LOCUS       NM_007223               3912 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens G protein-coupled receptor 176 (GPR176), transcript
            variant 1, mRNA.
ACCESSION   NM_007223
VERSION     NM_007223.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3912)
  AUTHORS   Yang,N., Yun,W.J., Cui,Z.G. and Zheng,H.C.
  TITLE     The oncogenic roles of GPR176 in ovarian cancer: a molecular target
            for aggressiveness and gene therapy
  JOURNAL   J Obstet Gynaecol 44 (1), 2347430 (2024)
   PUBMED   38835234
  REMARK    GeneRIF: The oncogenic roles of GPR176 in ovarian cancer: a
            molecular target for aggressiveness and gene therapy.
REFERENCE   2  (bases 1 to 3912)
  AUTHORS   Okamoto,Y., Kitakaze,K., Takenouchi,Y., Matsui,R., Koga,D.,
            Miyashima,R., Ishimaru,H. and Tsuboi,K.
  TITLE     GPR176 promotes fibroblast-to-myofibroblast transition in organ
            fibrosis progression
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (7), 119798 (2024)
   PUBMED   39047914
  REMARK    GeneRIF: GPR176 promotes fibroblast-to-myofibroblast transition in
            organ fibrosis progression.
REFERENCE   3  (bases 1 to 3912)
  AUTHORS   Yun,W.J., Li,J., Yin,N.C., Zhang,C.Y., Cui,Z.G., Zhang,L. and
            Zheng,H.C.
  TITLE     The promoting effects of GPR176 expression on proliferation,
            chemoresistance, lipogenesis and invasion of oesophageal cancer
  JOURNAL   J Cancer Res Clin Oncol 149 (16), 14641-14655 (2023)
   PUBMED   37584712
  REMARK    GeneRIF: The promoting effects of GPR176 expression on
            proliferation, chemoresistance, lipogenesis and invasion of
            oesophageal cancer.
REFERENCE   4  (bases 1 to 3912)
  AUTHORS   Zhang,Y., Gu,X., Zhu,F., Li,Y., Huang,Y. and Ju,S.
  TITLE     High expression of GPR176 predicts poor prognosis of gastric cancer
            patients and promotes the proliferation, migration, and invasion of
            gastric cancer cells
  JOURNAL   Sci Rep 13 (1), 9360 (2023)
   PUBMED   37291181
  REMARK    GeneRIF: High expression of GPR176 predicts poor prognosis of
            gastric cancer patients and promotes the proliferation, migration,
            and invasion of gastric cancer cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3912)
  AUTHORS   Tang,J., Peng,W., Ji,J., Peng,C., Wang,T., Yang,P., Gu,J., Feng,Y.,
            Jin,K., Wang,X. and Sun,Y.
  TITLE     GPR176 Promotes Cancer Progression by Interacting with G Protein
            GNAS to Restrain Cell Mitophagy in Colorectal Cancer
  JOURNAL   Adv Sci (Weinh) 10 (12), e2205627 (2023)
   PUBMED   36905238
  REMARK    GeneRIF: GPR176 Promotes Cancer Progression by Interacting with G
            Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer.
REFERENCE   6  (bases 1 to 3912)
  AUTHORS   Goto,K., Doi,M., Wang,T., Kunisue,S., Murai,I. and Okamura,H.
  TITLE     G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16
            tunes time in the center of the circadian clock [Review]
  JOURNAL   Endocr J 64 (6), 571-579 (2017)
   PUBMED   28502923
  REMARK    GeneRIF: Data suggest that Gpr176 is an SCN-(suprachiasmatic
            nucleus-)enriched orphan GPCR (G-protein-coupled receptor) that
            sets the pace of circadian behavior. [REVIEW]
            Review article
REFERENCE   7  (bases 1 to 3912)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   8  (bases 1 to 3912)
  AUTHORS   Hata,S., Emi,Y., Iyanagi,T. and Osumi,T.
  TITLE     cDNA cloning of a putative G protein-coupled receptor from brain
  JOURNAL   Biochim Biophys Acta 1261 (1), 121-125 (1995)
   PUBMED   7893747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012377.5 and AC023908.6.
            
            On Jul 25, 2019 this sequence version replaced NM_007223.2.
            
            Summary: Members of the G protein-coupled receptor family, such as
            GPR176, are cell surface receptors involved in responses to
            hormones, growth factors, and neurotransmitters (Hata et al., 1995
            [PubMed 7893747]).[supplied by OMIM, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: D38449.1, JQ308174.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000561100.2/ ENSP00000453076.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               AC012377.5         158991-159402       c
            413-665             AC023908.6         121308-121560       c
            666-3912            AC023908.6         113310-116556       c
FEATURES             Location/Qualifiers
     source          1..3912
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q14-q15.1"
     gene            1..3912
                     /gene="GPR176"
                     /gene_synonym="HB-954"
                     /note="G protein-coupled receptor 176"
                     /db_xref="GeneID:11245"
                     /db_xref="HGNC:HGNC:32370"
                     /db_xref="MIM:612183"
     exon            1..412
                     /gene="GPR176"
                     /gene_synonym="HB-954"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..1788
                     /gene="GPR176"
                     /gene_synonym="HB-954"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable G-protein coupled receptor 176"
                     /codon_start=1
                     /product="G-protein coupled receptor 176 isoform 1"
                     /protein_id="NP_009154.1"
                     /db_xref="CCDS:CCDS10051.1"
                     /db_xref="GeneID:11245"
                     /db_xref="HGNC:HGNC:32370"
                     /db_xref="MIM:612183"
                     /translation="MGHNGSWISPNASEPHNASGAEAAGVNRSALGEFGEAQLYRQFT
                     TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILS
                     TSPHCCWWIYTMLFCKVVKFLHKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSR
                     ELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNSLGHLVYVLVYNITTVIVPV
                     VVVFLFLILIRRALSASQKKKVIIAALRTPQNTISIPYASQREAELHATLLSMVMVFI
                     LCSVPYATLVVYQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRKCLIGT
                     LVQLHHRYSRRNVVSTGSGMAEASLEPSIRSGSQLLEMFHIGQQQIFKPTEDEEESEA
                     KYIGSADFQAKEIFSTCLEGEQGPQFAPSAPPLSTVDSVSQVAPAAPVEPETFPDKYS
                     LQFGFGPFELPPQWLSETRNSKKRLLPPLGNTPEELIQTKVPKVGRVERKMSRNNKVS
                     IFPKVDS"
     exon            413..665
                     /gene="GPR176"
                     /gene_synonym="HB-954"
                     /inference="alignment:Splign:2.1.0"
     exon            666..3912
                     /gene="GPR176"
                     /gene_synonym="HB-954"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3758..3763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR176"
                     /gene_synonym="HB-954"
                     /note="hexamer: AATAAA"
     polyA_site      3779
                     /gene="GPR176"
                     /gene_synonym="HB-954"
                     /note="major polyA site"
     regulatory      3880..3885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR176"
                     /gene_synonym="HB-954"
                     /note="hexamer: AATAAA"
     polyA_site      3912
                     /gene="GPR176"
                     /gene_synonym="HB-954"
ORIGIN      
        1 cttgtggctg ctgactggga tccaggaggg agtgggcatg gggcgcagcc gcgcctccct
       61 ccctccccgc ctcccgggcg ccggggttgg cgatgtggag acgtgagggg acccgtcggc
      121 tgctccggct tctccaggac tccgccaggc gcccgcgcgt ccctcctcac ccggaggagg
      181 agaggctccg cgcggggctc cgaggcgggc ggcgcgcgga gccggagtcc cagcctcgcc
      241 atgggacata acgggagctg gatctctcca aatgccagcg agccgcacaa cgcgtccggc
      301 gccgaggctg cgggtgtgaa ccgcagcgcg ctcggggagt tcggcgaggc gcagctgtac
      361 cgccagttca ccaccaccgt gcaggtcgtc atcttcatag gctcgctgct cggaaacttc
      421 atggtgttat ggtcaacttg ccgcacaacc gtgttcaaat ctgtcaccaa caggttcatt
      481 aaaaacctgg cctgctcggg gatttgtgcc agcctggtct gtgtgccctt cgacatcatc
      541 ctcagcacca gtcctcactg ttgctggtgg atctacacca tgctcttctg caaggtcgtc
      601 aaatttttgc acaaagtatt ctgctctgtg accatcctca gcttccctgc tattgctttg
      661 gacaggtact actcagtcct ctatccactg gagaggaaaa tatctgatgc caagtcccgt
      721 gaactggtga tgtacatctg ggcccatgca gtggtggcca gtgtccctgt gtttgcagta
      781 accaatgtgg ctgacatcta tgccacgtcc acctgcacgg aagtctggag caactccttg
      841 ggccacctgg tgtacgttct ggtgtataac atcaccacgg tcattgtgcc tgtggtggtg
      901 gtgttcctct tcttgatact gatccgacgg gccctgagtg ccagccagaa gaagaaggtc
      961 atcatagcag cgctccggac cccacagaac accatctcta ttccctatgc ctcccagcgg
     1021 gaggccgagc tgcacgccac cctgctctcc atggtgatgg tcttcatctt gtgtagcgtg
     1081 ccctatgcca ccctggtcgt ctaccagact gtgctcaatg tccctgacac ttccgtcttc
     1141 ttgctgctca ctgctgtttg gctgcccaaa gtctccctgc tggcaaaccc tgttctcttt
     1201 cttactgtga acaaatctgt ccgcaagtgc ttgataggga ccctggtgca actacaccac
     1261 cggtacagtc gccgtaatgt ggtcagtaca gggagtggca tggctgaggc cagcctggaa
     1321 cccagcatac gctcgggtag ccagctcctg gagatgttcc acattgggca gcagcagatc
     1381 tttaagccca cagaggatga ggaagagagt gaggccaagt acattggctc agctgacttc
     1441 caggccaagg agatatttag cacctgcctg gagggagagc aggggccaca gtttgcgccc
     1501 tctgccccac ccctgagcac agtggactct gtatcccagg tggcaccggc agcccctgtg
     1561 gaacctgaaa cattccctga taagtattcc ctgcagtttg gctttgggcc ttttgagttg
     1621 cctcctcagt ggctctcaga gacccgaaac agcaagaagc ggctgcttcc ccccttgggc
     1681 aacaccccag aagagctgat ccagacaaag gtgcccaagg taggcagggt ggagcggaag
     1741 atgagcagaa acaataaagt gagcattttt ccaaaggtgg attcctagca aggattgtaa
     1801 attcttggaa gcaacgggga gcttccatat tcccaccaga gtgtgggaat gctgtggcca
     1861 tgtgattgta tgatctcctt gcaactcagt gtgagttgat tcctccaata tgggccagat
     1921 gcttttgaat gatagggaaa tctacataaa atccagtgtc ctctttattg agggagtata
     1981 tgtatccatc tcagtgatcc atgtccttag tgaagtccac attattctct gtggggacaa
     2041 gagctgggca gttttgaatg ggtcttgagg tgggtacccc atgtgcactt tctgaggatg
     2101 cctcacttcc ctgggctctg cagagaacac acagagagaa gactttcaga gctcacagga
     2161 gcagggagca ggagcactct aagggaattc caagatcatg atggagcatg gtggctccag
     2221 agaaaatgcc tgtttgatga acttaaacat gtcaaacatt ttctgttgag aaggtaggga
     2281 tttggtgtct tacactgttt ctctggaagc cccagtcata tgactcactg tttctcctga
     2341 tacccttcgt ccctttcatt gggatgtagg taaggaatga cgattcctca cctatggtac
     2401 acatggcgat agatgtgccc gggagtaagg gagatatttt gtccttgata attctgattt
     2461 tcccttggca tcaccaacgc ctcagagaga tacacctgca ccctccagtc agggtcagtg
     2521 ttggctggaa aacactgaaa agtcttcgct ctgtctttca ccttaaattg tgttttctca
     2581 acaaatgaga gagaagctta cgggggagat gcctgagaga tgcctatggc gctgtagttt
     2641 ttttttcttc cctatgatct cacatgaaag gtgctatgta acaaccagta tgagtcaaat
     2701 atattgaaaa aatcatctta tgcaaacttt aggaattaaa aggtattttt aaaatggaga
     2761 gttagtgtaa gctgggtcct ttggaaacat caaactgaaa aggcctgatt tggaaaggtg
     2821 actctgccca aaaggttggc aagaatctga caaagatggt ttccttccga ggaagactcc
     2881 ggaactcagg tgtggccagt ctccttttca gtctgtttgt acagctgcgg ttctctctta
     2941 attttggaca cagaggagga acagaacagg gagaaataat cattgtagag tgccaaggca
     3001 acatctgacc cagatgagct cttcacttcc tccttccctg tcgttgtaga gccagactgg
     3061 gtagaagagg gagggcagtg tcctcaactc atcagcctca caagcaattt gggacccctc
     3121 tggggtggat ttcaccaggt tgaattagaa ccgcagataa tacttccctg ttagtgagga
     3181 caaaccaagc gccagctctg cccttttctc tagagtgttg tgttcttgct cttggtactt
     3241 acaggagcta gtctggtgcc ttgagcaagc ttgaagggaa gtgggtgtcc tcaccagcaa
     3301 acttccacat ctcaactcgt gccctctttt ggccacactg gccccgtctc ttggagggag
     3361 cccagaccct gtagggagtt ttgttttcct ttcttctctt gggtgtggtg tcttgtgttt
     3421 ctgaatgtga acccaaagac cctacccctg gagaggaagc accttcctct ttgtgttggt
     3481 ctcctcatag cactgtttgc tcacagcaga aacggggctg ccacagcctc ctgcggctct
     3541 gctgccttct gggccctgcg tgcatggcat ctatagctcc ttgccctgat agtcaatgct
     3601 gtggcccttc aagcttgtct ttcaaagctt tcacaatcat tacaactttt atcaagggga
     3661 ataataatct ctaggaaaat tatgtccact ttaggagaat ctgtcaagtg tagccacttt
     3721 ggtgttgttc tgataatata ctgtatatgt acaacttaat aaattttgat gaggcagaat
     3781 ctggttgggt atgtttctta tatatgtttg aagcagatgg ctgactacta acaggtcatt
     3841 gccaggtgta tttctatact ctttgaagaa taacatttta ataaaaaatt gaaaagcagt
     3901 ttctgaactc aa
//
