LOCUS       NM_153002               4573 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens G protein-coupled receptor 156 (GPR156), transcript
            variant 1, mRNA.
ACCESSION   NM_153002 XM_005247165
VERSION     NM_153002.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4573)
  AUTHORS   Ramzan,M., Bozan,N., Seyhan,S., Zafeer,M.F., Ayral,A., Duman,D.,
            Bademci,G. and Tekin,M.
  TITLE     Novel GPR156 variants confirm its role in moderate sensorineural
            hearing loss
  JOURNAL   Sci Rep 13 (1), 17010 (2023)
   PUBMED   37814107
  REMARK    GeneRIF: Novel GPR156 variants confirm its role in moderate
            sensorineural hearing loss.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4573)
  AUTHORS   Shimada,M., Miyagawa,T., Kawashima,M., Tanaka,S., Honda,Y.,
            Honda,M. and Tokunaga,K.
  TITLE     An approach based on a genome-wide association study reveals
            candidate loci for narcolepsy
  JOURNAL   Hum Genet 128 (4), 433-441 (2010)
   PUBMED   20677014
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 4573)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   4  (bases 1 to 4573)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   5  (bases 1 to 4573)
  AUTHORS   Calver,A.R., Michalovich,D., Testa,T.T., Robbins,M.J., Jaillard,C.,
            Hill,J., Szekeres,P.G., Charles,K.J., Jourdain,S., Holbrook,J.D.,
            Boyfield,I., Patel,N., Medhurst,A.D. and Pangalos,M.N.
  TITLE     Molecular cloning and characterisation of a novel GABAB-related
            G-protein coupled receptor
  JOURNAL   Brain Res Mol Brain Res 110 (2), 305-317 (2003)
   PUBMED   12591167
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC063952.15, AC092897.6, CD638213.1, AF488739.1, BX115336.1 and
            AI201720.1.
            
            On or before Jan 30, 2020 this sequence version replaced
            XM_005247165.3, NM_153002.2.
            
            Summary: G protein-coupled receptors (GPCRs) are a large
            superfamily of cell surface receptors characterized by 7 helical
            transmembrane domains, together with N-terminal extracellular and
            C-terminal intracellular domains.[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1102331.1,
                                           SRR14038196.2156255.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968832 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000464295.6/ ENSP00000417261.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AC063952.15        19538-19731         c
            195-377             AC092897.6         103842-104024       c
            378-574             CD638213.1         261-457             c
            575-2121            AF488739.1         1-1547
            2122-2350           AC092897.6         27247-27475         c
            2351-3019           AF488739.1         1777-2445
            3020-3120           BX115336.1         392-492
            3121-4078           AC092897.6         25519-26476         c
            4079-4570           AI201720.1         8-499               c
            4571-4573           AC092897.6         25024-25026         c
FEATURES             Location/Qualifiers
     source          1..4573
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.33"
     gene            1..4573
                     /gene="GPR156"
                     /gene_synonym="DFNB121; GABABL; PGR28"
                     /note="G protein-coupled receptor 156"
                     /db_xref="GeneID:165829"
                     /db_xref="HGNC:HGNC:20844"
                     /db_xref="MIM:610464"
     exon            1..194
                     /gene="GPR156"
                     /gene_synonym="DFNB121; GABABL; PGR28"
                     /inference="alignment:Splign:2.1.0"
     exon            195..670
                     /gene="GPR156"
                     /gene_synonym="DFNB121; GABABL; PGR28"
                     /inference="alignment:Splign:2.1.0"
     CDS             575..3019
                     /gene="GPR156"
                     /gene_synonym="DFNB121; GABABL; PGR28"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable G-protein coupled receptor 156; GABAB-related
                     G-protein coupled receptor; G protein-coupled receptor
                     PGR28"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 156 isoform
                     1"
                     /protein_id="NP_694547.2"
                     /db_xref="CCDS:CCDS2997.1"
                     /db_xref="GeneID:165829"
                     /db_xref="HGNC:HGNC:20844"
                     /db_xref="MIM:610464"
                     /translation="MEPEINCSELCDSFPGQELDRRPLHDLCKTTITSSHHSSKTISS
                     LSPVLLGIVWTFLSCGLLLILFFLAFTIHCRKNRIVKMSSPNLNIVTLLGSCLTYSSA
                     YLFGIQDVLVGSSMETLIQTRLSMLCIGTSLVFGPILGKSWRLYKVFTQRVPDKRVII
                     KDLQLLGLVAALLMADVILLMTWVLTDPIQCLQILSVSMTVTGKDVSCTSTSTHFCAS
                     RYSDVWIALIWGCKGLLLLYGAYLAGLTGHVSSPPVNQSLTIMVGVNLLVLAAGLLFV
                     VTRYLHSWPNLVFGLTSGGIFVCTTTINCFIFIPQLKQWKAFEEENQTIRRMAKYFST
                     PNKSFHTQYGEEENCHPRGEKSSMERLLTEKNAVIESLQEQVNNAKEKIVRLMSAECT
                     YDLPEGAAPPASSPNKDVQAVASVHTLAAAQGPSGHLSDFQNDPGMAARDSQCTSGPS
                     SYAQSLEGPGKDSSFSPGKEEKISDSKDFSDHLDSGCSQKPWTEQSLGPERGDQVPMN
                     PSQSLLPERGGSDPQRQRHLENSEEPPERRSRVSSVIREKLQEVLQDLGLGPEASLST
                     APSCHQQTWKNSAAFSPQKMPLSKELGFSPYMVRRRRAAQRARSHFPGSAPSSVGHRA
                     NRTVPGAHSRLHVQNGDSPSLAPQTTDSRVRRPSSRKPSLPSDPQDRPGTLEGSKQSQ
                     TEPEGARGSKAAFLRQPSGSGRAPSPAAPCLSKASPDLPEQWQLWPPVPSGCASLSSQ
                     HSYFDTESSSSDEFFCRCHRPYCEICFQSSSDSSDSGTSDTDPEPTGGLASWEKLWAR
                     SKPIVNFKDDLKPTLV"
     exon            671..807
                     /gene="GPR156"
                     /gene_synonym="DFNB121; GABABL; PGR28"
                     /inference="alignment:Splign:2.1.0"
     exon            808..937
                     /gene="GPR156"
                     /gene_synonym="DFNB121; GABABL; PGR28"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1048
                     /gene="GPR156"
                     /gene_synonym="DFNB121; GABABL; PGR28"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1174
                     /gene="GPR156"
                     /gene_synonym="DFNB121; GABABL; PGR28"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1270
                     /gene="GPR156"
                     /gene_synonym="DFNB121; GABABL; PGR28"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1507
                     /gene="GPR156"
                     /gene_synonym="DFNB121; GABABL; PGR28"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1666
                     /gene="GPR156"
                     /gene_synonym="DFNB121; GABABL; PGR28"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..4573
                     /gene="GPR156"
                     /gene_synonym="DFNB121; GABABL; PGR28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3921..3926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR156"
                     /gene_synonym="DFNB121; GABABL; PGR28"
                     /note="hexamer: AATAAA"
     polyA_site      3963
                     /gene="GPR156"
                     /gene_synonym="DFNB121; GABABL; PGR28"
     regulatory      4550..4555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR156"
                     /gene_synonym="DFNB121; GABABL; PGR28"
                     /note="hexamer: ATTAAA"
     polyA_site      4573
                     /gene="GPR156"
                     /gene_synonym="DFNB121; GABABL; PGR28"
                     /note="major polyA site"
ORIGIN      
        1 agaggcctgc gccgccgtcc cgccgcctcc acgccaggct cccggcgcgg cgatgggcgc
       61 gggcccctgt ctctgccccg gcccgcccct tcccgcccct tccagccccg cgaacgcgcg
      121 agacgccggg ggaccgtggg cgtcctgcac atagcagcgg gcttggcgct tctcggcggt
      181 ccgacgctga tgaggaacca gagtgagggt actcgaacag tgactgccat ctggtggtta
      241 accagaatca tcaccttgtg tagcctgatg gttactaaga tgtccactct tgactcacat
      301 ggcatgcact cgcagcaggg gaccagttga aggatgtctg actttggagg gtcaccagtt
      361 gaaggatgtc tgatgaagga gcctagcgaa ataacccttt gcttctacct gaatgggttg
      421 ttcactctgg attctgagcc tgcagccagc tccaaaatgg ggcctctgaa gaaaagattt
      481 gagttgctct tgtgtcttag tcaaagatct acatccctac cagtgggtaa ccaagactgt
      541 gaataagcac acaccaacag gggcatgtgg tgacatggag cctgaaataa actgctctga
      601 attgtgtgac agttttcctg gccaggagct ggatcggaga ccccttcatg atctctgcaa
      661 gacaacaatt acatcttccc accacagcag taagaccatc tcttcattat ctcctgtcct
      721 cttgggtatt gtttggactt ttctcagctg tggacttctg ctgatacttt tctttcttgc
      781 ctttacaatt cactgcagga agaacaggat tgtgaagatg tccagtccca atctgaacat
      841 tgtgacctta ctgggcagtt gtctcactta cagtagcgct tacctctttg ggattcagga
      901 tgttttagtg gggagctcaa tggaaactct cattcagaca agactgtcca tgctgtgcat
      961 tgggacctcc cttgtgtttg gccccattct gggaaagagc tggcgactct acaaggtgtt
     1021 tacccaaagg gtcccggaca agagagtgat tatcaaagac ctgcagttgc tggggttggt
     1081 ggcagccctg ttgatggctg atgtgatcct gctcatgacg tgggtgctga ctgatcccat
     1141 ccagtgcctc cagattctca gtgtcagtat gacggtgaca gggaaagacg tgtcctgcac
     1201 ttcgaccagc acccacttct gtgcttcccg gtattccgat gtttggattg ctctcatttg
     1261 gggatgcaag ggtctgctcc tgctgtatgg tgcctacctg gctggcctga ctggccatgt
     1321 cagctcccct cctgtgaatc agtccttaac catcatggtg ggggtcaacc tccttgtact
     1381 ggctgctggg ctgctttttg tagtcaccag atacttgcat tcctggccca acctggtctt
     1441 tggactcaca tctggaggga tctttgtttg tacaactaca atcaactgct tcatcttcat
     1501 tccccagctg aagcaatgga aggcatttga agaggaaaac caaacaatca gacgcatggc
     1561 caaatatttc agcactccca acaaaagctt ccatacccag tatggtgagg aggagaactg
     1621 ccacccgagg ggagagaaaa gctccatgga gaggctcctc acagaaaaaa atgctgtgat
     1681 tgaaagcctg caggaacaag taaacaacgc caaagagaag attgtgaggc tgatgtcagc
     1741 tgagtgcacc tatgacctcc cagagggggc tgccccacct gcctcttccc cgaacaagga
     1801 cgtccaggcg gtagcctcgg tccacaccct ggcagctgct caggggcctt cgggtcacct
     1861 ctctgacttt cagaatgatc ctggcatggc tgcccgggat tcccagtgca cttcagggcc
     1921 ctcctcatat gcacaaagcc ttgaggggcc tgggaaggac tccagcttct ccccagggaa
     1981 ggaggagaag atatctgact caaaagactt ttctgatcat ttagactcag gttgtagcca
     2041 gaagccatgg actgagcaaa gcctgggtcc agaaagagga gaccaagtcc ccatgaaccc
     2101 cagccagagt ctcctaccag aaagaggcgg ctcagatccc cagagacaga ggcatctgga
     2161 gaactcagag gagcccccag agcggcggtc acgggttagt tcagtaatca gggagaaact
     2221 tcaggaggtc ttacaagatc tgggcctggg ccctgaggct tccctctcca ccgccccctc
     2281 ttgtcatcag caaacctgga agaacagtgc tgccttcagc ccccaaaaga tgcccctctc
     2341 caaggagctc ggctttagcc cttacatggt gaggagaagg cgggcagctc agcgggcccg
     2401 ctcacacttt cctggctctg caccctcatc tgtggggcat cgggcaaaca ggactgttcc
     2461 tggggcacac agcaggctac atgtgcagaa tggggacagc cccagcctgg ccccacaaac
     2521 tactgattcc agagtacgaa gaccttcttc caggaagcct tcactacctt cagatcctca
     2581 agacagacca ggtaccctgg agggcagcaa acaaagccag acagagcccg agggggctag
     2641 agggagcaaa gcagcctttc ttcgccagcc ttctggttct ggccgggccc caagtcctgc
     2701 tgccccatgc ctctccaaag cctcacctga cttgcctgaa cagtggcagc tgtggccccc
     2761 agtgccctca ggctgtgcct ccctgtcttc tcaacacagc tattttgata ctgagtccag
     2821 cagctcagat gagttcttct gccgctgcca ccggccctac tgtgaaatct gcttccagag
     2881 ctcttctgac tctagtgaca gtggcacatc agacactgac cctgagccta ctggggggct
     2941 ggcttcctgg gaaaagctgt gggcccgctc caagcctatt gtgaacttca aagatgactt
     3001 gaaacccacg ctggtgtgaa aagcaacaga gctggtctag acacagaggt cagtccaaga
     3061 gaagctgtac caaggcccac aggagaagag ccaatttctg gtctttgggg aacagattag
     3121 tgccctgcat ttgaccagcc cataccatgt ttcagctagg ctcactgtgt tactttgagt
     3181 acttcttgat ctataaaaag agaggcattg cctgtcctgt tactacctcg cagccttact
     3241 ataaaagact ccagttgagt gactatgaaa gacactgact ccttggataa aaggtgctga
     3301 atgaacacat aggattttct gtccaggtca gcctacattc tgtaaaactc ttaatatatt
     3361 cagatggatg gctgaatgga cagacagatg gagagatgca tgggaaattt ctgtagaact
     3421 tgaggtgtgg actgtgaccc atcaaactgg ccttttggtg gacagaccta ccaggaagat
     3481 aagtctccta catccttggg cctcccactc ctggaaggca gtggttttat ttctgctgaa
     3541 tgttgtgaac agcacctccc tagattccag cttctggcca gacccagctc agagccaccc
     3601 ctacaccact atttcttgat ggtgtctttc caccattatg gcactttacc ctcctctctg
     3661 agacagatct ccatgcgccc gcaggcttcc cagatctctc ccctgggatc ggatgtacct
     3721 gaggtcctga ctgtccccac tgtccccttg tcctgtggct catcctcgat tcacccactg
     3781 atgcagtttt gtactgcggg gaggcacaca ccagcaattt ctgttggggt atgggagaac
     3841 ctgttggtca agagtgcttt tggttccatt ggggttacat gactaccaac agacacataa
     3901 acctggaagc caaatggaga aataaaaagg aagacacgag ggacacgaaa acaggaaaga
     3961 aaacaggatt tgaatatttc acttgagtcc agcatagtac ttggcaatat catatttttg
     4021 tgattccttt tgataaccct gtgaagtaga cactttcatt tttacagaca aggattatga
     4081 ggcttagaga aatgaggtag tttcccgcaa catcacactg ctggacagag atgtacacac
     4141 agctcctggg actcaagtag gtgggttttc ccagggacac atggcttcat gtgttcttct
     4201 gggaatggca ggtgacgctt ggcagacgag acaacaaagc aaggctcatg taagaaagct
     4261 gggatgtgct cccctatagt ccagaataat agacctgggt cctcacctca ggaaacgggc
     4321 ctccacttcc tcactgccaa aggccacact ggcacctccc aagggagctg gggagctggt
     4381 gaaggatgag tgcgaggaac tcagccacca ccagagccac agggagagca cacctgggtc
     4441 cactgtgctt attgctgagc tggctgtcat gtccaggctg tcccctgccc cgagtcctgt
     4501 gtatacatct gtgggtgtgc acatgtttgc atgaaggaat tcaggcctta ttaaatattc
     4561 tcagaggggg gca
//
