LOCUS       NM_032553               5494 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens G protein-coupled receptor 174 (GPR174), mRNA.
ACCESSION   NM_032553 XM_001715858
VERSION     NM_032553.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5494)
  AUTHORS   Liu,G., Li,X., Wang,Y., Zhang,X. and Gong,W.
  TITLE     Structural basis for ligand recognition and signaling of the
            lysophosphatidylserine receptors GPR34 and GPR174
  JOURNAL   PLoS Biol 21 (12), e3002387 (2023)
   PUBMED   38048360
  REMARK    GeneRIF: Structural basis for ligand recognition and signaling of
            the lysophosphatidylserine receptors GPR34 and GPR174.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5494)
  AUTHORS   Liang,J., Inoue,A., Ikuta,T., Xia,R., Wang,N., Kawakami,K., Xu,Z.,
            Qian,Y., Zhu,X., Zhang,A., Guo,C., Huang,Z. and He,Y.
  TITLE     Structural basis of lysophosphatidylserine receptor GPR174 ligand
            recognition and activation
  JOURNAL   Nat Commun 14 (1), 1012 (2023)
   PUBMED   36823105
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5494)
  AUTHORS   Wei,W., Mu,S., Han,Y., Chen,Y., Kuang,Z., Wu,X., Luo,Y., Tong,C.,
            Zhang,Y., Yang,Y. and Song,Z.
  TITLE     Gpr174 Knockout Alleviates DSS-Induced Colitis via Regulating the
            Immune Function of Dendritic Cells
  JOURNAL   Front Immunol 13, 841254 (2022)
   PUBMED   35669778
  REMARK    GeneRIF: Gpr174 Knockout Alleviates DSS-Induced Colitis via
            Regulating the Immune Function of Dendritic Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5494)
  AUTHORS   Wang,J., Hu,Y., Kuang,Z., Chen,Y., Xing,L., Wei,W., Xue,M., Mu,S.,
            Tong,C., Yang,Y. and Song,Z.
  TITLE     GPR174 mRNA Acts as a Novel Prognostic Biomarker for Patients With
            Sepsis via Regulating the Inflammatory Response
  JOURNAL   Front Immunol 12, 789141 (2022)
   PUBMED   35173706
  REMARK    GeneRIF: GPR174 mRNA Acts as a Novel Prognostic Biomarker for
            Patients With Sepsis via Regulating the Inflammatory Response.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5494)
  AUTHORS   Cho,W.K., Shin,H.R., Lee,N.Y., Kim,S.K., Ahn,M.B., Baek,I.C.,
            Kim,T.G. and Suh,B.K.
  TITLE     GPR174 and ITM2A Gene Polymorphisms rs3827440 and rs5912838 on the
            X chromosome in Korean Children with Autoimmune Thyroid Disease
  JOURNAL   Genes (Basel) 11 (8), 858 (2020)
   PUBMED   32727090
  REMARK    GeneRIF: GPR174 and ITM2A Gene Polymorphisms rs3827440 and
            rs5912838 on the X chromosome in Korean Children with Autoimmune
            Thyroid Disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5494)
  AUTHORS   Zhao,S.X., Xue,L.Q., Liu,W., Gu,Z.H., Pan,C.M., Yang,S.Y., Zhan,M.,
            Wang,H.N., Liang,J., Gao,G.Q., Zhang,X.M., Yuan,G.Y., Li,C.G.,
            Du,W.H., Liu,B.L., Liu,L.B., Chen,G., Su,Q., Peng,Y.D., Zhao,J.J.,
            Ning,G., Huang,W., Liang,L., Qi,L., Chen,S.J., Chen,Z., Chen,J.L.
            and Song,H.D.
  CONSRTM   China Consortium for the Genetics of Autoimmune Thyroid Disease
  TITLE     Robust evidence for five new Graves' disease risk loci from a
            staged genome-wide association analysis
  JOURNAL   Hum Mol Genet 22 (16), 3347-3362 (2013)
   PUBMED   23612905
REFERENCE   7  (bases 1 to 5494)
  AUTHORS   Chu,X., Shen,M., Xie,F., Miao,X.J., Shou,W.H., Liu,L., Yang,P.P.,
            Bai,Y.N., Zhang,K.Y., Yang,L., Hua,Q., Liu,W.D., Dong,Y.,
            Wang,H.F., Shi,J.X., Wang,Y., Song,H.D., Chen,S.J., Chen,Z. and
            Huang,W.
  TITLE     An X chromosome-wide association analysis identifies variants in
            GPR174 as a risk factor for Graves' disease
  JOURNAL   J Med Genet 50 (7), 479-485 (2013)
   PUBMED   23667180
  REMARK    GeneRIF: The finding of an X-linked risk locus for Graves' disease
            expands our understanding of the role of the X chromosome in
            disease susceptibility.
REFERENCE   8  (bases 1 to 5494)
  AUTHORS   Sugita,K., Yamamura,C., Tabata,K. and Fujita,N.
  TITLE     Expression of orphan G-protein coupled receptor GPR174 in CHO cells
            induced morphological changes and proliferation delay via
            increasing intracellular cAMP
  JOURNAL   Biochem Biophys Res Commun 430 (1), 190-195 (2013)
   PUBMED   23178570
  REMARK    GeneRIF: These results suggested that GPR174 was a putative LysoPS
            receptor conjugating with Galpha(s), and its expression induced
            morphological changes in CHO cells by constitutively activating
            adenylyl cycles accompanied with cell conjunctions and delay of
            proliferation.
REFERENCE   9  (bases 1 to 5494)
  AUTHORS   Qin,Y., Verdegaal,E.M., Siderius,M., Bebelman,J.P., Smit,M.J.,
            Leurs,R., Willemze,R., Tensen,C.P. and Osanto,S.
  TITLE     Quantitative expression profiling of G-protein-coupled receptors
            (GPCRs) in metastatic melanoma: the constitutively active orphan
            GPCR GPR18 as novel drug target
  JOURNAL   Pigment Cell Melanoma Res 24 (1), 207-218 (2011)
   PUBMED   20880198
REFERENCE   10 (bases 1 to 5494)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590222.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 6, 2020 this sequence version replaced NM_032553.2.
            
            Summary: This gene encodes a protein belonging to the G
            protein-coupled receptor superfamily. These proteins are
            characterized by the presence of seven alpha-helical transmembrane
            domains, and they activate or interact with various endogenous or
            exogenous ligands, including neurotransmitters, hormones, and
            odorant and taste substances. This family member is classified as
            an orphan receptor because the cognate ligand has not been
            identified. [provided by RefSeq, Sep 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2138586.1,
                                           SRR14038197.805288.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000645147.2/ ENSP00000494310.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-530               AL590222.4         34338-34867
            531-627             AL590222.4         46472-46568
            628-5494            AL590222.4         60102-64968
FEATURES             Location/Qualifiers
     source          1..5494
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.1"
     gene            1..5494
                     /gene="GPR174"
                     /gene_synonym="FKSG79; GPCR17; LPS3; LYPSR3"
                     /note="G protein-coupled receptor 174"
                     /db_xref="GeneID:84636"
                     /db_xref="HGNC:HGNC:30245"
                     /db_xref="MIM:300903"
     exon            1..530
                     /gene="GPR174"
                     /gene_synonym="FKSG79; GPCR17; LPS3; LYPSR3"
                     /inference="alignment:Splign:2.1.0"
     exon            531..627
                     /gene="GPR174"
                     /gene_synonym="FKSG79; GPCR17; LPS3; LYPSR3"
                     /inference="alignment:Splign:2.1.0"
     exon            628..5494
                     /gene="GPR174"
                     /gene_synonym="FKSG79; GPCR17; LPS3; LYPSR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             1184..2185
                     /gene="GPR174"
                     /gene_synonym="FKSG79; GPCR17; LPS3; LYPSR3"
                     /note="lysophosphatidylserine receptor 3"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 174"
                     /protein_id="NP_115942.1"
                     /db_xref="CCDS:CCDS14443.1"
                     /db_xref="GeneID:84636"
                     /db_xref="HGNC:HGNC:30245"
                     /db_xref="MIM:300903"
                     /translation="MPANYTCTRPDGDNTDFRYFIYAVTYTVILVPGLIGNILALWVF
                     YGYMKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNM
                     YASIYFLVCISVRRFWFLMYPFRFHDCKQKYDLYISIAGWLIICLACVLFPLLRTSDD
                     TSGNRTKCFVDLPTRNVNLAQSVVMMTIGELIGFVTPLLIVLYCTWKTVLSLQDKYPM
                     AQDLGEKQKALKMILTCAGVFLICFAPYHFSFPLDFLVKSNEIKSCLARRVILIFHSV
                     ALCLASLNSCLDPVIYYFSTNEFRRRLSRQDLHDSIQLHAKSFVSNHTASTMTPELC"
     regulatory      5464..5469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR174"
                     /gene_synonym="FKSG79; GPCR17; LPS3; LYPSR3"
                     /note="hexamer: AATAAA"
     polyA_site      5494
                     /gene="GPR174"
                     /gene_synonym="FKSG79; GPCR17; LPS3; LYPSR3"
                     /note="major polyA site"
ORIGIN      
        1 agtgtacaca gagagtggct tgcatatttc actctgacat cttactacta tgcttttcaa
       61 catgatagtg gttagatatt cctgataatt ttaatttttt ttccttttgc tttcataatt
      121 tttcttttgg ctttctttta ttttgtatta tttttacttt tatttatttt cttccctccc
      181 tccttctctc ctgtattcat tccttccttc cttccttctt ccttccttcc ctccttcctc
      241 tcctttcctt ttctttcttt ctttttcttt ctttctttct ctttctttct ttttctttct
      301 ttctttctct ctctctctct ttctttcttt ctttctttct ttctttcttt ctttctttct
      361 ttctttcttt ctttcttttt tttctccttt tgctagtgaa ggagaattgg attggttatt
      421 ttcagaacag gcagcctaaa ttgatgcaca aatcagtagc atcctttttg gagtggccat
      481 cacatgaatt ctttggagat ctctgaagaa aacagaaaga aactgaaatg gcatgaatga
      541 attaatcgtg ccagattctc caacacttcc tcaggagacc ctattgctct gatcaagaag
      601 ttccatcagc accgaagaaa acagcagctc tgcctttgtt tcctactttt tagcttttga
      661 cctatagctg aaaaagtccc agaaagctga tctttccaag ttaatcatcc ctgaagagtg
      721 gcggactcat tgtgcactaa agcaatcctt tcttctatgt gagccaaaaa aagaaaaacg
      781 gcctgccaga cacctgtaaa gagaaggcta tcgtcatata ggaatttgag gaactgctat
      841 atggtacatt ccttttccaa atgggagaga ataagctctc atgatgtccc agagggcctt
      901 aaaataaaca agaggggaaa ttgtaacagc ttgtcatctg tgcttgtaca ctagacttcc
      961 atgtagttac tctagagaaa tctaaatcaa aaatgcagat cattctttga aaaatcccca
     1021 aatcatacgt agagactcag acagatgtgg taaaaagagg aaggttattt tatacttcgt
     1081 atctccaacc cactggcaat caatcttttg gaaggaacag cagttgattg tgaatttagt
     1141 tttgaaccac cattaggcaa agatagtttc tctagagaga atcatgcctg ctaattacac
     1201 gtgtaccagg ccagatggag acaatacaga ttttcgatac tttatttatg cagtgacata
     1261 cactgtcatt cttgtgccag gtctcatagg gaatatatta gccctgtggg tattctatgg
     1321 ttatatgaaa gaaacaaaac gagctgtgat atttatgata aacttagcca ttgctgactt
     1381 actacaagtt ctttccttgc cactgaggat cttctactac ttgaatcatg actggccatt
     1441 tgggcctggt ctctgcatgt tctgtttcta cctgaagtat gtcaacatgt atgcaagcat
     1501 ctacttcttg gtctgcatca gtgtgcgacg attttggttt ctcatgtacc cctttcgctt
     1561 ccatgactgc aaacagaaat atgacctgta catcagcatt gctggctggc tgatcatctg
     1621 ccttgcctgt gtactctttc cactcctcag aaccagtgat gatacctctg gcaataggac
     1681 caaatgcttt gtggatcttc ctaccaggaa tgtcaacctg gcccagtccg ttgttatgat
     1741 gaccattggc gagttgattg ggtttgtaac tccgcttctg attgtcctat attgtacctg
     1801 gaagacggtt ttatcactgc aagataaata tcccatggcc caagatcttg gagagaaaca
     1861 gaaagccttg aagatgattc taacctgtgc aggggtattc ctaatttgct ttgcacctta
     1921 tcatttcagt tttcctttag atttcctggt gaagtccaat gaaattaaaa gctgcctagc
     1981 cagaagggtg attctaatat ttcattctgt ggcattgtgt cttgctagtc tgaattcatg
     2041 tcttgaccca gtcatatact acttttccac taatgagttc cgaagacggc tttcaagaca
     2101 agatttgcat gacagcatcc aactccatgc aaaatccttt gtgagtaacc atacagcttc
     2161 caccatgaca cctgaattat gctaaaacaa aaaaccaaac tgaatgtgac ctgaaatgca
     2221 agtacatcag aacatatctg caatacccaa gccacaggga agaacttgca aaacaacaca
     2281 gcttttcagt tctgctctat cttactgcta tggggaattc acttcttcaa agcaggacct
     2341 atttggagca ttacgatcca cgattattga tgttgacatg tccatgtagt aatttttctt
     2401 caagtctgta aatcttaaaa tatcaaattt ctgtgacatc ctataaacat atgcactcaa
     2461 ctgtagtcag tacttttacc tgtgaacctc aggcacaaaa agattattag cttggagtca
     2521 ccataaacat ttagttttgt tgcaacagat actgagtctt tatgttcaga ggaaatgtaa
     2581 gtgtcttttt atattagtaa tcacagttta catgccattt tcatatgttt ggttatattt
     2641 tagtgggata gatgatatat taccctgtgt aaagaaaatg taaacataag atcattttta
     2701 tctctcaagt gtgattactc ttcagagttt gaagattaaa atagctattt tcttcatttt
     2761 tgtgtcaaca tgaaacatca tttgtcacac ctgttcacag aatgaaaatc tgaactcagg
     2821 cctctggcat atttaaacta agaacaatat acatatttac atacgacaac cctctgtgac
     2881 tggaaaagat gccgtgttgc atctacctag gacaggtagt ttgtcaaagt ccatacaagg
     2941 tgactcaatt gggctctagg cctaggagaa agcagaaagg tgacaatcac aattctgctc
     3001 tcttacactt tttctaaaga acacttctgg agatgtatgg acccgcctag tagaggaagt
     3061 ttttatcatg tttctagaga tacattgagg taatgttgac aggttcctgc actttctgag
     3121 cctgtggaag aagtagtgca ctaatgaatc attaaacctg ggccagagtg aaaagatgaa
     3181 gcaaagttgg gtaatctttt taaaattctc atcacattgt atttcttact ctaatacaag
     3241 gacacttact tagcttagac tgccaagtta cttacacaag ccagagtaag tctctctgcc
     3301 ccatcattgc atacatatta cagtcagtca catggaccct agaatccaca ttgatttttt
     3361 ttggtctagc tttgccccag acataccatt ctaaagccta caaagcctag ctcttagcag
     3421 ctggggaagg caattatttc acctcttgaa aaatgcatag aagattaatt tggtcagcct
     3481 ttggcaacca atggccaatg acttgcctac tacctgtttg gtactattgt gtgggaaaca
     3541 gacccaggat attagtcgta attaaacctt aggttgtaag tattagaata ttttgaaaca
     3601 tgttttagca aaaagctcta actttaagaa agttctactt aaaatctgtg tgctatataa
     3661 tgaagatacc ttctacgtct cacagaagga atgtagaacc caatcaaagg ctttatcata
     3721 tttagaggaa aggggttgtt ttaggcatac agttatgata ctaatacatt aggggaaaac
     3781 tggtgacatc aaaatgaatt ctaatatcta gactgatgga aagttttcta aagttttctt
     3841 tggacaagtg ttgattttac acatatgttg ttattaagat aataccctat tagaaaactg
     3901 actttgtgct gctagcaagt gtatctatgt gtctcctaac taatcattgt aaggtatatg
     3961 ttttgatgtg ttaaataagt tttcaataag tgttaaactg tattttaaat agggcatcta
     4021 taactgtgtc ttgtctcttt gctttaaagt gtcttttgtt tgactataat ttagtgttgc
     4081 aataggattg caagtaataa ttttgtggaa ttgtgaaata actgtgggta cttttaatgt
     4141 gagagtctta tctatagtat ttgtgcttag tattttctag attagcatga attacacttc
     4201 ctaaggtcac tttggaagat gattgatttg atttaattaa catattgatt tcactttgac
     4261 tatatttttc ttaaagagga agggaaatat tttcaggaga tgtttgacct tcttagatga
     4321 atggttgagg gtagggccca tttgttaggc agcccattta catcattcca aaaaaggacc
     4381 agtattcagt gttatgctgc ttagctgagg acaccctttt tccccaggcc tgcccatcta
     4441 cgtttgtatt cagtgctctg atttacttta ttcacccctt atcccatcaa tatgttttgt
     4501 cttctgcttg attcccttgc tctcccaggc agcaacctga tcaattcatt cacaccatgg
     4561 tgctaatagc taatgttagg ttcatattaa tttacccagg aatatctgaa ttccaggctt
     4621 taggactagg cattaaacca aagtggtgac tttcaatgga gggctaatac atactgaagc
     4681 agacagactg gagggaaaga aattttggat aaagtgggtc ccacagcact gcctttcata
     4741 ttgcatacag taagcaaaca cctactttgg ttaccataat gggaatgctg acttttaaga
     4801 aattaagaaa tgtatccatg aacatggcta tcagtttctc agatgtctgc tcaccttctt
     4861 ttcattttgc ctctctcctt tcctacgttg ggcctgattt tcaggggaaa gtctaaacta
     4921 gtagcttact aatttaggag tactggtgca gctacgatcc agacagcagc ctgttctctg
     4981 agcttctcca ttccatggct tatccagact tctcatttat cactctctgg gttctatgaa
     5041 attgtggtgc aaagagtaaa caccctcaac catagtaatg tatacttcaa gataaataat
     5101 tccacatttc ctatataaag ttgttgaatt ttgattcaaa aatgcgtaag tattccaata
     5161 agaaaaactt tgtatgtagt gatttctatg taaaaatatt gttattatta ttatattcaa
     5221 atggtttata tgttttcatt gtcactcagt taagcagcca attctgttag ctggtaattc
     5281 cacaaagaga agccatctgc cccaggagca acagaccaag ctgccttggt ctgagagggt
     5341 gcatctgtgg aactcttgcg caacttacat tttatgtcac cttttgattt tactcccaag
     5401 atactgtgaa aatgttgcac ttggaattta tttatggcta taacttataa tattcatttt
     5461 aataataaag attgtctttg taattacata gaaa
//
