LOCUS       NM_180989               8884 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens G protein-coupled receptor 180 (GPR180), mRNA.
ACCESSION   NM_180989
VERSION     NM_180989.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8884)
  AUTHORS   Yoshida,K., Yokota,K., Watanabe,K., Tsuda,H., Matsumoto,A.,
            Mizukami,H. and Iwamoto,S.
  TITLE     Lack of GPR180 ameliorates hepatic lipid depot via downregulation
            of mTORC1 signaling
  JOURNAL   Sci Rep 13 (1), 1843 (2023)
   PUBMED   36726016
  REMARK    GeneRIF: Lack of GPR180 ameliorates hepatic lipid depot via
            downregulation of mTORC1 signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8884)
  AUTHORS   Balazova,L., Balaz,M., Horvath,C., Horvath,A., Moser,C.,
            Kovanicova,Z., Ghosh,A., Ghoshdastider,U., Efthymiou,V.,
            Kiehlmann,E., Sun,W., Dong,H., Ding,L., Amri,E.Z., Nuutila,P.,
            Virtanen,K.A., Niemi,T., Ukropcova,B., Ukropec,J., Pelczar,P.,
            Lamla,T., Hamilton,B., Neubauer,H. and Wolfrum,C.
  TITLE     GPR180 is a component of TGFbeta signalling that promotes
            thermogenic adipocyte function and mediates the metabolic effects
            of the adipocyte-secreted factor CTHRC1
  JOURNAL   Nat Commun 12 (1), 7144 (2021)
   PUBMED   34880217
  REMARK    GeneRIF: GPR180 is a component of TGFbeta signalling that promotes
            thermogenic adipocyte function and mediates the metabolic effects
            of the adipocyte-secreted factor CTHRC1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8884)
  AUTHORS   Pozza,E., Verdin,H., Deconinck,H., Dheedene,A., Menten,B., De
            Baere,E. and Balikova,I.
  TITLE     Microcoria due to first duplication of 13q32.1 including the GPR180
            gene and maternal mosaicism
  JOURNAL   Eur J Med Genet 63 (5), 103918 (2020)
   PUBMED   32200002
  REMARK    GeneRIF: Microcoria due to first duplication of 13q32.1 including
            the GPR180 gene and maternal mosaicism.
REFERENCE   4  (bases 1 to 8884)
  AUTHORS   Fares-Taie,L., Gerber,S., Tawara,A., Ramirez-Miranda,A.,
            Douet,J.Y., Verdin,H., Guilloux,A., Zenteno,J.C., Kondo,H.,
            Moisset,H., Passet,B., Yamamoto,K., Iwai,M., Tanaka,T.,
            Nakamura,Y., Kimura,W., Bole-Feysot,C., Vilotte,M., Odent,S.,
            Vilotte,J.L., Munnich,A., Regnier,A., Chassaing,N., De Baere,E.,
            Raymond-Letron,I., Kaplan,J., Calvas,P., Roche,O. and Rozet,J.M.
  TITLE     Submicroscopic deletions at 13q32.1 cause congenital microcoria
  JOURNAL   Am J Hum Genet 96 (4), 631-639 (2015)
   PUBMED   25772937
  REMARK    GeneRIF: A null GPR180 mutation segregates over two generations
            with iridocorneal angle dysgenesis, consistent with the view that
            deletions of this gene are the cause of MCOR.
REFERENCE   5  (bases 1 to 8884)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   6  (bases 1 to 8884)
  AUTHORS   Tsukada,S., Iwai,M., Nishiu,J., Itoh,M., Tomoike,H., Horiuchi,M.,
            Nakamura,Y. and Tanaka,T.
  TITLE     Inhibition of experimental intimal thickening in mice lacking a
            novel G-protein-coupled receptor
  JOURNAL   Circulation 107 (2), 313-319 (2003)
   PUBMED   12538434
REFERENCE   7  (bases 1 to 8884)
  AUTHORS   Iida,A., Tanaka,T. and Nakamura,Y.
  TITLE     High-density SNP map of human ITR, a gene associated with vascular
            remodeling
  JOURNAL   J Hum Genet 48 (4), 170-172 (2003)
   PUBMED   12730718
  REMARK    GeneRIF: 22 SNPs were isolated from the ITR locus by systematically
            screening genomic DNA from 48 healthy Japanese individuals
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD110068.1, BC052243.1,
            DB150630.1, AL359708.8 and AL049452.1.
            
            On Nov 22, 2018 this sequence version replaced NM_180989.5.
            
            Summary: This gene encodes a protein that is a member of the G
            protein-coupled receptor superfamily. This protein is produced
            predominantly in vascular smooth muscle cells and may play an
            important role in the regulation of vascular remodeling. [provided
            by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.224667.1,
                                           SRR1660805.140334.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376958.5/ ENSP00000366157.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                CD110068.1         35-80
            47-922              BC052243.1         1-876
            923-923             DB150630.1         451-451
            924-1667            BC052243.1         878-1621
            1668-8291           AL359708.8         40879-47502
            8292-8868           AL049452.1         1-577
            8869-8884           AL359708.8         48080-48095
FEATURES             Location/Qualifiers
     source          1..8884
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q32.1"
     gene            1..8884
                     /gene="GPR180"
                     /gene_synonym="ITR"
                     /note="G protein-coupled receptor 180"
                     /db_xref="GeneID:160897"
                     /db_xref="HGNC:HGNC:28899"
                     /db_xref="MIM:607787"
     exon            1..216
                     /gene="GPR180"
                     /gene_synonym="ITR"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1394
                     /gene="GPR180"
                     /gene_synonym="ITR"
                     /note="intimal thickness-related receptor; integral
                     membrane protein GPR180"
                     /codon_start=1
                     /product="integral membrane protein GPR180 precursor"
                     /protein_id="NP_851320.1"
                     /db_xref="CCDS:CCDS9472.1"
                     /db_xref="GeneID:160897"
                     /db_xref="HGNC:HGNC:28899"
                     /db_xref="MIM:607787"
                     /translation="MGGLRLLAVALTCCWWPQGSQGKTLRGSFSSTAAQDAQGQRIGH
                     FEFHGDHALLCVRINNIAVAVGKEAKLYLFQAQEWLKLQQSSHGYSCSEKLSKAQLTM
                     TMNQTEHNLTVSQIPSPQTWHVFYADKYTCQDDKENSQVEDIPFEMVLLNPDAEGNPF
                     DHFSAGESGLHEFFFLLVLVYFVIACIYAQSLWQAIKKGGPMHMILKVLTTALLLQAG
                     SALANYIHFSSYSKDGIGVPFMGSLAEFFDIASQIQMLYLLLSLCMGWTIVRMKKSQS
                     RPLQWDSTPASTGIAVFIVMTQSVLLLWEQFEDISHHSYHSHHNLAGILLIVLRICLA
                     LSLGCGLYQIITVERSTLKREFYITFAKGCILWFLCHPVLACISVIFSDYQRDKVITI
                     GVILCQSVSMVILYRLFLSHSLYWEVSSLSSVTLPLTISSGHKSRPHF"
     exon            217..375
                     /gene="GPR180"
                     /gene_synonym="ITR"
                     /inference="alignment:Splign:2.1.0"
     exon            376..576
                     /gene="GPR180"
                     /gene_synonym="ITR"
                     /inference="alignment:Splign:2.1.0"
     exon            577..757
                     /gene="GPR180"
                     /gene_synonym="ITR"
                     /inference="alignment:Splign:2.1.0"
     exon            758..807
                     /gene="GPR180"
                     /gene_synonym="ITR"
                     /inference="alignment:Splign:2.1.0"
     exon            808..965
                     /gene="GPR180"
                     /gene_synonym="ITR"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1157
                     /gene="GPR180"
                     /gene_synonym="ITR"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1235
                     /gene="GPR180"
                     /gene_synonym="ITR"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..8884
                     /gene="GPR180"
                     /gene_synonym="ITR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3484..3489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR180"
                     /gene_synonym="ITR"
                     /note="hexamer: ATTAAA"
     polyA_site      3506
                     /gene="GPR180"
                     /gene_synonym="ITR"
                     /note="major polyA site"
     regulatory      3886..3891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR180"
                     /gene_synonym="ITR"
                     /note="hexamer: ATTAAA"
     polyA_site      3912
                     /gene="GPR180"
                     /gene_synonym="ITR"
     regulatory      8842..8847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR180"
                     /gene_synonym="ITR"
                     /note="hexamer: AATAAA"
     polyA_site      8884
                     /gene="GPR180"
                     /gene_synonym="ITR"
ORIGIN      
        1 agctgccgac gtggggcggg cagccgccgg cggctgggag ccgaggcgtc ggtgcagacc
       61 tggagacggg catggggggg ctgcggctgc tggctgtggc cctcacgtgc tgctggtggc
      121 cgcagggcag ccagggtaag accctgcggg gcagcttcag cagcaccgcg gcccaggacg
      181 cccagggcca gcgcatcggc cacttcgagt tccatggtga ccatgctctt ctgtgtgtca
      241 gaatcaacaa catagcagta gctgttggaa aagaagctaa actctacctg ttccaagccc
      301 aggaatggct aaagctacag caaagcagtc atggttatag ctgtagtgaa aaattatcca
      361 aagctcagtt gacaatgacc atgaaccaga ccgaacataa tctgacagtg tcccagattc
      421 cgtctccaca aacgtggcat gtgttttatg cagacaagta tacatgccaa gatgacaagg
      481 agaattctca ggtggaagat atcccatttg aaatggtgtt actaaaccca gatgccgaag
      541 ggaatccatt tgatcatttt agtgctggag aatctgggtt acatgagttc tttttcctcc
      601 tagtcctagt gtactttgtg attgcttgca tttatgctca atcattgtgg caggctatta
      661 agaaaggcgg acccatgcac atgattttaa aggttctgac aactgcattg ctgttacaag
      721 ctggttcagc tttagctaat tacattcatt tctccagtta ctccaaagat ggaatagggg
      781 taccatttat gggaagtttg gcagaatttt ttgacatcgc ttcccaaatt cagatgttat
      841 acttactttt gagtctatgc atgggttgga caatagtcag aatgaagaag tctcaaagca
      901 gacctctcca gtgggattct acgcctgcat ccactggcat tgcagtattc attgtcatga
      961 cacagagtgt tttgctactt tgggaacagt ttgaagatat cagtcatcat agctaccatt
     1021 cacaccacaa cttagcaggg atcctcctaa ttgttctaag aatttgccta gcattgtcat
     1081 taggctgtgg actctatcag atcatcacag tggagagaag tacactcaaa agggagttct
     1141 acatcacatt tgccaaaggc tgtatcttgt ggtttttatg ccatccagtt cttgcatgca
     1201 tttctgtcat ttttagcgac taccaaagag acaaggttat tacaataggt gttatccttt
     1261 gccagtctgt ttccatggtt attctctaca gactctttct gtctcacagt ctatactggg
     1321 aagtttcttc actttcttca gtaacactac cactgaccat atcatctgga cacaaaagtc
     1381 gccctcattt ctgatacttg atttttgttg agaggaaaag tgaattggtt aaaagagtgc
     1441 aataaggatc caaatacagt gacttttttt tcatacattt agtatgaaaa cttgaacagc
     1501 gaaagcagag catgttattt atataactgc atttaagcag taccaagact gaaaaaaaag
     1561 gtaataaatg aaatgttttg aaatatactt aaacaacaaa ctttgaagaa agtgttgtta
     1621 taaaattatt gaagcgattt ctatgtggaa ataaatgtga aaaataacta tgatattttg
     1681 gtaaaatatt caccacttat aatgcctcat cttaatagct aactcaggtt taatagtctt
     1741 ataaaaagta atcagttaaa tgattacttg cttataaata tctaaactag tccagttatg
     1801 aaatcagtgt aatacattga tttttaaaac tgctgctttt tatgctttaa ggaaaatgta
     1861 tttcatattt gagtttaaag gaattgaaat tacttcagga aatgaatata aaataggttc
     1921 acagttaaat gaataagctt ttgtttattt gtgggtggag ttattctcca attttttctg
     1981 ccatttttgg ctctagttca ggttttagct tgattagcaa aggtttttga caaacagttt
     2041 atgaaaaaat aaaacttaaa tacattacac gggttgtaag gacaaaggat tttaaaatct
     2101 gagcacttag gtgaagggac aagcaggttt atgtgtttaa acagaaagaa gggaaaaggt
     2161 actatgtgat atggtactga aattttgatc ccaatagaat tcatttctct tacgttgaat
     2221 ccccaatcat aattaagccg tatacacaga ttaaattaac agaagcattt cacataaatg
     2281 ttggtttcag tcatcaacta cccatgaatt cctgcccaag gatacttaat caggattaaa
     2341 ttttctatga ataattgaaa aacaaaacac tcactggatt tgttataatc cgtgttggca
     2401 ctggattcta agtagttgcc atcttgaatc ctttgtaata aagccatact tttgtgtgtg
     2461 tgtgtgatgc cccagtattg agtatgctag ctaaaaaata tcaagtgcct gattaaagaa
     2521 ttgctaaatg gttgtcaata ctcgctgtat aaaatgagta ttcccattaa tagtcactga
     2581 ttggaaatta ttctgttgct gtttgtcaag ctgttcaggc cttttccttt ttacttctgg
     2641 cttattttaa aaatattttt tatctattta ctgtgtgttt aagcaagcaa cagtgcactg
     2701 atctggtagt taaatttttt aattaaatag ttaaaataat gtagtgcaac ttaaaaatat
     2761 ctatggcttt gtttttgttt ttcttttgta cctagtctca ttggaaatga ctagtattct
     2821 gcctcatttt cagggcagaa tatgtgtttg tgacccaaaa tgacaaagtt accaagttca
     2881 acctgctcat taaatcatct ctctattagt tctttgtaaa tcacttagta cattagagct
     2941 acaggttaag actagaaagt ctgagttatg ttttaggtat acatgatcgt ctgagtggtc
     3001 ataacctttt cttttatcat gtctcgctaa taaccccagc tattgtctgt tgtgttcagc
     3061 tgagatgcaa aaaagaaatt aagcaaaaaa gaaaaagatg aagacttttc atgaattttg
     3121 tgaacttgcc aaaaggggaa gggaaaaatc tttgtgttac ttcactcaaa gaacataagt
     3181 aactgcaatt aacatatatg aaatttatta ctctgcttgc atttatgaaa ctaaccagtt
     3241 ttttaaactt taattcttaa atttatggtt ggaaatgctg ataatttatt ttgttattta
     3301 agagctgttg ttaagtggag gaaagtagtt gttaataaat gtataaaact gttcttgact
     3361 agtaatcagg gacaaaattt atagttcata agtcatgaca cagtattcgc tctttttctg
     3421 aatgtttaca tagagattca tcactgcaga ttacagaaag ttaagtgtat actacaaact
     3481 ctaattaaag ataaaaatct tttctacttt tctttgtcag ataatgcttt tttatgtgtt
     3541 tttacatttt ttgaaagaag ataaatggtt catccagagc tttattaaga agcatttctt
     3601 ttcttccctt aaaaaataga tgcttatttt tattgacatg tgtataataa gatgggtgcc
     3661 tactgtgatg cattttacca ggcattttac cttcattatt actcatctct attgtgataa
     3721 ccaggctccc atttaactga gtataagaga gaataaatga tttctctaag gtcatcaaac
     3781 tatttagttt ttccacttta ccttcatgat ttaaggaaca tgtattagct gtgttttagt
     3841 gagaatgaat tgctatccat cataattttt gctgttgatt tgaacattaa aactggaatt
     3901 gtgctaaaat cagaacatgc gcttgaatat ctgtaagacc tcagcacact tcagtatttg
     3961 aacctggctt ttaaccagac agtattacta gcaggagagt taatctaggc agaagagctt
     4021 gctttagggt aattatttat tatctccagt aaagtcacat ctgatgaaca taggagatac
     4081 acaaatctga gatcatctct aaaataatga gactagaacc tatctatcaa catgaacatg
     4141 ggctccttca gcatgtttct tctaggagac tgcacgttct ttggaatttg gaaatttgga
     4201 attatctgtg aaacattttc ttaaatagct tctgtggtat caaatcattg aggttgtttt
     4261 ttgtttgttt tgagaattga tatgattgtt agaagtagcc agatacgaag aggtaatact
     4321 gttttttatt ccaacatgta tttgtgaatt gagactaaaa taatgagatt ggttttcctc
     4381 tgtgatctga aagtagtgtg gtagaagcac cgtagcttga tttcttgcaa tagctctcta
     4441 agtaatatta ccatgtccac acttgggcag ccttctgcac agctccaggg gcatcatatg
     4501 tgttgtgctg taggagtgcc atgaagcctg gaggtgagga aagaagtgat cctgcccact
     4561 agggccattc tccacagtgt agccaaaaca atctcttaaa aatggaaatc atctggatga
     4621 tgagcataca gaaattcttt gtgctaatct tgtaattttt ttgtaagttt gaaattattt
     4681 caaaaagttt aaaaatcata taaatcagat caaactacta cttccctgac aaaaaccctc
     4741 catgtgcctc tcattgcact taggaaaaga agtcctcact cattactatg ttctgcaagg
     4801 cccatatgat ctggttatct cttaatttgt accactctct cacacacata tcccagcctc
     4861 attgtccttc atcaaaaaaa gatctagctt atatcacacc ctcagatact tggcactagc
     4921 catcttctct gcctgggaca ttctcttcca aatcttagca tggttggaag gctgaatcct
     4981 catccttcag gttctcagct gagatgtctt ttagagaact caccatctgt ggtggattta
     5041 tatggtgcag tttagtcaac ctggagatag gttctgcaga attctcttcc atgcataatt
     5101 tcaggacaat gtaggccata agaaatgttt gatacaagat atagaaggca gaagtaaagt
     5161 agcagccaga tctgcattct ttttgtaaga ggaagggcca gacaaggcac aaggcacaag
     5221 gcactgttgc agcttatcca cattattgct tatctgttgg cttctcttgg cctgtgggac
     5281 aacagccagg cccacaggaa caccagttcc tgccggaatg gctccttcag cttctctggc
     5341 tcctgggcca ggtgtgcgtt ttactctgac aaagggtgcc agcttctgct ggacaactcc
     5401 atcattcaca ctggaggatt agaggcaggg agagacctgt atggcttcca gtccatcctc
     5461 acaagttcca ctcagttccc acaggttcta ctcatcctag caagttcctt gcttccccca
     5521 tttcccatgt cttccctttc caactgccag acacaaaaga aaccgcctcc tataatccct
     5581 ataataagcc ccttattttg aatattaaga tatgtgtatg tgtattagat cctagtggtt
     5641 cttttctgat cagaccctga ttaaccatac catcctacct aatgctattc ccccatccta
     5701 gttctatcat attatccctt tttttgtttg ttgtacttag ctggtttatc tttgtcatct
     5761 ctcaaattag aatataaatt ttaagtgagt ttgtctctat tgttcattgc tgtatgccta
     5821 atactaggac actccctggt gcatactaga tgctcaaaaa tatttttgag tgaatgaagg
     5881 caatgctgaa aaagttccaa atctgtactt aacagtgtag tattaattat gtaatagaag
     5941 tacccgtagt gacttcaata ataccttgcc tattctttgt tcaattgcat ggaacttggt
     6001 agtgtgtaaa aatcttgact agtcaagtag ttgtcataaa acatcagtta cgagaggatt
     6061 tctcaaattc tcacagaggc agtttctctt tattttatgt agtcctgtaa taggaccatg
     6121 tgtctggttt ctggcctgcc acaaccagaa gcaccaattt aaaagagaag tttctagtca
     6181 gctagaggag ggaatgttga cagtagtcag aagcagctgg gaaaagatgg gaaaactaga
     6241 aatgacaata acactcaaat tgcagcagcc tggggtcatt tagtgtaggt gaaagcagcc
     6301 ctgtgttgtg tatctcagta gactcttaag agatttgttg ttcaatgtat tcatgacagt
     6361 gactgatggt aatcaagaaa atattaagtt ataagttatg ttcagtagcc tcaaagaagt
     6421 atgcgaaaac cttctaatgt tttcttcttg ttaaacaggt aatatatgca cattgtacaa
     6481 aaatcagaaa gttgaaaaag gtggggaaaa gaagtccttc tctcactcat ttcccttccc
     6541 tgaatccaaa ctctgttacc agttatcttt ctagaaatgg ccccatgcac atataaacat
     6601 atatgaaaca caaattatag cataacatac agacttttgc acattcagca atttattctg
     6661 tagccttacc tagaattgtc ccattttttt caccaattgc atagaactcc attatatgga
     6721 tgtattttga ttttttcaaa gaatcagttc tgttactgca cgttgttggt tttcagtctt
     6781 gctaatacag acaaggctga aattaagaca gtaatcaaga atttgccaag acttccttcc
     6841 ctcctcccaa aatgcctcca ctccaggttc caggtctaga tccttgggat tttctaggtg
     6901 atggaagtat ctttgttatt catagtgagc tctgatagtt acgctaacca gatgactcaa
     6961 ataggggcta gccacaccag aagaccaacc attggattag agggttggag ttttgagtca
     7021 tatgatatta gcccaacctc tgaggtggag agaggggtta gagatggagt tcagctttat
     7081 atagagattg agtcaattaa tcatgcctgt catgaaaccc cgagagaaac tctggtcagt
     7141 gatgctcaag tgaacttccc tggttggcaa tactctggtg tgttctagga gggtgacatg
     7201 tccctgaggg cacagaaact ttgtgtttgg gatcctctta caccttgctc tatgtatgtc
     7261 ttcttttggc tgttctgatt tgtatccttt tgctataata aactgtaata gtacgcatag
     7321 cactttgctg agttctgtga gttgttctat ttaattatag aacctgaagg tattgtgggg
     7381 acccctgaac ttgcagccag ttggtcagaa gtaaggatgg tcctgggaat gcccaaagtt
     7441 gctagtttct gaagtgaggg cagtcatatg gaggactggg cccttaatct gtgaagtttg
     7501 gcttaacttc aggcagttgg tgtcagaagc cattgcaaat atcctgatga tccgtgcaaa
     7561 acaaaaacac ttaacagaaa attacgttgt actctctgta cggataattt tcggttaagt
     7621 gtttttgttt tccatggatt gtactagata tcaatctgat aaataacttt tattcattat
     7681 agttttaatt tgcatttctc ttattaattt ttgttttaaa accattttct ttccagttct
     7741 acgatctgtt aacatatttt tcccactttt ctattgggtt ggttgtcttt ttcttattga
     7801 tttgttaaaa ctctttataa cagaaattgg tcatttgtga tatgagtctg aactgtgttt
     7861 ctcaatttgt gatttttctc tttacttttt taatggtgtc tttttcttgt agttttttta
     7921 atgcaggtgg aattatcagt ctttcatttt tttcttctgt gttctacctg tttcacaggt
     7981 agaaaagcct tagctctttg agattatgtt taaatgccct gtattttcat ctagtggttt
     8041 tatggtttta ttttgtatgt ttttttcatc cacctggaat ttattttgct gttaaaatat
     8101 gaattagaga tccaacttaa tttttttcag atggttgttg acttattgca atatcatgtg
     8161 ttatataatc catctttact gattcgttgc taattggttt ctggactttt aaggctatct
     8221 gatgaactgt tgatctggta ccacactgtt tcaattattg tagtcttaaa attgctgtac
     8281 gctttggtag ggataatttt ctgttaagtg tttttgtttt ttataatttt ccaattagtc
     8341 ttgctcattt tttatataaa ctttgaaatc aatttttctg attttcaaaa gaaaaaaaat
     8401 cctgtttagt attcttagtg gaatgaatta aatttccata gcaatttagg gaaatttgac
     8461 tttcttaacg tgttgagtgt taaacccaca ggtggtagca tgacattgac tcctcagcca
     8521 agcatattat caactgtcgg aaactaggtt ttcccatagt gatccaagaa actagtacga
     8581 aatgcctttc tgatttttta aaacttgtat acatatatag tacatattat atatacttat
     8641 atattaagta atcagaagta tgtgtttctc aatcaccttt taaagacttc tttatatagc
     8701 tcttgtacat ttcttgatat gaatatgtta atgttttctt tcattatgtt gcatatggct
     8761 tttgttttct gcatgaaaac tattgatttc tgcattctaa ttttgttccc agtcacctaa
     8821 ctgaattctt ctaacagttg taataaattt ctggttggct ctcttgtgtt ttctaggtaa
     8881 acaa
//
