga
     2161 tctaggaaac ttccagactt ctagggagac acagagctac cagaaagccc aacccacccc
     2221 catctctttc tctccagatc ataggaaagt atcaagggat gtcattccgg gagcagccct
     2281 tgggacagcc agcagcaggt gctggcagat gctctgtcct tcaccctctg tccccggcac
     2341 cagatgggga aggccacagt ggaaacttct caattccgtc acagggcaga gctctgacac
     2401 tgttataagt cagttctccc tggccatgtc ttttcctaat tttcctgtcc cacaacttag
     2461 gttccttaac acttgttcta cagatgaaac aaaaaagtcc tctgttaaca agtagacctt
     2521 ctggaaaagg atcacttatg tttgggagac taggaccctg tccatgaaga actctgaagt
     2581 aaaggcctaa gaacaggatc tagtttccgc cttccaattc cacgtccttt gcctcttaat
     2641 cctgcccgtg gtaaggggac tggatggaat cactgatagc ctcttcacca tctcctctgt
     2701 cctgcttaag tgctccatgt gtctggaatg tttaacttgg agtaactact cactgacttg
     2761 gagaccacct gttctacttt gagaaatcag aactgttctg tggatgcact gacagcgtgc
     2821 tccaactgca tatgcaccca ggtttgtcag gagcatggaa ggaaacctgc atctccctgt
     2881 ttactgggcc caaacctgaa agggtcttaa gctgcagaca gcttctcagt agcacagagc
     2941 tgaaggcttt ttgaaccagg agtctgggtt gtggcttggg tcgcagtaag ggcttagcct
     3001 atcaatgcag aattcacatt gaaaaagact ttcctctctt gtcccaacac aaaaaagcaa
     3061 gccaagatct gatgcccata tcactgcctc ctctgacttg ggctacagga gtttcctgaa
     3121 ggaaaccaaa ttttacatct ctgtcacatt ccagatcacc ttagaggcca cgctcccaag
     3181 attagttatc accctggcag tatgaatact tccctaaggc ctcccatcca tggaggggaa
     3241 gagtgggaac cagctgttac actcagcatc tactgagcac tgatgggagc cctgcctggg
     3301 ccatgtgctg tggggccaaa tggacatcac tccctaactt cttgaggtct gtctcctctg
     3361 tggattcacg catgtatcaa cctcattaaa ctatgccaaa cttttgcctc c
//
