LOCUS       NM_014373               1962 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens G protein-coupled receptor 160 (GPR160), mRNA.
ACCESSION   NM_014373
VERSION     NM_014373.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1962)
  AUTHORS   Guo,W., Zhang,J., Zhou,Y., Zhou,C., Yang,Y., Cong,Z., Dong,J.,
            Yang,D., Dai,B. and Wang,M.W.
  TITLE     GPR160 is a potential biomarker associated with prostate cancer
  JOURNAL   Signal Transduct Target Ther 6 (1), 241 (2021)
   PUBMED   34168114
  REMARK    GeneRIF: GPR160 is a potential biomarker associated with prostate
            cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1962)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1962)
  AUTHORS   Yang,H., Liu,H., Chen,H., Mo,H., Chen,J., Huang,X., Zheng,R.,
            Liu,Z., Feng,Y., Liu,F. and Ge,B.
  TITLE     G protein-coupled receptor160 regulates mycobacteria entry into
            macrophages by activating ERK
  JOURNAL   Cell Signal 28 (9), 1145-1151 (2016)
   PUBMED   27259691
  REMARK    GeneRIF: these findings suggest an important role of GPR160 in
            regulating the entry of BCG into macrophages by targeting the ERK
            signaling pathway.
REFERENCE   4  (bases 1 to 1962)
  AUTHORS   Zhou,C., Dai,X., Chen,Y., Shen,Y., Lei,S., Xiao,T., Bartfai,T.,
            Ding,J. and Wang,M.W.
  TITLE     G protein-coupled receptor GPR160 is associated with apoptosis and
            cell cycle arrest of prostate cancer cells
  JOURNAL   Oncotarget 7 (11), 12823-12839 (2016)
   PUBMED   26871479
  REMARK    GeneRIF: Our data suggest that the expression level of endogenous
            GPR160 is associated with the pathogenesis of prostate cancer
REFERENCE   5  (bases 1 to 1962)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   6  (bases 1 to 1962)
  AUTHORS   Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Association of genetic variants with hemorrhagic stroke in Japanese
            individuals
  JOURNAL   Int J Mol Med 25 (4), 649-656 (2010)
   PUBMED   20198315
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1962)
  AUTHORS   Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am J Hypertens 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1962)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
REFERENCE   9  (bases 1 to 1962)
  AUTHORS   Conklin,D., Yee,D.P., Millar,R., Engelbrecht,J. and Vissing,H.
  TITLE     Mining of assembled expressed sequence tag (EST) data for protein
            families: application to the G protein-coupled receptor superfamily
  JOURNAL   Brief Bioinform 1 (1), 93-99 (2000)
   PUBMED   11466977
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX400356.2, BC000181.2, BX414005.1 and AI560646.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014373.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.401608.1,
                                           SRR1163657.296953.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355897.10/ ENSP00000348161.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BX400356.2         47-63
            18-1653             BC000181.2         1-1636
            1654-1953           BX414005.1         10-309              c
            1954-1962           AI560646.1         12-20               c
FEATURES             Location/Qualifiers
     source          1..1962
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.2"
     gene            1..1962
                     /gene="GPR160"
                     /gene_synonym="GPCR1; GPCR150"
                     /note="G protein-coupled receptor 160"
                     /db_xref="GeneID:26996"
                     /db_xref="HGNC:HGNC:23693"
     exon            1..221
                     /gene="GPR160"
                     /gene_synonym="GPCR1; GPCR150"
                     /inference="alignment:Splign:2.1.0"
     exon            222..350
                     /gene="GPR160"
                     /gene_synonym="GPCR1; GPCR150"
                     /inference="alignment:Splign:2.1.0"
     exon            351..474
                     /gene="GPR160"
                     /gene_synonym="GPCR1; GPCR150"
                     /inference="alignment:Splign:2.1.0"
     exon            475..1962
                     /gene="GPR160"
                     /gene_synonym="GPCR1; GPCR150"
                     /inference="alignment:Splign:2.1.0"
     CDS             543..1559
                     /gene="GPR160"
                     /gene_synonym="GPCR1; GPCR150"
                     /note="putative G protein-coupled receptor; hGPCR1;
                     G-protein coupled receptor GPCR1"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 160"
                     /protein_id="NP_055188.1"
                     /db_xref="CCDS:CCDS3211.1"
                     /db_xref="GeneID:26996"
                     /db_xref="HGNC:HGNC:23693"
                     /translation="MTALSSENCSFQYQLRQTNQPLDVNYLLFLIILGKILLNILTLG
                     MRRKNTCQNFMEYFCISLAFVDLLLLVNISIILYFRDFVLLSIRFTKYHICLFTQIIS
                     FTYGFLHYPVFLTACIDYCLNFSKTTKLSFKCQKLFYFFTVILIWISVLAYVLGDPAI
                     YQSLKAQNAYSRHCPFYVSIQSYWLSFFMVMILFVAFITCWEEVTTLVQAIRITSYMN
                     ETILYFPFSSHSSYTVRSKKIFLSKLIVCFLSTWLPFVLLQVIIVLLKVQIPAYIEMN
                     IPWLYFVNSFLIATVYWFNCHKLNLKDIGLPLDPFVNWKCCFIPLTIPNLEQIEKPIS
                     IMIC"
     regulatory      1634..1639
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR160"
                     /gene_synonym="GPCR1; GPCR150"
                     /note="hexamer: AATAAA"
     polyA_site      1653
                     /gene="GPR160"
                     /gene_synonym="GPCR1; GPCR150"
                     /note="major polyA site"
     regulatory      1940..1945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR160"
                     /gene_synonym="GPCR1; GPCR150"
                     /note="hexamer: ATTAAA"
     polyA_site      1962
                     /gene="GPR160"
                     /gene_synonym="GPCR1; GPCR150"
ORIGIN      
        1 gcatttcctg gtctggagcc ggctgagcca cagcagggtc gccgcggggt cccggggccg
       61 tgctcccctg cccctcccgg gagcgcgcgg ggcggggcgg ggcggggcgg gaccaggcgg
      121 gcgagctggg ccctcgcccc tccctcgggc ggtcacctgg gcacgggcgc tgcaggtgtc
      181 ggggcctcaa ccttgcggag ccgacagcca tcgatcctcg ggtggcctcg aggtggtggc
      241 agggccgccc cctgcagtcc ggagacgaac gcacggaccg ggcctccgga ggcaggttcg
      301 gctggaagga accgctctcg cttcgtccta cacttgcgca aatgtctccg agcttactca
      361 catagcatat tggtatatca aaatgaaatg caaggaacca aaaataacat aattgaaggc
      421 agtaaaagtg aaattaaata ggaagatcat cagtcaagga agacccactg gagaggacag
      481 aaaatgaagc agtgttttat catgtgtatt tcagcaggtc ttcttgaaat ttaactaaaa
      541 atatgactgc tctctcttca gagaactgct cttttcagta ccagttacgt caaacaaacc
      601 agcccctaga tgttaactat ctgctattct tgatcatact tgggaaaata ttattaaata
      661 tccttacact aggaatgaga agaaaaaaca cctgtcaaaa ttttatggaa tatttttgca
      721 tttcactagc attcgttgat cttttacttt tggtaaacat ttccattata ttgtatttca
      781 gggattttgt acttttaagc attaggttca ctaaatacca catctgccta tttactcaaa
      841 ttatttcctt tacttatggc tttttgcatt atccagtttt cctgacagct tgtatagatt
      901 attgcctgaa tttctctaaa acaaccaagc tttcatttaa gtgtcaaaaa ttattttatt
      961 tctttacagt aattttaatt tggatttcag tccttgctta tgttttggga gacccagcca
     1021 tctaccaaag cctgaaggca cagaatgctt attctcgtca ctgtcctttc tatgtcagca
     1081 ttcagagtta ctggctgtca tttttcatgg tgatgatttt atttgtagct ttcataacct
     1141 gttgggaaga agttactact ttggtacagg ctatcaggat aacttcctat atgaatgaaa
     1201 ctatcttata ttttcctttt tcatcccact ccagttatac tgtgagatct aaaaaaatat
     1261 tcttatccaa gctcattgtc tgttttctca gtacctggtt accatttgta ctacttcagg
     1321 taatcattgt tttacttaaa gttcagattc cagcatatat tgagatgaat attccctggt
     1381 tatactttgt caatagtttt ctcattgcta cagtgtattg gtttaattgt cacaagctta
     1441 atttaaaaga cattggatta cctttggatc catttgtcaa ctggaagtgc tgcttcattc
     1501 cacttacaat tcctaatctt gagcaaattg aaaagcctat atcaataatg atttgttaat
     1561 attattaatt aaaagttaca gctgtcataa gatcataatt ttatgaacag aaagaactca
     1621 ggacatatta aaaaataaac tgaactaaaa caacttttgc cccctgactg atagcatttc
     1681 agaatgtgtc ttttgaaggg ctatgatacc agttattaaa tagtgtttta ttttaaaaac
     1741 aaaataattc caagaagttt ttatagttat tcagggacac tatattacaa atattacttt
     1801 gttattaaca caaaaagtga taagagttaa catttggcta tactgatgtt tgtgttactc
     1861 aaaaaaacta ctggatgcaa actgttatgt aaatctgaga tttcactgac aactttaaga
     1921 tatcaaccta aacattttta ttaaatgttc aaatgaaagc aa
//
