LOCUS       NM_001004334            9165 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens G protein-coupled receptor 179 (GPR179), mRNA.
ACCESSION   NM_001004334 XM_496215
VERSION     NM_001004334.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9165)
  AUTHORS   Patil,D.N., Pantalone,S., Cao,Y., Laboute,T., Novick,S.J.,
            Singh,S., Savino,S., Faravelli,S., Magnani,F., Griffin,P.R.,
            Singh,A.K., Forneris,F. and Martemyanov,K.A.
  TITLE     Structure of the photoreceptor synaptic assembly of the
            extracellular matrix protein pikachurin with the orphan receptor
            GPR179
  JOURNAL   Sci Signal 16 (795), eadd9539 (2023)
   PUBMED   37490546
  REMARK    GeneRIF: Structure of the photoreceptor synaptic assembly of the
            extracellular matrix protein pikachurin with the orphan receptor
            GPR179.
REFERENCE   2  (bases 1 to 9165)
  AUTHORS   Orlandi,C., Omori,Y., Wang,Y., Cao,Y., Ueno,A., Roux,M.J.,
            Condomitti,G., de Wit,J., Kanagawa,M., Furukawa,T. and
            Martemyanov,K.A.
  TITLE     Transsynaptic Binding of Orphan Receptor GPR179 to
            Dystroglycan-Pikachurin Complex Is Essential for the Synaptic
            Organization of Photoreceptors
  JOURNAL   Cell Rep 25 (1), 130-145 (2018)
   PUBMED   30282023
  REMARK    GeneRIF: Authors identify that major components of the
            extracellular matrix proteins present in the synaptic cleft-members
            of the heparan sulfate proteoglycan (HSPG) family-associate with
            the GPR158/179 group of orphan receptors.
REFERENCE   3  (bases 1 to 9165)
  AUTHORS   Dan,H., Song,X., Li,J., Xing,Y. and Li,T.
  TITLE     Mutation screening of the LRIT3, CABP4, and GPR179 genes in Chinese
            patients with Schubert-Bornschein congenital stationary night
            blindness
  JOURNAL   Ophthalmic Genet 38 (3), 206-210 (2017)
   PUBMED   27428514
  REMARK    GeneRIF: In this study, a novel compound heterozygous mutation,
            c.[1A>G]; [608G>T] (p.[0?]; p.[W203L]), was identified in the LRIT3
            gene of a proband. No mutations were identified in the CABP4 or
            GPR179 gene.
REFERENCE   4  (bases 1 to 9165)
  AUTHORS   Klooster,J., van Genderen,M.M., Yu,M., Florijn,R.J., Riemslag,F.C.,
            Bergen,A.A., Gregg,R.G., Peachey,N.S. and Kamermans,M.
  TITLE     Ultrastructural localization of GPR179 and the impact of mutant
            forms on retinal function in CSNB1 patients and a mouse model
  JOURNAL   Invest Ophthalmol Vis Sci 54 (10), 6973-6981 (2013)
   PUBMED   24084093
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9165)
  AUTHORS   Bijveld,M.M., Florijn,R.J., Bergen,A.A., van den Born,L.I.,
            Kamermans,M., Prick,L., Riemslag,F.C., van Schooneveld,M.J.,
            Kappers,A.M. and van Genderen,M.M.
  TITLE     Genotype and phenotype of 101 dutch patients with congenital
            stationary night blindness
  JOURNAL   Ophthalmology 120 (10), 2072-2081 (2013)
   PUBMED   23714322
  REMARK    GeneRIF: We found 1 mutation in GPR179 in congenital stationary
            night blindness.
REFERENCE   6  (bases 1 to 9165)
  AUTHORS   Pharoah,P.D., Tsai,Y.Y., Ramus,S.J., Phelan,C.M., Goode,E.L.,
            Lawrenson,K., Buckley,M., Fridley,B.L., Tyrer,J.P., Shen,H.,
            Weber,R., Karevan,R., Larson,M.C., Song,H., Tessier,D.C., Bacot,F.,
            Vincent,D., Cunningham,J.M., Dennis,J., Dicks,E., Aben,K.K.,
            Anton-Culver,H., Antonenkova,N., Armasu,S.M., Baglietto,L.,
            Bandera,E.V., Beckmann,M.W., Birrer,M.J., Bloom,G., Bogdanova,N.,
            Brenton,J.D., Brinton,L.A., Brooks-Wilson,A., Brown,R., Butzow,R.,
            Campbell,I., Carney,M.E., Carvalho,R.S., Chang-Claude,J.,
            Chen,Y.A., Chen,Z., Chow,W.H., Cicek,M.S., Coetzee,G., Cook,L.S.,
            Cramer,D.W., Cybulski,C., Dansonka-Mieszkowska,A., Despierre,E.,
            Doherty,J.A., Dork,T., du Bois,A., Durst,M., Eccles,D., Edwards,R.,
            Ekici,A.B., Fasching,P.A., Fenstermacher,D., Flanagan,J., Gao,Y.T.,
            Garcia-Closas,M., Gentry-Maharaj,A., Giles,G., Gjyshi,A., Gore,M.,
            Gronwald,J., Guo,Q., Halle,M.K., Harter,P., Hein,A., Heitz,F.,
            Hillemanns,P., Hoatlin,M., Hogdall,E., Hogdall,C.K., Hosono,S.,
            Jakubowska,A., Jensen,A., Kalli,K.R., Karlan,B.Y., Kelemen,L.E.,
            Kiemeney,L.A., Kjaer,S.K., Konecny,G.E., Krakstad,C.,
            Kupryjanczyk,J., Lambrechts,D., Lambrechts,S., Le,N.D., Lee,N.,
            Lee,J., Leminen,A., Lim,B.K., Lissowska,J., Lubinski,J.,
            Lundvall,L., Lurie,G., Massuger,L.F., Matsuo,K., McGuire,V.,
            McLaughlin,J.R., Menon,U., Modugno,F., Moysich,K.B., Nakanishi,T.,
            Narod,S.A., Ness,R.B., Nevanlinna,H., Nickels,S., Noushmehr,H.,
            Odunsi,K., Olson,S., Orlow,I., Paul,J., Pejovic,T., Pelttari,L.M.,
            Permuth-Wey,J., Pike,M.C., Poole,E.M., Qu,X., Risch,H.A.,
            Rodriguez-Rodriguez,L., Rossing,M.A., Rudolph,A., Runnebaum,I.,
            Rzepecka,I.K., Salvesen,H.B., Schwaab,I., Severi,G., Shen,H.,
            Shridhar,V., Shu,X.O., Sieh,W., Southey,M.C., Spellman,P.,
            Tajima,K., Teo,S.H., Terry,K.L., Thompson,P.J., Timorek,A.,
            Tworoger,S.S., van Altena,A.M., van den Berg,D., Vergote,I.,
            Vierkant,R.A., Vitonis,A.F., Wang-Gohrke,S., Wentzensen,N.,
            Whittemore,A.S., Wik,E., Winterhoff,B., Woo,Y.L., Wu,A.H.,
            Yang,H.P., Zheng,W., Ziogas,A., Zulkifli,F., Goodman,M.T., Hall,P.,
            Easton,D.F., Pearce,C.L., Berchuck,A., Chenevix-Trench,G.,
            Iversen,E., Monteiro,A.N., Gayther,S.A., Schildkraut,J.M. and
            Sellers,T.A.
  CONSRTM   Australian Cancer Study; Australian Ovarian Cancer Study Group
  TITLE     GWAS meta-analysis and replication identifies three new
            susceptibility loci for ovarian cancer
  JOURNAL   Nat Genet 45 (4), 362-370 (2013)
   PUBMED   23535730
REFERENCE   7  (bases 1 to 9165)
  AUTHORS   Peachey,N.S., Ray,T.A., Florijn,R., Rowe,L.B., Sjoerdsma,T.,
            Contreras-Alcantara,S., Baba,K., Tosini,G., Pozdeyev,N.,
            Iuvone,P.M., Bojang,P. Jr., Pearring,J.N., Simonsz,H.J., van
            Genderen,M., Birch,D.G., Traboulsi,E.I., Dorfman,A., Lopez,I.,
            Ren,H., Goldberg,A.F., Nishina,P.M., Lachapelle,P., McCall,M.A.,
            Koenekoop,R.K., Bergen,A.A., Kamermans,M. and Gregg,R.G.
  TITLE     GPR179 is required for depolarizing bipolar cell function and is
            mutated in autosomal-recessive complete congenital stationary night
            blindness
  JOURNAL   Am J Hum Genet 90 (2), 331-339 (2012)
   PUBMED   22325362
REFERENCE   8  (bases 1 to 9165)
  AUTHORS   Audo,I., Bujakowska,K., Orhan,E., Poloschek,C.M.,
            Defoort-Dhellemmes,S., Drumare,I., Kohl,S., Luu,T.D., Lecompte,O.,
            Zrenner,E., Lancelot,M.E., Antonio,A., Germain,A., Michiels,C.,
            Audier,C., Letexier,M., Saraiva,J.P., Leroy,B.P., Munier,F.L.,
            Mohand-Said,S., Lorenz,B., Friedburg,C., Preising,M., Kellner,U.,
            Renner,A.B., Moskova-Doumanova,V., Berger,W., Wissinger,B.,
            Hamel,C.P., Schorderet,D.F., De Baere,E., Sharon,D., Banin,E.,
            Jacobson,S.G., Bonneau,D., Zanlonghi,X., Le Meur,G., Casteels,I.,
            Koenekoop,R., Long,V.W., Meire,F., Prescott,K., de Ravel,T.,
            Simmons,I., Nguyen,H., Dollfus,H., Poch,O., Leveillard,T.,
            Nguyen-Ba-Charvet,K., Sahel,J.A., Bhattacharya,S.S. and Zeitz,C.
  TITLE     Whole-exome sequencing identifies mutations in GPR179 leading to
            autosomal-recessive complete congenital stationary night blindness
  JOURNAL   Am J Hum Genet 90 (2), 321-330 (2012)
   PUBMED   22325361
  REMARK    GeneRIF: Additional screening with Sanger sequencing of 40 patients
            identified three other cCSNB patients harboring additional allelic
            mutations in GPR179.
            Erratum:[Am J Hum Genet. 2012 Jul 13;91(1):209]
REFERENCE   9  (bases 1 to 9165)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
REFERENCE   10 (bases 1 to 9165)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R. and Schioth,H.B.
  TITLE     The gene repertoire and the common evolutionary history of
            glutamate, pheromone (V2R), taste(1) and other related G
            protein-coupled receptors
  JOURNAL   Gene 362, 70-84 (2005)
   PUBMED   16229975
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244092.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 5, 2019 this sequence version replaced NM_001004334.3.
            
            Summary: This gene encodes a member of the glutamate receptor
            subfamily of G protein-coupled receptors. The encoded protein has
            an EGF-like calcium binding domain and a seven transmembrane domain
            in the N-terminal region of the protein. Mutations in this gene are
            associated with congenital stationary night blindness type 1E.
            [provided by RefSeq, Apr 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY584611.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968968,
                                           SAMEA2145245 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000616987.5/ ENSP00000483469.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-961               AC244092.2         28838-29798
            962-1070            AC244092.2         33269-33377
            1071-1158           AC244092.2         35074-35161
            1159-1394           AC244092.2         35581-35816
            1395-1463           AC244092.2         36650-36718
            1464-1573           AC244092.2         37094-37203
            1574-1812           AC244092.2         37523-37761
            1813-1951           AC244092.2         37952-38090
            1952-2057           AC244092.2         38756-38861
            2058-2204           AC244092.2         39397-39543
            2205-9165           AC244092.2         41263-48223
FEATURES             Location/Qualifiers
     source          1..9165
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..9165
                     /gene="GPR179"
                     /gene_synonym="CSNB1E; GPR158L; GPR158L1"
                     /note="G protein-coupled receptor 179"
                     /db_xref="GeneID:440435"
                     /db_xref="HGNC:HGNC:31371"
                     /db_xref="MIM:614515"
     exon            1..961
                     /gene="GPR179"
                     /gene_synonym="CSNB1E; GPR158L; GPR158L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..7271
                     /gene="GPR179"
                     /gene_synonym="CSNB1E; GPR158L; GPR158L1"
                     /note="probable G-protein coupled receptor 179;
                     GPR158-like 1; probable G-protein coupled receptor
                     158-like 1"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 179
                     precursor"
                     /protein_id="NP_001004334.3"
                     /db_xref="CCDS:CCDS42308.1"
                     /db_xref="GeneID:440435"
                     /db_xref="HGNC:HGNC:31371"
                     /db_xref="MIM:614515"
                     /translation="MGTRGAVMPPPMWGLLGCCFVCAWALGGPRPIRSLPPLSSQVKP
                     GSVPMQVPLEGAEAALAYLYSGDAQQLSQVNCSERYEARGAGAMPGLPPSLQGAAGTL
                     AQAANFLNMLLQANDIRESSVEEDVEWYQALVRSVAEGDPRVYRALLTFNPPPGASHL
                     QLALQATRTGEETILQDLSGNWVQEENPPGDLDTPALKKRVLTNDLGSLGSPKWPQAD
                     GYVGDTQQVRLSPPFLECQEGRLRPGWLITLSATFYGLKPDLSPEVRGQVQMDVDLQS
                     VDINQCASGPGWYSNTHLCDLNSTQCVPLESQGFVLGRYLCRCRPGFYGASPSGGLEE
                     SDFQTTGQFGFPEGRSGRLLQCLPCPEGCTSCMDATPCLVEEAAVLRAAVLACQACCM
                     LAIFLSMLVSYRCRRNKRIWASGVVLLETVLFGFLLLYFPVFILYFKPSVFRCIALRW
                     VRLLGFAIVYGTIILKLYRVLQLFLSRTAQRSALLSSGRLLRHLGLLLLPVLGFLAVW
                     TVGALERGIQHAPLVIRGHTPSGRHFYLCHHDRWDYIMVVAELLLLCWGSFLCYATRA
                     VLSAFHEPRYMGIALHNELLLSAAFHTARFVLVPSLHPDWTLLLFFFHTHSTVTTTLA
                     LIFIPKFWKLGAPPREEMVDEVCEDELDLQHSGSYLGSSIASAWSEHSLDPGDIRDEL
                     KKLYAQLEVHKTKEMAANNPHLPKKRGSSCQGLGRSFMRYLAEFPEALARQHSRDSGS
                     PGHGSLPGSSRRRLLSSSLQEPEGTPALHKSRSTYDQRREQDPPLLDSLLRRKLAKKA
                     SRTESRESVEGPPALGFRSASAHNLTVGERLPRARPASLQKSLSVASSREKALLMASQ
                     AYLEETYRQAKEREERKKAKAAMASLVRRPSARRLERPRGAPLSAPPSPAKSSSVDSS
                     HTSGRLHEEARRRLPHPPIRHQVSTPILALSGGLGEPRMLSPTSTLAPALLPALAPTP
                     APALAPVPVSPQSPNLLTYICPWENAELPAKQENVPQEGPSGPERGHHSPAPARARLW
                     RALSVAVEKSRAGENEMDAEDAHHQREANDVDEDRPKIFPKSHSLKAPVQQGSMRSLG
                     LAIKALTRSRSTYREKESVEESPEGQNSGTAGESMGAPSRSPRLGRPKAVSKQAALIP
                     SDDKESLQNQQNAHTSRMLQVCQREGSREQEDRGRRMTQGLGERKAERAGKTGLAMLR
                     QVSRDKNIKQSKETPVGWQELPKAGLQSLGSADHRVAEVCPWEVTESETRQPDSGNKA
                     EICPWETSEGAPESRALRQDPGDSQKKRGEARGKSEPIDVVPMMRKKPERLVREQEAV
                     CPWESADRGGLSPGSAPQDPGRIRDKSEAGDSVEARKVEKPGWEAAGPEAHTPDITKA
                     EPCPWEASEGGEDGKPAQEAVKDLPQEKQKTRKATFWKEQKPGGDLESLCPWESTDFR
                     GPSAVSIQAPGSSECSGSLGSGIAEVCLWEAGDAPAIQKAEICPWELDDNVMGQEMLS
                     LGTGRESLQEKEKASRKGSFGEMGEQTVKAVQKLSQQQESVCPRESTVPGHSSPCLDN
                     SSSKAGSQFLCNGGSRATQVCPQEDLRPEAQEATPAKTEICPWEVNERTREEWTSAQV
                     PRGGESQKDKEKMPGKSEIEDVTAWEKPEGQIQKQEAVGPWESVDPGSFSPQPRPQDT
                     ERPQTLLQMSGSVGSKAADICPLDVEENLTAGKAEICPWEVGAGAGEERALGAEAIRK
                     SPNDTGKVSADLGPRERAVTAPEKPQKPTPEWEVACPWGSVGPGACSQHPGTLDADGP
                     KAGFQELDHMGCRPGEVCPWEAQEAATSEKAKICPWEVSEGTTGKGLDQKAGSESAEQ
                     REKALEKGRLTSLGEDVSKGMAKLCQQQETICIWENKDLRESPAQAPKISDLPSSMSS
                     EVAEGHSLEATEKGDLRQDPKTGSFPEHITQEKAPAADTEEFTTEDGEKTSHELQSVC
                     PWETTAPADSVSHLDRQRPDQPKASSQRLVSTGGRAADVCPWDVPDAGVYKSDSSAKA
                     ETCPWEVTERIPVKGVSRQDGKGDSQEEKGRAPEKSEPKGVPVQKKPEMADFRQQEAV
                     CPWESQDGKGLSPQPAPDASDRSRGSSEAAGSVETRVAEVCLWEVVEAPSAKKAEICP
                     WEAGGGAAEEGEQERESQGQGEMFLQKAGPGGTEEHFSKAAAKPREQEAVCPGEGTGS
                     GGLLPQSGALDPELKVSPKEAGSMGSRMAELCQWEITDPEGNKIKGTMADICPGEETG
                     VPSEESGLLALTATRREFFPTAPEKPLCLLVHGPLDHFFPESKIPCPKVSRPASTFTL
                     EGVRELQGPSGLEPRTSLAPEPSLQEAESQSSSLTEDSGQVAFEAQYEEFTPPTVYPW
                     DWE"
     exon            962..1070
                     /gene="GPR179"
                     /gene_synonym="CSNB1E; GPR158L; GPR158L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1158
                     /gene="GPR179"
                     /gene_synonym="CSNB1E; GPR158L; GPR158L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1394
                     /gene="GPR179"
                     /gene_synonym="CSNB1E; GPR158L; GPR158L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1463
                     /gene="GPR179"
                     /gene_synonym="CSNB1E; GPR158L; GPR158L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1573
                     /gene="GPR179"
                     /gene_synonym="CSNB1E; GPR158L; GPR158L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1812
                     /gene="GPR179"
                     /gene_synonym="CSNB1E; GPR158L; GPR158L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1951
                     /gene="GPR179"
                     /gene_synonym="CSNB1E; GPR158L; GPR158L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2057
                     /gene="GPR179"
                     /gene_synonym="CSNB1E; GPR158L; GPR158L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2204
                     /gene="GPR179"
                     /gene_synonym="CSNB1E; GPR158L; GPR158L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..9165
                     /gene="GPR179"
                     /gene_synonym="CSNB1E; GPR158L; GPR158L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9144..9149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR179"
                     /gene_synonym="CSNB1E; GPR158L; GPR158L1"
                     /note="hexamer: AATAAA"
     polyA_site      9165
                     /gene="GPR179"
                     /gene_synonym="CSNB1E; GPR158L; GPR158L1"
                     /note="major polyA site"
ORIGIN      
        1 gagaagaaaa aagcaggcga gctggcacca gcgtgagagg gagacggaga gaggaagaag
       61 gaacgccagc ataggaggcg tggaggccga cagcccccag actgcagcca gcctctgcct
      121 gggctctcct gagcctggac cccagggtcc tgagagctgc cccaaggatg ggcaccaggg
      181 gagcggtcat gccccctcct atgtgggggc tgctgggctg ctgttttgtc tgtgcctggg
      241 ctctgggggg tccacggccc atccgctctc tgccccctct gtcttcccaa gtcaagccag
      301 gatctgtacc catgcaggtg cccctagagg gggccgaggc cgccctcgct tatctctact
      361 ctggagatgc ccagcagcta tcacaggtga attgcagtga gcgctatgaa gcgcgtgggg
      421 caggagccat gccagggctc cccccaagcc tacagggggc agcgggcacc cttgcccagg
      481 ccgccaattt tctcaacatg ctgctgcaag ccaacgacat ccgtgagtcc agtgtggagg
      541 aggatgtgga atggtaccag gcactggtcc gcagcgtggc cgagggggac ccaagagtgt
      601 acagggcttt gctgaccttt aaccctccac caggggccag ccacctacag ctggccctgc
      661 aggccacccg gactggggag gaaaccatcc tgcaggactt gtctgggaac tgggtgcagg
      721 aggagaaccc tcctggggac ctggacaccc ctgccctgaa gaagcgagtg ttgaccaatg
      781 acctagggag cctcggcagc cccaagtggc cgcaggcaga tggatatgtg ggggacacgc
      841 agcaggtgag gctgtctcct cctttcctgg aatgccagga gggacggctc cgacctggat
      901 ggctgatcac actctctgcc accttctatg gactcaagcc agacctcagc ccagaagtca
      961 gggggcaggt gcagatggac gtagatctcc agagtgtgga catcaatcag tgtgcaagtg
     1021 gcccaggctg gtactctaac acacacctgt gtgatctcaa cagcacccag tgtgtccccc
     1081 tggagagtca gggctttgtt cttggccgct acctctgccg ctgccgacct ggattctacg
     1141 gggcaagccc ctctgggggg ttagaggaga gtgacttcca gactaccggg caattcgggt
     1201 tcccagaagg cagatctggg agactgctgc agtgtctgcc atgtcctgag ggctgcacca
     1261 gctgcatgga tgccacaccg tgcctggtgg aagaggccgc ggtgctgcgg gccgctgtgc
     1321 tggcctgcca ggcctgctgc atgctggcca tcttcctgag catgctggtc tcctaccgct
     1381 gccgccggaa caagaggatc tgggcatctg gagtggtcct gctggaaact gtcctttttg
     1441 gattcctgct gctttacttt cctgtcttca tcctatactt caagcccagt gtattccgct
     1501 gcatcgctct tcgctgggtg cggctgctgg gttttgccat cgtctacggc accatcatac
     1561 tcaagcttta cagagtgctg cagctgtttc tgtctcgaac ggcccagcgg agtgcccttc
     1621 tgagcagcgg gcggctgctg cggcacctgg ggctgctcct gctacctgtg ctgggcttcc
     1681 tggctgtgtg gaccgtgggc gccctggagc gaggcatcca gcacgcacct ctggtgatcc
     1741 gaggccacac tcccagtggc cgccatttct acctctgtca ccacgaccgc tgggactaca
     1801 tcatggttgt ggctgagctg ctgctgctgt gctggggcag cttcctctgc tacgccacac
     1861 gggctgtgct ctcggccttc catgagccac gctacatggg catcgccctg cacaatgagc
     1921 tactgctttc cgctgccttc cacacagcca ggtttgtgct ggttccctct ctgcacccgg
     1981 actggaccct cctcctcttc ttcttccaca cccacagcac agtcaccacc acgctggctc
     2041 tgatcttcat ccctaagttc tggaagctgg gggctcctcc ccgggaggag atggtggatg
     2101 aggtgtgtga ggacgagctg gacctgcagc actcaggctc ctaccttggc agcagcatcg
     2161 cctcagcctg gagtgagcac agcctggacc ctggagacat tcgggacgag ctgaagaagc
     2221 tctatgccca gctagaggtc cacaaaacca aggaaatggc cgcaaacaac ccccacctgc
     2281 ccaagaagcg aggcagctca tgccagggac tgggccgctc cttcatgagg tacctggcgg
     2341 aattccccga ggccctggcc aggcagcact cccgggactc aggatcccca ggccacggca
     2401 gcctgcccgg ctcctcccgc cgccggctcc tcagctccag cctccaggaa cccgagggga
     2461 caccagctct gcacaagtcc cgcagcacct atgaccagcg cagggagcag gacccgcctc
     2521 ttcttgactc actgctgagg aggaagctgg ccaagaaggc ctctcgaaca gagagccggg
     2581 agtcggtgga ggggccccct gccctgggct tcaggtcagc cagcgcccac aacctgacgg
     2641 tgggagagag gctacccaga gcccggcccg cctctctgca gaagtcgctc agtgtggcca
     2701 gctccaggga aaaggccttg ctcatggcca gccaggccta cctggaggag acctaccggc
     2761 aagcaaagga gcgggaggag cggaagaagg ccaaggcagc catggccagc ctggtgcgga
     2821 ggccatcagc caggaggctg gagcggcctc gaggggcccc cctgtcagct ccaccttccc
     2881 ctgccaagag cagcagcgtg gacagctctc acacctctgg gaggcttcat gaggaggcta
     2941 ggagaaggct gcctcatcca cccatcaggc accaggtttc tacccccatc ttggccctgt
     3001 ctgggggcct gggagagcca aggatgctat ctcccacctc caccttggct ccagctctgc
     3061 tgccagctct agctccaacc ccagcccctg ccctggcacc agtcccagta tccccacaaa
     3121 gccccaactt actcacctac atctgcccct gggagaacgc agaactgcca gccaagcaag
     3181 aaaatgtgcc ccaggaaggc ccctcagggc cagagcgagg ccaccactcc cctgccccag
     3241 ctcgagccag gctctggagg gccctctctg ttgcagtaga gaaaagcagg gctggggaga
     3301 atgagatgga cgcagaggat gcacatcacc agagggaagc taatgatgtg gacgaagaca
     3361 ggcccaagat cttccctaaa tcccacagcc tcaaggcccc tgttcagcag ggttccatgc
     3421 gcagcctggg gctggcgatt aaagctctga cccgttctcg gagcacctac agagagaagg
     3481 agagtgtgga ggagagtccc gaggggcaga acagcgggac tgcgggagag agtatggggg
     3541 caccctcccg atcgcccagg ctaggccggc ccaaggcggt gagtaagcag gccgctctta
     3601 tcccctccga tgacaaggag tccctccaga accaacagaa cgctcacacc agcaggatgc
     3661 tccaagtctg tcaacgggag ggcagcaggg aacaagaaga cagaggcagg aggatgaccc
     3721 agggtctagg ggaacggaaa gctgagagag caggtaaaac agggcttgcc atgctgaggc
     3781 aagtttccag ggacaaaaac atcaagcaat caaaagaaac ccctgtcggg tggcaggaac
     3841 tgcccaaagc tggcctccag tccctgggca gcgctgacca cagggtggca gaggtatgcc
     3901 cctgggaggt cactgaatca gaaacgcgtc agccagacag tggcaacaag gccgaaatct
     3961 gcccctggga gacgagtgaa ggagccccag agtcgagggc actaagacaa gacccaggtg
     4021 actcccaaaa aaagagaggg gaggcccggg gaaaatcaga gcccatagat gtggttccca
     4081 tgatgcggaa aaagccagag aggctggtga gggagcagga agcagtgtgt ccctgggaga
     4141 gtgccgatcg aggaggtctg tcccctgggt cagctcctca ggaccctggc agaatcagag
     4201 acaaatctga ggcgggggac agtgtggagg ccaggaaggt ggagaagcct gggtgggaag
     4261 ctgctggccc agaagctcat acccctgaca tcaccaaggc agagccgtgt ccctgggagg
     4321 caagtgaagg aggcgaggat gggaaaccag cccaagaggc agtgaaggat ctccctcagg
     4381 aaaagcagaa aaccaggaaa gcaacctttt ggaaagaaca gaaaccggga ggagacttgg
     4441 agtctctttg tccatgggag agtacagatt tccggggccc ctcagcagtc tcaattcagg
     4501 ccccaggaag ctcagagtgt tcagggagtt tgggcagtgg cattgctgaa gtgtgtctgt
     4561 gggaggcagg agatgctcct gctatccaga aagcagagat ctgtccctgg gagctggatg
     4621 ataacgtgat ggggcaggaa atgctgagtc tggggacagg tagagaatct cttcaagaaa
     4681 aggaaaaagc ctccagaaaa ggaagctttg gagagatggg ggaacaaact gtgaaagcag
     4741 tgcagaaatt aagtcaacag caggagtcag tttgtcccag ggagagcacg gtccctgggc
     4801 actccagccc atgtctagac aattcctcat ccaaagctgg tagccaattc ctatgcaatg
     4861 gaggaagcag agcaacgcag gtgtgtccac aggaagatct caggccggag gcacaggaag
     4921 caacacctgc caaaacagaa atctgtccct gggaggtaaa tgaaagaaca agagaggaat
     4981 ggacatcagc acaggtgcca agaggaggag aatctcaaaa ggacaaggag aaaatgcctg
     5041 gaaaatcgga aatcgaagat gtcacagctt gggaaaagcc tgaggggcag atccaaaagc
     5101 aagaagcggt cggcccctgg gagagtgtgg accctggcag cttctcccca caaccacgtc
     5161 ctcaagacac agagagaccc caaacccttc tccagatgtc aggcagtgtg ggaagcaaag
     5221 ctgccgacat ttgccctttg gatgtggagg aaaacttgac tgctgggaag gcagaaatct
     5281 gtccctggga ggtgggtgct ggagcagggg aggaaagggc tttgggagct gaggccatta
     5341 ggaaatctcc aaatgataca ggcaaggttt ctgcagatct tggacccagg gagagagctg
     5401 ttactgctcc agagaagcca cagaagccaa ccccagagtg ggaggtggct tgtccctggg
     5461 ggagtgtggg tccaggggcc tgttctcagc atccaggtac tctagatgct gatggaccaa
     5521 aagctgggtt ccaggaactg gatcatatgg gctgcaggcc aggtgaagtg tgtccctggg
     5581 aagcacagga agctgctacc agtgaaaaag ccaagatctg tccctgggag gtaagtgaag
     5641 gaactactgg gaagggattg gaccaaaagg cagggagtga atcagcagag cagagggaga
     5701 aagctctaga aaaggggaga ctcacttccc tgggagaaga cgtatcaaaa gggatggcaa
     5761 aactgtgtca acaacaggaa actatttgta tttgggagaa caaggacttg agggaatccc
     5821 ctgctcaggc ccccaagatc tcagacttgc ccagcagcat gagtagtgaa gtggcagagg
     5881 gacattcctt ggaagcaaca gagaaggggg acctgagaca agacccaaag acaggttcct
     5941 tcccagaaca cataacccaa gaaaaagctc cagctgcaga cacagaagaa ttcactactg
     6001 aagatgggga aaaaacaagc catgagctac aatccgtctg tccatgggag accactgccc
     6061 cagcagattc cgtctctcac ctagacagac agcgccctga ccaacctaaa gctagctccc
     6121 agagactggt cagcactggg ggcagggccg ctgacgtgtg cccatgggat gttcctgatg
     6181 caggtgtgta taaatctgac agcagtgcca aggctgagac ctgtccctgg gaagtgactg
     6241 aaagaatccc tgtcaaaggg gtgtcaaggc aggatggaaa aggggactct caagaagaga
     6301 aaggcagagc cccagaaaaa tcagagccaa aaggtgtgcc agttcagaaa aagccagaga
     6361 tggcagactt caggcagcag gaggctgtgt gtccctggga gagtcaagat ggcaagggtc
     6421 tgtccccaca gccagcccca gatgcttctg acagaagcag aggcagttct gaggcagcag
     6481 gcagtgtgga gaccagggta gcggaagtgt gtctgtggga agtggtagag gctccctctg
     6541 ccaagaaagc agagatctgc ccttgggagg cgggtggagg agcagcagag gaaggggaac
     6601 aggaaagaga atcacaaggg caaggagaga tgttccttca gaaggcagga cctggaggga
     6661 cggaagaaca cttctcaaaa gcagcagcaa agcccagaga gcaggaggca gtctgccctg
     6721 gggaaggcac aggctcagga gggctcttgc cccagtcagg tgccctggac ccagaactca
     6781 aagtcagccc caaggaagca ggcagcatgg gaagcaggat ggcagagctg tgccaatggg
     6841 aaatcacaga tccagaagga aataaaataa agggtaccat ggcagacatc tgtcctgggg
     6901 aggaaactgg agtcccatct gaggaatctg gcctcctggc tttaacagca actcggagag
     6961 aatttttccc cacagctcct gaaaaaccac tatgcctttt agtccatggg cctctggatc
     7021 acttctttcc agaaagcaaa atcccctgcc ccaaggtaag caggccagcc agtactttca
     7081 ctctagaagg tgtcagagaa ctacaaggac cttcagggct tgagccaagg accagcttag
     7141 ccccagagcc aagtctccag gaagctgagt ctcagtcttc gtccttaact gaagactcag
     7201 gccaagtggc ttttgaagct cagtatgaag aattcacccc tcccactgtc tatccttggg
     7261 attgggagta acagccttat taggtgaggt caaacacaga gctagctttc aggagccaag
     7321 gccctttcca agtccaggtg ttcccaaaga gctgaatcaa agacagcttg gccacttccc
     7381 ctccttgaga agaccagaag tcaacccatc ccaaagacaa actgcatgaa aagggtacag
     7441 cttagacccc aatgggaagg cccaccctct ctttacttct aacttttctt cctgtttgag
     7501 gaaacaaaga ctggacactc tacttctaag gacgcctccc atccacctac agtactcaca
     7561 acacaaacca cccgagtctg gacactcacc cacaaagcca ctgttaggga tgaaaaaagt
     7621 cagttgtgcc cagcctacct tctctcacag ggggacccaa ttctctgaag tctacgatgg
     7681 agcatttttt gagaagaaac taaaccatac aaagtgttgg caacgtaggg atggtggacc
     7741 acagaaggct ataaaggcca ccatagaaag ctgaagagcc atttaattga agcggaagat
     7801 aaattggggg aaaagctaaa atgactcaaa ataggggcct gaaaatgctt taaggacctt
     7861 gtcattttga ctttgaatct cctgtttctg ctttattgct tctcatacct gccctgcttg
     7921 actgctgaag cagaaacaat caggcacgct gacaccctta tcagcatctg gcatccaaag
     7981 caacatcaga gagagagaac acagaagaaa agcaattgcc ccaggtcctc cccacagtca
     8041 agggagctct tccttccaga catccttgtg tgcctcttgc tagtttttta gggggtctcc
     8101 ccctcttcct gccctagctc tcaccagtct ccagagctcg tctcactggc tcatttcctt
     8161 ccccctagct tttcagcgct gccatcaaca ggacctctct cttttgtcaa ggcaactgga
     8221 gtcaagggga atctctggtt ctgatgcaag acccatccac cctcccccac ccctccccgc
     8281 ccaagaatca cttgctcagt aacaagaggc cacatcaatc tccttccaga ggagctcaag
     8341 aaaggcagtc ctgtacacag ccagcactct acttcttctg ccctctaaaa gaggagtgct
     8401 acagggcaag ttagaagcct gagagctggg aaaagggcac tgtgtgaaga caaagccttc
     8461 tttcttaggg agctctctct ttcttggctc ccttctctcg tcagttcagg ctacacttgc
     8521 ttaagcagta ctagattaca aattgctggg attagatgat aataccagag ggaaaggaag
     8581 aaggagaaaa acatacaaag aagtcccaag attggcaaag ggaggtggga gaggggggaa
     8641 ggggcagcta gagaaggcag agctgcacag gggcactaaa gatggcagta agtcacgccc
     8701 tctaacagta caacagtaca gacattgatg tcattcatgg ggagaaaaag acaaacaggg
     8761 agaccaaata cccaaaggga aaaagagcca ttaacatcta gtctgcatgt aaatatgctg
     8821 ggcggttatg ggacttcaca gagaaagtaa aaaagtactc catttccaaa agggaacaga
     8881 ggaatggagt aacctactct cctttgggga ccagatgtcc tcattctctt acctagggcc
     8941 cttattctgg gcttttggag cagtaattga agtgtgttgt tgttctgggc tctggctagt
     9001 tagccttacg gcttctgagc taaagtggat tttgctgtgc accccaaaac aatcccattg
     9061 ggtctggtct agctggaaac agcaaagttg ccgccaaaca cactcttgtg aaataaacca
     9121 tggggtgggg ggggcggggc ggaaataaag aatgcttttt cttga
//
