LOCUS       NM_207373                825 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens G protein-coupled receptor 15 ligand (GPR15LG), mRNA.
ACCESSION   NM_207373
VERSION     NM_207373.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 825)
  AUTHORS   Chen,C., Cai,R., Zhou,J., Zhang,D. and Chen,L.
  TITLE     GPR15LG regulates psoriasis-like inflammation by down-regulating
            inflammatory factors on keratinocytes
  JOURNAL   Biosci Rep 44 (6) (2024)
   PUBMED   38393364
  REMARK    GeneRIF: GPR15LG regulates psoriasis-like inflammation by
            down-regulating inflammatory factors on keratinocytes.
REFERENCE   2  (bases 1 to 825)
  AUTHORS   Tseng,P.Y. and Hoon,M.A.
  TITLE     GPR15L is an epithelial inflammation-derived pruritogen
  JOURNAL   Sci Adv 8 (24), eabm7342 (2022)
   PUBMED   35704588
REFERENCE   3  (bases 1 to 825)
  AUTHORS   Bauer,M.
  TITLE     The Role of GPR15 Function in Blood and Vasculature
  JOURNAL   Int J Mol Sci 22 (19), 10824 (2021)
   PUBMED   34639163
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 825)
  AUTHORS   Okamoto,Y. and Shikano,S.
  TITLE     Tyrosine sulfation and O-glycosylation of chemoattractant receptor
            GPR15 differentially regulate interaction with GPR15L
  JOURNAL   J Cell Sci 134 (8) (2021)
   PUBMED   33758080
REFERENCE   5  (bases 1 to 825)
  AUTHORS   Chen,C., Wu,N., Duan,Q., Yang,H., Wang,X., Yang,P., Zhang,M.,
            Liu,J., Liu,Z., Shao,Y. and Zheng,Y.
  TITLE     C10orf99 contributes to the development of psoriasis by promoting
            the proliferation of keratinocytes
  JOURNAL   Sci Rep 8 (1), 8590 (2018)
   PUBMED   29872130
  REMARK    GeneRIF: Results indicate that chromosome 10 open reading frame 99
            protein (C10orf99) plays a contributive role in psoriasis
            pathogenesis and may serve as a new target for psoriasis treatment.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 825)
  AUTHORS   Suply,T., Hannedouche,S., Carte,N., Li,J., Grosshans,B.,
            Schaefer,M., Raad,L., Beck,V., Vidal,S., Hiou-Feige,A., Beluch,N.,
            Barbieri,S., Wirsching,J., Lageyre,N., Hillger,F., Debon,C.,
            Dawson,J., Smith,P., Lannoy,V., Detheux,M., Bitsch,F.,
            Falchetto,R., Bouwmeester,T., Porter,J., Baumgarten,B.,
            Mansfield,K., Carballido,J.M., Seuwen,K. and Bassilana,F.
  TITLE     A natural ligand for the orphan receptor GPR15 modulates lymphocyte
            recruitment to epithelia
  JOURNAL   Sci Signal 10 (496) (2017)
   PUBMED   28900043
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 825)
  AUTHORS   Ocon,B., Pan,J., Dinh,T.T., Chen,W., Ballet,R., Bscheider,M.,
            Habtezion,A., Tu,H., Zabel,B.A. and Butcher,E.C.
  TITLE     A Mucosal and Cutaneous Chemokine Ligand for the Lymphocyte
            Chemoattractant Receptor GPR15
  JOURNAL   Front Immunol 8, 1111 (2017)
   PUBMED   28936214
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 825)
  AUTHORS   Yang,M., Tang,M., Ma,X., Yang,L., He,J., Peng,X., Guo,G., Zhou,L.,
            Luo,N., Yuan,Z. and Tong,A.
  TITLE     AP-57/C10orf99 is a new type of multifunctional antimicrobial
            peptide
  JOURNAL   Biochem Biophys Res Commun 457 (3), 347-352 (2015)
   PUBMED   25585381
  REMARK    GeneRIF: Compared with other antimicrobial peptides, AP-57 has its
            distinct characteristics, including longer sequence length, four
            cysteines, highly cationic character, cell-specific toxicity, DNA
            binding and tissue-specific expressing patterns.
REFERENCE   9  (bases 1 to 825)
  AUTHORS   Pan,W., Cheng,Y., Zhang,H., Liu,B., Mo,X., Li,T., Li,L., Cheng,X.,
            Zhang,L., Ji,J., Wang,P. and Han,W.
  TITLE     CSBF/C10orf99, a novel potential cytokine, inhibits colon cancer
            cell growth through inducing G1 arrest
  JOURNAL   Sci Rep 4, 6812 (2014)
   PUBMED   25351403
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 825)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AW351839.1, AY358751.1 and AI831407.1.
            
            On Nov 22, 2018 this sequence version replaced NM_207373.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358751.1, BE899580.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372126.4/ ENSP00000361199.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AW351839.1         4-13
            11-814              AY358751.1         1-804
            815-825             AI831407.1         8-18                c
FEATURES             Location/Qualifiers
     source          1..825
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.1"
     gene            1..825
                     /gene="GPR15LG"
                     /gene_synonym="AP-57; AP57; C10orf99; CSBF; GPR15L;
                     UNQ1833"
                     /note="G protein-coupled receptor 15 ligand"
                     /db_xref="GeneID:387695"
                     /db_xref="HGNC:HGNC:31428"
                     /db_xref="MIM:617775"
     exon            1..121
                     /gene="GPR15LG"
                     /gene_synonym="AP-57; AP57; C10orf99; CSBF; GPR15L;
                     UNQ1833"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..297
                     /gene="GPR15LG"
                     /gene_synonym="AP-57; AP57; C10orf99; CSBF; GPR15L;
                     UNQ1833"
                     /note="RLLV1833; colon-derived SUSD2 binding factor;
                     anti-microbial peptide with 57 amino acid residues;
                     antimicrobial peptide-57; protein GPR15L; secreted protein
                     C10orf99; antimicrobial peptide with 57 amino acid
                     residues; protein GPR15 ligand; protein GPR15LG"
                     /codon_start=1
                     /product="protein GPR15LG precursor"
                     /protein_id="NP_997256.1"
                     /db_xref="CCDS:CCDS7371.1"
                     /db_xref="GeneID:387695"
                     /db_xref="HGNC:HGNC:31428"
                     /db_xref="MIM:617775"
                     /translation="MRLLVLSSLLCILLLCFSIFSTEGKRRPAKAWSGRRTRLCCHRV
                     PSPNSTNLKGHHVRLCKPCKLEPEPRLWVVPGALPQV"
     exon            122..211
                     /gene="GPR15LG"
                     /gene_synonym="AP-57; AP57; C10orf99; CSBF; GPR15L;
                     UNQ1833"
                     /inference="alignment:Splign:2.1.0"
     exon            212..825
                     /gene="GPR15LG"
                     /gene_synonym="AP-57; AP57; C10orf99; CSBF; GPR15L;
                     UNQ1833"
                     /inference="alignment:Splign:2.1.0"
     regulatory      805..810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR15LG"
                     /gene_synonym="AP-57; AP57; C10orf99; CSBF; GPR15L;
                     UNQ1833"
                     /note="hexamer: AATAAA"
     polyA_site      825
                     /gene="GPR15LG"
                     /gene_synonym="AP-57; AP57; C10orf99; CSBF; GPR15L;
                     UNQ1833"
                     /note="major polyA site"
ORIGIN      
        1 acttctgcag cacagctccc ttcccaggac gtgaaaatct gccttctcac catgaggctt
       61 ctagtccttt ccagcctgct ctgtatcctg cttctctgct tctccatctt ctccacagaa
      121 gggaagaggc gtcctgccaa ggcctggtca ggcaggagaa ccaggctctg ctgccaccga
      181 gtccctagcc ccaactcaac aaacctgaaa ggacatcatg tgaggctctg taaaccatgc
      241 aagcttgagc cagagccccg cctttgggtg gtgcctgggg cactcccaca ggtgtagcac
      301 tcccaaagca agactccaga cagcggagaa cctcatgcct ggcacctgag gtacccagca
      361 gcctcctgtc tcccctttca gccttcacag cagtgagctg caatgttgga gggcttcatc
      421 tcgggctgca aggaccctgg gaaagttcca gaactccacg tccttgtctc aattgtgcca
      481 tcaactttca gagctatcat gagccaacct caccccacag ggcctcagtc gccaccatgt
      541 gggcctctcc agtgcaaacc accgagcatt ccaccatgac cggtcacagc tacaaatcca
      601 gagaccatca atcctgctag agtgcagggt ggcaagcacc caagggtggc tgaccaagac
      661 tgcagagtct cctccatctt caggtccatt cagcctcctg gcatttaact accagcatcc
      721 agtggtcccc aaggaatccc ttcctagcct cctgacatga gtctgctgga aagagcatcc
      781 aaacaaacaa gtaataaata aataaataaa ctcaatgcag acaca
//
