LOCUS       NM_019858               2495 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens G protein-coupled receptor 162 (GPR162), transcript
            variant A-2, mRNA.
ACCESSION   NM_019858
VERSION     NM_019858.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2495)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2495)
  AUTHORS   Caruso,V., Sreedharan,S., Carlini,V.P., Jacobsson,J.A., Haitina,T.,
            Hammer,J., Stephansson,O., Crona,F., Sommer,W.H., Riserus,U.,
            Lannfelt,L., Marcus,C., Heilig,M., de Barioglio,S.R.,
            Fredriksson,R. and Schioth,H.B.
  TITLE     mRNA GPR162 changes are associated with decreased food intake in
            rat, and its human genetic variants with impairments in glucose
            homeostasis in two Swedish cohorts
  JOURNAL   Gene 581 (2), 139-145 (2016)
   PUBMED   26827797
  REMARK    GeneRIF: Data show certain SNPs variants in GPR162 gene associated
            with impairments in glucose homeostasis in obese patients.
REFERENCE   3  (bases 1 to 2495)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 2495)
  AUTHORS   Gloriam,D.E., Schioth,H.B. and Fredriksson,R.
  TITLE     Nine new human Rhodopsin family G-protein coupled receptors:
            identification, sequence characterisation and evolutionary
            relationship
  JOURNAL   Biochim Biophys Acta 1722 (3), 235-246 (2005)
   PUBMED   15777626
REFERENCE   5  (bases 1 to 2495)
  AUTHORS   Ansari-Lari,M.A., Shen,Y., Muzny,D.M., Lee,W. and Gibbs,R.A.
  TITLE     Large-scale sequencing in human chromosome 12p13: experimental and
            computational gene structure determination
  JOURNAL   Genome Res 7 (3), 268-280 (1997)
   PUBMED   9074930
REFERENCE   6  (bases 1 to 2495)
  AUTHORS   Ansari-Lari,M.A., Muzny,D.M., Lu,J., Lu,F., Lilley,C.E., Spanos,S.,
            Malley,T. and Gibbs,R.A.
  TITLE     A gene-rich cluster between the CD4 and triosephosphate isomerase
            genes at human chromosome 12p13
  JOURNAL   Genome Res 6 (4), 314-326 (1996)
   PUBMED   8723724
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U47928.1 and U47924.1.
            
            On Nov 23, 2018 this sequence version replaced NM_019858.1.
            
            Summary: This gene was identified upon genomic analysis of a
            gene-dense region at human chromosome 12p13. It appears to be
            mainly expressed in the brain; however, its function is not known.
            Alternatively spliced transcript variants encoding different
            isoforms have been identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (A-2) represents the longer
            transcript, and encodes the longer isoform (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.541449.1, U47928.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311268.8/ ENSP00000311528.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2492              U47928.1           25-2516
            2493-2495           U47924.1           39430-39432
FEATURES             Location/Qualifiers
     source          1..2495
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..2495
                     /gene="GPR162"
                     /gene_synonym="A-2; GRCA"
                     /note="G protein-coupled receptor 162"
                     /db_xref="GeneID:27239"
                     /db_xref="HGNC:HGNC:16693"
     exon            1..80
                     /gene="GPR162"
                     /gene_synonym="A-2; GRCA"
                     /inference="alignment:Splign:2.1.0"
     exon            81..1378
                     /gene="GPR162"
                     /gene_synonym="A-2; GRCA"
                     /inference="alignment:Splign:2.1.0"
     CDS             512..2278
                     /gene="GPR162"
                     /gene_synonym="A-2; GRCA"
                     /EC_number="1.14.11.7"
                     /note="isoform 2 is encoded by transcript variant A-2;
                     probable G-protein coupled receptor 162; gene rich
                     cluster, A; gene-rich cluster gene A protein"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 162 isoform
                     2"
                     /protein_id="NP_062832.1"
                     /db_xref="CCDS:CCDS8563.1"
                     /db_xref="GeneID:27239"
                     /db_xref="HGNC:HGNC:16693"
                     /translation="MARGGAGAEEASLRSNALSWLACGLLALLANAWIILSISAKQQK
                     HKPLELLLCFLAGTHILMAAVPLTTFAVVQLRRQASSDYDWNESICKVFVSTYYTLAL
                     ATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHNNG
                     ERYYARGCQFIVSKIGLGFGVCFSLLLLGGIVMGLVCVAITFYQTLWARPRRARQARR
                     VGGGGGTKAGGPGALGTRPAFEVPAIVVEDARGKRRSSLDGSESAKTSLQVTNLVSAI
                     VFLYDSLTGVPILVVSFFSLKSDSAPPWMVLAVLWCSMAQTLLLPSFIWSCERYRADV
                     RTVWEQCVAIMSEEDGDDDGGCDDYAEGRVCKVRFDANGATGPGSRDPAQVKLLPGRH
                     MLFPPLERVHYLQVPLSRRLSHDETNIFSTPREPGSFLHKWSSSDDIRVLPAQSRALG
                     GPPEYLGQRHRLEDEEDEEEAEGGGLASLRQFLESGVLGSGGGPPRGPGFFREEITTF
                     IDETPLPSPTASPGHSPRRPRPLGLSPRRLSLGSPESRAVGLPLGLSAGRRCSLTGGE
                     ESARAWGGSWGPGNPIFPQLTL"
     exon            1379..1568
                     /gene="GPR162"
                     /gene_synonym="A-2; GRCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1726
                     /gene="GPR162"
                     /gene_synonym="A-2; GRCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..2495
                     /gene="GPR162"
                     /gene_synonym="A-2; GRCA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2468..2473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR162"
                     /gene_synonym="A-2; GRCA"
                     /note="hexamer: ATTAAA"
     polyA_site      2495
                     /gene="GPR162"
                     /gene_synonym="A-2; GRCA"
                     /note="major polyA site"
ORIGIN      
        1 agccggcagg cagcgggagc ccgagagagc cgcgtcggga gtgcggtctc catggcagtg
       61 ctgggcgcag ccggagagag cctgtccagg gggctgagcc ccacccccaa atccctgggg
      121 catccagaag attcctgact ggtcaagaac cagaggcaaa agagacctgg aagtcccagc
      181 atggggacca gaacccccca gccagcctca tagttgggaa agtagccagc ttgcctgccc
      241 catcaattgc agggatgctt aaggaaggcc ccgcccagta tgaaagctga ggattgcctc
      301 tgctgaccct cagtctcctc ccctgccctc tacatctgcc ctcagctggg tccatcatgc
      361 aatgctgagc actggggtga gcctgggggc agcctgcctg ctgacagggc gaggattgtg
      421 gggatcatgg gagtgtttgt gagtggggct cctgggtgag acctagcccc cacccccaca
      481 gagctcaagg gggtgggggg ctgaggatag gatggctcgg ggcggggcgg gggcagagga
      541 ggcctccctg cgctccaacg cattgtcctg gctggcctgt gggctcctgg cgctgctggc
      601 caatgcctgg atcatcctca gcatctcggc caagcagcag aagcacaagc cactggagct
      661 gctgctctgc ttcctagcgg gcacacacat actcatggca gctgtgcccc tcaccacctt
      721 tgccgtggtg cagctgcgtc gtcaggcttc ctccgactat gactggaacg agagtatctg
      781 caaggtcttc gtgtccacct actacaccct ggcgctggcc acctgcttca cggtcgcctc
      841 cctctcctac catcgcatgt ggatggtgcg ctggcccgtc aactaccgcc tcagcaacgc
      901 caagaagcag gcactgcatg ccgtcatggg catctggatg gtcagcttca tcctctccac
      961 actgccctcc attggctggc acaacaacgg cgagcgctac tatgcccgcg gctgccagtt
     1021 catagtctcc aagatcggcc tcggctttgg cgtttgcttc agcctcttgc tacttggggg
     1081 aattgtcatg ggtctggtct gtgtggccat caccttctac cagacactgt gggcccggcc
     1141 ccggagggct cggcaggccc ggagagtggg gggtggtggg gggaccaaag cgggtgggcc
     1201 aggggccttg ggtacccggc cagcttttga ggtaccagcc attgtggtgg aggatgcccg
     1261 agggaagcgg cggtcctcgc tggatggctc ggagtctgcc aagacatccc tgcaggtcac
     1321 caacttggtc agcgccatcg tctttctcta tgactcactc acaggggtgc ccatcttggt
     1381 ggtgagcttc ttctccctca agtcggactc ggcgcccccc tggatggtgc tggctgtgct
     1441 gtggtgctcc atggcacaga cgctgctgct gccctccttc atctggtcct gcgagcgcta
     1501 ccgcgccgac gtgcgcacag tgtgggagca atgcgtggcc atcatgtctg aggaggatgg
     1561 agatgacgat gggggctgtg acgactatgc agagggccga gtttgcaaag ttcgctttga
     1621 tgctaacgga gccacaggac cagggagccg ggaccccgcc caggtgaagc tgctgcctgg
     1681 aaggcacatg ctcttccctc ctcttgagag agtccactac ttacaggtcc ccctatcccg
     1741 gcgtctgtcc catgatgaga caaacatctt ctctacccct cgggaaccag gctccttcct
     1801 gcacaagtgg tcatcctctg atgacatccg ggtcctccca gcccagagcc gggccctcgg
     1861 gggtcctcct gagtacctgg gacaaagaca caggttggag gacgaggagg acgaggaaga
     1921 ggctgaaggt ggggggctgg ccagccttcg ccaattcttg gagagtgggg ttctggggtc
     1981 aggtggggga cccccacggg gtcctggctt cttccgggag gagatcacca ccttcatcga
     2041 tgagacacct ctgccttctc cgactgcctc accagggcac tctcctcgtc ggccccggcc
     2101 actgggcctc tcaccccgcc gactctccct tgggtcccct gagagcagag ccgttggact
     2161 tcctttggga ctaagcgcag ggagacgctg ctccctgacg gggggtgaag aaagtgcaag
     2221 ggcttgggga ggatcctggg gcccaggcaa ccccatcttt ccccagctga ccctgtgagc
     2281 ccaagcaggc ctgctgaact cagaggagaa agcctgagtg agtaacacct cattctggcc
     2341 gagagtaggg cagctgcctc cagactctgg ggagacgggc gctagatttg gggctcagaa
     2401 ggccctgctc tctcccatcc aagtgaccag atgccctact cagcttccat cacccctagc
     2461 aatatgtatt aaagtctgaa gtgttgccat ggaaa
//
