LOCUS       NM_001375883            7815 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens G protein-coupled receptor 161 (GPR161), transcript
            variant 12, mRNA.
ACCESSION   NM_001375883 XM_005245056
VERSION     NM_001375883.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7815)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 7815)
  AUTHORS   Begemann,M., Waszak,S.M., Robinson,G.W., Jager,N., Sharma,T.,
            Knopp,C., Kraft,F., Moser,O., Mynarek,M., Guerrini-Rousseau,L.,
            Brugieres,L., Varlet,P., Pietsch,T., Bowers,D.C., Chintagumpala,M.,
            Sahm,F., Korbel,J.O., Rutkowski,S., Eggermann,T., Gajjar,A.,
            Northcott,P., Elbracht,M., Pfister,S.M., Kontny,U. and Kurth,I.
  TITLE     Germline GPR161 Mutations Predispose to Pediatric Medulloblastoma
  JOURNAL   J Clin Oncol 38 (1), 43-50 (2020)
   PUBMED   31609649
  REMARK    GeneRIF: Authors describe a novel brain tumor predisposition
            syndrome that is caused by germline GPR161 mutations and
            characterized by MBSHH in infants.
REFERENCE   3  (bases 1 to 7815)
  AUTHORS   Kim,S.E., Lei,Y., Hwang,S.H., Wlodarczyk,B.J., Mukhopadhyay,S.,
            Shaw,G.M., Ross,M.E. and Finnell,R.H.
  TITLE     Dominant negative GPR161 rare variants are risk factors of human
            spina bifida
  JOURNAL   Hum Mol Genet 28 (2), 200-208 (2019)
   PUBMED   30256984
  REMARK    GeneRIF: rare variants of GPR161 from Spina bifida infants and
            determination of their functional relevance in the Shh and Wnt
            signaling pathways
REFERENCE   4  (bases 1 to 7815)
  AUTHORS   Shimada,I.S., Hwang,S.H., Somatilaka,B.N., Wang,X., Skowron,P.,
            Kim,J., Kim,M., Shelton,J.M., Rajaram,V., Xuan,Z., Taylor,M.D. and
            Mukhopadhyay,S.
  TITLE     Basal Suppression of the Sonic Hedgehog Pathway by the
            G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma
            Pathogenesis
  JOURNAL   Cell Rep 22 (5), 1169-1184 (2018)
   PUBMED   29386106
  REMARK    GeneRIF: Gpr161 restricts cerebellar granule cell progenitor
            production by preventing premature and sonic hedgehog-dependent
            pathway activity, highlighting the importance of basal pathway
            suppression in tumorigenesis
REFERENCE   5  (bases 1 to 7815)
  AUTHORS   Hwang,S.H., White,K.A., Somatilaka,B.N., Shelton,J.M.,
            Richardson,J.A. and Mukhopadhyay,S.
  TITLE     The G protein-coupled receptor Gpr161 regulates forelimb formation,
            limb patterning and skeletal morphogenesis in a primary
            cilium-dependent manner
  JOURNAL   Development 145 (1) (2018)
   PUBMED   29222391
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7815)
  AUTHORS   Leung,T., Humbert,J.E., Stauffer,A.M., Giger,K.E., Chen,H.,
            Tsai,H.J., Wang,C., Mirshahi,T. and Robishaw,J.D.
  TITLE     The orphan G protein-coupled receptor 161 is required for
            left-right patterning
  JOURNAL   Dev Biol 323 (1), 31-40 (2008)
   PUBMED   18755178
REFERENCE   7  (bases 1 to 7815)
  AUTHORS   Matteson,P.G., Desai,J., Korstanje,R., Lazar,G., Borsuk,T.E.,
            Rollins,J., Kadambi,S., Joseph,J., Rahman,T., Wink,J., Benayed,R.,
            Paigen,B. and Millonig,J.H.
  TITLE     The orphan G protein-coupled receptor, Gpr161, encodes the
            vacuolated lens locus and controls neurulation and lens development
  JOURNAL   Proc Natl Acad Sci U S A 105 (6), 2088-2093 (2008)
   PUBMED   18250320
REFERENCE   8  (bases 1 to 7815)
  AUTHORS   Small,K.M., Seman,C.A., Castator,A., Brown,K.M. and Liggett,S.B.
  TITLE     False positive non-synonymous polymorphisms of G-protein coupled
            receptor genes
  JOURNAL   FEBS Lett 516 (1-3), 253-256 (2002)
   PUBMED   11959142
  REMARK    GeneRIF: False positive non-synonymous polymorphisms of G-protein
            coupled receptor genes.
REFERENCE   9  (bases 1 to 7815)
  AUTHORS   Schoneberg,T., Schulz,A. and Gudermann,T.
  TITLE     The structural basis of G-protein-coupled receptor function and
            dysfunction in human diseases
  JOURNAL   Rev Physiol Biochem Pharmacol 144, 143-227 (2002)
   PUBMED   11987825
  REMARK    Review article
REFERENCE   10 (bases 1 to 7815)
  AUTHORS   Raming,K., Konzelmann,S. and Breer,H.
  TITLE     Identification of a novel G-protein coupled receptor expressed in
            distinct brain regions and a defined olfactory zone
  JOURNAL   Recept Channels 6 (2), 141-151 (1998)
   PUBMED   9932290
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL033532.36.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 5, 2019 this sequence version replaced XM_005245056.2.
            
            Summary: The protein encoded by this gene is an orphan G
            protein-coupled receptor whose ligand is unknown. This gene is
            overexpressed in triple-negative breast cancer, and disruption of
            this gene slows the proliferation of basal breast cancer cells.
            Therefore, this gene is a potential drug target for triple-negative
            breast cancer. [provided by RefSeq, Mar 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138528.517176.1,
                                           ERR3218372.941707.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682931.1/ ENSP00000506967.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               AL033532.36        65576-65767         c
            193-610             AL033532.36        33314-33731         c
            611-1335            AL033532.36        25345-26069         c
            1336-1440           AL033532.36        19401-19505         c
            1441-1560           AL033532.36        16422-16541         c
            1561-7815           AL033532.36        8379-14633          c
FEATURES             Location/Qualifiers
     source          1..7815
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..7815
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /note="G protein-coupled receptor 161"
                     /db_xref="GeneID:23432"
                     /db_xref="HGNC:HGNC:23694"
                     /db_xref="MIM:612250"
     exon            1..192
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /inference="alignment:Splign:2.1.0"
     exon            193..610
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..1826
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /note="isoform 2 is encoded by transcript variant 12;
                     G-protein coupled receptor RE2"
                     /codon_start=1
                     /product="G-protein coupled receptor 161 isoform 2"
                     /protein_id="NP_001362812.1"
                     /db_xref="CCDS:CCDS1268.1"
                     /db_xref="GeneID:23432"
                     /db_xref="HGNC:HGNC:23694"
                     /db_xref="MIM:612250"
                     /translation="MSLNSSLSCRKELSNLTEEEGGEGGVIITQFIAIIVITIFVCLG
                     NLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNF
                     SALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSLIGCL
                     PPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVARVK
                     ARKVHCGTVVIVEEDAQRTGRKNSSTSTSSSGSRRNAFQGVVYSANQCKALITILVVL
                     GAFMVTWGPYMVVIASEALWGKSSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRKE
                     LLGMCFGDRYYREPFVQRQRTSRLFSISNRITDLGLSPHLTALMAGGQPLGHSSSTGD
                     TGFSCSQDSGTDMMLLEDYTSDDNPPSHCTCPPKRRSSVTFEDEVEQIKEAAKNSILH
                     VKAEVHKSLDSYAASLAKAIEAEAKINLFGEEALPGVLVTARTVPGGGFGGRRGSRTL
                     VSQRLQLQSIEEGDVLAAEQR"
     exon            611..1335
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1440
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1560
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..7815
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2706..2711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /note="hexamer: ATTAAA"
     polyA_site      2727
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /note="major polyA site"
     regulatory      7791..7796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /note="hexamer: ATTAAA"
     polyA_site      7815
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /note="major polyA site"
ORIGIN      
        1 acttggcctg cgcccgcccg ggtccgcgtg ctggtggctg gcccgcggga ggagcgaagc
       61 ggggctcggt gggctgaaac ccgaaacctc cagtcccgga gcgcggcggg gaggaaggaa
      121 gcggcggcgg cggtggccga ggcggggagg cggctgggcc ggggcctgag ctgccgcggc
      181 ggccgctcct cgtcgtccag catgctctgc ccaccccacg ccgaggtgca ctgaccatga
      241 gcctcaactc ctccctcagc tgcaggaagg agctgagtaa tctcactgag gaggagggtg
      301 gcgaaggggg cgtcatcatc acccagttca tcgccatcat tgtcatcacc atttttgtct
      361 gcctgggaaa cctggtcatc gtggtcacct tgtacaagaa gtcctacctc ctcaccctca
      421 gcaacaagtt cgtcttcagc ctgactctgt ccaacttcct gctgtccgtg ttggtgctgc
      481 cttttgtggt gacgagctcc atccgcaggg aatggatctt tggtgtagtg tggtgcaact
      541 tctctgccct cctctacctg ctgatcagct ctgccagcat gctaaccctc ggggtcattg
      601 ccatcgaccg ctactatgct gtcctgtacc ccatggtgta ccccatgaag atcacaggga
      661 accgggctgt gatggcactt gtctacatct ggcttcactc gctcatcggc tgcctgccac
      721 ccctgtttgg ttggtcatcc gtggagtttg acgagttcaa atggatgtgt gtggctgctt
      781 ggcaccggga gcctggctac acggccttct ggcagatctg gtgtgccctc ttcccctttc
      841 tggtcatgct ggtgtgctat ggcttcatct tccgcgtggc cagggtcaag gcacgcaagg
      901 tgcactgtgg cacagtcgtc atcgtggagg aggatgctca gaggaccggg aggaagaact
      961 ccagcacctc cacctcctct tcaggcagca ggaggaatgc ctttcagggt gtggtctact
     1021 cggccaacca gtgcaaagcc ctcatcacca tcctggtggt cctcggtgcc ttcatggtca
     1081 cctggggccc ctacatggtt gtcatcgcct ctgaggccct ctgggggaaa agctccgtct
     1141 ccccgagcct ggagacttgg gccacatggc tgtcctttgc cagcgctgtc tgccaccccc
     1201 tgatctatgg actctggaac aagacagttc gcaaagaact actgggcatg tgctttgggg
     1261 accggtatta tcgggaacca tttgtgcaac gacagaggac ttccaggctc ttcagcattt
     1321 ccaacaggat cacagacctg ggcctgtccc cacacctcac tgcgctcatg gcaggtggac
     1381 agcccctggg gcacagcagc agcacggggg acactggctt cagctgctcc caggactcag
     1441 ggacagatat gatgctgctt gaggactaca cgtctgatga caaccctccc tctcactgca
     1501 cttgcccacc caagagaagg agctcggtga catttgagga tgaagtggaa caaatcaaag
     1561 aagctgccaa gaactcgatt cttcatgtga aagctgaagt acacaagtcc ttggacagtt
     1621 acgcagcaag cttggccaaa gccattgagg ccgaagccaa aatcaactta tttggggagg
     1681 aggctttgcc aggggtcttg gttacagcac ggactgtccc ggggggcggc ttcgggggcc
     1741 gccgaggcag cagaactctt gtgagccaga ggctgcagtt gcagagcatc gaagaaggag
     1801 atgttttagc tgccgagcag agatgagggc ctcagggtgc cgtggggctg cagcctgaga
     1861 ggctggcccg gggaggagtt cccatcaccg cctgtgccgc ggccttggga gcatgtcact
     1921 gtgtacagct ggccacacac agggaaggag cagcatctgg tatgcagcca ccaggacaag
     1981 gactgaaaat aatgtctaca gtccacagct tcagcatttc cagagaccac atgtgagctt
     2041 cttttaggtc ccagtgatgg gaccagaagc atctaaagca aaaaaaaaac caaaaaaaaa
     2101 tctagagatg tggctgtggc tttttgggag gtggggcatg ggaggaccag agacgaaggg
     2161 cttggaagga gacccccaca tgcatcattt cctcctcttc acagtgtgct gggagtccag
     2221 ccgtgcactg tgccagatgc ctcaggagga gaaccctccc cagtgtactg tgaaggatga
     2281 cacagcactt cttcctaatg acacgcgacc gtcctggtgc ctctacatgg ttgatgcggg
     2341 cagtgtggga ccctcagttc taggactggt ccgcagagaa agcacccagg agcagagcgc
     2401 ttcggagcgg tcctcagtgg cgccacctgc tggtgctaat agggacagcc acaggcctct
     2461 tgcagactgg cccaccctgc ctacttccct actgacaagt tctttggtat ttcaaaaggg
     2521 agaaaccact ataaaagaca agaggaaggg caggtactag gtgtttcatt tccagaatta
     2581 aaaaaaaaat ccatttaaga cgtaccactg ttttaccgga ctgaatggga ctgtagtgcc
     2641 aagcacagcc aggaaataga gaaactgtta ttatggaagg gaatttgttc acatgggaaa
     2701 gcctcattaa atagattcta tgtgtgatgt ttgagtgacc aatgaaaata gctggcctca
     2761 gttctgcatg gcacactccc aagagcaaca gttactatta tcacaagcct ggtataaata
     2821 agatagaagc agccctggac ccacagccag caacctgggt tattggccca gctctgtctt
     2881 tgtgtgcaca tgtcatttgg acatcttgtc acctttctag gtcctctgta aagtgggaaa
     2941 acagagtgga gttggattga atggtctcca agatcatttc cagctctgac ctttggtgtt
     3001 ctcaggattt gtaaagcaga gataggtaaa acacaaaagc agacccacgg accgaccttt
     3061 gtataacttt ggagtgtggt tgctcatgca catgtgaagt gcaggcagat caaggttctg
     3121 tggctttgtc tgccctgtcc attagagcac aatctggata gaatgccagc caccaagatg
     3181 catgaggggc agggtcacca tctcagaagg ggaagcacag gaatgtgatt gggatggtta
     3241 aacctctctt ctcctccctt tgtgctggaa cagcagttga agtttggtcc tggagtaatt
     3301 gctgtgatga cttgggaagc cactgatctc ctcttgcgtc tgcccttggc ctgcatcatg
     3361 actaaataag ttcaggactt ctctgctttg gttggcagaa ggtagattcc aaggagatct
     3421 tgctggttgc tgagaggcag ctgttctaga aagtgaatta cccttgtggt tttttctttg
     3481 gggcccagct agctcctggt gaggttgtgt ttttgtgttg tgtggcagaa accaatggtt
     3541 agctggtccc ctggtctgca gtttgtaaaa gacctttcat gaggcctgga gtcttgctac
     3601 ctgtggtgat tgaactcaac tattctgggt cacctggatg ccaggcgctg gcctagcttc
     3661 tggatgggag tgggaaggag cagagggcag gttcacctgt gcaggtcaga cactctgctt
     3721 ccatcactgg atggcattcc tacgtctgcg tgtggttcac gttttctata tatattccct
     3781 gtatatattt ttttctagca cttgtctact ttctgaaggg accatattcc tgatcaacta
     3841 gtgtgcacag aggtggaaca gggcagagag acctttatct ctaggatggg ttgctggtta
     3901 ggtgtaggca ttcttgagtg cagcagcttg gctttgaaac gcaagggttg gagaatgttc
     3961 ccctgactgt actagactgg gctctaggga aagaatcctg agacagcccc ccactccccc
     4021 actgacccca cactagctgg gctattatag aatttaatct aaatctagaa atactgcatt
     4081 tcacaaaatg attcactgtg tttccctttt tttactgagg tccaattcat ttagtcgtct
     4141 accagacact gcacatccag tgtatgcgaa gcaccaggct aggctctgta ggcaatacca
     4201 ctaaagtgtg cactctgatt tagggagcag gacctgtgga taccgattct aataactagc
     4261 aaagtcaagt cgtggttata gaaagaagtg tggcttcaga gggaggtggg tatttccaaa
     4321 tatggagtta gggatggctc catgaggtaa gtgacagttt gagctaagtc ttgaaggatg
     4381 cttggcagct agaaccatat tttccatatt caggaattca aatttgcctt tattcagcta
     4441 gagagaaaga gagaaggggg tgtgggggag aaggaaaaga gaattttcac acattttgaa
     4501 gttcctgaga gcatttctga ggatatctgc cgttagtgca gaaggtcgaa accccaagtg
     4561 cccccactaa acccaggctc tttagctgta aactgccatg cagtggcagg cctgcagcct
     4621 tcctgatggg accacatgga cagtggcaca tgggacattt ggctactcgt tagcttaaac
     4681 aactcagtcc tgtgtcttct ggttttgaca agaccacatt taggactgct gcccacctct
     4741 gcctctttca ttgagatttc cgccttattg ggtccctgtg ctatgccaca gataccaggt
     4801 ttggggttgt tttgacccag aaggcattgg gagtcccaca ttacagagca cacacacagc
     4861 tcaacacagc catttccctg gccagaggca ccaagactga agttcaggcc cttagacact
     4921 aggtggcagc ggtgtggctg tgcagagcca aggatgaacc tgagagcttg tttgcctctg
     4981 gctgggcact cttgttttga attcctttgc ccttatcgtg tagtccacgg ccttggtgac
     5041 caaggaccac ctggctagcc tgcttacatg catgacccca tccaggttca caggtattgc
     5101 cactgagtga tcttaggtag atcactgctc ctggagaagc agagttgagg agtgtaagac
     5161 aagggccatc tagtgccaat gttccttgat tcttatttga ggagctacta tgtggtcttt
     5221 ctgtaaacaa gtgaacaacc aatgagacta aatatttgca atagataggc taaggaattt
     5281 gggttgagac aggagacgga ggaaaaatgc tttgatacaa tgacagatgg ttagtctctt
     5341 cagatttccc tgaatatttt ccatcccgac aatatgcctc ttagatactt gcagattaga
     5401 catgtctctg gatggaccac aagatacatt cacaacatgt gttcagcctt gagccctggc
     5461 tgtgtcctgt ctggaaggaa ctgaggatga tgtggctata aagaggaggc agtgagctgg
     5521 catgtgactg ccttctgtgg gcctgacctg tttgacattt gagggcctat gatgtgctag
     5581 gtgctgtgtt aggtacttcc aaatgcttta tctcatttta ccccagtgca agtgtgatat
     5641 agtgaggatg gtgaagacgt gggtatggtt aagtcatgag ttcagatccc gtgcttccaa
     5701 ttacatgggt gttttcaaac aagtcactac ttatgagttt cctcatctgt gaagggaagt
     5761 ttagtcatct gtttcaatgt ggagacacac aggattgagg gagtcctccg tcacagggtg
     5821 actgtctgga ttctatgagg aaatacttgg aaagcatgca gcacaatgcc tggggtgcag
     5881 ctgaagctga gccactggtg tttcttcaca gtatctctgt ggggagggtg tattattcct
     5941 ttttataggg atctctataa tgaagtgaga atcttgaaaa tataagtgtt atcctagatg
     6001 ggaggtgtta aaggtttttg ccttgggaat tttgtcatat ttgttgcaca gcaaggaagg
     6061 actttcagaa aagcagggat gtggtgagga agagcaggca atagagagca gggaggaaag
     6121 gctaagtagc atctggaact tgagaagtct aagggagcca aaatgagatt ttctattaaa
     6181 aatgtctatc ctcagccggg cgtggtagct cacgcctgta atcccagcac tttggggggt
     6241 cgagatgggc agatcacctg aggtcaggag ttcgagacca gcctgaccaa tatggagaaa
     6301 ccccgtctct actaaaaata caaaattagt tgcgcgtggt ggtgggcgcc tgtaatccca
     6361 gctactcagg agcctgaggc aggagaatca cttaaaccca ggaggcggag gttgcagtga
     6421 gccgagatcg cgccattgca ctccagcctg ggcaacaaga gcgaaacccc gcctaaaaaa
     6481 agaaaaaaaa gaaaaagtct atcctctatg ctactggcct gtttgtacaa agataaaatc
     6541 attctaattt gtccggaatg actatcaaag atgatcaaat ccccagggcc tggtgtaacg
     6601 ttccaaatca tagcacaaat acagcttgac cttccttaca gtccagaaag gacattctcc
     6661 ctgagaaatg cccttggttg ctgaggacag ctctgtcctg tagtgacaga gtgactgcct
     6721 ggctgtggct cttgggttca cagaatccct aatcctccaa gcccctaaga ggcagggcag
     6781 ggatgctacc cacaatatat gcagaacccc agatggagcc tgtgggagag agaggaaatt
     6841 accgtcttca ctgtaggcaa aggagaatgg ctgtgattag ccatatatgc ctataagaag
     6901 gagcagagcc atactgtcct tgtgggttgg gagaggggac acagaatcca gggcaattgt
     6961 ctgaggtctc aaagtaagtt aagccagagt caaagccaaa ctccaagtct tggccaaggg
     7021 gatgagaaaa gcaaggagct agtcttatag gtcaaggaag atgaggtata gttaagagtc
     7081 atcagtatca cagaacaggc cagcagggct ttattaggta tgtagaacta ttataaacca
     7141 aggatcttgg gagatattaa tatctgctgg ccagacctaa aaaaaactga aggcccaagg
     7201 aaagtgactg gactcactgg aaagtatcta acaaatactt tggattccaa agtatttcca
     7261 ataccttgaa gattcctttg aaaacatcaa agcacaaact caaatctgca caagattaca
     7321 aaagcacaat tttggtgtta tttttagaat gcaatacaca aagctatgtt catttctctc
     7381 agcaagcatt ttcctgggta gtagtaatag cttaggaatc aaatgccact tttgtttttc
     7441 cttttttcac tagtttgaaa taccacaaat cacaggtgag tcagtcctcc cagaggaaaa
     7501 gacagtccta gggagaatca caggcctggc agacaagacc acactgagag cagtagaagg
     7561 aacctgcatg cttaagggac agaggactgt gttgtgttct cataatagac cgctggatga
     7621 agaagtggtt aaaaaccaac cctcgaaaaa caaaaatccc tggctaatcc tgaaatatat
     7681 ttaacttgaa gtctttggat gattttttta aggttaaaaa aaagtttagg attattataa
     7741 atcaatattt ataaataagc aacaatgtat ttggaatttt tgtttacctg attaaatatg
     7801 tttttggtat gtgta
//
