LOCUS       NM_018969               4787 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens G protein-coupled receptor 173 (GPR173), mRNA.
ACCESSION   NM_018969 XM_938451
VERSION     NM_018969.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4787)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4787)
  AUTHORS   Gu,Z., Xie,D., Ding,R., Huang,C. and Qiu,Y.
  TITLE     GPR173 agonist phoenixin 20 promotes osteoblastic differentiation
            of MC3T3-E1 cells
  JOURNAL   Aging (Albany NY) 13 (4), 4976-4985 (2020)
   PUBMED   33196456
  REMARK    GeneRIF: GPR173 agonist phoenixin 20 promotes osteoblastic
            differentiation of MC3T3-E1 cells.
REFERENCE   3  (bases 1 to 4787)
  AUTHORS   Zhang,H., Zhang,Y., Wang,Y.F., Morris,D., Hirankarn,N., Sheng,Y.,
            Shen,J., Pan,H.F., Yang,J., Yang,S., Cui,Y., Ye,D.Q., Vyse,T.J.,
            Zhang,X., Lau,Y.L. and Yang,W.
  TITLE     Meta-analysis of GWAS on both Chinese and European populations
            identifies GPR173 as a novel X chromosome susceptibility gene for
            SLE
  JOURNAL   Arthritis Res Ther 20 (1), 92 (2018)
   PUBMED   29724251
  REMARK    GeneRIF: Single-nucleotide polymorphism rs13440883 in GPR173 was
            found to be significantly associated with systemic lupus
            erythematous
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4787)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 4787)
  AUTHORS   Yanai,T., Kurosawa,A., Nikaido,Y., Nakajima,N., Saito,T., Osada,H.,
            Konno,A., Hirai,H. and Takeda,S.
  TITLE     Identification and molecular docking studies for novel inverse
            agonists of SREB, super conserved receptor expressed in brain
  JOURNAL   Genes Cells 21 (7), 717-727 (2016)
   PUBMED   27184081
  REMARK    GeneRIF: a molecular model of GPR173 was constructed using the
            screening results. The combination of computational and biological
            methods will provide a unique approach to ligand identification for
            orphan GPCRs and brain research.
REFERENCE   6  (bases 1 to 4787)
  AUTHORS   Tarpey,P.S., Smith,R., Pleasance,E., Whibley,A., Edkins,S.,
            Hardy,C., O'Meara,S., Latimer,C., Dicks,E., Menzies,A.,
            Stephens,P., Blow,M., Greenman,C., Xue,Y., Tyler-Smith,C.,
            Thompson,D., Gray,K., Andrews,J., Barthorpe,S., Buck,G., Cole,J.,
            Dunmore,R., Jones,D., Maddison,M., Mironenko,T., Turner,R.,
            Turrell,K., Varian,J., West,S., Widaa,S., Wray,P., Teague,J.,
            Butler,A., Jenkinson,A., Jia,M., Richardson,D., Shepherd,R.,
            Wooster,R., Tejada,M.I., Martinez,F., Carvill,G., Goliath,R., de
            Brouwer,A.P., van Bokhoven,H., Van Esch,H., Chelly,J., Raynaud,M.,
            Ropers,H.H., Abidi,F.E., Srivastava,A.K., Cox,J., Luo,Y.,
            Mallya,U., Moon,J., Parnau,J., Mohammed,S., Tolmie,J.L.,
            Shoubridge,C., Corbett,M., Gardner,A., Haan,E., Rujirabanjerd,S.,
            Shaw,M., Vandeleur,L., Fullston,T., Easton,D.F., Boyle,J.,
            Partington,M., Hackett,A., Field,M., Skinner,C., Stevenson,R.E.,
            Bobrow,M., Turner,G., Schwartz,C.E., Gecz,J., Raymond,F.L.,
            Futreal,P.A. and Stratton,M.R.
  TITLE     A systematic, large-scale resequencing screen of X-chromosome
            coding exons in mental retardation
  JOURNAL   Nat Genet 41 (5), 535-543 (2009)
   PUBMED   19377476
REFERENCE   7  (bases 1 to 4787)
  AUTHORS   Matsumoto,M., Saito,T., Takasaki,J., Kamohara,M., Sugimoto,T.,
            Kobayashi,M., Tadokoro,M., Matsumoto,S., Ohishi,T. and Furuichi,K.
  TITLE     An evolutionarily conserved G-protein coupled receptor family,
            SREB, expressed in the central nervous system
  JOURNAL   Biochem Biophys Res Commun 272 (2), 576-582 (2000)
   PUBMED   10833454
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX322635.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 4, 2019 this sequence version replaced NM_018969.5.
            
            Summary: This gene encodes a member of the G-protein coupled
            receptor 1 family. This protein contains 7 transmembrane domains
            and conserved cysteine residues. [provided by RefSeq, Nov 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR4368410.453695.1, BC009861.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332582.5/ ENSP00000331600.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-696               BX322635.6         22885-23580
            697-4787            BX322635.6         50621-54711
FEATURES             Location/Qualifiers
     source          1..4787
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..4787
                     /gene="GPR173"
                     /gene_synonym="SREB3"
                     /note="G protein-coupled receptor 173"
                     /db_xref="GeneID:54328"
                     /db_xref="HGNC:HGNC:18186"
                     /db_xref="MIM:300253"
     exon            1..696
                     /gene="GPR173"
                     /gene_synonym="SREB3"
                     /inference="alignment:Splign:2.1.0"
     exon            697..4787
                     /gene="GPR173"
                     /gene_synonym="SREB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             794..1915
                     /gene="GPR173"
                     /gene_synonym="SREB3"
                     /note="super conserved receptor expressed in brain 3"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 173"
                     /protein_id="NP_061842.1"
                     /db_xref="CCDS:CCDS14349.1"
                     /db_xref="GeneID:54328"
                     /db_xref="HGNC:HGNC:18186"
                     /db_xref="MIM:300253"
                     /translation="MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILS
                     LLVLKERALHKAPYYFLLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFM
                     AVLFCFHAAFMLFCISVTRYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVF
                     DVGTYKFIREEDQCIFEHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMK
                     PVQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMD
                     EVKGEKQLGRMFYAITLLFLLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAA
                     VNPIVCFLLNKDLKKCLRTHAPCWGTGGAPAPREPYCVM"
     regulatory      4765..4770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR173"
                     /gene_synonym="SREB3"
                     /note="hexamer: CATAAA"
     polyA_site      4787
                     /gene="GPR173"
                     /gene_synonym="SREB3"
                     /note="major polyA site"
ORIGIN      
        1 accccctctt tctggcgtcc atcccctccc caacaccacc tctgctgctg cctctggctg
       61 tggacctgca cctcttcccc atccccgcca ggcccgggga gcggggtgag cctggatgag
      121 agccccccca acctggggct ctcccaggcc atggcccgtg tgctcccagg gaggagcccc
      181 ggaccctgag catctgctgg aggcttggca gaggccccgc ggggaccgtg tcttctgagg
      241 acaaaaggcg gcggccagca ggcagacgga gggggggggt ggggggtggg gggggtaggg
      301 ggaccggcag ccaggcaggc agacgggtag caggggccag cactggcccc cctcccagct
      361 tggcagtggc atgaagatgg gagtgggagt gtatagtgga ggaagcacct gccgggaccc
      421 ccacctgcca gctagttgga caccccaagg ctgtgtgctg cccacctggt gttccccaac
      481 acccccagcc ctacccagtg cacccctccg gtgcctgctt tccctgatgc ctgcgattta
      541 gaccagcccg gctgtatcca cggcaacaga agcaggagtg tcactggccg ccagatcact
      601 gagggtccca caatgtggcc cgggctgtga tttacctggg tgagacagct tgagccccat
      661 cgtggattcc aagacatccc tgctgagaga gccaaggtgc aatgtagcag gacaactcat
      721 ggagcccccc cgggcccatc gagtaccgga ctggctgacc ccctagggtt ggcagtagcc
      781 cctgaccctc agtatggcca acactaccgg agagcctgag gaggtgagcg gcgctctgtc
      841 cccaccgtcc gcatcagctt atgtgaagct ggtactgctg ggactgatta tgtgcgtgag
      901 cctggcgggt aacgccatct tgtccctgct ggtgctcaag gagcgtgccc tgcacaaggc
      961 tccttactac ttcctgctgg acctgtgcct ggccgatggc atacgctctg ccgtctgctt
     1021 cccctttgtg ctggcttctg tgcgccacgg ctcttcatgg accttcagtg cactcagctg
     1081 caagattgtg gcctttatgg ccgtgctctt ttgcttccat gcggccttca tgctgttctg
     1141 catcagcgtc acccgctaca tggccatcgc ccaccaccgc ttctacgcca agcgcatgac
     1201 actctggaca tgcgcggctg tcatctgcat ggcctggacc ctgtctgtgg ccatggcctt
     1261 cccacctgtc tttgacgtgg gcacctacaa gtttattcgg gaggaggacc agtgcatctt
     1321 tgagcatcgc tacttcaagg ccaatgacac gctgggcttc atgcttatgt tggctgtgct
     1381 catggcagct acccatgctg tctacggcaa gctgctcctc ttcgagtatc gtcaccgcaa
     1441 gatgaagcca gtgcagatgg tgccagccat cagccagaac tggacattcc atggtcccgg
     1501 ggccaccggc caggctgctg ccaactggat cgccggcttt ggccgtgggc ccatgccacc
     1561 aaccctgctg ggtatccggc agaatgggca tgcagccagc cggcggctac tgggcatgga
     1621 cgaggtcaag ggtgaaaagc agctgggccg catgttctac gcgatcacac tgctctttct
     1681 gctcctctgg tcaccctaca tcgtggcctg ctactggcga gtgtttgtga aagcctgtgc
     1741 tgtgccccac cgctacctgg ccactgctgt ttggatgagc ttcgcccagg ctgccgtcaa
     1801 cccaattgtc tgcttcctgc tcaacaagga cctcaagaag tgcctgagga ctcacgcccc
     1861 ctgctggggc acaggaggtg ccccggctcc cagagaaccc tactgtgtca tgtgaagcag
     1921 gctggtaggc agacaggcag agagaaggtc atggccaccg tgatggggcc aacagcaagg
     1981 gaggggtagg ggcccataca ggagtcctcc tttctgagct ccagccccag cccctcgaac
     2041 cacctgtaat ctaggcacct ttgccaacac ctcccaagga tggaggactg ggcgagggac
     2101 tgggaaagag gcatatttag ttttgtgggg cctgtctccg ctgcctcctt ctccacttct
     2161 acaatctcat tctctctctc tctctctctg tctctctctc tctctctctc tctctctcag
     2221 aagtgacaat tcagaaaaag aaaagaacac tgagaatgca ggtttttcta ctaacagctg
     2281 aggagacagg ctttcttact ttaatgtctc tccttctgac actgtccaga agggggaatt
     2341 tgtcctgtaa aatagacttc cagagctctt ttgccccctc tgctcccatg caccctcccc
     2401 ttccaagtcc tttagcaagg cctggatgtt tagggagaaa gtggtccaag gctgctgaca
     2461 agagggacca aagggggtgc tgggttccca gggagcaggg atgtttaatt actatgtcat
     2521 gtgcaatgtt gttttaggcc aacccttgcc ccaagcccag tctcttctcc ctccccacca
     2581 tgtccagacc tcccaaatgg ttcttgtgca tctgttggag aagtcaaggg agtagggaga
     2641 agggccccaa ggatgggccc aggttaggtg aagagtaaga tgtgagctga actcctcgaa
     2701 ctgaagagac ccacacttgg tcacattctc tcacgctgcc ttcaggatcc ccagccccca
     2761 actcttcttc ctgaggatgg aaatccactc cagccccact aggactgatg tgggtgccat
     2821 acaggcagga gcagcccacc aggaaagtgt aaggagggag ctgaactccc cagagtagct
     2881 ggaccacaga gacttgggtc agagctgatt tcaaccccag aattgtctct cgggttcacc
     2941 ctactcttct gaagatgaaa atttgtttgg ggccttggta accgatagcg gtacaaactc
     3001 caaggcactg tggacttgag tccattccta tctgacctct ttttgtcccc ctcaagcctc
     3061 aggggcctca agcccctcct tagtagccct tggctgactg ggccctgagc cccaagcatc
     3121 cttctttccc aacaaccctc cttccccatc cttcccccac ccttacctac acccaaagtg
     3181 gagcacactg cagtcagatt ctccaggagg gagatccaag cctcctccca ggggtggagt
     3241 ccactctggg cttactttga ggcctgttct gtggattggt gagccaagct ggcactcctt
     3301 gccctggtct tacccaggct ctctgtcccc ctctcacttc ctgtggggcc ggaatctgta
     3361 tttatccatc cccctttccc ttctttatag aagtccctgt cctaaactcc ctccctagcc
     3421 caagagagcc ccagaactgg ggaagcctga cccatacaga atggggaggg cactctaggc
     3481 aggagagaca ttaatgagcc tggctgcaga gtggccctgg aaaggcaggc cagagtggct
     3541 gagaggctgg gagtagggga gcctgttctc tcagcgatag tgatgggggt gcctttccga
     3601 gggggtgggg tgggaagacc aagggggtgg ggggtagata gggtacattt aggagggttt
     3661 tcctccattt cttttttcta actgcctgga ttcaccattg gattttgtaa atggaaaaac
     3721 tgaaatgaac aatgctatac tggatgtttt ctctttctga ctgtgtgtgt gtgtgtgcgt
     3781 gcgtgcgtgc atgtgccctg tctgaccaca tgtggagaga catgattgag tgatagtgtg
     3841 tgtctgtgtg actttgtgtg gggaggcact cctgaagaaa acttgcccgg tgcacacacg
     3901 taaaatgcct gtatatgggg acagatacag cacgtgcatg catacacaca cacacacaca
     3961 caccacagtt gagaggagac aaactagagt atgtgcccgt ggtaggaagt cgagtggtca
     4021 agagatggat cttggaaact acataggtcg gtagcaagag ggtagactcc catctcacaa
     4081 gatgggcctc ccttggccca ggccctgagc acgggagggc tggggccgcc agggaacttg
     4141 aaaacctcat ctcctcacaa agcctgtagc cccatctcaa ccccgtctca gtctccttcc
     4201 caaactcaaa caaggtgttc ctaaaattgg accaccatgg agaatgggga ctgggaattg
     4261 aggatcaaat gtgagggaaa ctgatgaggt taggaaatgc cccccacaaa gtaatggctt
     4321 ctggagggac tgctcagtct gggatgggag cccttcctag gggccactgt atgcagctgg
     4381 gactttggtc agctttgacc aaatttagag ggagggatgt catggggaaa aaaaacccaa
     4441 gcccaggagt ctacccagcc agcctgctcc ctagacagtt aatttactat ctggttattc
     4501 tctcaggtgc acagaattga gttgaccata ctcctcagtt cttggcacac tatatcatca
     4561 ttggtccatg tgaggccctt ttattttttt ttcttcagtt ttgtcccctt catcacccat
     4621 tcctgatccc atcctccccg ccccctacac aggcacccac tctcgtgtat ttaacgtacg
     4681 tccttccaat ccaccgttca tgtgtttatt tacatatatg tgtatctgtg aaaaatgtat
     4741 ggtattgctg tgtgttttaa tttacataaa cagtattgta ctataaa
//
