LOCUS       NM_001161417            2016 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens G protein-coupled receptor 17 (GPR17), transcript
            variant 4, mRNA.
ACCESSION   NM_001161417
VERSION     NM_001161417.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2016)
  AUTHORS   Konda Mani,S., Thiyagarajan,R., Yli-Harja,O., Kandhavelu,M. and
            Murugesan,A.
  TITLE     Structural analysis of human G-protein-coupled receptor 17 ligand
            binding sites
  JOURNAL   J Cell Biochem 124 (4), 533-544 (2023)
   PUBMED   36791278
  REMARK    GeneRIF: Structural analysis of human G-protein-coupled receptor 17
            ligand binding sites.
REFERENCE   2  (bases 1 to 2016)
  AUTHORS   Daniele,S., Saporiti,S., Capaldi,S., Pietrobono,D., Russo,L.,
            Guerrini,U., Laurenzi,T., Ataie Kachoie,E., Palazzolo,L., Russo,V.,
            Abbracchio,M.P., Eberini,I. and Trincavelli,M.L.
  TITLE     Functional Heterodimerization between the G Protein-Coupled
            Receptor GPR17 and the Chemokine Receptors 2 and 4: New Evidence
  JOURNAL   Int J Mol Sci 24 (1), 261 (2022)
   PUBMED   36613703
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2016)
  AUTHORS   Nguyen,P., Doan,P., Murugesan,A., Ramesh,T., Rimpilainen,T.,
            Candeias,N.R., Yli-Harja,O. and Kandhavelu,M.
  TITLE     GPR17 signaling activation by CHBC agonist induced cell death via
            modulation of MAPK pathway in glioblastoma
  JOURNAL   Life Sci 291, 120307 (2022)
   PUBMED   35016881
  REMARK    GeneRIF: GPR17 signaling activation by CHBC agonist induced cell
            death via modulation of MAPK pathway in glioblastoma.
REFERENCE   4  (bases 1 to 2016)
  AUTHORS   Lin,K.N., Zhang,K., Zhao,W., Huang,S.Y. and Li,H.
  TITLE     Insulin-like Growth Factor 1 Promotes Cell Proliferation by
            Downregulation of G-Protein-Coupled Receptor 17 Expression via
            PI3K/Akt/FoxO1 Signaling in SK-N-SH Cells
  JOURNAL   Int J Mol Sci 23 (3), 1513 (2022)
   PUBMED   35163437
  REMARK    GeneRIF: Insulin-like Growth Factor 1 Promotes Cell Proliferation
            by Downregulation of G-Protein-Coupled Receptor 17 Expression via
            PI3K/Akt/FoxO1 Signaling in SK-N-SH Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2016)
  AUTHORS   Conley,J.M., Sun,H., Ayers,K.L., Zhu,H., Chen,R., Shen,M.,
            Hall,M.D. and Ren,H.
  TITLE     Human GPR17 missense variants identified in metabolic disease
            patients have distinct downstream signaling profiles
  JOURNAL   J Biol Chem 297 (1), 100881 (2021)
   PUBMED   34144038
  REMARK    GeneRIF: Human GPR17 missense variants identified in metabolic
            disease patients have distinct downstream signaling profiles.
REFERENCE   6  (bases 1 to 2016)
  AUTHORS   Dowal,L., Provitera,P. and Scarlata,S.
  TITLE     Stable association between G alpha(q) and phospholipase C beta 1 in
            living cells
  JOURNAL   J Biol Chem 281 (33), 23999-24014 (2006)
   PUBMED   16754659
REFERENCE   7  (bases 1 to 2016)
  AUTHORS   Blasius,R., Weber,R.G., Lichter,P. and Ogilvie,A.
  TITLE     A novel orphan G protein-coupled receptor primarily expressed in
            the brain is localized on human chromosomal band 2q21
  JOURNAL   J Neurochem 70 (4), 1357-1365 (1998)
   PUBMED   9523551
REFERENCE   8  (bases 1 to 2016)
  AUTHORS   Macrez-Lepretre,N., Kalkbrenner,F., Morel,J.L., Schultz,G. and
            Mironneau,J.
  TITLE     G protein heterotrimer Galpha13beta1gamma3 couples the angiotensin
            AT1A receptor to increases in cytoplasmic Ca2+ in rat portal vein
            myocytes
  JOURNAL   J Biol Chem 272 (15), 10095-10102 (1997)
   PUBMED   9092554
REFERENCE   9  (bases 1 to 2016)
  AUTHORS   Raport,C.J., Schweickart,V.L., Chantry,D., Eddy,R.L. Jr.,
            Shows,T.B., Godiska,R. and Gray,P.W.
  TITLE     New members of the chemokine receptor gene family
  JOURNAL   J Leukoc Biol 59 (1), 18-23 (1996)
   PUBMED   8558062
  REMARK    Review article
REFERENCE   10 (bases 1 to 2016)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK292725.1 and BC039595.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001161417.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. The encoded isoform
            (b) is shorter than isoform a. Both variants 3 and 4 encode the
            same isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031653.1, SRR3476690.1175634.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000486700.2/ ENSP00000508383.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1221              AK292725.1         160-1380
            1222-2016           BC039595.1         1195-1989
FEATURES             Location/Qualifiers
     source          1..2016
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.3"
     gene            1..2016
                     /gene="GPR17"
                     /note="G protein-coupled receptor 17"
                     /db_xref="GeneID:2840"
                     /db_xref="HGNC:HGNC:4471"
                     /db_xref="MIM:603071"
     exon            1..92
                     /gene="GPR17"
                     /inference="alignment:Splign:2.1.0"
     exon            93..2016
                     /gene="GPR17"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1132
                     /gene="GPR17"
                     /note="isoform b is encoded by transcript variant 4;
                     uracil nucleotide/cysteinyl leukotriene receptor; R12;
                     P2Y-like receptor; UDP/CysLT receptor"
                     /codon_start=1
                     /product="uracil nucleotide/cysteinyl leukotriene receptor
                     isoform b"
                     /protein_id="NP_001154889.1"
                     /db_xref="CCDS:CCDS92862.1"
                     /db_xref="GeneID:2840"
                     /db_xref="HGNC:HGNC:4471"
                     /db_xref="MIM:603071"
                     /translation="MNGLEVAPPGLITNFSLATAEQCGQETPLENMLFASFYLLDFIL
                     ALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEI
                     ACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWVVVA
                     VAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCYLLIIRS
                     LRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQRILA
                     LANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKTNESSLS
                     AKSEL"
     regulatory      1993..1998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR17"
                     /note="hexamer: AATATA"
     polyA_site      2016
                     /gene="GPR17"
                     /note="major polyA site"
ORIGIN      
        1 aaggagcccc ctgccaccac cgacacccac gggcggagat cacctgctgc cccgcagacc
       61 cctgtccctt cctcccggac cagcagctag aggctctgac tccagccaaa gcatgaatgg
      121 ccttgaagtg gctcccccag gtctgatcac caacttctcc ctggccacgg cagagcaatg
      181 tggccaggag acgccactgg agaacatgct gttcgcctcc ttctaccttc tggattttat
      241 cctggcttta gttggcaata ccctggctct gtggcttttc atccgagacc acaagtccgg
      301 gaccccggcc aacgtgttcc tgatgcatct ggccgtggcc gacttgtcgt gcgtgctggt
      361 cctgcccacc cgcctggtct accacttctc tgggaaccac tggccatttg gggaaatcgc
      421 atgccgtctc accggcttcc tcttctacct caacatgtac gccagcatct acttcctcac
      481 ctgcatcagc gccgaccgtt tcctggccat tgtgcacccg gtcaagtccc tcaagctccg
      541 caggcccctc tacgcacacc tggcctgtgc cttcctgtgg gtggtggtgg ctgtggccat
      601 ggccccgctg ctggtgagcc cacagaccgt gcagaccaac cacacggtgg tctgcctgca
      661 gctgtaccgg gagaaggcct cccaccatgc cctggtgtcc ctggcagtgg ccttcacctt
      721 cccgttcatc accacggtca cctgctacct gctgatcatc cgcagcctgc ggcagggcct
      781 gcgtgtggag aagcgcctca agaccaaggc agtgcgcatg atcgccatag tgctggccat
      841 cttcctggtc tgcttcgtgc cctaccacgt caaccgctcc gtctacgtgc tgcactaccg
      901 cagccatggg gcctcctgcg ccacccagcg catcctggcc ctggcaaacc gcatcacctc
      961 ctgcctcacc agcctcaacg gggcactcga ccccatcatg tatttcttcg tggctgagaa
     1021 gttccgccac gccctgtgca acttgctctg tggcaaaagg ctcaagggcc cgccccccag
     1081 cttcgaaggg aaaaccaacg agagctcgct gagtgccaag tcagagctgt gagcgggggg
     1141 cgccgtccag gccgagcgca gactgtttag gactcagcag acccagcaag aggcatctgc
     1201 cctttcccca gccacctccc cagcaagcaa cctgaaatct cagcagatgc ccaccatttc
     1261 tctagatcgc ctagtctcaa cccataaaaa ggaagaactg acaaagggga tccatcggcc
     1321 acccctctgc aggggcttgt gatggctaca atggctccta gacactcaac gacttcatct
     1381 gtggcaggga gagaggaggc cggaagaaca acccctgaac aatggaggcc tttctttccc
     1441 gctaggctcc cagcctcctt cccgctacag aatcgctcat cggcgaggct cagcagaaag
     1501 accctgaagg caggctgcaa atgacccaga agagggacct gggagtcctg gtggggacgg
     1561 ggagggagtc tcaatactcc tttgcagtgc aaggtactct gagtcccctc tgtagtgcct
     1621 ctgccagaca cacactgcct gagttgaaga gacacaggcc acacatttca ggctggttgc
     1681 cagcggacgt cagcactcac ggcctgcagg gactcagcac agctctggat tctggatctc
     1741 tcctgctgta accccacgca caagcctgca acccccagag ctctttgaca ggctcccagg
     1801 cctcccagtc ctggacaagc atgtgcagtc acgggagctc agctcaggcc agggctgggc
     1861 tgtgcacctg cctcccactg acccagaccc acttcctcca gagaggcctc tctccgcctg
     1921 agctatttcc cttgctagtg tgcagatatt tccctaacat gtcctttttt gtatttgttt
     1981 gtacggacca taaatataac tgtagcttta agacta
//
